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[Confounding factor]. [混杂因素]。
Medecine sciences : M/S Pub Date : 2024-04-01 DOI: 10.1051/medsci/2024036
J. Hardelin
{"title":"[Confounding factor].","authors":"J. Hardelin","doi":"10.1051/medsci/2024036","DOIUrl":"https://doi.org/10.1051/medsci/2024036","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"43 11","pages":"381"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Gender-affirming hormone therapy in transgender persons]. [变性人的性别确认激素治疗]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-11-01 Epub Date: 2022-11-30 DOI: 10.1051/medsci/2022151
Nicolaï Johnson, Nathalie Chabbert-Buffet
{"title":"[Gender-affirming hormone therapy in transgender persons].","authors":"Nicolaï Johnson,&nbsp;Nathalie Chabbert-Buffet","doi":"10.1051/medsci/2022151","DOIUrl":"https://doi.org/10.1051/medsci/2022151","url":null,"abstract":"<p><p>Medical care for transgender patients is still characterized by an insufficient availability of healthcare services, as well as by poor provider education and training. Transgender patients often require gender-affirming hormone therapy (GAHT), and physicians, including endocrinologists, general practitioners, and others, should be trained to initiate and monitor these treatments throughout the transition process, and beyond. This article will address the specific issues surrounding GAHT in adult transgender women and men.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"905-912"},"PeriodicalIF":0.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40491660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Patient-derived tumor organoids (or tumoroid), a growing preclinical model for oncology]. [患者来源的肿瘤类器官(或类肿瘤)，肿瘤学临床前模型的发展]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-11-01 Epub Date: 2022-11-30 DOI: 10.1051/medsci/2022148
Lucie Thorel, Romane Florent, Marion Perréard, Audrey Vincent, Laurent Poulain, Louis-Bastien Weiswald
{"title":"[Patient-derived tumor organoids (or tumoroid), a growing preclinical model for oncology].","authors":"Lucie Thorel,&nbsp;Romane Florent,&nbsp;Marion Perréard,&nbsp;Audrey Vincent,&nbsp;Laurent Poulain,&nbsp;Louis-Bastien Weiswald","doi":"10.1051/medsci/2022148","DOIUrl":"https://doi.org/10.1051/medsci/2022148","url":null,"abstract":"<p><p>The recent emergence of tumor organoid cultures, or tumoroids, has enriched the repertoire of preclinical models in oncology. These microtumors are obtained in vitro by including cells from patient tumor samples in an extracellular matrix and cultured in specific media. Very close to the tumor of origin, tumoroids can be amplified fairly rapidly from a small quantity of tissue, established with high success rate for most tumor types, easily genetically engineered, and stored in biobanks. Tumoroids thus offer numerous possibilities in terms of basic research, such as the study of carcinogenesis or mechanisms of chemoresistance, but also the identification of new targets and preclinical validation of new anti-cancer compounds or personalized medicine. Technological developments and enrichment of tumoroids with other cell types are currently ongoing to optimally exploit the full potential of these models.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"880-887"},"PeriodicalIF":0.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40490153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Extended heredity in biomedicine: Breaking the silence]. 生物医学中的扩展遗传:打破沉默。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-11-01 Epub Date: 2022-11-30 DOI: 10.1051/medsci/2022147
Gaëlle Pontarotti
{"title":"[Extended heredity in biomedicine: Breaking the silence].","authors":"Gaëlle Pontarotti","doi":"10.1051/medsci/2022147","DOIUrl":"https://doi.org/10.1051/medsci/2022147","url":null,"abstract":"<p><p>The extension of biological inheritance beyond gene-centrism is at the center of many debates in evolutionary biology, but it has been relatively ignored in the field of biomedicine. The purpose of this prospective paper is to highlight the potential impact of a new vision of inheritance on medical theory, notably on the concept of hereditary disease. It is also to underline some related practical and social issues.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"936-940"},"PeriodicalIF":0.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40491662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Defective viral genomes from Chikungunya virus: A new broad-spectrum antiviral approach?] 基孔肯雅病毒的缺陷病毒基因组:一种新的广谱抗病毒方法?]
