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[Succinate dehydrogenase in cancer]. [癌症中的琥珀酸脱氢酶]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022024
Sophie Moog, Judith Favier
{"title":"[Succinate dehydrogenase in cancer].","authors":"Sophie Moog,&nbsp;Judith Favier","doi":"10.1051/medsci/2022024","DOIUrl":"https://doi.org/10.1051/medsci/2022024","url":null,"abstract":"<p><p>Succinate dehydrogenase (SDH) is a mitochondrial enzyme that participates in both the tricarboxylic acid cycle and the electron transport chain. Mutations in genes encoding SDH are responsible for a predisposition to pheochromocytomas and paragangliomas, and more rarely, to gastrointestinal stromal tumors or renal cell carcinomas. A decrease in SDH activity, not explained by genetics, has also been observed in more common cancers. One of the consequences of the inactivation of SDH is the excessive production of its substrate, succinate, which acts as an oncometabolite by promoting a pseudohypoxic status and an extensive epigenetic rearrangement. Understanding SDH-related oncogenesis now makes it possible to develop innovative diagnostic methods and to consider targeted therapies for the management of affected patients.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"255-262"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antibodies and DNA sensors act together to stimulate macrophage antiviral response]. 抗体和DNA传感器共同作用刺激巨噬细胞抗病毒反应。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022020
Fanny Darrault, Mohamed Ibrahmen, Sophie Dupré-Crochet
{"title":"[Antibodies and DNA sensors act together to stimulate macrophage antiviral response].","authors":"Fanny Darrault,&nbsp;Mohamed Ibrahmen,&nbsp;Sophie Dupré-Crochet","doi":"10.1051/medsci/2022020","DOIUrl":"https://doi.org/10.1051/medsci/2022020","url":null,"abstract":"Anticorps et senseurs de l’ADN agissent de concert pour stimuler la réponse anti-virale des macrophages.\u0000 Pour la sixième année consécutive, dans le cadre du module d’enseignement « Physiopathologie de la signalisation » proposé par l’université Paris-sud, les étudiants du Master « Biologie Santé » de l’université Paris-Saclay se sont essayés à l’écriture scientifique. Ils ont sélectionné une quinzaine d’articles scientifiques récents dans le domaine de la signalisation cellulaire, présentant des résultats originaux, via des approches expérimentales variées, sur des thèmes allant des relations hôte-pathogène aux innovations thérapeutiques, en passant par la signalisation hépatique et le métabolisme. Après un travail préparatoire réalisé avec l’équipe pédagogique, les étudiants, organisés en binômes, ont ensuite rédigé, guidés par des chercheurs, une Nouvelle soulignant les résultats majeurs et l’originalité de l’article étudié. Ils ont beaucoup apprécié cette initiation à l’écriture d’articles scientifiques et, comme vous pourrez le lire, se sont investis dans ce travail avec enthousiasme ! Deux de ces Nouvelles sont publiées dans ce numéro, les autres le seront dans des prochains numéros.","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"321-324"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40324844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tumor-associated macrophages: New targets to thwart 5-FU chemoresistance in colorectal cancers?] 肿瘤相关巨噬细胞:阻止结直肠癌5-FU化疗耐药的新靶点?］
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022017
Marie Malier, Khaldoun Gharzeddine, Marie-Hélène Laverriere, Thomas Decaens, Gael Roth, Arnaud Millet
{"title":"[Tumor-associated macrophages: New targets to thwart 5-FU chemoresistance in colorectal cancers?]","authors":"Marie Malier,&nbsp;Khaldoun Gharzeddine,&nbsp;Marie-Hélène Laverriere,&nbsp;Thomas Decaens,&nbsp;Gael Roth,&nbsp;Arnaud Millet","doi":"10.1051/medsci/2022017","DOIUrl":"https://doi.org/10.1051/medsci/2022017","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"243-245"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Brain training games: An effective tool in the fight against cognitive decline]. [大脑训练游戏:对抗认知衰退的有效工具]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022015
Bruno Bonnechère
{"title":"[Brain training games: An effective tool in the fight against cognitive decline].","authors":"Bruno Bonnechère","doi":"10.1051/medsci/2022015","DOIUrl":"https://doi.org/10.1051/medsci/2022015","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"294-295"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40324842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[What technologies bring in the field of neurological disorders: Current realities and future perspectives]. [什么技术带来了神经系统疾病领域:目前的现实和未来的展望]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022031
Alim Louis Benabid, John Mitrofanis, Stephan Chabardes, Philippe Garrec
{"title":"[What technologies bring in the field of neurological disorders: Current realities and future perspectives].","authors":"Alim Louis Benabid,&nbsp;John Mitrofanis,&nbsp;Stephan Chabardes,&nbsp;Philippe Garrec","doi":"10.1051/medsci/2022031","DOIUrl":"https://doi.org/10.1051/medsci/2022031","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"241-242"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Contraception in other countries: The example of Brazil]. [其他国家的避孕:以巴西为例]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022029
Marcio A Hipolito Rodrigues, Marcia Mendonça Carneiro
