Laurent Zikos, Antonio Pinti, Stéphane Ranfaing, Arnaud Kwiatkowski, Cécile Donze, Bruno Lenne, Béatrice Degraeve
{"title":"Temporal perception, attentional bias, and moral reasoning in multiple sclerosis: a moderated mediation analysis.","authors":"Laurent Zikos, Antonio Pinti, Stéphane Ranfaing, Arnaud Kwiatkowski, Cécile Donze, Bruno Lenne, Béatrice Degraeve","doi":"10.1093/arclin/acag041","DOIUrl":"10.1093/arclin/acag041","url":null,"abstract":"<p><strong>Objective: </strong>This study examines the relationships between future time perspective, attentional biases, and moral judgment in people with multiple sclerosis (pwMS) compared to healthy controls, testing a preregistered moderated mediation model derived from Socioemotional Selectivity Theory.</p><p><strong>Method: </strong>Ninety participants (45 relapsing-remitting pwMS, EDSS ≤4; 45 matched controls) completed neuropsychological assessments, a moral judgment task based on 20 validated dilemmas, two measures of future time perspective (the Future Time Perspective Scale and an implicit word-completion task), and a dot-probe task measuring attentional biases toward positive and negative stimuli. Logistic mixed-effects models and moderated mediation analyses were conducted.</p><p><strong>Results: </strong>pwMS exhibited a significantly lower probability of utilitarian responses compared to controls (OR = 0.42, 95% CI [0.27, 0.67], p < .001), consistent with a stronger deontological preference. They also displayed a more limited future time perspective on both the explicit scale (p = .038) and the implicit task (p = .049), as well as reduced attentional engagement with negative stimuli (p = .024). In this sample, the associations between future time perspective, attentional biases, and moral judgment did not follow the hypothesized SST-derived pathway.</p><p><strong>Conclusions: </strong>The findings highlight novel affective-motivational differences in pwMS, including a reduced future time perspective and diminished attention to negative cues. These results encourage further exploration of the cognitive-affective processes shaping moral reasoning in chronic neurological conditions.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 5","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148153178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karl S Grewal, Caitlin A Earle, Mark Buller, Candace Marsters
{"title":"Serial neuropsychological assessment of multiple meningioma complicated by psychosis following ventriculoperitoneal shunt revision: a case report.","authors":"Karl S Grewal, Caitlin A Earle, Mark Buller, Candace Marsters","doi":"10.1093/arclin/acag054","DOIUrl":"10.1093/arclin/acag054","url":null,"abstract":"<p><strong>Objective: </strong>Meningiomas are a common primary central nervous system tumor, with patients often found to have cognitive problems both pre- and post-operatively. In addition, meningiomas can have psychiatric manifestations including associated psychotic disturbances. To our knowledge, however, this is the first report of psychosis emerging following ventriculoperitoneal (VP) shunt revision in menigioma.</p><p><strong>Method: </strong>The current study presents Ms. M, a right-handed female in her early 40s, with a university education, who was diagnosed with multiple meningioma in 2014. She developed psychotic symptoms following left VP shunt revision in 2024. Ms. M was assessed by neuropsychology 5 times over a period of 10 years and entered the care of neuropsychiatry around the time of her most recent assessment. Case description integrates both neuropsychological and neuropsychiatric perspectives. To assist in quantifying neuropsychological change over time, reliable change methods were used alongside clinical inspection.</p><p><strong>Results: </strong>Ms. M's neuropsychological profile showed multidomain impairment over many years. Memory was her most striking across several assessments. Following psychosis onset, she reported increased difficulty with daily functioning and managing her cognitive issues, consistent with executive decrements diminishing compensatory abilities.</p><p><strong>Conclusions: </strong>The current study contributes to the growing body of literature examining neuropsychological deficits in meningioma through the addition of longitudinal data at the case level, critical given that long-term cognitive deficits can be detrimental to quality of life over time. In addition, description of post-revision psychosis constitutes a previously undescribed post-surgical development. The integration of the neuropsychiatric perspective also underscores the importance of interdisciplinary care, particularly in atypical presentations.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 5","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emilie Poulsen, Birna Ásbjörnsdóttir, Lena E Hjermind, Jørgen E Nielsen, Asmus Vogel
