Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists最新文献

{"title":"Rethinking apathy assessment in neurological disorders: conceptual and clinical challenges.","authors":"David de Noreña-Martínez, Marcos Ríos-Lago, Daniel Adrover-Roig, Ignacio Sánchez-Cubillo","doi":"10.1093/arclin/acag030","DOIUrl":"10.1093/arclin/acag030","url":null,"abstract":"<p><strong>Objective: </strong>Apathy is a prevalent and clinically consequential neuropsychiatric syndrome across neurological disorders, yet its assessment remains conceptually and methodologically challenging. This narrative review synthesizes current knowledge on the measurement of apathy, with particular emphasis on apathy-specific instruments validated in neurological populations and on the theoretical and practical factors that constrain their clinical utility.</p><p><strong>Method: </strong>Literature was identified through PubMed searches, citation tracking, and review of influential consensus statements and neurocognitive models. Instruments were critically examined with regard to their conceptual foundations, psychometric properties, and ecological validity in clinical neuropsychological contexts.</p><p><strong>Results: </strong>Despite broad agreement that apathy is a multidimensional construct, many widely used instruments retain predominantly unidimensional structures or show limited alignment with contemporary models, contributing to suboptimal discriminant validity-particularly in relation to depression-and inconsistent agreement across self-, informant-, and clinician-based assessments. Additional sources of bias include contextual and sensorimotor constraints, such as institutional environments and motor disability, which may inflate behavioral ratings and obscure primary motivational deficits.</p><p><strong>Conclusions: </strong>Recent advances, including dimensional and context-sensitive approaches, represent promising developments; however, improving diagnostic precision and clinical decision-making requires integrating standardized rating scales with complementary paradigms targeting core motivational processes, such as effort-based decision-making, reward anticipation, and emotional responsiveness. Greater conceptual consensus, clearer construct boundaries, improved cross-cultural adaptation, and more consistent reporting practices are essential to enhance comparability across studies and to support clinical neuropsychologists involved in differential diagnosis, longitudinal monitoring, and treatment planning in neurological populations.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147949797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The variable neuropsychological profile of Diets-Jongmans syndrome: a case series of four family members.","authors":"Sara Donaldson, Brian Long, Brittany Wolff, Cathryn McKenzie, Melanie Clark, Bree Mitchelson, Timothy S Milnes, Chloe Marshall-Cary, Daniel Clarke, Cherie Strikwerda-Brown","doi":"10.1093/arclin/acag040","DOIUrl":"10.1093/arclin/acag040","url":null,"abstract":"<p><strong>Objective: </strong>Diets-Jongmans syndrome (DIJOS) is a genetic, autosomal dominant condition caused by variation in the KDM3B gene on chromosome 5q31. Intellectual developmental disorder (IDD) is typically described as a key feature of the condition. This case series aimed to characterize the broader neuropsychological profile of DIJOS.</p><p><strong>Methods: </strong>Four family members with genetically confirmed DIJOS underwent comprehensive neuropsychological assessment. Additional information was obtained through behavioral observations, review of available medical and educational records, and clinical interviews.</p><p><strong>Results: </strong>All individuals presented with distinct cognitive profiles. Scores on intelligence measures for Cases 1-3 (aged 19, 21, and 46) ranged from Below Average to Average, though were predominantly within normative limits. Cases 1-3 displayed intact processing speed and verbal comprehension, weaknesses in working memory and aspects of executive functioning, and variable performance in perceptual reasoning and memory. By contrast, Case 4's (aged 15) data largely ranged from Exceptionally Low to Below Average, consistent with previously diagnosed IDD. All cases presented with learning difficulties, mental health symptoms, and features of autism spectrum disorder and attention-deficit hyperactivity disorder.</p><p><strong>Conclusion: </strong>The cognitive profile of DIJOS is more variable than suggested by existing literature, with only 1 of 4 family members meeting DSM-5-TR criteria for IDD. Recognizing the clinical heterogeneity of DIJOS may aid in earlier detection and provision of more individualized supports. Future longitudinal studies will be important for examining the role of genetic as opposed to environmental contributors to clinical presentation and characterizing symptom trajectory across the lifespan.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148020468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecological momentary assessment suggests greater sensitivity to clinical change in a compensatory strategy pilot clinical trial.","authors":"Catherine Luna, Reanne Cunningham Chilton, Diane J Cook, Maureen Schmitter-Edgecombe","doi":"10.1093/arclin/acag033","DOIUrl":"10.1093/arclin/acag033","url":null,"abstract":"<p><strong>Objective: </strong>Ecological momentary assessment (EMA) is increasingly used in psychological clinical trials to capture outcomes. This brief report compared EMA measures of everyday functioning and cognition with traditional measures administered pre- and post-intervention in a pilot clinical trial with older adults (OAs) experiencing cognitive concerns.