BioMedicine-Taiwan最新文献

{"title":"Efficacy of HMJ-38, a new quinazolinone analogue, against the gemcitabine-resistant MIA-PaCa-2 pancreatic cancer cells.","authors":"Mann-Jen Hour, Fuu-Jen Tsai, I-Lu Lai, Je-Wei Tsao, Jo-Hua Chiang, Yu-Jen Chiu, Hsing-Fang Lu, Yu-Ning Juan, Jai-Sing Yang, Shih-Chang Tsai","doi":"10.37796/2211-8039.1423","DOIUrl":"10.37796/2211-8039.1423","url":null,"abstract":"<p><p>Gemcitabine is frequently utilized to treat pancreatic cancer. The purpose of our study was to create a gemcitabine-resistant MIA-PaCa-2 pancreatic cancer cell line (MIA-GR100) and to evaluate the anti-pancreatic cancer efficacy of HMJ-38, a new quinazolinone analogue. Compared to their parental counterparts, MIA-PaCa-2, established MIA-GR100 cells were less sensitive to gemcitabine. MIA-GR100 cell viability was not affected by 10, 50 and 100 nM gemcitabine concentrations. HMJ-38 reduced MIA-GR100 cell growth and induced autophagy and apoptosis. When stained with monodansylcadaverine (MDC), acridine orange (AO), and terminal deoxynucleotide transferase dUTP nick end labeling (TUNEL), MIA-GR100 cells shrunk, punctured their membranes, and produced autophagy vacuoles and apoptotic bodies. Combining chloroquine (CQ) and 3-methyladenine (3-MA) with HMJ-38 dramatically reduced cell viability, indicating that autophagy function as a cytoprotective mechanism. MIA-GR100 cells treated with both z-VAD-FMK and HMJ-38 were much more viable than those treated with HMJ-38 alone. HMJ-38 promotes apoptosis in MIA-GR100 cells by activating caspases. Epidermal growth factor receptor (EGFR) is one of HMJ-38's principal targets, as determined <i>via in silico</i> target screening with network prediction. HMJ-38 also inhibited EGFR kinase activity and EGFR-associated signaling in MIA-GR100 cells. HMJ-38 may be an effective chemotherapeutic adjuvant for gemcitabine-resistant pancreatic cancer cells, in which it induces an antitumor response.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"13 4","pages":"20-31"},"PeriodicalIF":1.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celastrol restricts experimental periodontitis related alveolar bone loss by suppressing inflammatory cytokine response.","authors":"Ahmet Altın, Meltem Zihni Korkmaz, Mehtap Atak, Tolga Mercantepe, Hülya Kılıç Yılmaz","doi":"10.37796/2211-8039.1421","DOIUrl":"10.37796/2211-8039.1421","url":null,"abstract":"<p><strong>Introduction: </strong>Periodontitis is a common chronic inflammatory disease characterized by the destruction of the supporting structures of the teeth. The host defense mechanisms are responsible for inflamatuar and destructive reactions in periodontitis. Celastrol is one of the most promising components of the plant in Eastern and Southern China that has a long history of use in traditional medicine for the treatment of inflammatory conditions.</p><p><strong>Aim: </strong>The aim of this animal study was to inspect the preventive or restrictive effects of celastrol on periodontitis-related inflammatory host response and alveolar bone loss.</p><p><strong>Methods: </strong>24 male Sprague Dawley rats were randomly assigned into 3 groups: control, experimental periodontitis (Ep), and experimental periodontitis-celastrol (Ep-Cel). Periodontitis was induced by placing ligatures sub-paramarginally around the mandibular first molars of the rats in the Ep and Ep-Cel groups and maintaining the ligatures for 15 days. For 14 days following the ligature placement, celastrol administration (1 mg/kg BW day) for the Ep-Cel group and vehicle injection for the control and Ep groups was carried out. At the end of the experiment, mandibula and gingiva samples were obtained after the euthanasia. Alveolar bone loss was measured on serial histological slices; Tumor Necrosis Factor-α and Interleukin-1β levels were measured on gingiva samples by ELISA.</p><p><strong>Results: </strong>Systemic celastrol administration significantly restricted the alveolar bone loss that was higher in rats with periodontitis. (p < 0.05) Tumor Necrosis Factor-α and Interleukin-1β levels that were high in the gingiva of the rats with periodontitis were found significantly lower in rats administered celastrol. (p < 0.05).</p><p><strong>Conclusion: </strong>Celastrol restricted periodontitis-related alveolar bone loss by suppressing the inflammatory response.