BioMedicine-Taiwan最新文献

{"title":"Russell's viper envenomation: The challenge of diagnosis.","authors":"Jing-Hua Lin, Wang-Chou Sung, Jiunn-Wang Liao, Dong-Zong Hung","doi":"10.37796/2211-8039.1649","DOIUrl":"10.37796/2211-8039.1649","url":null,"abstract":"<p><p>Russell's viper envenomation is rare in Taiwan, and its typical clinical presentations, including consumption coagulopathy, acute renal failure, haemolysis, and increased capillary permeability, have been reported in the literature as case reports or series. Here, we report a case with an atypical presentation, and suspected to be a Russell's viper bite due to the distinct distribution characteristics of the snake and some progressive clinical signs/symptoms. He returned to health successfully after the correct antivenom was administered, and envenomation was ultimately confirmed by venom detection in the patient's serum and urine samples.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"15 2","pages":"50-53"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective role of Astaxanthin against oxidative stress and inflammation in peritoneal dialysis rats.","authors":"Ratih Tri Kusuma Dewi, Bambang Purwanto, Brian Wasita, Vitri Widyaningsih","doi":"10.37796/2211-8039.1651","DOIUrl":"10.37796/2211-8039.1651","url":null,"abstract":"<p><strong>Background: </strong>Prolonged exposure of peritoneal membrane to dialysate solution is known to cause fibrosis mediated by imbalanced inflammatory response and oxidative stress. In this context, proinflammatory cytokines including TGF-β and IL-1β, along with oxidative stress markers namely SOD and MDA, present in circulation, could serve as indicators of fibrosis. This phenomenon has the potential to interfere with the optimization of Chronic Kidney Disease (CKD) treatment. Other oral antioxidant supplements have been widely studied to prevent peritoneal damage, but investigations regarding Astaxanthin (AST) effect on fibrosis marked with proinflammatory cytokine are still limited.</p><p><strong>Aims: </strong>This study aimed to investigate the protective role of AST supplementation against fibrosis in peritoneal dialysis by evaluating proinflammatory cytokine levels.</p><p><strong>Results: </strong>The results showed that AST supplementation reduced the levels of MDA, TGF-β, and IL-1β within the circulation while also improving SOD concentration in peritoneal dialysis-induced rats, as indicated by p < 0.001. The longer duration of supplementation, namely 14 vs. 21 days, showed a better outcome against oxidative stress and inflammatory response, as indicated by p < 0.05.</p><p><strong>Conclusion: </strong>This study found that AST supplementation might prevent peritoneal fibrosis by decreasing MDA, TGF-β, and IL-1β, as well as increasing SOD levels in serum.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"15 2","pages":"1-7"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic spine surgery - Surgical technique and nuances for improving safety.","authors":"Mun Chun Lai, Pirateb Paramasivam Meenakshi Sundaram, Arun-Kumar Kaliya-Perumal, Jacob Yoong-Leong Oh","doi":"10.37796/2211-8039.1644","DOIUrl":"10.37796/2211-8039.1644","url":null,"abstract":"<p><p>The integration of robotic technology into spinal surgery has led to a remarkable transformation, offering improved precision and safety. The \"CT-Fluoro merge\" and \"Scan-and-Plan\" methods for pedicle screw application promise numerous advantages, minimizing risks associated with traditional approaches. Our early series of patients who underwent robot-assisted pedicle screw placements for various indications, predominantly lumbar spondylosis, revealed no complications related to screws, neurological deficits, or unplanned returns to the operating theatre, thus emphasizing the safety and effectiveness of the robot. Studies have consistently demonstrated the superiority of robot-assisted pedicle screw placement in terms of accuracy, with decreasing rates of technical issues indicating improvements in reliability and precision. Our experiences align with these findings, signalling the emergence of robotic spine surgery as the forthcoming standard of care in the field. This short communication explores the steps involved in robotic pedicle screw placement, discusses nuances for improving safety, and emphasizes its benefits and implications for the future of spinal care.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"15 1","pages":"1-5"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-silico study of rosmarinic acid roles in inhibiting breast cancer progression.","authors":"Ngakan Putu Krishna Mahayana, Ngurah Bagus Agung Surya Nanda Jayesvara Dwi Sutanegara, Made Dwinanda Prabawa Mahardana, Desak Made Wihandani","doi":"10.37796/2211-8039.1638","DOIUrl":"10.37796/2211-8039.1638","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the highest cancer incidence in the world. Chemotherapy is currently one of the main breast cancer treatments besides surgery. It is capable of evolving to become resistant to chemotherapy agents. Chemotherapy also has significant side effects. Rosmarinic acid could become an anti-cancer agent candidate for the treatment of breast cancer, but its molecular mechanism is still unclear.