BioMedicine-Taiwan最新文献_第10页

Vitamin D deficiency in patients with Type 2 diabetes mellitus: its association with microvascular complications 2型糖尿病患者维生素D缺乏与微血管并发症的关系

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-05-26 DOI: 10.51248/.v43i02.1360

Vishnumoorthy, Smitha S. Bhat

{"title":"Vitamin D deficiency in patients with Type 2 diabetes mellitus: its association with microvascular complications","authors":"Vishnumoorthy, Smitha S. Bhat","doi":"10.51248/.v43i02.1360","DOIUrl":"https://doi.org/10.51248/.v43i02.1360","url":null,"abstract":"Introduction and Aim: A worldwide epidemic, type 2 diabetes affects 382 million people. Nephropathy, neuropathy, and retinopathy are examples of microvascular consequences. According to estimates, 1 billion people, or close to 15% of the world's population, are vitamin D deficient. There is proof that inadequate vitamin D levels are linked to poor glycaemic management. However, there is a dearth of information from India on a potential connection between a vitamin D deficit and microvascular problems. Therefore, the purpose of our study was to determine if individuals with microvascular consequences of diabetes are more likely to suffer from vitamin D insufficiency.\u0000 \u0000Materials and Methods: This cross-sectional study was done on 72 diabetic subjects availing the inpatient services of Father Muller Medical College Hospital. Diabetes was diagnosed as per American Diabetes Association guidelines. Subjects were examined for presence of neuropathy, nephropathy and retinopathy by nerve conduction study, urine protein creatinine ratio and fundus examination respectively. Serum vitamin D levels were assessed. Data was recorded and statistically analysed.\u0000 \u0000Results: Seventy-two patients fulfilling the selection criteria were recruited for this study. 77.8% of subjects had poorly controlled diabetes and 66.66% had vitamin D deficiency. 39 (54.16%) of subjects had microvascular complications of which 28 (38.8%) had neuropathy, 14 (19.4%) had retinopathy and 28 (38.9%) had nephropathy. 71% of patients with microvascular complications had vitamin D deficiency.\u0000 \u0000Conclusion: Poor glycemic control is strongly correlated with vitamin D insufficiency. Individuals who suffer from microvascular problems tend to have inadequate levels of vitamin D more frequently than people without such difficulties.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42088993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteochondral lesion of the talus: presentation and management - A case report 距骨软骨病变:表现与治疗- 1例报告

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-05-26 DOI: 10.51248/.v43i02.2551

Parishekh Jawahar, Menon P. Gopinath, Ashok T. R., S. Chokkalingam, Sashaank S. Srijay

引用次数: 0

A study on anemia among the reproductive age group women using a rapid diagnostic test (RDT) kit 应用快速诊断试剂盒对育龄妇女贫血的研究

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-05-26 DOI: 10.51248/.v43i02.2469

J. Shetty K, Nanjesh Kumar S., Shrisharath K., Chandrika Rao

{"title":"A study on anemia among the reproductive age group women using a rapid diagnostic test (RDT) kit","authors":"J. Shetty K, Nanjesh Kumar S., Shrisharath K., Chandrika Rao","doi":"10.51248/.v43i02.2469","DOIUrl":"https://doi.org/10.51248/.v43i02.2469","url":null,"abstract":"Introduction: Iron deficiency is the commonest nutritional disorder in the world. The common prevalent type of anemia is caused by nutritional factors, and it is particularly prevalent in women of childbearing age, pregnant women, and nursing mothers. Anemia is indicative of poor intake of nutrition and leads to ill health. The present study aims to estimate anemia among women of the childbearing age group at the field level using an RDT kit.\u0000 \u0000Methodology: A community-based cross-sectional study was conducted among reproductive age group women to estimate the hemoglobin using an RDT kit at the field level in the coastal area of Dakshina Kannada and Udupi districts.\u0000 \u0000Results: Out of 663 subjects, 17.3% participants were from the age group 35-39 and 40-44 years each. Based on the educational status, graduates and postgraduates accounted for 32.3%. Among the study subjects 63.34% were pregnant and lactating. 77.2% of the subjects were Hindus. Among the study subjects 59.57% had hemoglobin above 12 g/dl. 40.42% had <12 g/dl hemoglobin levels.\u0000 \u0000Conclusion: The Hemocue 301 RDT kit can be used at the field levels for the estimation of hemoglobin by gross route health care works.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45297328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A safety profile of Siddha formulation Karisalai Chooranam in Wistar albino rats 白化病大鼠的安全性研究