</p><p><strong>Method: </strong>Sixty-two OAs enrolled in a remote trial; 39 met EMA compliance at baseline, and 26 both pre- and post-intervention. EMA included smartwatch-delivered Likert questions and a cognitive task collected 4x daily for 1 week; traditional measures included questionnaires and neuropsychological tests.</p><p><strong>Results: </strong>EMA mean scores correlated significantly with corresponding traditional measures at baseline, supporting convergent validity. Limited associations between EMA-derived variability and standardized measures suggest EMA captures unique, dynamic aspects of functioning. EMA measures showed small-to-moderate effect sizes (Hedges' gs > 0.22) for improved mean scores and reduced variability; traditional measures did not.</p><p><strong>Conclusions: </strong>EMA may offer unique insights about functional stability beyond traditional measures.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A psychometric comparison of automated neuropsychological assessment metrics with laptop and tablet administration.","authors":"Jacques Arrieux, Brian Ivins, M Victoria Ingram, Stephanie Sloley","doi":"10.1093/arclin/acag031","DOIUrl":"10.1093/arclin/acag031","url":null,"abstract":"<p><strong>Objective: </strong>Determine whether Automated Neuropsychological Assessment Metrics administered with laptop and tablet platforms produces comparable scores. The study quantified the direction and magnitude of differences using a clinically relevant analytical approach.</p><p><strong>Method: </strong>Randomized, within-subjects, counterbalanced, repeated-measures study with 302 active-duty service members. Participants completed the 10-subtest battery in two consecutive sessions (Tablet-Laptop, Laptop-Tablet, Tablet-Tablet, and Laptop-Laptop). Analyses included between-group comparisons, within-subject change, and Reliable Change Index base rates.</p><p><strong>Results: </strong>Laptop scores were significantly higher than tablet scores on 9 of 10 subtests, with effect sizes from d = 0.11 to 1.15. Within-subjects analyses indicated a consistent pattern of performance declines in the Laptop-Tablet Group and improvements in the Tablet-Laptop Group. Reliable Change Index base rates showed that 73% of participants in the Laptop-Tablet Group reliably declined on ≥2 subtests versus 10% in the Tablet-Laptop Group. After correcting tablet controller timing artifacts, effects on fast reaction time (RT) tasks were substantially attenuated, while effects on learning-, memory-, and accuracy-based subtests remained significant with large effect sizes. The Laptop-Tablet Group decline rate decreased from 73% to 57% but remained 4 times the same-platform reference rate.</p><p><strong>Conclusion: </strong>Tablet and laptop scores may not be interchangeable. Hardware timing corrections attenuated effects on fast RT subtests but did not reduce effects on accuracy-based measures, indicating factors beyond RT measurement error contribute to cross-platform differences. Interpreting tablet-based administration with laptop-based normative data or baselines could misclassify examinees. Until validated tablet-specific interpretive criteria are established, cross-platform comparisons should be avoided.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The experience of behavioral observation in neuropsychological assessment: a conventional content analysis.","authors":"Lodovica Bicego, Eric B Vogel, Kathleen E Kendra","doi":"10.1093/arclin/acag019","DOIUrl":"10.1093/arclin/acag019","url":null,"abstract":"<p><strong>Objective: </strong>Behavioral observation in neuropsychology involves the systematic recording of an individual's behaviors during the assessment process by a qualified observer. The role of behavioral observation is to identify how patients function in their environment, as well as how they approach tasks during the assessment process. Observations identify cognitive patterns that may not be revealed through testing. There is a gap in the literature regarding how practitioners routinely conceptualize and use such observations. This qualitative study aimed to explore clinical neuropsychologists' experiences related to behavioral observation.</p><p><strong>Method: </strong>Researchers recruited 10 U.S.-based licensed clinical neuropsychologists with experience using behavioral observation in neuropsychological assessments for dementia. Participation involved semi-structured interviews. The data were analyzed using conventional qualitative content analysis.</p><p><strong>Results: </strong>Findings indicate that neuropsychologists rely on behavioral observations to capture patterns that standardized tests might overlook. Data analysis yielded 6 categories, each with 2-3 subcategories. The categories were: (1) complexity of behavioral observation requires individualized experiential training approaches; (2) behavioral observation should be continuous throughout all patient contacts; (3) behavioral observations contextualize findings; (4) testing can reveal deficits not apparent from observation; (5) challenges related to dependence on the judgment of trained observers; and (6) formalizing behavioral observation involves challenges, risks, and potential benefits.