Reproduction, fertility, and development最新文献

{"title":"Post-transcriptional regulatory mechanisms of dosage compensation in vertebrates.","authors":"Nicholas C Lister, Kim L McIntyre, Paul D Waters","doi":"10.1071/RD25177","DOIUrl":"10.1071/RD25177","url":null,"abstract":"<p><p>Sex chromosome dosage compensation is thought to be essential in species with heteromorphic sex chromosomes. There has been a large emphasis on transcriptional regulation as the primary mechanism restoring gene dosage balance. However, emerging evidence across vertebrate lineages indicates that post-transcriptional mechanisms make critical contributions to balancing X/Z gene dosage in the proteome. Here, we propose potential mechanisms that may be responsible for this post-transcriptional regulation, including nonsense mediated decay (NMD), N6-methyladenosine RNA methylation (m6A) and sex specific micro-RNAs (miRNAs). We propose that multi-layered regulation of sex chromosome dosage is an ancient and widespread strategy. Recognizing the role of post-transcriptional processes not only reframes current models of dosage compensation, but also uncovers novel mechanisms underpinning development, reproduction and disease.</p>","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative reproductive biology, advances in reproductive health, and cultivating inclusion in the scientific community: highlights from the 2024 Annual Meeting of the Society for Reproductive Biology.","authors":"Hon Y Chan, Lauren R Alesi, Doan T Dinh, Kerrie L Foyle, Pierre Hofstee, Jennifer C Hutchison, Jennifer Stables, Natalie A Trigg, Amy L Wooldridge, Brendan J Houston","doi":"10.1071/RD25169","DOIUrl":"10.1071/RD25169","url":null,"abstract":"<p><p>In 2024, the reproductive biology research community in Australia and New Zealand reunited in Adelaide for the Society for Reproductive Biology (SRB) Annual Meeting. The conference showcased major advances made in key areas of reproductive biology, with symposia dedicated to five key themes: (1) exploring comparative reproductive biology across species; (2) the multifaceted impact of climate change on reproduction; (3) innovations in drug development and repurposing for reproductive health; (4) revolutionising fertility and assisted reproductive technologies; and (5) cultivating inclusion in the scientific community. This review summarises these symposia and discusses the relevant emerging research questions and the future research directions. Main advances from each theme include: (1) the utility of non-traditional model organisms and archival samples in research; (2) the importance of further understanding the effects of heat stress on male and female fertility during pregnancy in humans and broader species; (3) collaboration between researchers, industry and policymakers to overcome barriers in contraceptive development; (4) ensuring robust and ethical use of artificial intelligence for clinical and fundamental research; and (5) the significance of maintaining diversity and inclusion in science to promote discoveries and ensure health data is available for diverse population groups.</p>","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":"37 17","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The biology of the ovary -Honouring the contributions of Ken P McNatty and Rex J Scaramuzzi.","authors":"Jennifer Juengel, Graeme Martin","doi":"10.1071/RD25204","DOIUrl":"https://doi.org/10.1071/RD25204","url":null,"abstract":"<p><p>This Collection celebrates the work of Rex Scaramuzzi and Ken McNatty, two passionate researchers in the field of reproductive biology. Their impact was most profound in the area of ovarian biology in livestock, and that was our focus when we invited original contributions from colleagues, collaborators and friends. We have also included papers previously published by Scaramuzzi and McNatty in Reproduction, Fertility and Development. The coordinators of this Collection and authors of this foreword are co-Editors-in-Chief of the journal. To mitigate any potential conflict of interest they had no editor-level access to this manuscript during peer review.</p>","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145608195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data-driven biomarker discovery and risk profiling for polycystic ovary syndrome in Indian women using ensemble learning.","authors":"Pulkit Verma, Rekha Agarwal, Lokesh Kumar Sharma, Nidhi Sindwani","doi":"10.1071/RD25081","DOIUrl":"10.1071/RD25081","url":null,"abstract":"<p><strong>Context: </strong>Despite diagnostic advancements in India, the scarcity of Indian polycystic ovary syndrome (PCOS) data and varied diagnostic standards contribute to delays in PCOS detection, particularly in rural areas.</p><p><strong>Aims: </strong>We aim to build a predictive model based on an extensive dataset derived from Indian studies and perform risk-based stratification of samples.</p><p><strong>Methods: </strong>The PubMed database was queried for studies focused on the pathophysiology of PCOS in Indian women. Based on inclusion and exclusion criteria, six studies were selected. Corresponding clinical data was statistically synthesised based on study-specific baseline characteristics. The integrated dataset consisted of 11,258 samples (nPCOS = 7342; nControl = 3916) with 14 attributes: disease (PCOS vs control), age, body mass index, cholesterol, triglycerides, high-density and low-density lipoproteins, LH, FSH, testosterone, menarche age, systolic and diastolic blood pressure, and yearly menstrual cycles. After data pre-processing, missing values imputation, and feature engineering, model benchmarking was conducted using LazyPredict. LightGBM was selected for further hyperparameter tuning based on performance metrics. Lastly, feature importance analysis was performed, and predictive probabilities were utilised to categorise samples into different risk categories.