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Medecine sciences : M/S最新文献

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[A novel role for thrombospondins in the abnormal neuroplasticity associated with behavioral disorders in the adult mouse]. [血小板反应蛋白在成年小鼠与行为障碍相关的异常神经可塑性中的新作用]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-01-01 Epub Date: 2022-01-21 DOI: 10.1051/medsci/2021234
Vincent Vialou
{"title":"[A novel role for thrombospondins in the abnormal neuroplasticity associated with behavioral disorders in the adult mouse].","authors":"Vincent Vialou","doi":"10.1051/medsci/2021234","DOIUrl":"https://doi.org/10.1051/medsci/2021234","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 1","pages":"29-31"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39845602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Nobel Prize in Physiology or Medicine 2021: Temperature and touch sensors]. 【2021年诺贝尔生理学或医学奖:温度和触摸传感器】。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-01-01 Epub Date: 2022-01-21 DOI: 10.1051/medsci/2021248
Bertrand Coste
{"title":"[The Nobel Prize in Physiology or Medicine 2021: Temperature and touch sensors].","authors":"Bertrand Coste","doi":"10.1051/medsci/2021248","DOIUrl":"https://doi.org/10.1051/medsci/2021248","url":null,"abstract":"Prix Nobel de physiologie ou médecine 2021 - Les senseurs de la température et du toucher.\u0000 David Julius, 65 ans, professeur à l’université de Californie à Los Angeles (UCLA), et Ardem Patapoutian, 54 ans, professeur à l’institut de recherche Scripps à la Jolla (Californie), ont reçu le prix Nobel de physiologie ou médecine 2021 pour « leurs découvertes des récepteurs de la température et du toucher ». Leurs travaux sur la somesthésie, un sens global qui nous renseigne sur les forces physiques s’exerçant au sein de notre organisme et sur notre peau, ont permis de répondre à une question fondamentale : comment les stimulations thermiques et mécaniques sont-elles converties en signaux électriques dans le système nerveux ? Ces travaux ont conduit à l’identification des canaux ioniques qui sont à l’interface entre notre corps et son environnement.","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 1","pages":"96-98"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39846050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[medecine/sciences 2022, a passion for research…]. [医学/科学2022，对研究的热情…]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-01-01 Epub Date: 2022-01-21 DOI: 10.1051/medsci/2022001
Jean-Luc Teillaud
{"title":"[medecine/sciences 2022, a passion for research…].","authors":"Jean-Luc Teillaud","doi":"10.1051/medsci/2022001","DOIUrl":"https://doi.org/10.1051/medsci/2022001","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 1","pages":"7-8"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39959043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Super-resolution microscopy: A window into mechanobiology at the molecular level]. [超分辨率显微镜:分子水平上的机械生物学之窗]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-01-01 Epub Date: 2022-01-21 DOI: 10.1051/medsci/2021233
Filipe Nunes Vicente, Olivier Rossier, Grégory Giannone
{"title":"[Super-resolution microscopy: A window into mechanobiology at the molecular level].","authors":"Filipe Nunes Vicente, Olivier Rossier, Grégory Giannone","doi":"10.1051/medsci/2021233","DOIUrl":"https://doi.org/10.1051/medsci/2021233","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 1","pages":"15-17"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39959046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Starting to integrate artificial intelligence for treatment decisions in oncology]. [开始将人工智能整合到肿瘤学的治疗决策中]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-01-01 Epub Date: 2022-01-21 DOI: 10.1051/medsci/2021235
Christophe Le Tourneau, Ivan Bièche, Maud Kamal
{"title":"[Starting to integrate artificial intelligence for treatment decisions in oncology].","authors":"Christophe Le Tourneau, Ivan Bièche, Maud Kamal","doi":"10.1051/medsci/2021235","DOIUrl":"https://doi.org/10.1051/medsci/2021235","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 1","pages":"21-22"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39845598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Generating pancreatic islets organoids: Langerhanoids]. [生成胰岛类器官:Langerhanoids]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-01-01 Epub Date: 2022-01-21 DOI: 10.1051/medsci/2021244
Anastasia Papoz, Flora Clément, Camille Laporte, Emily Tubbs, Xavier Gidrol, Amandine Pitaval
