Eye and vision (London, England)最新文献

{"title":"Ultrathin Descemet stripping automated endothelial keratoplasty versus Descemet membrane endothelial keratoplasty: a fellow-eye comparison.","authors":"Rita Mencucci,&nbsp;Eleonora Favuzza,&nbsp;Elisa Marziali,&nbsp;Michela Cennamo,&nbsp;Cosimo Mazzotta,&nbsp;Ersilia Lucenteforte,&nbsp;Gianni Virgili,&nbsp;Stanislao Rizzo","doi":"10.1186/s40662-020-00191-6","DOIUrl":"https://doi.org/10.1186/s40662-020-00191-6","url":null,"abstract":"<p><strong>Background: </strong>To compare the visual outcome and patients' satisfaction after ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) performed on fellow eyes of the same patients.</p><p><strong>Methods: </strong>In this retrospective study, the records of 18 pseudophakic patients affected by Fuchs endothelial dystrophy who underwent DMEK in one eye and UT-DSAEK in the fellow eye were reviewed. Best corrected visual acuity (BCVA), corneal pachymetry, keratometry, corneal aberrations, photopic and mesopic contrast sensitivity, and endothelial cell counts measured 12 months after surgery in either eye were analyzed and compared. The results of a satisfaction questionnaire were also reviewed.</p><p><strong>Results: </strong>Twelve months after surgery, BCVA was not significantly different in UT-DSAEK and DMEK eyes (0.10 ± 0.04 and 0.07 ± 0.07 logMAR, respectively); at both 4- and 6 mm optical zones total and posterior corneal higher order aberrations (HOAs), posterior astigmatism and total coma were significantly lower after DMEK; BCVA in both groups was significantly correlated mainly with anterior corneal aberrations; contrast sensitivity was higher after DMEK especially in mesopic conditions and at medium spatial frequencies; the endothelial cell density was similar, although slightly higher in the UT-DSAEK group (<i>p</i> = 0.10). The satisfaction questionnaire showed that although patients were highly satisfied from both procedures, more than half of them preferred DMEK and reported a more comfortable and quicker postoperative recovery.</p><p><strong>Conclusions: </strong>DMEK and UT-DSAEK showed no evidence of difference in terms of postoperative BCVA, although DMEK had a better performance in terms of contrast sensitivity, posterior corneal aberrations and overall patient satisfaction.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"25"},"PeriodicalIF":4.2,"publicationDate":"2020-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00191-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37920449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current review of Excimer laser Trabeculostomy.","authors":"Georges M Durr,&nbsp;Marc Töteberg-Harms,&nbsp;Richard Lewis,&nbsp;Antonio Fea,&nbsp;Paola Marolo,&nbsp;Iqbal Ike K Ahmed","doi":"10.1186/s40662-020-00190-7","DOIUrl":"https://doi.org/10.1186/s40662-020-00190-7","url":null,"abstract":"<p><strong>Background: </strong>Excimer laser trabeculostomy (ELT) is a microinvasive glaucoma surgery (MIGS) that creates multiple laser channels through the trabecular meshwork using a cold laser system, which minimizes tissue fibrosis and aids in bypassing the main area of resistance to aqueous outflow. The purpose of this review is to evaluate the current body of evidence surrounding ELT in terms of efficacy and review the safety profile of the procedure.</p><p><strong>Main text: </strong>Studies screened had to show clear inclusion and exclusion criteria as well as well-defined outcome measures. PubMed, MEDLINE, EMBASE and the Cochrane Controlled Trial Database were searched. Preferred Reporting Items of Systematic Reviews (PRISMA) guidelines were used to assess for study quality and for any bias. Sixty-four articles were initially identified with 18 meeting preliminary screening criteria. Ultimately, 8 studies met inclusion criteria and 2 additional non-referenced publications were also included: 1 randomized control trial, 4 prospective case series and 5 retrospective studies. Overall studies showed moderate intraocular pressure (IOP) lowering of between 20% and 40% from baseline without medication washout and mostly a decrease in glaucoma medications with few complications.</p><p><strong>Conclusion: </strong>Current literature shows a significant IOP-lowering effect of ELT with a favorable safety-profile in standalone cases or combined with cataract surgery. Limitations to these studies are the lack of controls and washout IOP. Overall, ELT is an attractive MIGS option that does not require any residual device remaining in the angle.