Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists最新文献

{"title":"The social behavioral phenotype of Kabuki syndrome.","authors":"Rowena Ng, Philip Fanara, Lauren Meier, Jacqueline Harris","doi":"10.1093/arclin/acag069","DOIUrl":"10.1093/arclin/acag069","url":null,"abstract":"<p><strong>Objective: </strong>This study describes the social-communication and behavioral profile associated with Kabuki syndrome (KS), including exploratory comparisons between individuals with a pathogenic variant in KMT2D (KS1) versus KDM6A (KS2).</p><p><strong>Method: </strong>Thirty-five caregivers of children/adults with KS (25F, Mage = 13.45, SD = 7.60) completed the Social Responsiveness Scale 2nd Edition (SRS-2), Colorado Learning Difficulties Questionnaire, and/or Strengths and Difficulties Questionnaire. Descriptive analyses and non-parametric tests were conducted to examine behavioral trends in the entire cohort and to explore differences in social behaviors and autism characteristics between those with KS1 versus KS2.</p><p><strong>Results: </strong>About a third of the sample have a prior diagnosis of autism spectrum disorder, with rates more elevated in KS2 versus KS1 (67% vs. 23%). In the full cohort, 72% fell in borderline/clinical ranges for Peer Problems, while only 3% yielded atypical scores for Prosocial Behaviors. Those with KS1 were rated to show most challenges in restricted/repetitive behaviors (RRBs), which fell in the moderately severe range, compared to other social domains (social communication, social awareness, social motivation). In contrast, social motivation was the sole area rated within normal limits.</p><p><strong>Conclusion: </strong>Those with KS2 showed greater difficulties across all social behavior/cognitive domains than KS1 counterparts, albeit both presented with similar severity in RRB and prosocial behaviors. Prominent features of the KS social behavioral phenotype include pronounced difficulties with inflexible behaviors and restricted interests juxtaposed with strong prosocial tendencies. KS2 may confer increased risk for autism-related characteristics, underscoring the need for more systematic investigations.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148922358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring memories of everyday life: a validation study of L-RECAP.","authors":"Maud Billet, Lisa Dussard, Charline Colson, Marie Geurten, Sylvie Willems","doi":"10.1093/arclin/acag072","DOIUrl":"https://doi.org/10.1093/arclin/acag072","url":null,"abstract":"<p><strong>Objective: </strong>In six studies of healthy individuals, we examined the feasibility, validity, and reliability of L-RECAP, a new ecological measure of memory functioning based on the sampling of everyday experiences.</p><p><strong>Method: </strong>Participants received five notifications per day for 7 days via a mobile app, asking about their ongoing activities. Two days after the last notification, the accuracy, richness, specificity, and phenomenology of their memory for five of these activities were assessed with verbal recall. L-RECAP's feasibility and acceptability were examined through the notifications response rate and explicit feedback (n = 135; S1). Correlations with traditional neuropsychological assessments (n = 79; S2) and participants' memories of a previous session (n = 20; S3) were used to document convergent and divergent validity. Predictive validity was assessed using self-report memory questionnaires (n = 135; S4) and discriminant validity was tested by comparing individuals who were satisfied vs. dissatisfied with their memory functioning (n = 56; S5). Finally, test-retest reliability over 6 weeks was examined (n = 30; S6).</p><p><strong>Results: </strong>Participants reported good acceptability for L-RECAP. It correlated moderately with standard memory tests (r from 0.29 to 0.50) and self-report memory measures (r from 0.19 to 0.38). The specificity score correlated strongly with recall of a previous session (r = 0.54). The accuracy score distinguished between satisfied from dissatisfied participants (d = 0.34) and the task showed satisfactory test-retest reliability.</p><p><strong>Conclusions: </strong>Although further validation in clinical populations is needed, L-RECAP appears to be a feasible, reliable, and ecologically valid measure of everyday memory functioning.