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"13 4","pages":"44-50"},"PeriodicalIF":1.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous intrathecal saline infusion for treating refractory spontaneous intracranial hypotension: A case report.","authors":"Po-Fan Chiu, Yu-Hsiang Lin, Hui-Shan Lu, I-Han Hsiao, Hung-Lin Lin","doi":"10.37796/2211-8039.1417","DOIUrl":"10.37796/2211-8039.1417","url":null,"abstract":"<p><p>Spontaneous intracranial hypotension (SIH) is a poorly understood condition that presents with a wide variety of symptoms, ranging from mild headaches to coma. It is typically caused by continuous spontaneous leakage of spinal cerebrospinal fluid (CSF), resulting in orthostatic headaches. However, the appropriate management of refractory SIH remains unclear. A 50-year-old man presented with orthostatic headache followed by a rapid decline in mental status. The imaging findings were consistent with the diagnosis of SIH, with bilateral cerebral subdural hematomas and abnormal fluid collection in the posterior epidural space from the T2 to T12 levels. Computed tomography myelography of the whole spine revealed multiple high-flow CSF leakages at the T6 to T8 levels. Despite treatment with bilateral burr hole drainage for subdural hematomas and repeated lumbar epidural blood patch (EBP) three times, the patient's condition worsened and he developed stupor. A lumbar intrathecal saline bolus (90 ml) was administered to restore CSF depletion. The patient's verbal function improved immediately, and continuous intrathecal saline infusion was administered at a rate of 10 ml/h for two days. The patient's stupor gradually resolved, and after his symptoms improved, the EBP injection was repeated at the T8 level. The patient recovered completely, and during the six-year follow-up, there were no signs of recurrence. SIH may cause a refractory decline in mental status, and lumbar intrathecal saline infusion may help arrest or reverse an impending central (transtentorial) herniation. This case demonstrates an appropriate bolus and continuous infusion of normal saline, and documents the resolution of SIH. This maneuver may change the CSF flow pattern and aims to seal the CSF fistula. Further studies are needed to better understand the mechanism of intrathecal saline infusion and establish effective treatment strategies for refractory cases of SIH.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"13 4","pages":"51-56"},"PeriodicalIF":2.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutation patterns of integrase gene affect antiretroviral resistance in various non-B subtypes of human immunodeficiency virus Type-1 and their implications for patients' therapy.","authors":"Fauzia A Djojosugito, Arfianti Arfianti, Rudi Wisaksana, Agnes R Indrati","doi":"10.37796/2211-8039.1422","DOIUrl":"10.37796/2211-8039.1422","url":null,"abstract":"<p><p>Although primary integrase strand transfer inhibitor resistance mutations are currently uncommon, the increasing use of integrase strand transfer inhibitor as a key component of the first, second and third-line antiretroviral regimens suggests that the prevalence of integrase drug resistance mutations will likely increase. The rise of several polymorphic mutations and natural polymorphisms also affects the level of susceptibility of human immunodeficiency virus (HIV) type-1 to integrase strand transfer inhibitor. The considerable variability among the various subtypes of human immunodeficiency virus type-1 may contribute to differences in integrase mutations associated with integrase strand transfer inhibitors. Notably, non-B subtypes of HIV type-1 (HIV-1) are the predominant cause of human immunodeficiency virus infection worldwide. The presence of diverse integrase drug resistance mutations can have significant implications on the administration of integrase strand transfer inhibitor-based antiretroviral therapy to patients with human immunodeficiency virus infection.