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"24"},"PeriodicalIF":4.2,"publicationDate":"2020-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00190-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37920448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of intraocular lens power calculation formulae after laser refractive surgery in myopic eyes: a meta-analysis.","authors":"Hongyu Li,&nbsp;Li Nan,&nbsp;Jun Li,&nbsp;Hui Song","doi":"10.1186/s40662-020-00188-1","DOIUrl":"https://doi.org/10.1186/s40662-020-00188-1","url":null,"abstract":"<p><strong>Background: </strong>To compare the accuracy of intraocular lens power calculation formulae after laser refractive surgery in myopic eyes.</p><p><strong>Methods: </strong>We searched the databases on PubMed, EMBASE, Web of Science and the Cochrane library to select relevant studies published between Jan 1st, 2009 and Aug 11th, 2019. Primary outcomes were the percentages of refractive prediction error within ±0.5 D and ±1.0 D.</p><p><strong>Results: </strong>The final meta-analysis included 16 studies using seven common methods (ASCRS average, Barrett True-K no history, Double-K SRK/T, Haigis-L, OCT formula, Shammas-PL, and Wang-Koch-Maloney). ASCRS average yielded significantly higher percentage of refractive prediction error within ±0.5 D than Haigis-L, Shammas-PL and Wang-Koch-Maloney (<i>P</i> = 0.009, 0.01, 0.008, respectively). Barrett True-K no history also yielded significantly higher percentage of refractive prediction error within ±0.5 D than Shammas-PL and Wang-Koch-Maloney (<i>P</i> = 0.01, <i>P</i> < 0.0001, respectively), and a similar result was found when comparing OCT formula with Haigis-L and Shammas-PL (<i>P</i> = 0.03, <i>P</i> = 0.01, respectively).</p><p><strong>Conclusion: </strong>The ASCRS average or Barrett True-K no history should be used to calculate the intraocular lens power in eyes after myopic laser refractive surgery. The OCT formula if available, can also be a good alternative choice.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"37"},"PeriodicalIF":4.2,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00188-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38145889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 in the ocular surface of COVID-19 patients.","authors":"Hua-Tao Xie,&nbsp;Shi-Yun Jiang,&nbsp;Kang-Kang Xu,&nbsp;Xin Liu,&nbsp;Bing Xu,&nbsp;Lin Wang,&nbsp;Ming-Chang Zhang","doi":"10.1186/s40662-020-00189-0","DOIUrl":"https://doi.org/10.1186/s40662-020-00189-0","url":null,"abstract":"<p><p>The 2019 novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, while the routes of transmission of this virus are still controversial. We enrolled 33 patients, without any ocular manifestation, with their ocular surface swabs collected for virus detection. RNA was detected strong positive in samples of both eyes from two patients. Therefore, SARS-CoV-2 may exist in the normal ocular surface of COVID-19 patients, suggesting that this virus might be spread through conjunctival contact.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"23"},"PeriodicalIF":4.2,"publicationDate":"2020-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00189-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37889843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of machine learning in ophthalmic imaging modalities.","authors":"Yan Tong,&nbsp;Wei Lu,&nbsp;Yue Yu,&nbsp;Yin Shen","doi":"10.1186/s40662-020-00183-6","DOIUrl":"https://doi.org/10.1186/s40662-020-00183-6","url":null,"abstract":"<p><p>In clinical ophthalmology, a variety of image-related diagnostic techniques have begun to offer unprecedented insights into eye diseases based on morphological datasets with millions of data points. Artificial intelligence (AI), inspired by the human multilayered neuronal system, has shown astonishing success within some visual and auditory recognition tasks. In these tasks, AI can analyze digital data in a comprehensive, rapid and non-invasive manner. Bioinformatics has become a focus particularly in the field of medical imaging, where it is driven by enhanced computing power and cloud storage, as well as utilization of novel algorithms and generation of data in massive quantities. Machine learning (ML) is an important branch in the field of AI. The overall potential of ML to automatically pinpoint, identify and grade pathological features in ocular diseases will empower ophthalmologists to provide high-quality diagnosis and facilitate personalized health care in the near future. This review offers perspectives on the origin, development, and applications of ML technology, particularly regarding its applications in ophthalmic imaging modalities.