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Medecine sciences : M/S最新文献

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[MCH neurons regulate fenestration of the median eminence vascular loops reaching the arcuate nucleus of the hypothalamus]. [MCH神经元调节到达下丘脑弓状核的中央隆起血管袢的开窗]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022016
Alicia Sicardi, Vincent Prévot
{"title":"[MCH neurons regulate fenestration of the median eminence vascular loops reaching the arcuate nucleus of the hypothalamus].","authors":"Alicia Sicardi, Vincent Prévot","doi":"10.1051/medsci/2022016","DOIUrl":"https://doi.org/10.1051/medsci/2022016","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"248-251"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Occupational exposome: An organisational model]. [职业暴露:一个组织模型]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022022
Yves Roquelaure, Danièle Luce, Alexis Descatha, Nathalie Bonvallot, Bertrand Porro, Fabien Coutarel
{"title":"[Occupational exposome: An organisational model].","authors":"Yves Roquelaure,&nbsp;Danièle Luce,&nbsp;Alexis Descatha,&nbsp;Nathalie Bonvallot,&nbsp;Bertrand Porro,&nbsp;Fabien Coutarel","doi":"10.1051/medsci/2022022","DOIUrl":"https://doi.org/10.1051/medsci/2022022","url":null,"abstract":"<p><p>This article describes the concept of occupational exposome in highlighting the value of the concept in understanding the complexity of workplace exposures and their determinants. An organizational approach to the occupational exposome is proposed. The organizational approach is intended, from an interdisciplinary perspective, to broaden the levels of analysis of the exposures (whether they are) of the individual to the work situation (individual or collective), the work situation in the workshop or in the service, the company and the socio-economic environment of the company, the socio-economic environment of the company to the Society as a whole. The organizational approach of the occupational exposome helps to broaden the spectrum of health risk assessment and to promote a comprehensive and integrated approach to the prevention of arduousness at work and occupational wear and tear.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"288-293"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Epigenetics and oncology: Two faces of the personalization of medicine]. [表观遗传学和肿瘤学:医学个性化的两个方面]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022025
Lola Auroy, Séverine Louvel
{"title":"[Epigenetics and oncology: Two faces of the personalization of medicine].","authors":"Lola Auroy,&nbsp;Séverine Louvel","doi":"10.1051/medsci/2022025","DOIUrl":"https://doi.org/10.1051/medsci/2022025","url":null,"abstract":"<p><p>In this article, we outline the two dominant concepts of personalized medicine put forward by epigenetics in the field of oncology. First, knowledge on the molecular processes involved in tumor progression contributes to molecularize medicine, extending genomic medicine. Then, the identification of epigenetic mechanisms underlying the environmental causes of cancers brings scientific legitimacy to products and services whose advertising promotes the ability of each person to protect herself from cancer by adapting her lifestyle. Lastly, we argue that research in environmental epigenetics could open a new route for personalized medicine in oncology, where epigenetics contributes to an individualized assessment of patients' life paths.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"296-302"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Dual-use research on modified pathogens in the laboratory: What framework for what issue?] [实验室修饰病原体的军民两用研究:什么框架针对什么问题?]］
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022026
Fanny Velardo, Julie Prudhomme, Laura Temime, Kévin Jean
{"title":"[Dual-use research on modified pathogens in the laboratory: What framework for what issue?]","authors":"Fanny Velardo,&nbsp;Julie Prudhomme,&nbsp;Laura Temime,&nbsp;Kévin Jean","doi":"10.1051/medsci/2022026","DOIUrl":"https://doi.org/10.1051/medsci/2022026","url":null,"abstract":"<p><p>Technological advances in synthetic biology have made in vitro modification, or even creation, of viruses easier and more affordable. Several research studies using synthesis of potential pandemic pathogens led to controversies in the 2010's. More recently, the hypothesis that Covid-19 pandemics could originate from a lab escape is still under debate. In France, a legislative vacuum remains concerning the synthesis of modified pathogens. Initiating a collective reflection process towards setting of a legal framework on this type of work is timely so that research continues to provide profit to society rather than hazard.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"303-308"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[DNA repair and longevity in mice, other rodents and men]. [老鼠、其他啮齿动物和人类的DNA修复与长寿]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022019
Bertrand Jordan
{"title":"[DNA repair and longevity in mice, other rodents and men].","authors":"Bertrand Jordan","doi":"10.1051/medsci/2022019","DOIUrl":"https://doi.org/10.1051/medsci/2022019","url":null,"abstract":"<p><p>Large differences in maximum longevity exist between different rodent species. Determination of the spontaneous and mutagen-induced mutation rates in these species by single (somatic) cell sequencing suggests more efficient DNA repair in long-lived species (including humans), but the data is too noisy to prove a strong correlation between longevity and preservation of DNA integrity.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"317-319"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40324843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Apelin as a new therapeutic hope for cardiovascular diseases]. [Apelin是治疗心血管疾病的新希望]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022021