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"13 4","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematological biomarkers of troponin, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio serve as effective predictive indicators of high-risk mortality in acute coronary syndrome.","authors":"Bryan G de Liyis, Angela F Ciaves, Marwa H Intizam, Pierre J Jusuf, I Made J Rina Artha","doi":"10.37796/2211-8039.1425","DOIUrl":"10.37796/2211-8039.1425","url":null,"abstract":"<p><strong>Background: </strong>Assessing high-risk mortality in acute coronary syndrome (ACS) patients, encompassing ST-Elevation Myocardial Infarction (STEMI), Non-ST-Elevation Myocardial Infarction (NSTEMI), and Unstable Angina Pectoris (UAP), is crucial. However, the prognostic significance of hematological parameters in predicting high-risk mortality in ACS patients remains uncertain despite advancements in ACS research.</p><p><strong>Aim: </strong>The aim was to investigate prognostic significance of hematological parameters troponin, Creatine Kinase-MB (CKMB), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Monocyte-to-Lymphocyte Ratio (MLR), Basophil-to-Lymphocyte Ratio (BLR), and Eosinophil-to-Lymphocyte Ratio (ELR) levels in predicting high-risk mortality in ACS patients.</p><p><strong>Methods: </strong>In this retrospective observational study, data from medical records of 115 patients with ACS, including 40 with STEMI, 38 with NSTEMI, and 37 with UAP, were analyzed. Patients were selected using stratified random sampling, whereby five patients were randomly chosen each month from January 2021 to December 2022 while maintaining a 1:1:1 ratio of selection.</p><p><strong>Results: </strong>Troponin (r = 0.519) and NLR (r = 0.484) showed moderate positive correlations with high-risk STEMI mortality. Meanwhile, troponin (r = 0.387), NLR (r = 0.279), PLR (r = 0.276), MLR (r = 0.250), BLR (r = 0.237), and ELR (r = -0.344) were found to be significantly correlated with high-risk ACS mortality. Troponin, CKMB, NLR, and MLR were significant (AUC>0.7) for high-risk STEMI mortality, and Troponin, NLR, and MLR were significant for high-risk ACS mortality. The results of the multivariate regression analysis indicated that only Troponin (OR:2.049; 95%CI: 1.802-8.218; p = 0.014), NLR (OR:1.652; 95%CI: 1.306-7.753; p = 0.030), and MLR (OR:4.067; 95%CI: 1.182-13.987; p = 0.026) were capable of predicting high-risk ACS mortality. Sub-group analysis showed an increased risk of ACS mortality by GRACE score >140 in patients with elevated levels of Troponin (OR:2.787; 95%CI: 1.032-7.524; p < 0.05), NLR (OR:3.287; 95%CI: 1.340-8.059; p < 0.05), and MLR (OR:4.156; 95%CI: 1.634-10.569; p < 0.05) above the cut-off value.</p><p><strong>Conclusion: </strong>Troponin, NLR, and MLR levels above the cutoff independently predict high-risk mortality in ACS.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"13 4","pages":"32-43"},"PeriodicalIF":1.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of antibacterial efficacy of Lawsonia inermis Linn (henna) on periodontal pathogens using agar well diffusion and broth microdilution methods: an in-vitro study","authors":"Şevki Güler, D. Torul, Sevda Kurt-Bayrakdar, E. K. Tayyarcan, Cagri Camsari, I. Boyaci","doi":"10.37796/2211-8039.1411","DOIUrl":"https://doi.org/10.37796/2211-8039.1411","url":null,"abstract":"Background : Although widely explored in medicine, limited evidence exists in the literature regarding the ef fi cacy of Lawsonia inermis Linn (henna) in the dental fi eld. Aim : This study aimed to investigate the antibacterial effect of henna on Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in vitro. Methods : The agar well diffusion and broth microdilution methods were used to evaluate the antibacterial effect of henna extracts. Dimethyl sulfoxide was used to prepare the ethanol extract of henna, and distilled water was used to prepare the water extract. For both ethanol and water extracts, 4 different concentrations were prepared as 15, 30, 60, and 120 mg/mL. Results : It was determined that the water and ethanol extracts of the henna samples did not show an inhibition zone on P.gingivalis and A.actinomycetemcomitans. As a result of the evaluations made with the broth microdilution method, it was found that the ethanol extract had a higher inhibitory effect on both bacteria, and both extracts had more inhibitory effects against A.actinomycetemcomitans. Conclusion : To understand the effect of henna on periodontal pathogens, more comprehensive in vitro studies should be performed on henna samples at different concentrations and with different bases.