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-05-26 DOI: 10.51248/.v43i02.394

Sulekha S. Mary Princess, Reddy G. Dayanand, Muthuvel A.

{"title":"A safety profile of Siddha formulation Karisalai Chooranam in Wistar albino rats","authors":"Sulekha S. Mary Princess, Reddy G. Dayanand, Muthuvel A.","doi":"10.51248/.v43i02.394","DOIUrl":"https://doi.org/10.51248/.v43i02.394","url":null,"abstract":"Introduction and Aim: Karisalai Chooranam (KSC) is used in the traditional Siddha system of medicine for a long time to treat various ailments in the body. Its antistress and antioxidant properties were reported earlier. Investigating the acute and long-term toxicity of Karisalai Chooranam in Wistar albino rats was the goal of the current study.\u0000 \u0000Materials and Methods: For the acute toxicity investigation, Wistar rats were divided into four groups. For fourteen days, the animals were monitored for behavioural changes and toxicological complaints. For ninety days, a total of four categories of animal groups like control, forty mg/kg body weight, two hundred mg/kg body weight and thousand mg/kg body weight were utilized in a long - term toxicity study. The samples of blood were taken on the final day of the trial for biochemical and haematological examination. Animals were sacrificed for monitoring gross necropsy changes and histopathological examination of the liver, kidney and brain.\u0000 \u0000Results: There was no morbidity or death observed in the acute toxicity trial. In the research of long - term toxicity. KSC's haematological and biochemical parameters during analysis did not exhibit any appreciable changes. All the three doses of KSC, the renal and brain histology displayed normal architecture. When the medicine was given to the forty milligram and two hundred milligram dosage groups of animals for 90 days, no toxicity symptoms were present in the case of organ liver. After the medicine was given for 90 days to the thousand milligram dosage group, toxic signs such as programmed and localized cell death became apparent.\u0000 \u0000Conclusion: Toxicity studies proved the safety of KSC in animal models. If KSC is utilized clinically as prescribed in literature, it will not cause any adverse effects.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42066723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteoblastoma of the temporal bone – A familiar tumour at an uncommon site 颞骨成骨细胞瘤——一种常见但不常见的肿瘤

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-05-26 DOI: 10.51248/.v43i02.1479

Shubha P. Bhat, Premananda Kamat, T. Srinivas

引用次数: 0

Real world experience of Endoxifen augmentation therapy in a case of resistant OCD Endoxifen增强疗法治疗顽固性强迫症的现实经验

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-05-26 DOI: 10.51248/.v43i02.2554

S. Elangovan, Jayashri Sundaramoorthy, Saritha Dhuruvasan

引用次数: 0

TPO gene rs2071400 polymorphisms as an independent risk factor for hypothyroidism in Iraqi patients TPO基因rs2071400多态性是伊拉克甲状腺功能减退症患者的独立危险因素

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-05-26 DOI: 10.51248/.v43i02.2701

Sarah Mohssen M. Radhi, Essam Fadel Al-Jumaili, Muqdad Abdulhasan Al-Hilal, A. Tariq

