Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists最新文献

{"title":"Can Frontal Assessment Battery Discriminate between Patients with Alzheimer's and Frontotemporal Dementia?","authors":"Fabrissio Grandi, Loreto Olavarría, Mario A Parra, David Martínez-Pernía, Cesar Serey, Jose Lema, Carolina Delgado, Teresita Ramos, Patricia Lillo, Adolfo M García, Graciela Muniz-Terrera, Andrea Slachevsky","doi":"10.1093/arclin/acaf073","DOIUrl":"https://doi.org/10.1093/arclin/acaf073","url":null,"abstract":"<p><strong>Objectives: </strong>The Frontal Assessment Battery (FAB) is a widely used tool for assessing executive function. However, its ability to distinguish between Alzheimer's disease dementia (ADD) and behavioural variant frontotemporal dementia (bvFTD) remains under debate. This study assessed the diagnostic utility of the Chilean version of the FAB (FAB-Ch) in differentiating ADD from bvFTD and used data-driven cluster analysis to explore dysexecutive profiles.</p><p><strong>Method: </strong>A total of 288 participants were recruited: 45 with ADD, 33 with bvFTD, and 208 cognitively unimpaired controls (CU). Mean FAB-Ch total scores were compared across groups. Receiver operating characteristic (ROC) curves evaluated the instrument's ability to distinguish (i) dementia from no dementia, (ii) ADD from bvFTD, and (iii) executive dysfunction. Hierarchical cluster analysis was conducted to identify executive profiles among dementia patients.</p><p><strong>Results: </strong>FAB-Ch scores were significantly lower in individuals with dementia compared to controls (p < .001). However, there were no significant differences between ADD and bvFTD groups (p = .59). The FAB-Ch showed strong discriminatory power between dementia and controls (AUC = 0.882; sensitivity = 0.731; specificity = 0.885), but poor discrimination between ADD and bvFTD (AUC = 0.465; p = .59). Cluster analysis among patients with dementia revealed three distinct executive profiles corresponding to different levels of cognitive impairment (p < .001).</p><p><strong>Conclusion: </strong>The FAB-Ch effectively differentiates individuals with dementia from cognitively unimpaired controls but does not distinguish between ADD and bvFTD. Nevertheless, it is sensitive to executive dysfunction and can aid in the clinical characterization of dementia severity and heterogeneity.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice Effects and Long Delays: A Case Report Exploring a Novel Approach to Detecting Accelerated Long-Term Forgetting.","authors":"Chris Gaskell, Cleo Keeling-Ball, Callum Furniss, Jonathan Evans","doi":"10.1093/arclin/acaf077","DOIUrl":"https://doi.org/10.1093/arclin/acaf077","url":null,"abstract":"<p><strong>Objective: </strong>Accelerated Long-Term Forgetting (ALF) is when newly learned information \"decays\" faster than expected over an extended period and is associated with temporal-lobe epilepsy (TLE). There is no well-established method for assessing ALF despite its apparent prevalence. We hypothesized that evidencing an absence of practice effects may represent an effective approach to detecting ALF. We sought to determine if this method, along with the long-delay memory tests, could evidence ALF in a single case.</p><p><strong>Method: </strong>We present a 66-year-old male with TLE who had memory complaints despite a stable memory profile over 4 years. Memory tests that employ a short (20-30 min) and a long delay (4 days) condition were used to assess forgetting, whereas repeatedly administered tests were used to detect practice effects. We anticipated poorer memory performance on the long versus short-delay test condition and a lack of improvement on memory tests that were repeated.</p><p><strong>Results: </strong>For repeat administration tests, there was a marked score increase, indicating practice effects, for verbal and visual domains. For long delay tests, however, there was a notable drop with retention falling in the exceptionally low range.</p><p><strong>Conclusions: </strong>These findings suggest a dissociation between long delay and serial assessment tasks for detecting ALF.