</p><p><strong>Conclusions: </strong>The findings from this study highlight the contribution of behavioral observation to enhancing ecological validity in neuropsychological assessments, the vital role of individualized mentorship in training observational skills, and the challenges that make standardization difficult.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linguistic Barriers in U.S. Neuropsychological Assessment: A State-of-the-Art Review.","authors":"Ashby Martin","doi":"10.1093/arclin/acaf091","DOIUrl":"10.1093/arclin/acaf091","url":null,"abstract":"<p><p>In the USA, 67.86 million people speak a language other than English at home. Many of these homes speak both English and a non-English language, with varying degrees of English fluency. A sizable 25.70 million people (8% of the U.S. population) report speaking, reading, or writing English \"less than well\" or \"not at all.\" These individuals are referred to as limited English proficiency (LEP) speakers. Such persons often need speech interpreters in health care and human service settings. When a speech interpreter is utilized to assess a LEP patient, the typical dyadic clinician-patient interaction shifts to a triadic clinician-interpreter-patient interaction. Although triadic interpreter-mediated interactions are commonplace in neuropsychological assessment when LEP patients are being evaluated, few guidelines exist for these interactions. To illustrate the current state of interpreter-mediated neuropsychological assessment in the USA, literature on the following themes have been reviewed: (1) existing language accessibility options; (2) the history of speech interpretation, clinically; (3) key distinctions in the profile of U.S. patients; (4) what linguistics barriers exist, have been addressed, and have arisen from the implementation of language accommodations in clinical practice; and (5) what recommendations have been established for the neuropsychological assessment of LEP patients. By detailing these five areas in the context of local, state, and national-level variability, this review identifies some of the systemic roots of linguistic barriers in the USA. Updated recommendation guidelines are outlined to promote efficacious and equitable neuropsychological assessment of LEP patients for implementation in clinical practice.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Neighborhood Disadvantage, Brain Healthcare Access, and Neuropsychological Disparities in Underserved Older Adults.","authors":"Caroline Nester Rooney, Sarah Prieto, Madeline Rahilly, Eliana Boxerman, Laura E Korthauer","doi":"10.1093/arclin/acag020","DOIUrl":"10.1093/arclin/acag020","url":null,"abstract":"<p><strong>Objective: </strong>To understand community-based brain health disparities, we investigated demographic and neuropsychological differences by neighborhood disadvantage in older patients presenting for neuropsychological evaluation.</p><p><strong>Method: </strong>This retrospective chart review calculated patients' (N = 529, Mage = 73.5 ± 8.0, Meducation = 13.5 ± 3.2, %female = 61.8, %White = 86.8, %non-Hispanic = 95.3) state-level Area Deprivation Index (ADI) to compare patients from the 20% most disadvantaged (n = 61) to the 80% least disadvantaged areas (n = 468).</p><p><strong>Results: </strong>Patients from disadvantaged areas were less likely to access care (11.5% of sample), had lower educational attainment (p < .001, Cohen's d = 0.60), and were more likely to require a medical interpreter (p < .001, Cramer's V = 0.17). They had lower premorbid baselines (p < .001, Cohen's d = 0.52), had lower performances on tests of processing speed (p = .039, Cohen's d = .30), attention (p < .001, Cohen's d = 0.48), and executive functioning (p = .039, Cohen's d = 0.34), and endorsed more depressive symptoms (p = .026, Cohen's d = 0.33).</p><p><strong>Conclusions: </strong>Findings highlight the need for targeted outreach, culturally responsive care, and community-based brain health initiatives to foster cognitive resilience and equitable care access.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of multilevel neuropsychological group intervention (EXAT) in children with executive functioning and attention deficits: a comparative study with typically developing controls.","authors":"Elina Vierikko, Fiia Takio, Kati Rantanen","doi":"10.1093/arclin/acag028","DOIUrl":"10.1093/arclin/acag028","url":null,"abstract":"<p><strong>Objective: </strong>This study examined the effects of the multilevel EXAT (Rehabilitation of Executive Function and Attention) intervention on executive function (EF) in Finnish children with EF and attention deficits, compared to typically developing (TD) controls who received no EF intervention.</p><p><strong>Method: </strong>The study included 59 children aged 7-12 years with EF deficits and 78 age-matched non-intervention TD controls. The EXAT intervention lasted 9 months and comprised weekly sessions for children, monthly parent sessions, and 2-3 school consultations. Parent-rated EF intervention effects were assessed using the Behavior Rating Inventory of Executive Function (BRIEF). Baseline and post-assessment BRIEF T-scores were compared between groups using t-tests, reliable change indices were calculated for individual EF changes, and linear regression analyses were used to explore associations between background variables and EF changes.