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"22"},"PeriodicalIF":4.2,"publicationDate":"2020-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00183-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37861387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial neural network to guide intracorneal ring segments implantation for keratoconus treatment: a pilot study.","authors":"Chiara Fariselli,&nbsp;Alfredo Vega-Estrada,&nbsp;Francisco Arnalich-Montiel,&nbsp;Jorge L Alio","doi":"10.1186/s40662-020-00184-5","DOIUrl":"https://doi.org/10.1186/s40662-020-00184-5","url":null,"abstract":"<p><strong>Background: </strong>To analyze the clinical results of an artificial neural network (ANN) that has been processed in order to improve the predictability of intracorneal ring segments (ICRS) implantation in keratoconus.</p><p><strong>Methods: </strong>This retrospective, comparative, nonrandomized, pilot, clinical study included a cohort of 20 keratoconic eyes implanted with intracorneal ring segments KeraRing (Mediphacos, Belo Horizonte, Brazil) using the ANN (ANN group) and 20 keratoconic eyes implanted with KeraRing using the manufacturer's nomograms (nomogram group). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA) (visual acuity is expressed in decimal value and in LogMAR value in brackets), manifest refraction, corneal topography, tomography, aberrometry, pachymetry and volume analysis (Sirius System. CSO, Firenze, Italy) were performed during the preoperative visit; and the two groups, ANN group and nomogram group, did not differ significantly preoperatively in all of the parameters evaluated. These preoperative values were compared with the results obtained at the third-month visit. Mann-Whitney test and Wilcoxon test were used for the statistical analyses.</p><p><strong>Results: </strong>The spherical equivalent and the keratometric values decreased significantly in both groups. The CDVA improved from 0.60 ± 0.23 (0.22 LogMAR) pre-operatively to 0.73 ± 0.21 (0.14 LogMAR) post-operatively in the ANN group (<i>p</i> < 0.005), and from 0.54 ± 0.19 (0.27 LogMAR) pre-operatively to 0.62 ± 0.19 (0.21 LogMAR) post-operatively in the nomogram group (<i>p</i> < 0.01), with statistically significant difference between the two groups (<i>p</i> < 0.05), being better in the ANN group. Coma-like aberrations decreased significantly in the ANN group, while in the nomogram group they did not change significantly, but no statistically significant difference was found between the two groups.</p><p><strong>Conclusions: </strong>ANN to guide ICRS provides an increase in the visual acuity, reduction in the spherical equivalent and improvement in the optical quality of keratoconus patients. ANN gives better results when compared with the manufacturer's nomograms in terms of better corrected vision and reduction of the coma-like aberrations. The constant inclusion of new cases will make the predictability of ANN increasingly better as the software finetunes its learning.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"20"},"PeriodicalIF":4.2,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00184-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37836149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decentration and tilt of plate-haptic multifocal intraocular lenses in myopic eyes.","authors":"Jiaqi Meng,&nbsp;Wenwen He,&nbsp;Xianfang Rong,&nbsp;Ao Miao,&nbsp;Yi Lu,&nbsp;Xiangjia Zhu","doi":"10.1186/s40662-020-00186-3","DOIUrl":"https://doi.org/10.1186/s40662-020-00186-3","url":null,"abstract":"<p><strong>Background: </strong>To investigate the decentration and tilt of plate-haptic multifocal intraocular lenses (MfIOLs) in myopic eyes.</p><p><strong>Methods: </strong>Myopic (axial length [AXL] > 24.5 mm) and non-myopic (21.0 mm < AXL ≤ 24.5 mm) cataract eyes were enrolled in this prospective study and randomly assigned to receive implantation of Zeiss AT LISA tri 839MP lenses (Group A) or Tecnis ZMB00 lenses (Group B). In total, 122 eyes of 122 patients were available for analysis. Decentration and tilt of MfIOLs, high-order aberrations (HOAs), and modulation transfer functions (MTFs) were evaluated using the OPD-Scan III aberrometer 3 months postoperatively. Subjective symptoms were assessed with a Quality of Vision questionnaire.