</p><p><strong>Aim: </strong>This study aimed to clarify the molecular mechanism of rosmarinic acid anti-breast cancer properties via an in-silico study.</p><p><strong>Methods: </strong>Web-based screening tools such as SwissTargetPrediction, Similarity Ensemble Approach (SEA), and TargetNet were used as initial screening. From web-based screening, potential proteins that interact with rosmarinic acid could be determined. Intersected proteins from 3 web-based screenings were assessed via literature review. We found 11 intersected proteins, and 6 of 11 proteins are involved in breast cancer development and progression. Those 6 proteins are MMP-1, MMP-2, MMP-9, MMP-12, aldose reductase, and M-phase Inducer Phosphatase 2 (CDC25B). Then molecular docking using Autodock 4.6.2 was used in ligand and protein interaction simulation. Those 6 proteins were selected as macromolecules in the docking study.</p><p><strong>Results: </strong>Based on the docking result, we found that rosmarinic acid can bind MMP-1, MMP2, MMP-9, and MMP-12 active sites. The binding profile of rosmarinic acid with aldose reductase has similarities with other confirmed inhibitors. Docking with CDC25B showed that rosmarinic acid also binds in the same place as cyclin-dependent kinases (CDKs).</p><p><strong>Conclusion: </strong>The ability of rosmarinic acid to inhibit MMP-1, MMP-2, MMP-9, aldose reductase, and CDC25B activity may underlie how rosmarinic acid is able to inhibit the development of breast cancer.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"15 1","pages":"23-30"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute phantosmia as the first manifestaton of brain metastases in a patient with breast cancer. Case report.","authors":"Georgios I Papageorgiou, Nikolaos Skouteris","doi":"10.37796/2211-8039.1641","DOIUrl":"10.37796/2211-8039.1641","url":null,"abstract":"<p><p>Phantosmia belongs to the group of olfactory dysfunctions. It is more commonly described in psychiatric conditions and some cases of viral infections, but it has been also rarely described in cancer patients who develop primary or metastatic central nervous system tumors; the early identification of this symptom in this population is crucial, as it could lead to timely diagnosis and treatment through a multidisciplinary approach. With the current report we present the case of a 60-year-old lady with metastatic breast cancer and without known preexisting brain metastases, who developed acute phantosmia without other neurological deficits; computed tomography of the brain revealed multiple brain metastases, which were attributed to the malignancy, and for which she was effectively treated with whole brain irradiation and antipsychotic as well as anticonvulsant medications. Furthermore, we underline the value of cooperation between the various specialties that could aid in diagnosis and management of this symptomatology. Phantosmia is an extremely rare symptom in cancer patients, and its appearance should alarm physicians to rapidly investigate a possible progression of disease in the central nervous system. Multidisciplinary approach is needed for the optimal management of these patients.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"15 1","pages":"53-56"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated levels of glycated albumin and C-reactive protein/total albumin ratio might distinguish prediabetics among the apparently healthy people and predict the vulnerability for development of steatohepatitis and cardiac risk.","authors":"Rizk S Sarhan, Raafat R Mohammed","doi":"10.37796/2211-8039.1639","DOIUrl":"10.37796/2211-8039.1639","url":null,"abstract":"<p><strong>Background: </strong>Prediabetes precedes Type-2 diabetes development, is characterized by impaired glucose tolerance (IGT) as judged by the 75-g oral glucose tolerance test (75-OGTT) and is associated with higher cardiac risk (CR), dyslipidemia, hepatosteatosis (HS) and cancer.</p><p><strong>Aims: </strong>The study aimed to determine the distinguishing ability of estimated levels of glycated albumin (GA) and hemoglobin A1c (HbA1c), and serum C-reactive protein (CRP) and serum total albumin (TA) levels for prediabetic out of apparently healthy subjects.</p><p><strong>Methods: </strong>IGT was diagnosed if fasting blood glucose (FBG) was 100-125 mg/dl and if < 100 mg/dl subject is normal glucose tolerant (NGT). CR, HS and insulin resistance (IR) were suggested if the calculated atherogenic index of plasma (AIP) was >0.1, HS index (HSI) was >36 with high computerized hepatorenal index (HRI) and the homeostasis model assessment of IR (HOMA-IR) score was >2, respectively.