{"title":"Emotion regulation across disease stages in Huntington's disease gene expansion carriers.","authors":"Emilie Poulsen, Birna Ásbjörnsdóttir, Lena E Hjermind, Jørgen E Nielsen, Asmus Vogel","doi":"10.1093/arclin/acag052","DOIUrl":"https://doi.org/10.1093/arclin/acag052","url":null,"abstract":"<p><strong>Objective: </strong>Emotion regulation difficulties are increasingly recognized in Huntington's disease (HD) yet remain understudied with inconsistent findings. While motor symptoms are prominent, patients and caregivers often describe emotional and behavioral changes as distressing. This study assessed perceived emotion regulation abilities and strategies across disease stages, with a focus on anger and irritability.</p><p><strong>Methods: </strong>We conducted a cross-sectional study including individuals with premanifest HD (n = 49), manifest HD (n = 41), and gene-negative family members previously at risk (n = 34). Participants completed the Difficulties in Emotion Regulation Scale (DERS) and the State-Trait Anger Expression Inventory (STAXI-2). Group differences were analyzed using one-way ANOVA or Kruskal-Wallis tests. Reference values for total DERS and STAXI-2 scores were derived from gene-negative family members, and percentile estimates were calculated.</p><p><strong>Results: </strong>Total scores on the DERS and STAXI-2 did not differ significantly between groups. However, both premanifest and manifest HD gene expansion carriers (HDGECs) scored significantly higher on the DERS Impulse Control subscale, indicating greater self-reported difficulties. One fourth of HDGECs scored within the 5th percentile on emotion regulation, and one third within the 10th percentile.</p><p><strong>Conclusions: </strong>Total emotion regulation scores did not differ significantly between HDGECs and family controls. However, both premanifest and manifest HDGECs reported significantly greater difficulties with impulse control, alongside marked variability in overall emotion regulation. These findings highlight selective impulse control difficulties and a subset of individuals whose self-reported emotion regulation difficulties may be obscured by group-level analyses, underscoring the need for further research to clarify their clinical relevance.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 5","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148475557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kechuang Zhang, Mengbi Yang, Min Xi, Shubin Si, Weixia Zhang
{"title":"Distinguishing depression from healthy controls using brain network features: A fNIRS and machine learning approach.","authors":"Kechuang Zhang, Mengbi Yang, Min Xi, Shubin Si, Weixia Zhang","doi":"10.1093/arclin/acag038","DOIUrl":"10.1093/arclin/acag038","url":null,"abstract":"<p><strong>Objective: </strong>This exploratory study aimed to investigate potential brain network biomarkers of depression by examining local connectivity features using functional near-infrared spectroscopy (fNIRS).</p><p><strong>Method: </strong>31 depressed students and 32 health controls were recruited. Data was collected from both groups during resting-state and verbal fluency task (VFT).</p><p><strong>Results: </strong>In the frontopolar region, depressed participants exhibited increased network connectivity during the resting state, while decreased connectivity was observed during the VFT. The AUC values for all classifiers exceeded 0.7, with the random forest model showing the highest AUC value and exhibiting strong specificity and sensitivity in VFT.</p><p><strong>Conclusions: </strong>The identified local brain network features with group differences suggest potential biomarkers for distinguishing depressed students, providing valuable insights for understanding depression.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 5","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148166748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dhruvi M Mehta, Jennifer L Thompson Kamar, Troy A Webber, Romeo Penheiro, Natalie C Ridgely, David Andrés González, Steven Paul Woods
{"title":"A preliminary examination of the psychometrics and cognitive correlates of an abbreviated version of the verbal naming test administered via telephone.","authors":"Dhruvi M Mehta, Jennifer L Thompson Kamar, Troy A Webber, Romeo Penheiro, Natalie C Ridgely, David Andrés González, Steven Paul Woods","doi":"10.1093/arclin/acag039","DOIUrl":"10.1093/arclin/acag039","url":null,"abstract":"<p><strong>Objective: </strong>Confrontational naming is an important part of many neuropsychological evaluations. Yet, data on the feasibility and psychometric properties of telephone-based confrontational verbal naming tests (VNTs) are quite limited. The current study conducted a preliminary, exploratory examination of the psychometrics and correlates of an abbreviated version of the 50-item VNT administered via telephone.</p><p><strong>Method: </strong>Participants were 220 healthy adults, including 110 younger adults (ages 18-35) and 110 middle-aged to older adults (ages 50-85). Participants completed a 15-item version of the VNT as part of a broader telephone-based cognitive battery.</p><p><strong>Results: </strong>Confirmatory factor analysis suggested support for a 12-item model of the VNT (VNT-T12) with acceptable fit. VNT-T12 scores were negatively skewed and demonstrated good internal consistency. A quantile regression predicting VNT-T12 from domain-level cognitive variables showed that executive functions (e.g., verbal fluency) and fund of verbal knowledge were significantly and positively associated with VNT-T12 scores at most percentile ranges. The VNT-T12 scores were also significantly associated with race/ethnicity and English as a second language at higher quantiles of performance. Demographically-adjusted coefficients and an associated calculator are provided as a normative resource.