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Battery length as a moderator of classification accuracy for cognitive impairment: a Monte Carlo simulation using actuarial and Bayesian methods.","authors":"Alexandra Davis","doi":"10.1093/arclin/acag078","DOIUrl":"https://doi.org/10.1093/arclin/acag078","url":null,"abstract":"<p><strong>Objective: </strong>This Monte Carlo simulation study examined whether neuropsychological test battery length impacts cognitive impairment classification accuracy using actuarial and Bayesian interpretive frameworks. Three hypotheses were tested: (a) longer batteries yield higher false-positive rates due to cumulative probability effects; (b) longer batteries show superior classification accuracy; and (c) abbreviated batteries have higher false-negative rates.</p><p><strong>Method: </strong>Four simulated batteries of varying length, domain coverage, and redundancy were applied to 10,000 virtual patient profiles. Sensitivity, specificity, predictive values, classification accuracy, and Bayesian post-test probabilities were evaluated across multiple prevalence conditions alongside base rates of low scores and resource demands.</p><p><strong>Results: </strong>Hypothesis 1 was supported: longer batteries produced higher base rates of low scores in healthy controls. However, applying actuarial and Bayesian frameworks prevented this from translating into inflated false-positive rates. Hypotheses 2 and 3 were not supported: abbreviated batteries maintained classification accuracy, discrimination (AUC), false-negative rates, and predictive values comparable to longer batteries. Adding tests yielded diminishing returns, reaching a psychometric plateau at approximately eight tests.</p><p><strong>Conclusions: </strong>Battery length does not meaningfully alter binary impairment classification when actuarial and Bayesian rules are applied. Brief core batteries maximize efficiency for global detection, while comprehensive batteries remain best suited for detailed cognitive profiling and differential diagnosis.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and cognitive performance in post-9/11 veterans accounting for trauma-related clinical burden.","authors":"Hura Behforuzi, Emily J Van Etten, Aubrey Knoff, William P Milberg, David H Salat, Catherine B Fortier","doi":"10.1093/arclin/acag080","DOIUrl":"https://doi.org/10.1093/arclin/acag080","url":null,"abstract":"<p><strong>Background: </strong>Post-9/11 Veterans experience a disproportionate burden of mental health conditions. Major depressive disorder (MDD) frequently co-occurs with trauma-related conditions, contributing to clinical heterogeneity. Clarifying how categorical and dimensional representations of depression relate to cognition while accounting for clinical comorbidity may improve understanding of depression and inform targeted interventions in Veterans.</p><p><strong>Objective: </strong>To assess how categorical and dimensional measures of depression relate to cognitive performance and clinical characteristics in post-9/11 Veterans.</p><p><strong>Method: </strong>This cross-sectional analysis included 970 U.S. post-9/11 Veterans (ages 18-67) from the Translational Research Center for TBI and Stress Disorders (TRACTS), a multisite longitudinal cohort. Depression was classified via structured clinical interviews as No, Lifetime, or Current Depression. Dimensional measures incorporated recent self-reported, current, and lifetime depression symptom severity. Age-standardized cognitive composites (Global, Memory, Attention, Processing Speed, Executive) were examined in multivariable models adjusting for demographics, estimated premorbid IQ, and clinical and trauma-related symptom burden.</p><p><strong>Results: </strong>Clinical and trauma-related burden increased progressively from No to Lifetime to Current Depression. Veterans with depression showed no evidence of reduced cognition compared with the non-depressed group. Modest depression-related differences were observed for processing speed, with slower performance in the Current Depression group. Military blast burden significantly moderated the association between depression and processing speed, with slower processing speed in Current Depression most evident at greater military blast burden.</p><p><strong>Conclusion: </strong>These findings suggest that depression is not characterized by broad cognitive impairment in post-9/11 Veterans but that the combination of military blast exposure and depression may subtly affect processing speed.