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Medecine sciences : M/S最新文献

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[Human genome: The end of the beginning]. [人类基因组:开始的结束]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022078
Bertrand Jordan
{"title":"[Human genome: The end of the beginning].","authors":"Bertrand Jordan","doi":"10.1051/medsci/2022078","DOIUrl":"https://doi.org/10.1051/medsci/2022078","url":null,"abstract":"<p><p>Two decades after its original publication, a new human genome sequence has just been published. Far from being an incremental improvement, it is at last really complete, covering each chromosome from one end to the other, with full elucidation of repeated sequences and an extremely low error rate. This is a major advance that tremendously increases our knowledge of our genome and will lead to important scientific and clinical developments.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"609-611"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40409417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[How dietary interventions can change lipid metabolism to affect tumor growth]. [饮食干预如何改变脂质代谢从而影响肿瘤生长]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022072
Jean Bastin, Fatima Djouadi
{"title":"[How dietary interventions can change lipid metabolism to affect tumor growth].","authors":"Jean Bastin,&nbsp;Fatima Djouadi","doi":"10.1051/medsci/2022072","DOIUrl":"https://doi.org/10.1051/medsci/2022072","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"526-528"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer]. [三级淋巴样结构在肾细胞癌中产生和繁殖抗肿瘤抗体浆细胞]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022069
Maxime Meylan, Catherine Sautès-Fridman, Wolf H Fridman
{"title":"[Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer].","authors":"Maxime Meylan,&nbsp;Catherine Sautès-Fridman,&nbsp;Wolf H Fridman","doi":"10.1051/medsci/2022069","DOIUrl":"https://doi.org/10.1051/medsci/2022069","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"536-538"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Role of inflammasome NLRP3 in the pathophysiology of viral infections: A focus on SARS-CoV-2 infection]. [炎性体NLRP3在病毒感染病理生理中的作用:以SARS-CoV-2感染为例]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022080
Marlène Chemarin, Océane Dufies, Anastassia Mazet, Eva Mellan, Rémy Coudereau, Bénédicte F Py, Laurent Boyer, Fabienne Venet
{"title":"[Role of inflammasome NLRP3 in the pathophysiology of viral infections: A focus on SARS-CoV-2 infection].","authors":"Marlène Chemarin,&nbsp;Océane Dufies,&nbsp;Anastassia Mazet,&nbsp;Eva Mellan,&nbsp;Rémy Coudereau,&nbsp;Bénédicte F Py,&nbsp;Laurent Boyer,&nbsp;Fabienne Venet","doi":"10.1051/medsci/2022080","DOIUrl":"https://doi.org/10.1051/medsci/2022080","url":null,"abstract":"<p><p>NLRP3 is one of the best characterized innate immune cytosolic sensor. As part of the innate immune response, the NLRP3 inflammasome detects a wide range of danger signals such as pathogens, tissue damages, cellular stress. The priming and activation of NLRP3 lead to the formation of an oligomeric intracellular complex and to the recruitment and activation of caspase-1. Once activated, not only this inflammasome complex controls the processing and release of pro-inflammatory factors including IL-1β and IL-18, but also the inflammatory cell death pyroptosis mediated by gasdermin D pores. In this review, we describe the role of the NLRP3 inflammasome activation in viral infections with a particular interest on SARS-CoV-2 infection. In addition, we present therapies evaluated or under evaluation targeting the NLRP3 inflammasome pathway as COVID-19 treatment.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"545-552"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
[Mitochondrial transport: How does it impact cancer?] 线粒体运输:它如何影响癌症?］
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022085
Morgane Morin, Hadia Moindjie, Clara Nahmias
{"title":"[Mitochondrial transport: How does it impact cancer?]","authors":"Morgane Morin,&nbsp;Hadia Moindjie,&nbsp;Clara Nahmias","doi":"10.1051/medsci/2022085","DOIUrl":"https://doi.org/10.1051/medsci/2022085","url":null,"abstract":"<p><p>Cancer cells are characterized by a deregulation of their metabolic activity, which allows them to meet a high energy demand. Mitochondria are key organelles that control several metabolic processes and represent the main source of energy in the form of ATP. Intracellular transport of mitochondria is essential for addressing these organelles to the right place at the right time according to energy requirement. Mitochondrial transport in cancer cells involves mitochondria-associated Miro/TRAK complexes that bind to motor proteins (kinesins, dyneins and myosins) to promote mitochondrial displacement along microtubules or actin filaments. This review focuses on the molecular players of intracellular mitochondrial transport along microtubules during cell migration and mitosis, and their deregulation in tissues from cancer patients. Intercellular mitochondrial transport upon cancer cell exposure to hypoxia or chemotherapy is also presented. This field of investigation opens new interesting perspectives in oncology, as targeting mitochondrial transport may represent an innovative strategy for treating cancer.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"585-593"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Getting in shape to divide: When oncogenes contribute to mitotic cell rounding]. [为分裂保持体形:当癌基因有助于有丝分裂细胞的圆切]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022066
Danièle Salaün, Pascal Verdier-Pinard, Ali Badache