</p><p><strong>Results: </strong>Near and distance visual acuities, tilt and horizontal decentration did not differ between the two groups, postoperatively. However, myopic eyes of Group B showed greater vertical decentration than those of Group A (- 0.17 ± 0.14 mm vs. -0.03 ± 0.09 mm, respectively), particularly when the MfIOLs were placed horizontally or obliquely. Overall decentration of myopic eyes was greater in Group B than in Group A (0.41 ± 0.15 mm vs. 0.16 ± 0.10 mm, respectively). In Group B, AXL was negatively correlated with vertical decentration and positively correlated with overall decentration. No such correlations were found in Group A. Intraocular total HOAs, coma, trefoil and spherical aberrations were lower in Group A than in Group B for a 6.0 mm pupil among myopic eyes. Generally, Group A had better MTFs and fewer subjective symptoms than Group B among myopic eyes.</p><p><strong>Conclusions: </strong>Plate-haptic design of MfIOLs may be a suggested option for myopic cataract eyes due to the less inferior decentration and better visual quality postoperatively.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"17"},"PeriodicalIF":4.2,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00186-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37827402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel ophthalmic viscosurgical device-free phakic intraocular lens implantation makes myopic surgery safer.","authors":"An-Peng Pan,&nbsp;Li-Jin Wen,&nbsp;Xu Shao,&nbsp;Kai-Jing Zhou,&nbsp;Qin-Mei Wang,&nbsp;Jia Qu,&nbsp;A-Yong Yu","doi":"10.1186/s40662-020-00185-4","DOIUrl":"https://doi.org/10.1186/s40662-020-00185-4","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the efficacy and safety of a novel ophthalmic viscosurgical device-free (OVD-free) method for posterior chamber phakic intraocular lens (PIOL) implantation in myopic eyes.</p><p><strong>Methods: </strong>In this retrospective cohort study, the medical records of myopic eyes that underwent PIOL (Implantable Collamer Lens, ICL) implantation for myopia correction at the Eye Hospital of Wenzhou Medical University between May 2015 and March 2017 were reviewed. A total of 49 eyes with complete data that met follow up requirements (2 h, 1 day, 1 week, 3 months postoperatively) were recruited. Based on the surgical techniques used, the eyes were divided into the OVD-free method group and the standard method group. The clinical data, including intraocular pressure (IOP), corrected distance visual acuity (CDVA) and spherical equivalent (SE), at each follow-up were collected for comparison. Endothelial cell loss and complications were also investigated.</p><p><strong>Results: </strong>Twenty-one eyes received the standard method, and 28 eyes received the OVD-free method. A rise in IOP > 22 mmHg at 2 h was noted in 14 eyes (66.7%) in the standard group and none (0%) in the OVD-free group (<i>p</i> < 0.001). The rise in IOP from baseline was significantly higher at 2 h in the standard group (10.5 ± 5.2 mmHg vs. 2.2 ± 3.3 mmHg, difference: 8.3, 95% CI 5.8 to 10.8; <i>p</i> < 0.001). There was a significant difference in the time course of LogMAR CDVA changes between the two groups (<i>p</i> = 0.047). The LogMAR CDVA was significantly better in the OVD-free method group compared to the standard group at 1 day (- 0.076, 95% CI - 0.134 to - 0.018; <i>p</i> = 0.012), 1 week (- 0.071, 95% CI - 0.135 to - 0.007; <i>p</i> = 0.03), but not at 3 months (- 0.046, 95% CI - 0.107 to 0.015; <i>p</i> = 0.134). There was no significant difference in the time course of SE changes between the two groups (<i>p</i> = 0.471; <i>p</i> = 0.705). In the OVD-free group, mean endothelial cell loss was 4.6% at 3 months (2522 ± 281 vs. 2407 ± 226 cells/mm², difference: -115, 95% CI - 295 to 65; <i>p</i> = 0.187). No complications were reported in both groups except for the early IOP elevation in the standard group during the observation period.</p><p><strong>Conclusions: </strong>The OVD-free method is safe and efficient for ICL implantation. It can be a safer method of ICL implantation compared to the standard method in that it completely eliminates ophthalmic viscoelastic devices-related complications without causing additional complications.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"18"},"PeriodicalIF":4.2,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00185-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37827403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced macular inner retinal thickness and microvascular density in the early stage of patients with dysthyroid optic neuropathy.","authors":"Yufei Wu,&nbsp;Yunhai Tu,&nbsp;Chaoming Wu,&nbsp;Lulu Bao,&nbsp;Jianhua Wang,&nbsp;Fan Lu,&nbsp;Meixiao Shen,&nbsp;Qi Chen","doi":"10.1186/s40662-020-00180-9","DOIUrl":"https://doi.org/10.1186/s40662-020-00180-9","url":null,"abstract":"<p><strong>Background: </strong>The goal was to investigate changes of the inner intra-retinal layer thicknesses and retinal capillary density (RCD) around the macula in thyroid-associated ophthalmopathy (TAO) patients with or without dysthyroid optic neuropathy (DON).