IF 0.7
Medecine sciences : M/S Pub Date : 2022-11-01 Epub Date: 2022-11-30 DOI: 10.1051/medsci/2022141
Sandra Khau, Cassandra Lopatynski
{"title":"[Defective viral genomes from Chikungunya virus: A new broad-spectrum antiviral approach?]","authors":"Sandra Khau,&nbsp;Cassandra Lopatynski","doi":"10.1051/medsci/2022141","DOIUrl":"https://doi.org/10.1051/medsci/2022141","url":null,"abstract":"Le Master 2 « Infectiologie, Immunologie, Vaccinologie et Biomédicaments (I2VB) », dispensé à la faculté de Pharmacie de l’université de Tours, propose de donner les bases conceptuelles et pratiques des différents aspects de l’infectiologie et de l’immunologie dans un contexte d’innovation thérapeutique. Il s’appuie sur une coopération exemplaire entre les équipes de recherche en infectiologie et en immunologie de l’université de Tours, et celles, entre autres, de l’unité « Infectiologie et Santé Publique » (ISP) et de l’unité « Physiologie de la Reproduction et des Comportements » (PRC) du Centre INRAE de Tours-Nouzilly, concrétisée par une profonde interaction entre chercheurs et enseignants-chercheurs. Cette formation aborde aussi bien les aspects fondamentaux et appliqués de l’infectiologie et de l’immunologie, allant de l’étude moléculaire des interactions entre le pathogène et son hôte, jusqu’à la conception et la mise sur le marché des produits de la vaccinologie, des biothérapies anti-infectieuses et des anticorps thérapeutiques.\u0000Le Master 2 I2VB a pour objectif de former :\u0000– de jeunes scientifiques aux enjeux actuels de l’infectiologie et des biomédicaments tels que les anticorps.\u0000– des experts pour gérer les risques d’émergences, et capables de comprendre les interactions complexes entre un agent infectieux et son hôte humain ou animal, capables de proposer des mesures préventives ou des thérapies innovantes.","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"955-959"},"PeriodicalIF":0.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40491664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Patient-derived tumor organoids (or tumoroid) as valuable precision medicine tools]. [患者来源的肿瘤类器官(或类肿瘤)作为有价值的精准医疗工具]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-11-01 Epub Date: 2022-11-30 DOI: 10.1051/medsci/2022149
Marion Perréard, Romane Florent, Lucie Thorel, Audrey Vincent, Louis-Bastien Weiswald, Laurent Poulain
{"title":"[Patient-derived tumor organoids (or tumoroid) as valuable precision medicine tools].","authors":"Marion Perréard,&nbsp;Romane Florent,&nbsp;Lucie Thorel,&nbsp;Audrey Vincent,&nbsp;Louis-Bastien Weiswald,&nbsp;Laurent Poulain","doi":"10.1051/medsci/2022149","DOIUrl":"https://doi.org/10.1051/medsci/2022149","url":null,"abstract":"<p><p>Review of literature shows that it is possible to establish tumor-derived organoids, or tumoroids, from almost any type of tumor, and that these \"micro-tumors\" could be used to develop functional assays allowing the prediction of the patient response to treatments and/or the identification of predictive molecular signatures associated with the development of these therapies. Although it is still essential to optimize culture conditions to promote and accelerate the establishment of tumoroids, or to recapitulate tumor microenvironment, many applications are now possible in the field of prediction of response to treatments and in guiding therapeutic decision-making. Using tumoroids as standard tools in clinical oncology could make precision oncology enter a new era in the coming decade. Numerous ongoing research and clinical trials conducted throughout the world aim to validate the interest of this approach.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"888-895"},"PeriodicalIF":0.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40490154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Care for transgender children and adolescents]. [照顾跨性别儿童和青少年]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-11-01 Epub Date: 2022-11-30 DOI: 10.1051/medsci/2022150
Élodie Fiot, Charlotte Lebrun, Clémence Delcour, Céline Rogez, Alicia Cohen, Lætitia Martinerie
