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[Blood pressure regulation: A crucial role of potassium intake]. [血压调节:钾摄入量的关键作用]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-08-01 Epub Date: 2022-09-12 DOI: 10.1051/medsci/2022115
Dicken Fardol, Aylin Gulmez, Zeynep Yoldas, Stéphane Lourdel
{"title":"[Blood pressure regulation: A crucial role of potassium intake].","authors":"Dicken Fardol, Aylin Gulmez, Zeynep Yoldas, Stéphane Lourdel","doi":"10.1051/medsci/2022115","DOIUrl":"https://doi.org/10.1051/medsci/2022115","url":null,"abstract":"Le Master de Biologie intégrative et physiologie (BIP) de Sorbonne Université recouvre un large champ disciplinaire, allant de la biologie du vieillissement à la physiopathologie, à la nutrition, aux bioressources marines et aux neurosciences, dont les enjeux sont essentiels aussi bien sur le plan fondamental qu’appliqué.\u0000L’objectif de la mention est de former des spécialistes de haut niveau aux concepts les plus récents de la biologie intégrative. La mention forme les étudiants à appréhender les mécanismes qui sous-tendent les différentes fonctions physiologiques et pathologiques depuis la cellule jusqu’à l’organisme, chez les animaux ou dans l’espèce humaine.","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"743-745"},"PeriodicalIF":0.7,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33462271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Double degree in Health and Sciences Curriculum at the Rouen Health UFR: Current situation and perspectives]. [鲁昂卫生大学卫生与科学双学位课程:现状与展望]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-08-01 Epub Date: 2022-09-12 DOI: 10.1051/medsci/2022106
Ivana Dabaj, Imran Lahmar, Anaëlle Gomez, Léo Barbey, Antonin Verdier, Colombe Delage, Eva Galateau, Raphaël Aubert, Alexandre Gehanno, Pauline Schaal, Lea Feldmann, Abdellah Tebani, François Estour, Soumeya Bekri
{"title":"[The Double degree in Health and Sciences Curriculum at the Rouen Health UFR: Current situation and perspectives].","authors":"Ivana Dabaj,&nbsp;Imran Lahmar,&nbsp;Anaëlle Gomez,&nbsp;Léo Barbey,&nbsp;Antonin Verdier,&nbsp;Colombe Delage,&nbsp;Eva Galateau,&nbsp;Raphaël Aubert,&nbsp;Alexandre Gehanno,&nbsp;Pauline Schaal,&nbsp;Lea Feldmann,&nbsp;Abdellah Tebani,&nbsp;François Estour,&nbsp;Soumeya Bekri","doi":"10.1051/medsci/2022106","DOIUrl":"https://doi.org/10.1051/medsci/2022106","url":null,"abstract":"<p><p>The Double degree in Health and Sciences (DCSS) provides an early training in research for future healthcare professionals. The profound transformation of the healthcare system and the advent of new analytical and digital technologies highlight the urgent need to link research to clinical practice. At the international level, especially in the United States, these programs point out the key role of healthcare professionals with both medical and scientific expertise. In France, a DCSS during medical studies was set up in the 2000's. This training is still heterogeneous and is not organized in all Faculties of Health Sciences. The Rouen Faculty of Health Sciences observed in 2016 that the number of students involved in DCSS was very low or even zero, depending on the year. The Rouen Faculty of Health Sciences initiated an institutional support in 2017 that led to the creation of a student mentorship dedicated to DCSS. This mentorship and the institutional leaders of this course have initiated a theoretical and practical training program. The organization of the DCSS of the Rouen Faculty of Health Sciences and the creation of a student mentorship program enabled us to increase the number of candidates interested in the DCSS (from 2 in 2016 to 26 in 2021) and to obtain an institutional recognition of this double major.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"698-706"},"PeriodicalIF":0.7,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33462335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Somatic mutations and longevity]. [体细胞突变与长寿]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-08-01 Epub Date: 2022-09-12 DOI: 10.1051/medsci/2022098
Bertrand Jordan
{"title":"[Somatic mutations and longevity].","authors":"Bertrand Jordan","doi":"10.1051/medsci/2022098","DOIUrl":"https://doi.org/10.1051/medsci/2022098","url":null,"abstract":"<p><p>New approaches allow precise measurement of somatic mutations in tissues. Applied to a diverse set of mammals, these methods show that somatic mutation load increases with age (as expected) but reaches similar levels near the end of life for animals with extremely different longevity. This is an important result that has many repercussions on concepts of aging and of evolution of longevity.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"723-725"},"PeriodicalIF":0.7,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33462337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[The digital twin in health: Organizational contributions and epistemological limits in a context of health crisis]. [健康中的数字孪生:健康危机背景下的组织贡献和认识论限制]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-08-01 Epub Date: 2022-09-12 DOI: 10.1051/medsci/2022105