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Risk of Mild Cognitive Impairment in Elderly Patients with Cardiovascular Disease.","authors":"María Mata, Magali González-Colaço Harmand, Pablo César Prada-Arrondo, Alberto Domínguez-Rodríguez, Jose Barroso, Iván Galtier","doi":"10.1093/arclin/acaf076","DOIUrl":"https://doi.org/10.1093/arclin/acaf076","url":null,"abstract":"<p><strong>Objective: </strong>Cardiovascular diseases (CVD) are showing an increasing incidence in the older adults and are frequently associated with higher risk of neurological complications in this population. Research on mild cognitive impairment (MCI) in elderly patients with CVD is extremely scarce. The aims of this research were to: (a) examine the frequency of MCI in CVD patients (aged 65 years or older) and explore their clinical and cognitive characteristics compared to healthy controls (HC); (b) investigate which components of the cognitive performance and clinical characteristics are better predictors of MCI.</p><p><strong>Method: </strong>This observational study included 34 CVD patients (mean age = 74.97; SD = 4.96) and 25 HC (mean age = 73.32; SD = 3.72). All participants underwent neuropsychological assessment. MCI diagnosis was established following clinical diagnostic criteria. Cognitive impairment was defined as performance ≤1.5 SD below the HC mean in neuropsychological tests. Relative risk, random forest regression models, and discriminant analysis were used for the prediction analysis.</p><p><strong>Results: </strong>The results showed that 41.2% of the CVD patients who were diagnosed with MCI. CVD-MCI showed an altered performance in all cognitive domains, with more relevance of visuospatial functions, language and verbal memory. Moreover, visuospatial functions and memory were significant predictors of MCI diagnosis.</p><p><strong>Conclusions: </strong>These findings indicate a high frequency of MCI in elderly patients with CVD, characterized by a heterogeneous pattern of cognitive impairment. These results are highly relevant for future investigations, considering increasing life expectancy, the high incidence of CVD in the older adults and the higher risk of neurological complications associated with this population.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Study of a Multilingual Individual with Primary Progressive Aphasia: Diagnostic Considerations and Implications for Language Representation.","authors":"Brianna E Kelly, Al Amira Safa Shehab","doi":"10.1093/arclin/acaf030","DOIUrl":"10.1093/arclin/acaf030","url":null,"abstract":"<p><strong>Objective: </strong>This study reports a case of primary progressive aphasia (PPA) in a multilingual Haitian American individual. Earlier literature has suggested that cases of PPA in multilingual individuals are relatively rare. Several factors complicate the assessment of language dysfunction and diagnosis of PPA in multilingualism, including age of language acquisition, degree of proficiency, language representation in the bilingual brain, and limited availability/validity of tests/norms for bilinguals.</p><p><strong>Method: </strong>This is a 69-year-old right-handed trilingual (French/English/Haitian Creole) Haitian American female with 16 years of education. Difficulties with word finding and speech production emerged two years prior to evaluation. Language was assessed with select subtests of the Boston Diagnostic Aphasia Examination (BDAE-3), Boston Naming Test (BNT), and Verbal Fluency. Positron emission tomography-computed tomography imaging displayed large areas of hypometabolism in the left and right frontal, temporal, and parietal lobes, with the left areas being more greatly impacted.</p><p><strong>Results: </strong>Neuropsychological testing showed impairments in visual and auditory naming, verbal fluencies, sentence repetition, and word reading. Reading comprehension and repetition of single words were relatively spared. There were deficits in learning/memory, visuospatial functioning, and processing speed. Speech was dysfluent with occasional agrammatism and mild dysarthria.</p><p><strong>Conclusions: </strong>Overlapping characteristics of both logopenic and non-fluent/agrammatic variants of PPA were evident. Patient's neuroimaging findings and clinical presentation suggest an advanced PPA syndrome. Cognitive/brain reserve and a globalized language representation, theorized in bilingual individuals, could be considered as contributors to the trajectory of her deficits. This case study contributes to the growing literature on PPA in diverse populations and multilingual individuals.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":" ","pages":"1266-1274"},"PeriodicalIF":2.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Mini-SEA: Validity and Normative Data for the French-Quebec Population Aged 50 Years and Above.","authors":"","doi":"10.1093/arclin/acaf070","DOIUrl":"10.1093/arclin/acaf070","url":null,"abstract":"","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":" ","pages":"1276-1277"},"PeriodicalIF":2.