{"title":"[Contraception in other countries: The example of Brazil].","authors":"Marcio A Hipolito Rodrigues,&nbsp;Marcia Mendonça Carneiro","doi":"10.1051/medsci/2022029","DOIUrl":"https://doi.org/10.1051/medsci/2022029","url":null,"abstract":"<p><p>In Brazil, women have free access to contraception through the public health system, the Unified Health System (SUS) which offers the following contraceptive methods: Male and female condoms, diaphragm, spermicide, copper intrauterine device (IUD), combined oral and injectable contraceptive hormones, progestin-only contraceptives and injections of medroxyprogesterone acetate (DMPA), emergency pill, female sterilization and vasectomy. However, difficulties in scheduling appointments, women's lack of information about contraceptive methods, and the limited availability of different methods all contribute to high rates of unintended pregnancies. The rate of contraceptive use by Brazilian women aged 18 to 49 is approximately 62%; poorer parts of the country and low levels of education are among the main factors associated with lower rates of contraceptive method use. There are therefore challenges to be taken up to minimize the rates of unwanted pregnancies, which are still too high, such as better distribution, better offer of different contraceptive methods for all regions of the country and better training of professionals involved in women's health care.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"280-287"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[The spectrum of the medicine of the future]. [未来医学的光谱]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022023
Anne Marie Moulin
{"title":"[The spectrum of the medicine of the future].","authors":"Anne Marie Moulin","doi":"10.1051/medsci/2022023","DOIUrl":"https://doi.org/10.1051/medsci/2022023","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"313-315"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40324846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Role of the membrane curvature factor IRSp53 in HIV-1 particle assembly and budding]. 膜曲率因子IRSp53在HIV-1颗粒组装和出芽中的作用。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022018
Delphine Muriaux
{"title":"[Role of the membrane curvature factor IRSp53 in HIV-1 particle assembly and budding].","authors":"Delphine Muriaux","doi":"10.1051/medsci/2022018","DOIUrl":"https://doi.org/10.1051/medsci/2022018","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"246-248"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Genetic of congenital hypothyroidism]. [先天性甲状腺功能减退症的遗传]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022028
Athanasia Stoupa, Dulanjalee Kariyawasam, Michel Polak, Aurore Carré
{"title":"[Genetic of congenital hypothyroidism].","authors":"Athanasia Stoupa,&nbsp;Dulanjalee Kariyawasam,&nbsp;Michel Polak,&nbsp;Aurore Carré","doi":"10.1051/medsci/2022028","DOIUrl":"https://doi.org/10.1051/medsci/2022028","url":null,"abstract":"<p><p>Congenital hypothyroidism (CH) is the most frequent neonatal endocrine disorder. CH is due to thyroid development or thyroid function defects (primary) or may be of hypothalamic-pituitary origin (central). Primary CH is caused essentially by abnormal thyroid gland morphogenesis (thyroid dysgenesis, TD) or defective thyroid hormone synthesis (dyshormonogenesis, DH). DH accounts for about 35% of CH and a genetic cause is identified in 50% of patients. However, TD accounts for about 65% of CH, and a genetic cause is identified in less than 5% of patients. The pathogenesis of CH is largely unknown and may include the contribution of individual and environmental factors. During the last years, detailed phenotypic description of patients, next-generation sequence technologies and use of animal models allowed the discovery of novel candidate genes in thyroid development and function. We provide an overview of recent genetic causes of primary and central CH. In addition, mode of inheritance and the oligogenic model of CH are discussed.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"263-273"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Avenues of reflection for endometriosis research in France]. 【法国子宫内膜异位症研究的思考途径】。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-03-01 Epub Date: 2022-03-25 DOI: 10.1051/medsci/2022027
Jean Rosenbaum, Nicolas Bourdel, Saadi Khochbin, Marina Kvaskoff, Sachiko Matsuzaki, Fatima Mechta-Grigoriou, Nicola Pluchino, Olivier Sandra, Daniel Vaiman
{"title":"[Avenues of reflection for endometriosis research in France].","authors":"Jean Rosenbaum,&nbsp;Nicolas Bourdel,&nbsp;Saadi Khochbin,&nbsp;Marina Kvaskoff,&nbsp;Sachiko Matsuzaki,&nbsp;Fatima Mechta-Grigoriou,&nbsp;Nicola Pluchino,&nbsp;Olivier Sandra,&nbsp;Daniel Vaiman","doi":"10.1051/medsci/2022027","DOIUrl":"https://doi.org/10.1051/medsci/2022027","url":null,"abstract":"<p><p>Endometriosis is a chronic disease in which lesions resembling endometrial tissue are found outside the uterus, mainly in the pelvis or abdomen. It may affect 10% of women of childbearing age. It is the cause of a significant alteration in quality of life and a major cost to the health system. Few research teams are working on this subject, and its pathophysiology is still poorly understood. This article proposes avenues of reflection for research on endometriosis in France, notably based on the mobilization of related scientific communities (involved in cancer, development, epigenetics, and neurosciences research studies).</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"274-279"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40326960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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