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42342193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hipoxia modulates the secretion of growth factors in of human umbilical cord-derived mesenchymal stem cells","authors":"Arfianti Arfianti, U. Ulfah, Leopold Sampetua Hutabarat, Agnes Ivana G, A. Budiarti, N. Sahara, Nicko Pisceski Kusika Saputra","doi":"10.37796/2211-8039.1416","DOIUrl":"https://doi.org/10.37796/2211-8039.1416","url":null,"abstract":"Background : Mesenchymal stem cell (MSC) has great potential as therapies due its ability to regenerate tissue damage and promote tissue homeostasis. Preconditioning of MSC in low oxygen concentration has been shown to affect the therapeutic potential of these cells. This study aimed to compare the characteristic and secretion of trophic factors of MSCs cultured under hypoxia and normoxia. Methods : MSCs were isolated from Wharton ' s jelly of human umbilical cord (UC) tissue by explant method and characterized by fl ow cytometry. Following 24 h of CoCl 2 -induced hypoxic culture, the viability and metabolic activity of MSC were analyzed by trypan blue exclusion test and methyl thiazolyl tetrazolium (MTT) assay, respectively. The secretion of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) was assessed in conditioned medium using enzyme-linked immunosorbent assay (ELISA) method. Results : Flow cytometry analysis showed > 99% of the population of MSCs cells were positive for CD73 and CD90 and > 62% were positive for CD105. While the cell viability of MSC was not affected by hypoxic cultured condition, the metabolic activity rate of these cells was decreased under hypoxic conditioning. In line with reduced metabolic activity, hypoxic human UC-derived MSC produced less HGF than normoxic counterpart. Compared to normoxic MSC, hypoxic preconditioned MSC secreted higher level of VEGF in the conditioned medium (p < 0.05). Conclusions : Hypoxia decreased the metabolic activity of MSCs associated with the modulation of HGF and VEGF secretions. It is suggested that hypoxia may also affect the therapeutic capacity of MSC cells.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45122123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid profile in patients with leiomyoma-A case-control study","authors":"Kishan Prasad H.L., Nimmy Maria Dasan, A. Kishan, S. Kumari N","doi":"10.51248/.v43i3.1443","DOIUrl":"https://doi.org/10.51248/.v43i3.1443","url":null,"abstract":"Introduction and Aim:  The most frequent gynaecological neoplasm in women of reproductive age is leiomyoma (Fibroid). They are hormone-dependent tumours, and estrogen will promote their development. It has been found that estrogen levels and cholesterol levels are inversely associated.  Few studies have shown no relation between lipid profile and leiomyoma, but few studies suggested a positive correlation. The lipid profile of patients with uterine fibroids (the case group) and women without fibroids (the control group) is compared in the current study.\u0000 \u0000Materials and Methods: The case-control study included fifty subjects between 20 to 40 years. Twenty-five serum samples collected from women without evidence of leiomyoma were considered the control group. Twenty-five cases were admitted with various symptoms, diagnosed and confirmed as leiomyoma on histopathology.\u0000 \u0000Results: There was a substantial difference in Total Cholesterol (TC) and Low-Density Lipoprotein cholesterol (LDL-C) levels between patients with leiomyoma and healthy people.  With a p-value of 0.04, the TC, LDL-C level in leiomyoma patients was substantially lower than that of healthy individuals in the general population. The levels of triglycerides, High-Density Lipoprotein cholesterol (HDL-C), and Very Low-Density Lipoprotein cholesterol (VLDL-C) were comparable across the case and control groups, though.\u0000 \u0000Conclusion: According to the study's findings, patients with leiomyoma have lower serum TC and LDL-C levels than healthy controls. This could be linked to patients with leiomyomas having higher estrogen levels. As a result, lipid profile variables like TC and LDL-C may be accurate indicators of leiomyoma. These findings point to the possibility of blood plasma lipid profiling for the non-invasive diagnosis of fibroids.