{"title":"[Generating pancreatic islets organoids: Langerhanoids].","authors":"Anastasia Papoz,&nbsp;Flora Clément,&nbsp;Camille Laporte,&nbsp;Emily Tubbs,&nbsp;Xavier Gidrol,&nbsp;Amandine Pitaval","doi":"10.1051/medsci/2021244","DOIUrl":"https://doi.org/10.1051/medsci/2021244","url":null,"abstract":"<p><p>The extension of islet transplantation to a wider number of Type 1 diabetic patients is compromised by the scarcity of donors, the reduced ex vivo survival of pancreatic islets and the use of immunosuppressive treatments. Islets of Langerhans isolated from brain-dead donors are currently the only cell source for transplantation. Thus, it is crucial to find an alternative and an abundant source of functional insulin secreting cells not only for clinical use but also for the development of research dedicated to the screening of drugs and to the development of new therapeutic targets. Several groups around the world, including ours, develop 3D culture models as Langerhanoids that closely mimick human pancreatic islets physiology. In this review, we describe recent advances to mimic the pancreatic niche (extracellular matrix, vascularization, microfluidics) allowing better functionality of Langerhanoids.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 1","pages":"52-58"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39845606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[A critique of the managerial model of research]. [对研究管理模式的批判]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-01-01 Epub Date: 2022-01-21 DOI: 10.1051/medsci/2021247
Romain Brette
{"title":"[A critique of the managerial model of research].","authors":"Romain Brette","doi":"10.1051/medsci/2021247","DOIUrl":"https://doi.org/10.1051/medsci/2021247","url":null,"abstract":"<p><p>To be a scientist is to make an implicit ethical commitment: to try to tell the truth about the world. The managerial model of research, which is the ideological foundation of modern political reforms of the research system around the world, stands in direct conflict with this assertion. It consists in identifying the scientist with a homo economicus looking to maximize its own profit, which a bureaucracy is tasked to align with performance objectives. This model is incoherent and destructive. Science is made possible by curiosity, emulation and intellectual ethics. These are the human traits that a rational research organization should try to favor and exploit.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 1","pages":"84-88"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39846048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
[Melatonin: A short clarification for the over-enthusiasts]. [褪黑素:对过度狂热者的简短澄清]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-01-01 Epub Date: 2022-01-21 DOI: 10.1051/medsci/2021115
Jean A Boutin
{"title":"[Melatonin: A short clarification for the over-enthusiasts].","authors":"Jean A Boutin","doi":"10.1051/medsci/2021115","DOIUrl":"https://doi.org/10.1051/medsci/2021115","url":null,"abstract":"<p><p>Melatonin is a naturally occurring molecule derived from tryptophan. Melatonin is a key player in relaying the circadian rhythm between our environment and our body. It has also a key role in rhythming the seasons (more production during long nights and less during short ones) as well as in the reproduction cycles of the mammals. Melatonin is often and surprisingly presented as a molecule with multiple therapeutic properties that can fix (or help to fix) many health issues, such as diseases (cancer, ageing, virus-induced affections including COVID-19, etc…) or toxicological situations (metals, venoms, chemical such as adriamycin [doxorubicin], methotrexate or paclitaxel). The mechanistics behind those wonders is still missing and this is puzzling. In the present commentary, the main well-established biological properties are presented and briefly discussed with the aim of delineating the borders between facts and wishful thinking.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 1","pages":"89-95"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39846049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Restriction of transposable elements and genome evolution: A fine balance to set up]. [转座因子的限制与基因组进化:建立一个良好的平衡]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-01-01 Epub Date: 2022-01-21 DOI: 10.1051/medsci/2021231
Amandine Bonnet, Pascale Lesage
{"title":"[Restriction of transposable elements and genome evolution: A fine balance to set up].","authors":"Amandine Bonnet,&nbsp;Pascale Lesage","doi":"10.1051/medsci/2021231","DOIUrl":"https://doi.org/10.1051/medsci/2021231","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 1","pages":"18-20"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39845597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Basophilic granulocytes are sensitive to diverse innate stimuli]. [嗜碱性粒细胞对多种先天刺激敏感]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-01-01 Epub Date: 2022-01-21 DOI: 10.1051/medsci/2021229
Christophe Pellefigues
{"title":"[Basophilic granulocytes are sensitive to diverse innate stimuli].","authors":"Christophe Pellefigues","doi":"10.1051/medsci/2021229","DOIUrl":"https://doi.org/10.1051/medsci/2021229","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 1","pages":"22-24"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39845599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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