</p><p><strong>Conclusions: </strong>Findings provide mixed and preliminary support for the feasibility, psychometrics, and validity of a 12-item VNT administered via telephone. Future research on the psychometrics and validity of the VNT-T12 is warranted in samples with lower levels of education and in clinical populations.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148020380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Montefiore Einstein Robust Geriatric Normative Project (MERGER-NP): standardized regression-based formulas and multivariate base rates for evaluating cognitive change.","authors":"Bryan M Freilich, Roee Holtzer","doi":"10.1093/arclin/acag034","DOIUrl":"10.1093/arclin/acag034","url":null,"abstract":"<p><strong>Objective: </strong>This study extends the Montefiore Einstein Robust Geriatric (MERGER) norms by developing and validating standardized regression-based (SRB) change formulas for a co-normed neuropsychological battery in a robust sample of older adults. We also examine their clinical utility for differentiating mild cognitive impairment (MCI) and dementia and provide multivariate base rates of decline.</p><p><strong>Methods: </strong>Standardized regression-based equations were derived from a subsample of MERGER participants (n = 320) using backward regression to predict Time 2 scores from Time 1 performance and relevant demographic factors. Equations were validated in an independent subset (n = 100) and applied to 63 individuals with MCI and 32 with dementia who completed at least two study visits but were excluded from normative analyses. Clinical utility was examined by comparing predicted and observed performance across diagnostic groups. Categorical and multivariate base-rate analyses were used to establish clinically meaningful thresholds.</p><p><strong>Results: </strong>Baseline performance was the strongest predictor of follow-up scores, with demographic factors adding measure-specific variance. SRB equations performed well in the validation sample. Exploratory clinical validation analyses indicated that decline was uncommon in cognitively unimpaired (CU) participants but more frequent in MCI and dementia, particularly on memory and executive tasks. Multivariate analyses showed that decline on ≥3 measures was rare in CU participants but observed in nearly half of participants with MCI and most individuals with dementia.</p><p><strong>Conclusions: </strong>MERGER SRB change formulas offer a practical, individualized method for tracking cognitive change in older adults. Incorporating multivariate base rates of decline further improves differentiation between normal aging, MCI, and dementia, supporting more accurate longitudinal interpretation and clinical decision-making.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13182569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Megan S Barker, Arlene Mejia, Esther Zhiwei Zheng, Sandra Rizer, Scott M Reid, Udell Holmes Iii, Masood Manoochehri, Edward D Huey, Stephanie Cosentino
{"title":"Cueing to facilitate naming in MAPT-associated behavioral variant frontotemporal dementia: a preliminary report.","authors":"Megan S Barker, Arlene Mejia, Esther Zhiwei Zheng, Sandra Rizer, Scott M Reid, Udell Holmes Iii, Masood Manoochehri, Edward D Huey, Stephanie Cosentino","doi":"10.1093/arclin/acag032","DOIUrl":"10.1093/arclin/acag032","url":null,"abstract":"<p><strong>Objective: </strong>Naming deficits have been documented in carriers of pathogenic MAPT mutations with behavioral variant frontotemporal dementia (bvFTD). We aimed to examine the benefits of phonemic cueing to facilitate naming in MAPT-bvFTD.</p><p><strong>Method: </strong>MAPT mutation carriers with incipient bvFTD (N = 6) completed a test of confrontation naming during their very mild disease stage, and again ~2 years later. The proportion of correct responses with and without phonemic cueing was calculated. MAPT-bvFTD naming performance was compared to Alzheimer's disease (AD) (N = 6) and semantic variant primary progressive aphasia (svPPA) (N = 14).</p><p><strong>Results: </strong>Phonemic cueing facilitated naming in the MAPT-bvFTD and Alzheimer's groups at the mildest disease stage, and the utility of cues declined over time for both groups. Cueing provided minimal benefit in svPPA, even at the mildest disease stage.</p><p><strong>Conclusions: </strong>Phonemic cueing confers some benefit in MAPT-bvFTD at the very early stages of disease, similar to AD, but in contrast to svPPA.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147937069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Color Trails Test: regression-based norms for Russian-speakers.","authors":"Zarui A Melikyan, Jason R Bock, Anna V Agranovich","doi":"10.1093/arclin/acag035","DOIUrl":"10.1093/arclin/acag035","url":null,"abstract":"<p><strong>Objective: </strong>The Color Trails Test (CTT) is widely used across cultures and necessitates culture-relevant norms due to cultural differences in the test performance. However, no norms exist for Russian-speakers. The study aims to: (a) establish regression-based CTT norms for Russian-speaking adults, and (b) compare CTT T-scores for Russian-speakers derived using regression-based norms (RBNs) with the manual norms.