Sambre Mach, Nour Elhouda Bouddiaf, Philippe Robin
{"title":"[Apelin as a new therapeutic hope for cardiovascular diseases].","authors":"Sambre Mach,&nbsp;Nour Elhouda Bouddiaf,&nbsp;Philippe Robin","doi":"10.1051/medsci/2022021","DOIUrl":"https://doi.org/10.1051/medsci/2022021","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"324-326"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40324847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Astrocytes, guardians of critical period plasticity]. [星形胶质细胞，关键期可塑性的守护者]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022014
Jérôme Ribot, Rachel Breton, Glenn Dallérac, Nathalie Rouach
{"title":"[Astrocytes, guardians of critical period plasticity].","authors":"Jérôme Ribot,&nbsp;Rachel Breton,&nbsp;Glenn Dallérac,&nbsp;Nathalie Rouach","doi":"10.1051/medsci/2022014","DOIUrl":"https://doi.org/10.1051/medsci/2022014","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"251-254"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Scientific integrity principles that need to be observed in order to limit breaches in the field of research in psychology]. [为了限制心理学研究领域的违规行为，需要遵守的科学完整性原则]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-02-01 Epub Date: 2022-02-18 DOI: 10.1051/medsci/2021261
Oriane Simion
{"title":"[Scientific integrity principles that need to be observed in order to limit breaches in the field of research in psychology].","authors":"Oriane Simion","doi":"10.1051/medsci/2021261","DOIUrl":"https://doi.org/10.1051/medsci/2021261","url":null,"abstract":"Éléments d’intégrité scientifique à considérer pour limiter les manquements dans la recherche en psychologie.\u0000 La notion de consentement interpelle l’opinion publique, le corps médical, les tribunaux, et les chercheurs tentent d’en discerner les contours, le domaine de la recherche n’en étant pas exclu. En psychologie, les études explorent le fonctionnement de l’être humain et ne peuvent être effectuées sans le consentement du participant. Qu’elle soit conduite sur la population générale ou sur des personnes atteintes de troubles spécifiques, la recherche en psychologie doit intégrer la participation de personnes qui sont explicitement consentantes. Nous explorerons, dans cette revue, les spécificités et les obstacles du recrutement impliquant un consentement libre et éclairé en psychologie. Nous aborderons ensuite les éléments d’intégrité scientifique à considérer, afin de limiter les possibles inconduites scientifiques.","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 2","pages":"211-214"},"PeriodicalIF":0.7,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39810779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Vascular endothelial damages: A key role in COVID-19 multiorgan failure?] 血管内皮损伤:在COVID-19多器官衰竭中起关键作用?]
IF 0.7
Medecine sciences : M/S Pub Date : 2022-02-01 Epub Date: 2022-02-04 DOI: 10.1051/medsci/2021257
Annabelle Dupont, Mickaël Rosa, Antoine Rauch, Sophie Susen
{"title":"[Vascular endothelial damages: A key role in COVID-19 multiorgan failure?]","authors":"Annabelle Dupont,&nbsp;Mickaël Rosa,&nbsp;Antoine Rauch,&nbsp;Sophie Susen","doi":"10.1051/medsci/2021257","DOIUrl":"https://doi.org/10.1051/medsci/2021257","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 2","pages":"145-147"},"PeriodicalIF":0.7,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39888968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hans Driesch (1867-1941) and the end of any preformationist vision of development]. [Hans Driesch(1867-1941)，以及任何预形成主义发展观的终结]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-02-01 Epub Date: 2022-02-18 DOI: 10.1051/medsci/2021260
Christophe Chanoine
{"title":"[Hans Driesch (1867-1941) and the end of any preformationist vision of development].","authors":"Christophe Chanoine","doi":"10.1051/medsci/2021260","DOIUrl":"https://doi.org/10.1051/medsci/2021260","url":null,"abstract":"<p><p>While the work of early 19th century embryologists marked the end of preformation theory in its initial form, the first experimental attempts at the turn of the century led to the development of the concept of the mosaic egg - a more elaborate preformationist view of development - in which the embryo is made up of a mosaic of territories with a determined future and subjected to autonomous development. By separating sea urchin blastomeres at 2/4 cell stages, a young researcher, Hans Driesch shows that each of the blastomeres develops to form a complete and harmonious larva and that the young embryo is therefore capable of regulation. Thus this invalidated the concept of mosaic development, which predicted the independent development of two hemi-embryos and it opened up new fields of investigation for modern embryology.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 2","pages":"205-210"},"PeriodicalIF":0.7,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39810342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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