Medecine sciences : M/SPub Date : 2022-06-01Epub Date: 2022-06-29DOI: 10.1051/medsci/2022074
Romane Leboutet, Renaud Legouis
{"title":"[Autophagy facilitates mitochondrial network rebuilding after heat stress in the nematode C. elegans].","authors":"Romane Leboutet, Renaud Legouis","doi":"10.1051/medsci/2022074","DOIUrl":"https://doi.org/10.1051/medsci/2022074","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"517-519"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medecine sciences : M/SPub Date : 2022-06-01Epub Date: 2022-06-29DOI: 10.1051/medsci/2022079
Roger Frutos, Laurent Gavotte, Christian A Devaux
{"title":"[SARS-CoV-2 has no origin].","authors":"Roger Frutos, Laurent Gavotte, Christian A Devaux","doi":"10.1051/medsci/2022079","DOIUrl":"https://doi.org/10.1051/medsci/2022079","url":null,"abstract":"<p><p>Since the beginning of the COVID-19 pandemic, the question of the origin of this virus has been the subject of a vivid controversy. It is the question of the \"origin\" itself which is biased. Darwin showed that there is no determined origin to any animal or plant species, simply an evolutionary and selective process. The same is true for viruses, there is no origin, but an evolutionary process. Viruses circulate from host to host, animals or humans. Pandemic viruses are already circulating in humans and evolving before the onset of disease. This evolutionary process then continues and gives rise to successive variants. The solution is not to target the disease or the putative causative agent but rather to address the process of disease emergence.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"600-607"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40409416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medecine sciences : M/SPub Date : 2022-06-01Epub Date: 2022-06-29DOI: 10.1051/medsci/2022083
Cylia Dahmani, Eulalie Corre, Sarah Dandou, Alain Mangé, Ovidiu Radulescu, Peter J Coopman, Pierre Cuq, Romain M Larive
{"title":"[Resistance to BRAF inhibitors: A lesson from clinical observations].","authors":"Cylia Dahmani, Eulalie Corre, Sarah Dandou, Alain Mangé, Ovidiu Radulescu, Peter J Coopman, Pierre Cuq, Romain M Larive","doi":"10.1051/medsci/2022083","DOIUrl":"https://doi.org/10.1051/medsci/2022083","url":null,"abstract":"<p><p>The MAPK/ERK pathway is an essential intracellular signaling pathway. Its deregulation is involved in tumor transformation and progression. The discovery of activating mutations of BRAF in various cancers has opened new therapeutic avenues with BRAF protein kinase inhibitors. Depending on the type of cancers, these inhibitors have shown either insufficient efficacy due to primary resistance of tumor cells or transient efficacy due to the development of acquired resistance. In this review, we revisit the discoveries that led to the development of BRAF inhibitors and detail the molecular and cellular mechanisms of resistance in cancers treated with these inhibitors. Understanding these mechanisms is crucial for developing more efficient therapeutic strategies.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"570-578"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medecine sciences : M/SPub Date : 2022-03-01Epub Date: 2022-03-25DOI: 10.1051/medsci/2022030
Virgile Clergue-Duval
{"title":"[Ethical questioning on the posture of the physician-scientist].","authors":"Virgile Clergue-Duval","doi":"10.1051/medsci/2022030","DOIUrl":"https://doi.org/10.1051/medsci/2022030","url":null,"abstract":"Questionnement éthique sur la posture du médecin-chercheur.\u0000 À l’occasion d’un projet de recherche clinique réalisé dans le cadre de mon travail de thèse de science et de ma pratique de recherche clinique en médecine, j’ai été confronté au refus d’un patient de participer à un protocole. Ce refus n’était pas le premier auquel j’étais confronté, mais il m’a surpris et m’a fait m’interroger sur ma pratique en tant que chercheur et sur ma manière d’introduire la problématique de la recherche dans mon exercice de médecin addictologue.","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 3","pages":"309-311"},"PeriodicalIF":0.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40324841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}