{"title":"[DNA repair and longevity in mice, other rodents and men].","authors":"Bertrand Jordan","doi":"10.1051/medsci/2022019","DOIUrl":null,"url":null,"abstract":"<p><p>Large differences in maximum longevity exist between different rodent species. Determination of the spontaneous and mutagen-induced mutation rates in these species by single (somatic) cell sequencing suggests more efficient DNA repair in long-lived species (including humans), but the data is too noisy to prove a strong correlation between longevity and preservation of DNA integrity.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"317-319"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medecine sciences : M/S","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1051/medsci/2022019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/3/25 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Large differences in maximum longevity exist between different rodent species. Determination of the spontaneous and mutagen-induced mutation rates in these species by single (somatic) cell sequencing suggests more efficient DNA repair in long-lived species (including humans), but the data is too noisy to prove a strong correlation between longevity and preservation of DNA integrity.
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