{"title":"[Care for transgender children and adolescents].","authors":"Élodie Fiot,&nbsp;Charlotte Lebrun,&nbsp;Clémence Delcour,&nbsp;Céline Rogez,&nbsp;Alicia Cohen,&nbsp;Lætitia Martinerie","doi":"10.1051/medsci/2022150","DOIUrl":"https://doi.org/10.1051/medsci/2022150","url":null,"abstract":"<p><p>Transgender children and adolescents can be supported in France by multidisciplinary teams since the creation of dedicated consults in 2014. The personalized support provided relies on international recommendations based on scientific studies that have demonstrated the beneficial impact of such support in the short and medium term. However, many ethical and medical questions remain, particularly on the long-term effects of treatments or the impact on fertility. The continuing accumulation of data will provide these young people and their families with the most enlightened information possible.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"897-904"},"PeriodicalIF":0.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40491659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Fertility preservation in transgender people]. [变性人的生育能力保存]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-11-01 Epub Date: 2022-11-30 DOI: 10.1051/medsci/2022154
Vincent Puy, Fanny Magnan, Johanna Lousqui, Yasmine Boumerdassi, Badria Bennani Smires, Nicolas Mendes, Florence Eustache
{"title":"[Fertility preservation in transgender people].","authors":"Vincent Puy,&nbsp;Fanny Magnan,&nbsp;Johanna Lousqui,&nbsp;Yasmine Boumerdassi,&nbsp;Badria Bennani Smires,&nbsp;Nicolas Mendes,&nbsp;Florence Eustache","doi":"10.1051/medsci/2022154","DOIUrl":"https://doi.org/10.1051/medsci/2022154","url":null,"abstract":"<p><p>Most of transgender people plan to have a family but their fertility may be affected by gender affirmation. Hormone therapy can permanently affect gamete production, especially in trans women. Sex reassignment surgery leads to permanent sterility. In France, networks of health professionals have been organized and recommend access to fertility preservation for trans people. However, gamete collection is often difficult due to hormonal incongruence for trans women or to the invasive nature of the procedure for trans men. Future studies are required to assess the use of self-preserved gametes by trans people.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"926-933"},"PeriodicalIF":0.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40491661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Dog breeds and behaviour]. [狗的品种和行为]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-11-01 Epub Date: 2022-11-30 DOI: 10.1051/medsci/2022140
Bertrand Jordan
{"title":"[Dog breeds and behaviour].","authors":"Bertrand Jordan","doi":"10.1051/medsci/2022140","DOIUrl":"https://doi.org/10.1051/medsci/2022140","url":null,"abstract":"<p><p>It is commonly believed that a dog's breed predicts its behaviour. A 2019 paper seemed to confirm this, but had some serious limitations. An extensive new study shows that, in fact, breed is not a good predictor of behaviour at the individual level, and has only a weak influence on average characteristics.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"947-950"},"PeriodicalIF":0.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40491663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sociology of transidentities]. [跨界的社会学]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-10-01 Epub Date: 2022-10-11 DOI: 10.1051/medsci/2022129
Arnaud Alessandrin
{"title":"[Sociology of transidentities].","authors":"Arnaud Alessandrin","doi":"10.1051/medsci/2022129","DOIUrl":"https://doi.org/10.1051/medsci/2022129","url":null,"abstract":"<p><p>The sociology of transidentities allows us to shift the medical gaze on trans people and identities. Beyond the psychiatric or surgical issues, we are able to analyze the shift in representations and social consideration about transidentities in France, through a social history of transgender health, a sociology of transphobic experiences or the transformations of trans claims. Beyond its historical perspective, this article is based on recent work on the sociology of transidentities in France and presents various data from statistical surveys.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"816-820"},"PeriodicalIF":0.7,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33521578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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