{"title":"TPO gene rs2071400 polymorphisms as an independent risk factor for hypothyroidism in Iraqi patients","authors":"Sarah Mohssen M. Radhi, Essam Fadel Al-Jumaili, Muqdad Abdulhasan Al-Hilal, A. Tariq","doi":"10.51248/.v43i02.2701","DOIUrl":"https://doi.org/10.51248/.v43i02.2701","url":null,"abstract":"Introduction and Aim: Thyroid peroxidase (TPO) is a thyroid-specific antigen, and the presence of TPO antibodies is known to be associated with developing hypothyroidism. In this study we aimed to investigate the genotypes prevalent for the SNP rs2071400 of the TPO gene and its association to the development of autoimmune thyroid disease.\u0000 \u0000Materials and Methods: This study involved 43 patients with hypothyroidism and 44 healthy controls. Genotyping of the TPO SNP rs2071400 (C/T) was undertaken using Quantitative Real-Time Polymerase Chain Reaction using the TaqMan® Assay. Data obtained was subjected to statistical analysis using the SPSS 25 software\u0000 \u0000Results: TPO rs2071400 T carriers (CT + TT genotypes) were more frequent in patients with hypothyroidism compared with healthy control (P=0.0006), with an adjusted odds ratio of 8.0. Serum levels of Anti-TPOAb were also significantly higher in hypothyroid patients. There was no significant correlation between rs2071400 T mutation and the presence of high Anti-TPOAb.\u0000 \u0000Conclusion: Study revealed TPO rs2071400 polymorphism to be an independent risk factor for developing hypothyroidism in those with or without high serum levels of TPOAb.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43582708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients’ perception of gustatory changes after lower molar extractions 下磨牙拔除后患者味觉知觉的变化

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-05-26 DOI: 10.51248/.v43i02.1093

Tasneem Sakinatul Ain, Usha Balan, Atheer Mohammed Al-Muteb, Areej Ayed Al Sanad, Shugufta Mir, S. N C

{"title":"Patients’ perception of gustatory changes after lower molar extractions","authors":"Tasneem Sakinatul Ain, Usha Balan, Atheer Mohammed Al-Muteb, Areej Ayed Al Sanad, Shugufta Mir, S. N C","doi":"10.51248/.v43i02.1093","DOIUrl":"https://doi.org/10.51248/.v43i02.1093","url":null,"abstract":"Introduction and Aim: Gustatory changes in the form of loss of taste or alteration of taste or lingual paresthesia are often encountered post-extraction of molar teeth. The aim of this study was to assess patients' perception of gustatory changes/taste alterations following lower molar extractions in female patients attending the OPD (dentistry-clinics) at College of Dentistry, King Khalid University, Abha, Saudi Arabia.\u0000 \u0000Materials and Methods: Thirty consecutive new female adult patients indicated for extraction due to grossly decayed mandibular molars between the age of 19-45 were included in the study. These patients were evaluated using a self-administered interview to assess the lingual tactile and gustatory function impairments immediately after surgical procedures/extraction involving the lower molar region. They were re-evaluated seven days and one month after the surgical procedure. ANOVA for repeated measures was used to assess the statistical difference between patient responses at baseline (before the procedure), seven days, and one month after the surgical procedure. Tukey HSD post hoc multiple comparisons were made to find the group that is significantly different from others. \u0000 \u0000Results: There were no statistically significant differences between the responses at baseline, seven days, and one month after the surgical procedure concerning all the questions asked except Q2 and Q7 that dealt with the presence of tingling sensation on the tongue and ability to continue with their usual diet after the dental procedure, respectively.\u0000 \u0000Conclusion: There was only a transient change in a small proportion of patients in the lingual tactile and gustatory function after surgical extraction of mandibular molars, which was self-limiting and resolved by one month postoperatively.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70666493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on antioxidant potential and total phenolic contents of dried powder and pulp of raw and ripe Carica papaya fruit 生熟番木瓜干粉和果肉抗氧化能力及总酚含量的研究

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-05-26 DOI: 10.51248/.v43i02.2361