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47560798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypervitaminosis D induced hypercalcemia leading to coma: A case report","authors":"Bimal K. Agrawal, Manu Mathew, S. Kalia, Aditi Tongar","doi":"10.51248/.v43i3.3192","DOIUrl":"https://doi.org/10.51248/.v43i3.3192","url":null,"abstract":"An elderly female presented with abdominal pain, vomiting and easy fatigability. Her sensorium gradually declined and became comatose. She was on Methotrexate, folic acid and prednisolone for her rheumatoid arthritis. The neurological examination and neuroimaging did not contribute in making the diagnosis. It is challenging to diagnose a metabolic cause of coma. Once diagnosis is established, the management becomes easier. On detailed investigation, she was found to have severe hypercalcemia with corrected serum calcium level being 18.2 mg%. Serum vitamin D level was also high, 150 ng/ml. On probing for detailed history, it was revealed that she had been taking a weekly dose of 60,000 IU of vitamin D for nearly 5 years. In recent times, association of various diseases has been reported with vitamin D deficiency. Vitamin D supplementation seems justified in this patient considering her age and the fact that she had rheumatoid arthritis; she was also taking corticosteroid. The recommended dose of vitamin D has been 400–800 IU/day. However, it is often prescribed at a dose of 60,000 IU/week, and sometimes patients self-medicate. There are no guidelines available for prescribing vitamin D at such a strength. Though safety of vitamin D has been established, vitamin D toxicity can occur sporadically with serious consequences. This was managed with intravenous fluids and diuretics. The patient also required subcutaneous calcitonin and low dose of corticosteroid, in addition to a session of haemodialysis for her hypercalcemia. The patient’s sensorium gradually improved as her calcium level returned to normalcy.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":"1 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41320009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the cognitive status of Covid -19 patients and its correlation to blood pressure","authors":"Mamatha S.D., Priya S.A., S. L., Shivakumar K.M., Smitha Malenahalli Chandrashekarappa","doi":"10.51248/.v43i3.2264","DOIUrl":"https://doi.org/10.51248/.v43i3.2264","url":null,"abstract":"Introduction and Aim: The disease caused by Corona virus (Covid-19) has become a public health importance in recent times as its human-to-human transmission is faster when compared to other pandemic of recent times. Since the outbreak of Covid-19, epidemiology and clinical characteristics of the disease including spread of the disease and mortality have been reported extensively. Little is known about Covid 19 impact on cognition; hence the present was undertaken. The study aimed at assessing the cognitive status in patients admitted for infection with corona and to determine the correlation between cognitive status and blood pressure in the same patients. \u0000  \u0000Materials and Methods: The study is a cross-sectional study that included 300 adults of both genders admitted in the tertiary care hospital with RTPCR positive for Covid-19. A cognition failure questionnaire was used to record the patient’s response and also BP was recorded. \u0000      \u0000Results: For analysis Descriptive statistics like mean and Standard Deviation, and to find association between parameters - Spearman correlation, Mann Whitney U Test were used. Analysis was done using SPSS version 22. Even though there was no significant association seen between Overall cognitive scores, forgetfulness scores, and false triggering scores with gender, there was significant association seen between overall cognitive scores and false triggering scores with age. Applying spearman correlation with respect to overall cognitive failure with duration of hospital stay showed statistically significance*(p<0.001) and between cognitive failure and diastolic blood pressure showed statistical significance with respect to overall cognition. \u0000  \u0000Conclusion: Infection with Covid-19 has an effect on cognition. Duration of hospital stay has an impact on cognition with associated blood pressure changes in the Covid-19 disease.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46557930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}