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and specificity of the attention, memory, and frontal abilities screening test to identify objective cognitive impairment in older adults: a pilot study.","authors":"Javier Oltra-Cucarella, Beatriz Bonete-López, Clara Iñesta, Daniel Guillén-Torrano, Oier Ripoll, Carla Okéghene Obodo-Arroyo, Rubén Pérez-Elvira, David Wöbbeking, Miriam Sánchez-Sansegundo, Mario Tomé, Bryan Freilich, Inmaculada Abellán-Miralles, Natalia Pérez-Carmona, Marina Ruiz-Piñero, Esther Sitges-Maciá","doi":"10.1093/arclin/acag075","DOIUrl":"https://doi.org/10.1093/arclin/acag075","url":null,"abstract":"<p><strong>Objective: </strong>The use of screening tests is part of the neuropsychological assessment. Recently, the Attention, Memory and Frontal Abilities Screening Test (AMFAST) has been developed and translated to Spanish. However, its diagnostic properties have never been compared to other tests used to identify cognitive impairment. The goal of this pilot study is to compare the diagnostic properties of the AMFAST with those of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD)-Neuropsychological Battery (CERAD-NB) in their ability to distinguish pre-defined clinical groups in a heterogeneous clinical sample of Spanish older adults.</p><p><strong>Methods: </strong>Ninety-four participants (66 cognitively unimpaired - CU; 28 cognitively impaired - CI) aged 50 or older were assessed with the AMFAST and the CERAD-NB, and differences between groups were analyzed with beta-binomial models. The diagnostic properties of both tests were calculated with adjusted-ROC curves, and areas under the curve (AUCs) were compared.</p><p><strong>Results: </strong>The CU group outperformed the CI group both on the AMFAST (b = -1.67, std. error (SE) = 0.19, p < .001) and on the CERAD-NB (b = -1.02, SE = 0.12, p < .001). The adjusted-ROC curves showed no differences in sensitivity and specificity compared to the model with test scores only, neither for the AMFAST (z = -1.03, p = .305) nor for the CERAD (z = -1.16, p = .246), with no statistically significant differences in the AUC (AMFAST = 0.954, CERAD = 0.954, p = .989).</p><p><strong>Conclusions: </strong>Our preliminary results based on a small, diagnostically heterogeneous sample suggest that the AMFAST and the CERAD-NB did not differ significantly to identify objective cognitive impairment. Future studies with larger, more homogenous samples are needed.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective memory in breast cancer survivors treated with endocrine therapy: findings from an ecological virtual reality task.","authors":"Mylène Duivon, Joy Perrier, François Christy, Jean-Michel Grellard, Bénédicte Clarisse, Florence Joly, Marie Fernette, François Gernier, Julien Geffrelot, George Emile, Christelle Lévy, Grégory Lecouvey, Fausto Viader, Francis Eustache, Bénédicte Giffard","doi":"10.1093/arclin/acag073","DOIUrl":"https://doi.org/10.1093/arclin/acag073","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive effects of endocrine therapy (ET) in breast cancer are often subtle and may escape detection by standard neuropsychological assessments. Prospective memory (PM)-the ability to carry out intended actions-is particularly sensitive to mild cognitive changes, and crucial for autonomy and treatment adherence. This study examined the impact of ET, administered without chemotherapy, on PM using a virtual reality (VR)-based paradigm.</p><p><strong>Method: </strong>Thirty-eight postmenopausal breast cancer survivors treated with ET (ET+) or without ET (ET-), and 21 healthy controls were evaluated. To isolate the cognitive effects of ET, none of the patients had received chemotherapy. Participants completed standardized neuropsychological tests, self-report questionnaires, and a VR-based PM task assessing recall of event-based (EB) and time-based (TB) intentions after short (10-min) and long (10 h) delays.</p><p><strong>Results: </strong>Despite preserved performance on standard neuropsychological measures, ET+ patients showed significantly lower PM performance than ET- patients, specifically for TB intentions after the short delay (p.adj = .002). The prospective component of these TB intentions was particularly less frequently retrieved (p.adj = .014), despite preserved storage.</p><p><strong>Conclusions: </strong>This study provides preliminary evidence suggesting that ET, independent of chemotherapy-related neurotoxicity, may be associated with alterations in PM. The pattern of PM performance in ET+ patients suggests a disruption in self-initiated retrieval processes during early consolidation, when memory traces remain labile and vulnerable to interference. The use of an immersive VR-based PM paradigm revealed subtle cognitive changes not captured by conventional assessments, underscoring the clinical value of ecologically valid tools.