Sandra Bertezene
{"title":"[The digital twin in health: Organizational contributions and epistemological limits in a context of health crisis].","authors":"Sandra Bertezene","doi":"10.1051/medsci/2022105","DOIUrl":"https://doi.org/10.1051/medsci/2022105","url":null,"abstract":"<p><p>A digital twin is the virtual double of a system. This article shows how, within a hospital, decision-makers can mobilize this technology to improve the quality of care. Specifically, digital twins of services and care processes can be performant in risk management inherent in a health crisis. However, the articulation of virtual twins with simulations in the real world seems the best option for professionals to become rational and pragmatic practitioners, able to apprehend uncertainty and prepared to face the unknown in the troubled context that we know.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"663-668"},"PeriodicalIF":0.7,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33461980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pseudohypoparathyroidism and variants: A translational medicine success story]. 假性甲状旁腺功能低下及其变异:一个转化医学的成功案例。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-08-01 Epub Date: 2022-09-12 DOI: 10.1051/medsci/2022103
Marie-Laure Kottler
{"title":"[Pseudohypoparathyroidism and variants: A translational medicine success story].","authors":"Marie-Laure Kottler","doi":"10.1051/medsci/2022103","DOIUrl":"https://doi.org/10.1051/medsci/2022103","url":null,"abstract":"<p><p>Pseudohypoparathyroidism (PHP) is an uncommon disorder which is characterized by end-organ PTH resistance. The genetic defect is located at the GNAS locus that encodes the alpha-subunit of the stimulatory G protein (Gα<sub>s</sub>) and several splice variants thereof. This complex locus undergoes parental specific methylation changes that result in tissue-specific silencing of the paternal allele. Heterozygous inactivating mutations that disrupt Gα<sub>s</sub> function or epigenetics changes that impair Gα<sub>s</sub> expression contribute to a wide clinical spectrum of the disease: PHP1A, PHP1B, osseous heteroplasia, osteodystrophy, obesity, intrauterine growth retardation… whose mechanisms at the molecular level remain unresolved.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"655-662"},"PeriodicalIF":0.7,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33461979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The transitional care from pediatrics to adult medicine within the rare autoimmune and autoinflammatory diseases network]. 【罕见自身免疫性和自身炎症性疾病网络中从儿科到成人医学的过渡护理】。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-08-01 Epub Date: 2022-09-12 DOI: 10.1051/medsci/2022107
Muriel Herasse, Mélanie Romier, Véronique Hentgen, Agnès Duquesne, Jean-Paul Larbre, Hélène Maillard, Micheline Pha, Pascal Pillet, Héloïse Reumaux, Marie-Elise Truchetet, Sophie Georgin-Lavialle, Alexandre Belot
{"title":"[The transitional care from pediatrics to adult medicine within the rare autoimmune and autoinflammatory diseases network].","authors":"Muriel Herasse,&nbsp;Mélanie Romier,&nbsp;Véronique Hentgen,&nbsp;Agnès Duquesne,&nbsp;Jean-Paul Larbre,&nbsp;Hélène Maillard,&nbsp;Micheline Pha,&nbsp;Pascal Pillet,&nbsp;Héloïse Reumaux,&nbsp;Marie-Elise Truchetet,&nbsp;Sophie Georgin-Lavialle,&nbsp;Alexandre Belot","doi":"10.1051/medsci/2022107","DOIUrl":"https://doi.org/10.1051/medsci/2022107","url":null,"abstract":"<p><p>The committee involved in transitional care within the French network on rare autoimmune and auto-inflammatory diseases has developed tools and published recommendations for the care during the transition of adolescents and young adults suffering from these chronic diseases which often demonstrate flares. As the challenge is the compliance to the continuation of care in the adult world, the therapeutic alliance between the young patient and his/her pediatrician and then his/her adult doctor is particularly important. The working group thus carried out a survey on how doctors and young patients perceive their relationship during the period of transition in medical supervision.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"686-692"},"PeriodicalIF":0.7,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33462334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[From a care protocol to the success of a clinical trial: Iccarre, QUATUOR, and Jacques Leibowitch]. [从护理方案到临床试验的成功:Iccarre, QUATUOR和Jacques Leibowitch]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-08-01 Epub Date: 2022-09-12 DOI: 10.1051/medsci/2022109
Caroline Petit