{"title":"[Getting in shape to divide: When oncogenes contribute to mitotic cell rounding].","authors":"Danièle Salaün,&nbsp;Pascal Verdier-Pinard,&nbsp;Ali Badache","doi":"10.1051/medsci/2022066","DOIUrl":"https://doi.org/10.1051/medsci/2022066","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"514-516"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Toward precision surgery for Head and Neck tumors]. [头颈部肿瘤的精准手术]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022082
Zuzana Saidak, Antoine Galmiche, Martial Ouendo, Denis Chatelain, Jean-Marc Constans, Sylvie Testelin
{"title":"[Toward precision surgery for Head and Neck tumors].","authors":"Zuzana Saidak,&nbsp;Antoine Galmiche,&nbsp;Martial Ouendo,&nbsp;Denis Chatelain,&nbsp;Jean-Marc Constans,&nbsp;Sylvie Testelin","doi":"10.1051/medsci/2022082","DOIUrl":"https://doi.org/10.1051/medsci/2022082","url":null,"abstract":"Surgical resection is the most frequent curative treatment proposed to patients with head and neck cancers. It is currently integrated into specific therapeutic schemes and therapeutic stratification, but the surgical procedure itself as well as its evaluation do not rely on tumor biology. Here, we present a number of recent studies, mostly based on system analyses and genomics, that show how tumor analyses could help to: i) define the indications and the extent of surgical resections; ii) personalize the perioperative management; iii) facilitate the detection of post-surgical tumor recurrence. Overall, these studies provide a proof of principle that precision surgery, i.e. based on tumor biology, similarly to precision medicine, is applicable to head and neck cancers.","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"562-569"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40409413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A behavioral economics approach for individual decisions in the face of COVID-19: Successes and disappointments]. [面对COVID-19个人决策的行为经济学方法:成功与失望]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022077
Thierry Blayac, Dimitri Dubois, Sébastien Duchene, Phu Nguyen-Van, Ismaël Rafaï, Bruno Ventelou, Marc Willinger
{"title":"[A behavioral economics approach for individual decisions in the face of COVID-19: Successes and disappointments].","authors":"Thierry Blayac,&nbsp;Dimitri Dubois,&nbsp;Sébastien Duchene,&nbsp;Phu Nguyen-Van,&nbsp;Ismaël Rafaï,&nbsp;Bruno Ventelou,&nbsp;Marc Willinger","doi":"10.1051/medsci/2022077","DOIUrl":"https://doi.org/10.1051/medsci/2022077","url":null,"abstract":"Les attendus d’une approche d’économie comportementale pour les décisions individuelles face à la pandémie de COVID-19 : succès et déceptions.\u0000 Dans le cadre du premier appel à projet « Flash-COVID-19 » de l’Agence nationale de la recherche, nous avons mobilisé des méthodes récentes de l’économie comportementale afin de mieux comprendre les décisions des individus face à la crise sanitaire due à la pandémie de COVID-19 (coronavirus disease 2019) et d’identifier les paramètres pouvant influencer le respect des mesures sanitaires. Cet article introduit brièvement l’économie comportementale, présente un compte rendu des attendus du projet CONFINOBS (Observance et observation des mesures barrières et du confinement : une approche d’économie comportementale) et de ses méthodes, puis il propose une synthèse des résultats obtenus.","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"594-599"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40409414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
[Involvement of MEK1 and MEK2 kinases in the maturation of the mouse immune system]. [MEK1和MEK2激酶参与小鼠免疫系统成熟]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022071
Nicolas Houde, Marion Espéli, Jean Charron
{"title":"[Involvement of MEK1 and MEK2 kinases in the maturation of the mouse immune system].","authors":"Nicolas Houde,&nbsp;Marion Espéli,&nbsp;Jean Charron","doi":"10.1051/medsci/2022071","DOIUrl":"https://doi.org/10.1051/medsci/2022071","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"529-532"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Measles subacute sclerosing panencephalitis (SSPE): A still present and still mysterious fatal disease. History, Diagnosis and Assumptions]. 麻疹亚急性硬化性全脑炎(SSPE):一种仍然存在且仍然神秘的致命疾病。病史、诊断和假设]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022081
Pierre Lebon, Antoinette Gelot, Shen-Ying Zhang, Jean-Laurent Casanova, Jean-Jacques Hauw
{"title":"[Measles subacute sclerosing panencephalitis (SSPE): A still present and still mysterious fatal disease. History, Diagnosis and Assumptions].","authors":"Pierre Lebon,&nbsp;Antoinette Gelot,&nbsp;Shen-Ying Zhang,&nbsp;Jean-Laurent Casanova,&nbsp;Jean-Jacques Hauw","doi":"10.1051/medsci/2022081","DOIUrl":"https://doi.org/10.1051/medsci/2022081","url":null,"abstract":"<p><p>Subacute sclerosing panencephalitis, a late complication of measles, is still present during epidemics of this disease due to insufficient vaccination. After a historical review, the importance of the diagnostic criteria and the pathophysiology of SSEP are discussed. Numerous studies on the parameters of innate immunity and interferon responses tend to show a decrease in the activity of cellular immunity. Several hypotheses are formulated based on the publications of the different forms of the disease: Congenital, perinatal, forms with short incubation similar to acute inclusion encephalitis (AIE), rapidly evolving forms, forms of the immunocompromised, or even adults. Familial forms have been identified, suggesting a genetic cause. Based on the duration of the latency period, two groups have been individualized, prompting a retrospective and prospective analysis of the exomes of these patients. The knowledge of the genes involved should be useful for the understanding of the pathophysiology of SSPE and other late neurological RNA virus infections.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"553-561"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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