</p><p><strong>Results: </strong>Children in the EXAT group showed significant improvements across all BRIEF indices and subscales, with small to moderate effect sizes. Individual-level analysis indicated that 22%-41% of participants achieved reliable EF improvements, mainly those with severe initial deficits. The control group exhibited minor, clinically insignificant changes.</p><p><strong>Conclusion: </strong>EXAT positively impacted EF, especially in behavior regulation and metacognition among children with substantial deficits. However, about one-quarter continued to experience EF challenges after the intervention. Findings highlight the importance of individualized assessment and intervention planning within group settings to address diverse EF profiles. Tailoring support to each child's strengths and weaknesses is essential for optimizing outcomes. Further research with larger, diverse samples and multi-informant assessments is needed to confirm results and examine long-term effects.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Goal-Oriented Attentional Self-Regulation Training Improves Executive Function and Complex Attention in Veterans With mTBI-Randomized-Control Study.","authors":"Rachel Santiago, Maria Kryza-Lacombe, Jillian Tessier, Anna Hwang, Brian A Maruyama, Sky Raptentsetsang, Gary Abrams, Pratik Mukherjee, Tatjana Novakovic-Agopian","doi":"10.1093/arclin/acaf087","DOIUrl":"10.1093/arclin/acaf087","url":null,"abstract":"<p><strong>Objective: </strong>Mild traumatic brain injury (mTBI) is the most common brain injury. Some individuals experience ongoing cognitive, physical, and emotional complaints post-mTBI. Goal-Oriented Attentional Self-Regulation (GOALS) is a cognitive rehabilitation training that incorporates applied mindfulness-based attention regulation strategies into its protocol and targets executive control difficulties. This study expands previous work that demonstrated improved executive function, functional outcomes, and emotional functioning among veterans with acquired brain injury and examines GOALS training effects in veterans with a history of mTBI, specifically.</p><p><strong>Method: </strong>Veterans with a history of mTBI at least 6 months post-injury (N = 32) were randomly assigned to GOALS (n = 18) or an intensity-matched active control group (Brain Health Education [BHE] training; n = 14). Evaluator blinded assessments at baseline and post-intervention included neuropsychological and complex functional task performance, and self-report measures of emotional functioning/regulation.</p><p><strong>Results: </strong>GOALS, but not BHE, showed significant improvements on a composite measure of overall Attention/Executive Function composite, and on measures of Working Memory, Sustained Attention, Inhibition, and complex functional ability. There was also a significant decrease in post-traumatic stress disorder symptoms.</p><p><strong>Conclusions: </strong>GOALS training improved performance on neuropsychological and ecologically valid functional measures of complex attention and executive function, as well as emotional functioning in veterans with mTBI. Improving executive functions may also improve functioning in other domains such as emotional regulation and functional performance, making it particularly relevant for veterans with a history of mTBI and comorbid psychiatric symptoms.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The MINT Sprint 2.0: a Picture Naming Test for Detection of Naming Impairments in ΜCI Due or Not to AD, Greek Version.","authors":"Aristi Alopoudi, Despina Moraitou, Thomas Tegos, Magda Tsolaki","doi":"10.1093/arclin/acaf106","DOIUrl":"10.1093/arclin/acaf106","url":null,"abstract":"<p><strong>Objective: </strong>Naming impairments are among the earliest cognitive deficits in Alzheimer's disease (ad), particularly affecting semantic memory and lexical retrieval. This study evaluated the diagnostic utility of the Greek adaptation of the MINT Sprint 2.0, a culturally tailored picture-naming test, in identifying naming deficits in preclinical and early ad.</p><p><strong>Method: </strong>A total of 170 Greek-speaking participants were classified into three diagnostic groups: (1) MCI biomarker positive (preclinical ad), (2) MCI biomarker negative, and (3) cognitively intact (CI) (biomarker negative). Participants completed the MINT Sprint 2.0, comprising naming accuracy (MINTFIRSTPASS) and response latency (MINTFIRSTPASSTIME). Multivariate and univariate ANOVAs were used to assess group differences.</p><p><strong>Results: </strong>Diagnosis significantly influenced performance across both measures, accounting for 26.5% of variance in accuracy and 52.7% in latency (p < .01). MANOVA revealed a large multivariate effect (Pillai's Trace V = 0.674, p < .01). Post hoc tests confirmed that all groups differed significantly on both variables, with biomarker-positive individuals performing worse and slower than other groups. MINT Sprint 2.0 elicited significantly different performance across diagnostic groups, supporting its potential utility in detecting early AD-related changes and offering enhanced sensitivity to early lexical retrieval deficits and response speed. Strong correlations between MINT Sprint and 15-BNT scores supported convergent validity.</p><p><strong>Conclusion: </strong>The Greek MINT Sprint 2.0 is a valid and sensitive tool for detecting early ad-related naming impairments. Its cultural relevance and inclusion of response time make it superior to traditional naming tests, offering potential as a primary screening measure in Greek-speaking populations.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}