{"title":"[From a care protocol to the success of a clinical trial: Iccarre, QUATUOR, and Jacques Leibowitch].","authors":"Caroline Petit","doi":"10.1051/medsci/2022109","DOIUrl":"https://doi.org/10.1051/medsci/2022109","url":null,"abstract":"D’un protocole de soin au succès d’un essai clinique - Iccarre, QUATUOR, et Jacques Leibowitch.\u0000 Les innovations pour traiter l’infection par le virus de l’immunodéficience humaine (VIH) n’ont pas cessé depuis les premières monothérapies et, en 1996, les premières trithérapies. L’une d’elles vient d’être validée par l’essai ANRS QUATUOR. Elle consiste à prendre deux fois moins de médicaments, en rendant le traitement intermittent. À la demande des patients non adhérents à sa prescription standard, Jacques Leibowitch a encadré cette pratique dès 2002, en s’appuyant sur une étude transgressant le dogme de l’adhésion stricte au traitement quotidien. Ce concept de traitement à temps partiel provenait des travaux du groupe d’Anthony Fauci, mais il le revisitera pour le pousser à son apogée avec la cohorte Iccarre. Son intention strictement thérapeutique s’inscrivit initialement dans le cadre du protocole de soin Iccarre qui, en 2020, comptait 96 patients, majoritairement en réduction médicamenteuse de 70 % grâce à l’ultra-intermittence thérapeutique. Il a posé les bases de l’essai contrôlé QUATUOR dont le résultat, récemment publié, montre la non infériorité des traitements intermittents à 4 jours/7 de médicaments par rapport au traitement standard.","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"707-713"},"PeriodicalIF":0.7,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33462336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Spinal cord injury and repetitive magnetic stimulation]. [脊髓损伤和重复磁刺激]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-08-01 Epub Date: 2022-09-12 DOI: 10.1051/medsci/2022108
Pauline Michel-Flutot, Stéphane Vinit
{"title":"[Spinal cord injury and repetitive magnetic stimulation].","authors":"Pauline Michel-Flutot,&nbsp;Stéphane Vinit","doi":"10.1051/medsci/2022108","DOIUrl":"https://doi.org/10.1051/medsci/2022108","url":null,"abstract":"<p><p>Spinal cord injuries induce motor and sensory deficits. The development of therapies aimed to improve these functions after spinal cord injury is therefore necessary. Repeated magnetic stimulation (rMS) is an innovative and non-invasive technique which has been used to modulate the activity of neuronal networks in various diseases such as bipolar disorder or Parkinson's disease. rMS could therefore display beneficial functional effects in people with spinal cord injury. Studies carried out in vitro, in vivo and ex vivo have made it possible to partly understand the mechanisms underlying the modulation of neuronal activity induced by rMS protocols. Its use in preclinical models of spinal cord injury has also shown beneficial functional effects. Thus, rMS seems to be a promising therapy in the recovery of lost functions after spinal cord injury.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":" ","pages":"679-685"},"PeriodicalIF":0.7,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33462338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[PAX7 acetylation controls muscle stem cell self-renewal]. [PAX7乙酰化控制肌肉干细胞自我更新]。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022073
Caroline E Brun, Marie-Claude Sincennes
{"title":"[PAX7 acetylation controls muscle stem cell self-renewal].","authors":"Caroline E Brun,&nbsp;Marie-Claude Sincennes","doi":"10.1051/medsci/2022073","DOIUrl":"https://doi.org/10.1051/medsci/2022073","url":null,"abstract":"","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"524-525"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Idiopathic pulmonary fibrosis]. 特发性肺纤维化。
IF 0.7
Medecine sciences : M/S Pub Date : 2022-06-01 Epub Date: 2022-06-29 DOI: 10.1051/medsci/2022084
Nathan Hennion, Jean-Luc Desseyn, Frédéric Gottrand, Lidwine Wémeau-Stervinou, Valérie Gouyer
{"title":"[Idiopathic pulmonary fibrosis].","authors":"Nathan Hennion,&nbsp;Jean-Luc Desseyn,&nbsp;Frédéric Gottrand,&nbsp;Lidwine Wémeau-Stervinou,&nbsp;Valérie Gouyer","doi":"10.1051/medsci/2022084","DOIUrl":"https://doi.org/10.1051/medsci/2022084","url":null,"abstract":"<p><p>Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease of unknown origin. It is characterized by aberrant scarring of the alveolar epithelium leading to an accumulation of extracellular matrix (ECM). Fibroblastic foci, consisting of fibroblasts and myofibroblasts, are responsible for the excessive production of ECM. The two therapeutic molecules available on the market to date only allow to slow down the evolution of the disease. In this review, we present the mechanisms involved in the progression of the disease, its treatments and the study models.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 6-7","pages":"579-584"},"PeriodicalIF":0.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40409412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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