M. Bhardwaj, B. Mahajan, Ankush Kumar, V. Parcha

{"title":"Studies on antioxidant potential and total phenolic contents of dried powder and pulp of raw and ripe Carica papaya fruit","authors":"M. Bhardwaj, B. Mahajan, Ankush Kumar, V. Parcha","doi":"10.51248/.v43i02.2361","DOIUrl":"https://doi.org/10.51248/.v43i02.2361","url":null,"abstract":"Introduction and Aim: Antioxidants are frequently used as active ingredients in anti-aging supplements with the intention of preserving health and preventing diseases. However, recent research has concentrated on conventional therapies that have a long history of successfully treating several diseases. C. papaya is a good alternative and exhibits significant antioxidant, diuretic, antihyperglycemic, anticancer, analgesic, and depressive properties from a key plant constituent. In this study, total phenolic content, and antioxidant potential of raw and ripe Carica papaya were examined.\u0000 \u0000Materials and Methods: C. Samples of raw and ripe Carica papaya were collected from the local market of Dehradun. Dried powder and fresh pulp of the raw and ripe Carica papaya was individually subjected to phytochemical test principles. Total phenolic contents were estimated using the Folin-Ciocalteu and antioxidant potential using DPPH and ferric chloride reducing power assay method.\u0000 \u0000Results: The fresh pulp and powder of ripe Carica papaya showed high content of phenolics in fresh ripe pulp, fresh raw pulp, dried ripe powder and raw dried powder as 200, 195,185 7 mg/100 g respectively with an antioxidant activity DPPH radical scavenging activity, 80.2, and 75. .76.4 and 74.5 respectively which is comparable to butylated hydroxy anisole (BHA) and diphenhydramine (DPPH) radical scavenging activity.\u0000 \u0000Conclusion: The fresh pulp and powder of ripe Carica papaya showed wide antioxidant activity (DPPH) radical scavenging activity. Hence, it can be effectively used as an organic substitute for chemical compounds (BHA, BHT) which have a lot of harmful side effects. Moreover, phytochemical studies of Carica papaya have shown the presence of phenolic compounds well justified by estimation of content which are responsible for its potent antioxidant activity.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43635370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An ayurvedic approach to a case of ulcerative keratitis (Savrana Shukra) 阿育吠陀治疗溃疡性角膜炎1例(Savrana Shukra)

IF 1.7

BioMedicine-Taiwan Pub Date : 2023-05-26 DOI: 10.51248/.v43i02.2327

S. K

{"title":"An ayurvedic approach to a case of ulcerative keratitis (Savrana Shukra)","authors":"S. K","doi":"10.51248/.v43i02.2327","DOIUrl":"https://doi.org/10.51248/.v43i02.2327","url":null,"abstract":"Ulcerative keratitis (UK) is one of the most prevalent ocular diseases characterized by partial or total loss of vision. While contact lens wear is the primary risk factor of the UK in the young, compromised ocular immunity is responsible for it in the old age group. Early diagnosis and treatment help to bring about better results. Antimicrobial therapy remains the mainstay of treatment in ulcerative keratitis, whereas adjunctive topical corticosteroid therapy remains a matter of debate. The UK signs and symptoms match that of Savrana Shukra mentioned in the Ayurvedic texts. We present the case of a 72-year-old male admitted for redness and blurred vision in the right eye, associated with ocular pain, tearing, and photophobia. We diagnosed the case as Savrana Shukra. He underwent Ayurvedic therapy in the form of internal medicines such as Amritotaram Kashaya, Manjistadi kashaya, Kaisora Guggulu and Pratimarsha Nasya with Anu tailam. He also underwent treatments such as Jalokavacharana, Netra Seka, Vidalaka and Anjana karma. After a month of treatment, the corneal ulcer healed completely and thinned down the scar on the cornea. His visual acuity improved from 6/60B to 6/6 in the affected eye. Ayurvedic treatment was effective in completely healing the corneal ulcer and controlling the active inflammation, thereby improving vision. However, more extensive studies with larger samples will yield more data to prove the potential of Ayurveda in such cases.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42427151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0