</p><p><strong>Results: </strong>253 subjects (50.8%) had IGT and were older, more obese and mainly females. IGT had higher GA%, HOMA-IR score, serum CRP and lower TA with high CRP/TA ratio (CAR) than NGT. The frequency of subjects had AIP>0.1, HSI>36 and high HRI was significantly higher among IGT subjects. Statistical analyses defined high GA% and CAR as predictors for IGT, HOMA-IR>36 and AIP score >0.1, while high CAR is the only predictor for HSI score >36 and high HIR score.</p><p><strong>Conclusion: </strong>Prediabetes is not uncommon and high GA% and CAR might differentiate them among the apparently healthy population, and could predict those at increased risk for IR, HS and at CR.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"15 1","pages":"42-52"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling role of oncogenic signalling pathways in complicating breast cancer.","authors":"Acharya Balkrishna, Sagar Kumar, Rohan Malik, Kuldeep Singh Mehra, Hariom Chaturvedi, Okeshwar, Rashmi Mittal","doi":"10.37796/2211-8039.1640","DOIUrl":"10.37796/2211-8039.1640","url":null,"abstract":"<p><p>Heterogeneous nature of breast cancer has significantly affected the overall survival, disease free survival and progression free survival amongst the diseased individuals. Metastasis of cancerous cells to distant sites including bone, lungs, liver, lymph node and others have further exhilarated the adverse effects. However, ER, PR and HER-2 are responsible for normal physiological development of women but in altered conditions they may act as initiator or progressor and so far 5 subtypes of disease have been identified. Alteration of pro-survival, pro-proliferative and anti-apoptotic pathways including JAK/STAT, MAPK, PI3K/AkT/mTOR, NF-κB, BCL2 and several others have induced oncogenic events including epithelial-mesenchymal transition, intra-vasation, extra-vasation and many more. Although several US-FDA approved drugs are available in market to target above mentioned signalling pathways but issues of resistance, side effects have restricted their efficacy. The present review article aims to highlight diverse molecular subtypes and the signalling pathways involved in complicating the disease along with the US-FDA approved drugs to target them. Potential herbal medicine to target the disease have also been emphasized that can be used either as mono-therapeutic approach or in combination with conventional therapeutic regimens to target breast cancer.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"15 1","pages":"13-21"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma levels of miR-21b and miR-146a can discriminate rheumatoid arthritis diagnosis and severity.","authors":"Rizk S Sarhan, Amr M El-Hammady, Yasmin M Marei, Sania K Elwia, Doaa M Ismail, Emtethal A S Ahmed","doi":"10.37796/2211-8039.1637","DOIUrl":"10.37796/2211-8039.1637","url":null,"abstract":"<p><strong>Objectives: </strong>This study tried to examine the ability of the estimated plasma gene-expression levels (PGEL) of microRNA (miR)-146a and miR-21b to distinguish patients with early rheumatoid arthritis (RA) out of arthritis patients who did not fulfill the diagnostic spectrum of either RA or osteoarthritis (OA); the diagnostic Gray-Zone (GZ).</p><p><strong>Patients & methods: </strong>Enrolled patients underwent full diagnostic workup and were categorized as highseropositive and fulfilled the diagnostic spectrum for RA (RA-group), seronegative and fulfilling the diagnostic spectrum of OA (OA-group) and low-seropositive or seronegative patients who did not fulfill diagnostic criteria of RA or OA (GZ-group). Blood samples were obtained for quantification of PGEL of miR-146a and miR-21-b using the quantitative Reverse-transcriptase polymerase chain reaction and results were related to patients' seropositivity and clinical data.</p><p><strong>Results: </strong>The mean fold change of PGEL of miR-146a and miR-21b was significantly higher in patients than in control samples, in samples of high-seropositive patients than in other samples, and in samples of low-seropositive than in seronegative patients. Both markers showed a positive significant correlation with Disease Activity Score-28 for RA-activity and seropositivity. Using the ROC curve analysis, the PGEL of both microRNAs could identify high-seropositive among the studied arthritis patients, but Regression Analysis defined high PGEL of miR-146a as the most significant predictor to identify RA patients and predict their disease activity. Statistical analyses defined miR-146a as the significant parameter that could differentiate between early RA and OA patients among GZ patients.