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there evidence for additive neurocognitive deficits in adults with attention-deficit/hyperactivity disorder and co-occurring conditions?","authors":"Allyson G Harrison, Nathaniel Davin, Dylan Kwan","doi":"10.1093/arclin/acag067","DOIUrl":"10.1093/arclin/acag067","url":null,"abstract":"<p><strong>Objective: </strong>Adults with attention-deficit/hyperactivity disorder (ADHD) frequently present with co-occurring anxiety and depressive symptoms, raising questions about whether such comorbidity is associated with additive neurocognitive impairment. Prior findings have been mixed and rarely account for symptom exaggeration or noncredible task engagement. This study examined whether adults with ADHD and elevated internalizing symptoms demonstrate additive neurocognitive deficits when symptom and performance validity are controlled.</p><p><strong>Method: </strong>Archival data were analyzed from 752 postsecondary students referred for psychoeducational/neuropsychological evaluation. Participants were classified into ADHD only, ADHD with elevated anxiety and/or depressive symptoms, anxiety only, depression only, and assessment-seeking clinical controls without formal diagnoses. Analyses were restricted to individuals who passed established presentation validity criteria. Neurocognitive performance was examined across intellectual functioning, executive functioning, memory, and academic achievement using mean-level comparisons and rates of scores at or below the 16th percentile.</p><p><strong>Results: </strong>Across domains, group means generally fell within the average range with substantial overlap among groups. Adults with ADHD and co-occurring anxiety and/or depressive symptoms did not demonstrate poorer neurocognitive performance than adults with ADHD alone. Statistically significant group differences emerged on select measures but were small, inconsistent, and not specific to comorbid ADHD groups. Rates of low scores (e.g., ≤ 16th percentile) were comparable across groups.</p><p><strong>Conclusions: </strong>When presentation validity is established, co-occurring anxiety and/or depressive symptoms were not associated with consistent or clinically meaningful additive neurocognitive deficits in adults with ADHD. These findings underscore the importance of validity-controlled assessment and caution against inferring objective cognitive impairment solely from diagnostic comorbidity.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13565143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing neuropsychological performance and its nutritional, visual, and physiological correlates in children.","authors":"Isaiah Osei Duah Junior, Nana Aba Senuwah Ashon, Wendy Ofori-Asare, Elizabeth J Johnson, Mary Amoako, Dorcas Adu-Owusu, Josephine Ampomah Boateng, Charllote Boateng, Kwadwo Owusu Akuffo","doi":"10.1093/arclin/acag071","DOIUrl":"https://doi.org/10.1093/arclin/acag071","url":null,"abstract":"<p><strong>Objective: </strong>To characterize neuropsychological performance in Ghanaian preadolescent children and examine its associations with demographic, health, nutritional, and visual factors.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 290 preadolescent school children (median age: 11.0 years [IQR: 2.0]; range: 8-11 years; 54.8% female) from urban and rural public and private schools in the Ashanti Region of Ghana. Neuropsychological function was assessed using the Cambridge Neuropsychological Test Automated Battery, covering memory, executive function, attention, and psychomotor domains (minimum analytical sample: n = 150). Spearman's rank correlations assessed convergent validity and domain-specific independence. Associations between participant characteristics and cognitive performance were examined using multivariable linear regression, with Benjamini-Hochberg false discovery rate (FDR) correction applied across all regression tests. Statistical significance was defined as an FDR-adjusted q < 0.05, whereas both unadjusted p-values and adjusted q-values were reported for transparency.</p><p><strong>Results: </strong>Cognitive performance exhibited a predominantly modular structure, characterized by strong within-task coherence and limited cross-domain integration. Males performed better than females on visual learning and psychomotor speed tasks, particularly Paired Associates Learning and movement reaction time measures (p < .05), whereas simple reaction time did not differ between sexes (p > .05). Following Benjamini-Hochberg FDR correction, no associations between cognitive performance and demographic, health, nutritional, or visual factors remained statistically significant.