Polyphenols in bee products and prevention of cell senescence.

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL
BioMedicine-Taiwan Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI:10.37796/2211-8039.1458
Siti Nuriah M Noor, Marahaini Musa, Ahmad Azlina, Siew H Gan, Kannan P Thirumulu
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引用次数: 0

Abstract

Sustaining the continuity of cells and their homeostasis throughout the lifespan is compulsory for the survival of an organism. Cellular senescence is one of mechanisms involved in cell homeostasis and survival, and plays both important and detrimental roles in the maintenance of malfunctioned and normal cells. However, when exposed to various insults (genetic, metabolic and environmental), the cells undergo oxidative stress which may induce premature senescence, or so-called stress-induced premature senescence. Many age-related diseases are associated with premature senescence. Hence, there is growing interest in the intake of natural sources such as dietary food, which has protective functions on human health and diseases as well as on premature senescence. There are many natural food sources which have beneficial effects on delaying cell senescence, of which bee products are one of them. Bee products (honey, propolis, royal jelly, bee pollen, bee bread, venom and wax) are rich in polyphenols, a compound that exerts powerful antioxidant actions against oxidative stress and is able to delay premature senescence that is linked to ageing. This review describes the factors triggering senescence, the biomarkers involved and the prevention of senescence by the polyphenols present in bee products. Thus, it is hoped that this will provide new insights into the clinical management of age-related diseases.

蜂产品中的多酚和细胞衰老的预防。
在整个生命周期中保持细胞的连续性及其平衡是生物体生存的必要条件。细胞衰老是参与细胞平衡和存活的机制之一,在维持功能失常和正常细胞的过程中发挥着重要和有害的作用。然而,当暴露于各种损伤(遗传、代谢和环境)时,细胞会承受氧化应激,从而诱发早衰,即所谓的应激诱导早衰。许多与年龄有关的疾病都与早衰有关。因此,人们越来越关注摄入对人类健康和疾病以及早衰具有保护作用的天然来源,如膳食食品。有许多天然食物来源对延缓细胞衰老有好处,蜂产品就是其中之一。蜂产品(蜂蜜、蜂胶、蜂王浆、蜂花粉、蜂面包、蜂毒和蜂蜡)中含有丰富的多酚,这种化合物具有强大的抗氧化作用,可对抗氧化应激,并能延缓与衰老有关的早衰。本综述介绍了引发衰老的因素、相关的生物标志物以及蜂产品中的多酚对衰老的预防作用。因此,希望这将为老年相关疾病的临床治疗提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BioMedicine-Taiwan
BioMedicine-Taiwan MEDICINE, GENERAL & INTERNAL-
CiteScore
2.80
自引率
5.90%
发文量
21
审稿时长
24 weeks
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