</p><p><strong>Conclusion: </strong>Early arthritis that does not fulfill the diagnostic spectrum of a certain type of arthritis is not uncommon and challenges therapeutic decision-making. The estimated PGEL of MicroRNA-146a might enlighten this gray diagnostic zone and allow differentiation between patients with early RA and early OA, and help to stratify RA patients according to disease activity and severity.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"15 1","pages":"30-41"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distal femur fractures: The use of a fibular strut allograft with dual locking plates allows for early weight bearing.","authors":"Brian R K Chee, Chenghan Wu, Abhjeet A Salunke, Yongsheng Chen","doi":"10.37796/2211-8039.1642","DOIUrl":"10.37796/2211-8039.1642","url":null,"abstract":"<p><strong>Introduction: </strong>Distal femur fractures result in high morbidity and mortality - comparable to that of hip fractures. The commonly used surgical fixation techniques today, locked plating and intramedullary nailing, have shown high postoperative complication rates. Thus, many surgeons temporarily keep patients non-weight bearing in the early postoperative stage. Increased time to ambulation after surgery is known to increase systemic complications in patients. We aim to investigate if an augmented fixation technique involving the use of a fibular strut allograft with dual locking plates helps to allow early mobilization postoperatively without adverse outcomes.</p><p><strong>Methods: </strong>Five geriatric patients (four female, one male) with distal femur fractures (native or periprosthetic) were treated in our institution with the aforementioned technique, and were allowed early postoperative weight-bearing. These patients were followed up for postoperative outcomes. The primary outcomes studied were non union, implant failure and wound complications. Secondary outcomes studied include time to union, and Sander's functional score.</p><p><strong>Results: </strong>There were no cases of non-union, implant failure or wound related infection. All patients achieved radiological union (mean = 12.6 weeks). Using Sander's functional scoring, two patients achieved excellent, two achieved good and one had fair outcomes. All patients were followed up for at least 6 months after operation.</p><p><strong>Conclusion: </strong>Our method of augmented fixation with fibular strut allografts potentially allows for early weight bearing without adverse outcomes. Further studies with larger sample sizes are required to validate our findings.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"15 1","pages":"57-64"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mini-review of clinical data service platforms in the era of artificial intelligence: A case study of the iHi data platform.","authors":"Yu-Ting Lin, Ya-Chi Lin, Hung-Lin Chen, Che-Chen Lin, Min-Yen Wu, Sheng-Hsuan Chen, Zi-Han Lin, Yi-Ching Chang, Chuan-Hu Sun, Sheng-Ya Lu, Min-Yu Chiang, Hui-Chao Tsai, Mei-Ju Shih, David Ray Chang, Fuu-Jen Tsai, Hsiu-Yin Chiang, Chin-Chi Kuo","doi":"10.37796/2211-8039.1643","DOIUrl":"10.37796/2211-8039.1643","url":null,"abstract":"<p><p>In the past two decades, healthcare organizations have transitioned from the early stages of digitization and digitalization to a more comprehensive process of digital transformation, a shift significantly accelerated by the advent of artificial intelligence (AI). Consequently, the development of high-quality clinical data warehouses, derived from electronic health records (EHRs) and enriched with multidomain data, such as genomics, proteomics, and Internet of Things (IoT) information, has become essential for the creation of the modern patient digital twin (PDT). This approach is critical for leveraging AI in the evolving landscape of clinical practice. Leading medical centers and healthcare institutions have adopted this model, as summarized in this review. Since 2020, China Medical University Hospital (CMUH) has been constructing its data ecosystem by integrating EHRs with extensive genomic databases. This initiative has led to the development of a data service platform, the ignite Hyper-intelligence (iHi®) platform. The iHi platform serves as a case study exemplifying the workflow of the smart data chip, which facilitates the deep cleaning and reliable de-identification of clinical data while incorporating analytical platforms related to genomics and the microbiome to enhance insight extraction processes. The ability to predict complex interactions and disease trajectories among PDTs, digital counterparts of healthcare professionals, and virtual socioeconomic environments will be pivotal in advancing personalized healthcare and optimizing patient outcomes. Future challenges will involve the unification of cross-institutional data platforms and ensuring the interoperability of AI inferences-key factors that will define the next era of AI-driven healthcare.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"15 1","pages":"6-22"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}