</p><p><strong>Methods: </strong>Forty-four TAO patients including 23 non-DON and 21 DON patients, and 38 healthy participants were enrolled. Spectral domain optical coherence tomography equipped with Angiovue was used to obtain three-dimensional retinal thickness maps and microvascular images of the superficial and deep retinal capillary layers (SRCL and DRCL, respectively) around the macula. Quantitative analyses were performed using a custom automated algorithm.</p><p><strong>Results: </strong>The thicknesses of the nerve fiber layer, ganglion cell layer + inner plexiform layer, and ganglion cell complex (GCC) as well as the RCDs in the SRCL and DRCL in both TAO groups were significantly decreased compared to the controls. In addition, the RCDs in DRCL of the DON group were further decreased compared to the non-DON group. GCC thickness in both TAO groups was positively correlated with the RCDs of the SRCL in the total annular zone and in the temporal, inferior, and nasal sectors. The areas under the receiver operating characteristic curves for the GCC thickness combined with the RCD were generally larger than those of each single indicator.</p><p><strong>Conclusions: </strong>Thinned inner intra-retinal layers and decreased RCDs in the TAO patients without DON revealed that morphological changes might precede visual dysfunction. The composite index of the retinal structure and the microvascular density might be valuable in the diagnosing, monitoring, and intervention for early DON.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"16"},"PeriodicalIF":4.2,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00180-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37740933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo confocal microscopy: qualitative investigation of the conjunctival and corneal surface in open angle glaucomatous patients undergoing the XEN-Gel implant, trabeculectomy or medical therapy.","authors":"Stefano Baiocchi,&nbsp;Cosimo Mazzotta,&nbsp;Arianna Sgheri,&nbsp;Alessandro Di Maggio,&nbsp;Simone Alex Bagaglia,&nbsp;Matteo Posarelli,&nbsp;Leonardo Ciompi,&nbsp;Alessandro Meduri,&nbsp;Gian Marco Tosi","doi":"10.1186/s40662-020-00181-8","DOIUrl":"https://doi.org/10.1186/s40662-020-00181-8","url":null,"abstract":"<p><strong>Purpose: </strong>Assessing the quality of the ocular surface by in vivo scanning laser confocal microscopy (IVCM) in primary open angle glaucoma (POAG) patients treated by Xen 45 Gel Stent, medical therapy and trabeculectomy.</p><p><strong>Methods: </strong>Retrospective, single-center, single-masked, comparative study including 60 eyes of 30 patients (mean age 61.16 ± 10 years) affected by POAG. Eyes were divided into 3 groups: Group 1 eyes underwent the Xen 45 Gel Stent procedure, Group 2 eyes were under medical therapy, Group 3 eyes were surgically treated by trabeculectomy. All patients underwent HRT II IVCM analysis of cornea, limbus, conjunctiva, sub-tenionian space and sclera.</p><p><strong>Results: </strong>The Xen 45 Gel stent, if properly positioned in the sub-conjunctival space preserves goblet cells and limits ocular surface inflammation. Regular corneal epithelial cells with micro-cysts, and normo-reflective sub-epithelial nerve plexus are documented by IVCM. In sub Tenon's implants an alternative lamellar intra-scleral filtration is detectable. Combined surgical procedures show a noticeable number of inflammatory cells with rare micro-cysts. Post-trabeculectomy inflammatory reaction is more evident than Xen 45 Gel Stent associated surgical procedures, but less than medical therapy where a conspicuous presence of Langerhans cells, peri-neural infiltrates, marked loss of goblet cells and fibrosis is visible.</p><p><strong>Conclusion: </strong>Ocular surface inflammation was more notable in topical therapy than after trabeculectomy, which itself causes more inflammation than XEN Gel stents.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"15"},"PeriodicalIF":4.2,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00181-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37741516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}