</p><p><strong>Conclusion: </strong>Neuropsychological functioning in Ghanaian preadolescent children appears to be predominantly modular, with limited evidence that demographic, health, nutritional, or visual factors are independently associated with cognitive performance after correction for multiple comparisons.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148972912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter fluency and level of depression predict fear of falling in Parkinson's disease.","authors":"Christopher I Higginson, Victoria R Marcondes, Kimberly E Lanni, Elizabeth A Disbrow","doi":"10.1093/arclin/acag076","DOIUrl":"10.1093/arclin/acag076","url":null,"abstract":"<p><strong>Objective: </strong>Indicators of motor symptom severity, cognitive functioning, and level of depression have been independently associated with fear of falling in Parkinson's disease (PD); however, it is unclear how these variables combine to predict fear of falling and which specific measures of cognition are most related to fear of falling in PD. The goal of this study was to address these questions.</p><p><strong>Method: </strong>Fifty-eight (27 female) individuals diagnosed with PD completed the Falls Efficacy Scale International (FES), Part III of the Unified Parkinson's Disease Rating Scale, Geriatric Depression Scale, Symbol-Digit Modalities Test, and Trail Making, Verbal Fluency and Color-Word Interference Tests from the Delis-Kaplan Executive Function System. Scores from the motor, cognitive, and depression measures were entered into a standard multiple regression predicting FES scores.</p><p><strong>Results: </strong>All variables significantly correlated with the FES, with r-values ranging from .26 to .45. In the regression, the independent variables predicted 38.5% of the variance in FES, R2 = .385, F(5, 52) = 7.70, p < .001. Letter Fluency made the largest contribution to FES, β = -.38, t = -2.92, p = .005, with the Geriatric Depression Scale, β = .31, t = 2.48, p = .016 contributing significant additional unique variance in FES.</p><p><strong>Conclusions: </strong>Fear of falling is a multifactorial construct in PD and appears independently related to elements of executive functioning and level of depression.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13602271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet adoption and health trajectories in older adults during COVID-19: a longitudinal study.","authors":"Jun Xu, Zeyu Zhu, Xuan Sun, Liying Lu, Zimo Yao, Hongzhou Cai, Zhipeng Li, Zilu Chen","doi":"10.1093/arclin/acag064","DOIUrl":"https://doi.org/10.1093/arclin/acag064","url":null,"abstract":"<p><strong>Background: </strong>Population aging highlights the need to understand whether late-life internet use is associated with cognitive and mental health trajectories. Using the COVID-19 period as a unique social context, we examined whether first-time internet adoption was associated with changes in cognitive function and depressive symptoms among older Chinese adults.</p><p><strong>Methods: </strong>Using the 2018 and 2020 waves of CHARLS, we first compared three digital-social profiles in 2018: Inactive, Offline-only, and Dual-mode participants (n = 10,935). We then conducted a longitudinal change-score analysis among 3,346 baseline offline-only participants, of whom 1,699 became new internet adopters by 2020. Cognitive function was measured using a 10-point Minimum Mental State Examination (MMSE)-derived cognitive function score, and depressive symptoms were assessed using the 10-item Center for Epidemiologic Studies Depression Scale.</p><p><strong>Results: </strong>Cross-sectionally, Dual-mode participants, who combined internet use with offline social participation, showed the most favorable cognitive and depressive symptom profiles. Longitudinally, new internet adoption was associated with a greater increase in the 10-point MMSE-derived cognitive function score compared with consistent non-use (β = 0.28, 95% CI: 0.11 to 0.44, p < .001). This association remained consistent in propensity-score-weighted and baseline-adjusted sensitivity analyses. In contrast, internet adoption was not significantly associated with depressive symptom change in the primary model (β = -0.18, 95% CI: -0.59 to 0.22, p = .40).</p><p><strong>Conclusion: </strong>Internet adoption was associated with more favorable cognitive change, whereas evidence for depressive symptoms was weaker and less consistent. Digital inclusion may be relevant to cognitive health promotion, but should be complemented by offline social and community support.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":"41 7","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148972959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}