</p><p><strong>Method: </strong>Community-dwelling healthy Russian-speaking adults were administered the CTT using standard procedures. Multiple linear regression analysis was applied to establish RBNs. The participant data were used to calculate two sets of T-scores, using: (a) RBNs and the leave-one-out analysis, and (b) CTT manual norms. These two sets of T-scores were compared by t-test.</p><p><strong>Results: </strong>The mean age of the 196 participants was 37 years [range: 18-86]; 108 (55%) were women, and 102 (52%) had at least university education. CTT completion time was associated with age and education, but not sex. CTT1 T-scores derived from regression-based were higher than manual norms (M difference = 2.39, SD difference = 5.51, p < .001). There was no difference between CTT2 T-scores. Regression-based norms identified fewer participants as performing below average (T ≤36): 7% vs. 18% for CTT1 and 7% vs. 10% for CTT2, p < .001.</p><p><strong>Conclusions: </strong>The proposed RBNs, developed from a representative sample of Russian-speaking adults, will enhance assessment accuracy and improve diagnostic outcomes.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preliminary examination of symptom validity in veterans using the Rivermead post-concussion symptoms questionnaire.","authors":"Summer N Rolin, Jeremy J Davis","doi":"10.1093/arclin/acag037","DOIUrl":"10.1093/arclin/acag037","url":null,"abstract":"<p><strong>Objective: </strong>The Rivermead Post Concussion Symptoms Questionnaire (RPSQ) is commonly used post-concussive symptom measure. Simulation research has explored it as a symptom validity (SV) indicator. This project examined its use in a clinical sample using archival data from the Federal Interagency TBI Research Informatics System.</p><p><strong>Methods: </strong>The sample (N = 133; mean age = 39.6; 96% male) included veterans with (n = 91) and without (n = 42) history of mild TBI. SV status was determined via MMPI-2-RF overreporting scales (Fr, Fpr, Fs, FBSr, and RBS). We created three SV outcome variables: possible (one or more scales in the possible overreporting range), probable (two or more scales in the possible overreporting range), and definite overreporting (one or more scales, ≥100 T). Discrimination was evaluated using area under the receiver operating characteristic curve (AUC) with RPSQ total score predicting criterion SV status.</p><p><strong>Results: </strong>RPSQ and MMPI-2-RF scores were not significantly different by mild TBI history. RPSQ total scores showed excellent discrimination in all three models (AUC = 0.84-0.85). RPSQ total score cutoffs that demonstrated acceptable specificity (≥ 90%) varied by criterion SV: possible (RPSQ ≥32), probable (RPSQ ≥35), and definite (RPSQ ≥37) overreporting.</p><p><strong>Conclusions: </strong>Findings provide preliminary support for total score cutoffs on the RPSQ as SV indicators. Further research is warranted to cross-validate these cutoffs and extend findings to other populations.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148020399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nerea Carrión, Luis Heredia, Jordi Peña-Casanova, Margarita Torrente
{"title":"Clinical applicability of the BT2-NPS for assessing neuropsychiatric symptoms across the Alzheimer's disease continuum.","authors":"Nerea Carrión, Luis Heredia, Jordi Peña-Casanova, Margarita Torrente","doi":"10.1093/arclin/acag029","DOIUrl":"10.1093/arclin/acag029","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the clinical applicability of the Barcelona-2 Test Neuropsychiatric Symptomatology Scale (BT2-NPS) in a Spanish population comprising healthy controls (HC), individuals with single-domain amnestic mild cognitive impairment (aMCI), and individuals with Alzheimer's disease (AD). Specifically, the study sought to characterize the distinct trajectories of neuropsychiatric symptoms (Behavioral and Psychological Symptoms of Dementia [BPSD]) across the cognitive continuum and evaluate the scale's diagnostic utility.</p><p><strong>Method: </strong>A total of 37 HC, 31 aMCI, and 76 AD participants, aged 60-85 years, were assessed using the BT2-NPS. Quade's test (controlling for age and education) was used to examine the differences in BT2-NPS scores across diagnostic groups and Global Deterioration Scale (GDS) stages. Symptom progression was analyzed descriptively to identify patterns, and partial convergent validity was explored using the Goldberg Anxiety and Depression Scale (GADS).</p><p><strong>Results: </strong>The BT2-NPS Total score significantly differentiated between diagnostic groups and GDS stages. Three distinct symptom patterns emerged: a \"Severity-Dependent\" Pattern (e.g., apathy, insight loss) increasing linearly with severity; an \"Inverted-U Pattern\" (e.g., anxiety, depression) peaking in prodromal stages before declining; and a \"Late-Emergence Pattern\" (e.g., hallucinations) appearing only in advanced stages. No gender differences were observed. Correlations with self-reported GADS were weak.</p><p><strong>Conclusion: </strong>Findings support the BT2-NPS as a clinically meaningful tool for staging BPSD in older adults. Crucially, the study demonstrates that affective symptoms may decline in later stages not due to clinical remission, but due to the progression of apathy and loss of insight. The scale captures this complex behavioral landscape, contributing to more personalized and compassionate care approaches.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}