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of the Editors of the Archives of Clinical Neuropsychology regarding the March 2025 Minnesota Conference Guidelines.","authors":"Gregory Price Lee","doi":"10.1093/arclin/acaf068","DOIUrl":"10.1093/arclin/acaf068","url":null,"abstract":"","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":" ","pages":"1081"},"PeriodicalIF":2.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Validation of the Arabic Version of the Multiple Sclerosis Impact Scale (MSIS-29): a Rasch Analysis Study.","authors":"","doi":"10.1093/arclin/acaf059","DOIUrl":"10.1093/arclin/acaf059","url":null,"abstract":"","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":" ","pages":"1275"},"PeriodicalIF":2.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional Assessment of Social Cognition in Severe Traumatic Brain Injury: A Pilot Study Using a Non-Immersive Virtual Reality Serious Game.","authors":"Eva-Flore Msika, Victoire Roger, Nathalie Ehrlé, Alexandre Gaston-Bellegarde, Eric Orriols, Pascale Piolino, Pauline Narme","doi":"10.1093/arclin/acaf075","DOIUrl":"https://doi.org/10.1093/arclin/acaf075","url":null,"abstract":"<p><strong>Introduction: </strong>Social cognition is frequently impaired in traumatic brain injury (TBI). The lack of naturalistic and integrated assessments of social cognition has been highlighted. We investigated REALSoCog's feasibility, a new non-immersive virtual reality serious game, in severe TBI. Additionally, we explored the impact of post-traumatic stress disorder (PTSD).</p><p><strong>Methods: </strong>Ten severe TBI patients completed the REALSoCog task and the PTSD Checklist for DSM-5. They were compared with 27 matched healthy controls.</p><p><strong>Results: </strong>Reduced emotional empathy and difficulties in affective theory of mind were found in patients. PTSD was suspected in 60% of our sample. Individual analyses suggested that deficits in social-cognitive scores were more frequent in patients with PTSD.</p><p><strong>Conclusions: </strong>This study underscored the relevance of REALSoCog for social cognition assessment. It also suggests the possibility to objectively identify social-behavioral disturbances in patients with severe TBI. Finally, the impact of individual factors (PTSD) on such difficulties should be further explored.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Statement of the Editors of the Archives of Clinical Neuropsychology regarding the March 2025 Minnesota Conference Guidelines.","authors":"","doi":"10.1093/arclin/acaf079","DOIUrl":"10.1093/arclin/acaf079","url":null,"abstract":"","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Reported Fatigue Levels Predict Performance on Attention Measures in Multiple Sclerosis.","authors":"Deanna Eilenberger, Laura E Korthauer, Jonathan Cahill, Saima Chaudhry, Sarah Pillemer","doi":"10.1093/arclin/acaf074","DOIUrl":"https://doi.org/10.1093/arclin/acaf074","url":null,"abstract":"<p><strong>Objective: </strong>The present study investigates the relationship between cognitive performance, depression, anxiety, and factors of medical burden (i.e., polypharmacy, medical comorbidities, disease duration, disability level, and self-reported fatigue level) in a population of multiple sclerosis (MS) patients.</p><p><strong>Method: </strong>A retrospective investigation was conducted with data collected from 106 MS patients (87 female; 19 male) referred to an outpatient, hospital-based neuropsychology clinic. Participants underwent a comprehensive neuropsychological evaluation, which included measures of attention, processing speed, executive functioning, language, motor function, visuospatial abilities, and memory, as well as self-report assessments of depression, anxiety, and fatigue.</p><p><strong>Results: </strong>After correcting for multiple comparisons, bivariate pairwise correlations revealed positive relationships between number of medications and depression scores, Fatigue Questionnaire scores and depression scores, and Fatigue Questionnaire scores and trait anxiety scores. Hierarchical regression analysis showed that greater scores on the Fatigue Questionnaire predicted lower attention composite scores independent of participants' age or education. No significant relationships between psychiatric factors and cognitive composite scores were identified.</p><p><strong>Conclusions: </strong>Self-reported level of fatigue, an aspect of medical burden, was associated with cognitive performance in the domain of attention in a sample of MS patients.</p>","PeriodicalId":520564,"journal":{"name":"Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}