</p><p><strong>Key results: </strong>The optimised LightGBM model achieved 96.18% accuracy, 97.51% precision, 96.65% recall, and 99.31% receiver operating characteristic area under curve (ROC-AUC) score. Further, testosterone, menstrual cycles per year, triglycerides, LH, and diastolic blood pressure were the top five key attributes in PCOS. Risk categorisation of samples demonstrated substantial alignment with real diagnoses, validating the model's clinical significance.</p><p><strong>Conclusions: </strong>This study introduces the first comprehensively synthesised PCOS dataset for Indian women.</p><p><strong>Implications: </strong>Our framework facilitates prompt risk detection, providing an adaptable methodology for decision-making in PCOS management.</p>","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":"37 16","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined effects of the Booroola, Vacaria and Embrapa mutations on ovulation rate in a sheep flock with unique genetic background.","authors":"Carlos Jose Hoff de Souza, Magda Vieira Benavides, Jose Carlos Ferrugem Moraes","doi":"10.1071/RD25067","DOIUrl":"https://doi.org/10.1071/RD25067","url":null,"abstract":"<p><strong>Context: </strong>Improve lamb meat production in southern Brazil using genotype-assisted selection to enhance prolificacy.</p><p><strong>Aim: </strong>To evaluate the effect of the combined presence of single-nucleotide polymorphisms in the BMP1R (Booroola) and GDF9 (Vacaria, Embrapa) genes on ovulation rate.</p><p><strong>Methods: </strong>Ewes were genotyped using the tetra-primer amplification-refractory mutation system-polymerase chain reaction technique. Ovulation rate was assessed via laparoscopy following estrus synchronization with intravaginal progesterone sponges.</p><p><strong>Key results: </strong>The presence of the Vacaria (FecGV), Embrapa (FecGE), and Booroola (FecBB) alleles in different possible combinations adds between two and three ovulations in the corresponding genotypes.</p><p><strong>Conclusions: </strong>The effects of the FecGE, FecGV, and FecBB alleles on ovulation rate are additive and should be utilized individually or in pairs with the FecGE, avoiding excessive prolificacy when all three alleles are present in the same ewes.</p><p><strong>Implications: </strong>Genotype-assisted selection enables the development of genetically distinct lines tailored for different production systems based on desired levels of prolificacy. This strategy can be integrated with the selection of other major genes affecting productive traits, such as increased carcass yield and spontaneous wool shedding.</p>","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":"37 16","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genistein mitigates ovarian dysfunction in a PCOS mouse model by regulating steroidogenesis, apoptosis, and PARP-1 signaling.","authors":"Jin Wang, Fenglan Lu, Zhuoqian Guo, Qiuxian Meng, Tingting Gou, Wenkai Li, Xiaojuan Wan, Muhammad Faheem Akhta, Mahmoud M Azzam, Guoyun Wu","doi":"10.1071/RD25126","DOIUrl":"https://doi.org/10.1071/RD25126","url":null,"abstract":"<p><strong>Context: </strong>Polycystic ovary syndrome (PCOS) is a common endocrine disorder marked by hormonal and clinical imbalances. Genistein (GEN), a soy isoflavone with antioxidant properties, has shown promise in PCOS treatment, although its mechanisms remain unclear.</p><p><strong>Aims: </strong>This study aimed to investigate the effects of genistein on ovarian dysfunction in a letrozole-induced PCOS mouse model, focusing on steroidogenesis, apoptosis, and PARP-1 signaling.</p><p><strong>Methods: </strong>PCOS was induced by oral administration of letrozole (37.5 mg/kg.day) for 21 days. Mice were then divided into the following three groups (n = 10 each) for another 21-day treatment: control (corn oil), PCOS (continued letrozole), and PCOS + GEN (letrozole + genistein, 50 mg/kg.day, i.p.).</p><p><strong>Key results: </strong>Genistein restored estrous cyclicity in 80% of treated mice versus 0% in the PCOS group (P < 0.05). Histologically, it improved follicular morphology, increased granulosa cell thickness and density, and promoted corpora lutea formation. Genistein significantly reduced serum T and P4 concentrations (P < 0.05) and modulated expression of steroidogenic proteins (CYP11A1, CYP19A1, STAR). It also decreased cleaved Caspase-3 and cleaved PARP-1 expression (P < 0.05), and suppressed abnormal PARylation without affecting total PARP-1 expression levels.</p><p><strong>Conclusions: </strong>Genistein alleviates ovarian dysfunction in PCOS mice by restoring estrous cyclicity, enhancing follicular development, and normalizing hormone concentrations, through regulation of steroidogenic proteins, inhibition of apoptosis, and modulation of PARP-1 activity.</p><p><strong>Implications: </strong>These findings support genistein as a potential therapeutic agent for PCOS, targeting the PARP-1-pADPr axis and apoptosis. Further studies are needed to explore upstream mechanisms and evaluate its long-term effects on reproductive health.</p>","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":"37 15","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145552711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-rich plasma strategy against freezing damage in ram spermatozoa: its effect on miRNA, ion channels, growth factors, lipids and oxidative stress.","authors":"İbrahim Halil Güngör, Gaffari Türk, Aslıhan Çakır Cihangiroğlu, Gözde Arkalı, Ahmet Tektemur, Görkem Kırmızıkaya Özmen, Nida Badıllı, Tutku Can Acısu, Mustafa Sezer Bulan, Şeyma Özer Kaya, Mustafa Sönmez, Seyfettin Gür, Abdurrauf Yüce, Ökkeş Yilmaz, Erdoğan Memili, Zafer Çambay","doi":"10.1071/RD25064","DOIUrl":"https://doi.org/10.1071/RD25064","url":null,"abstract":"<p><strong>Context: </strong>Platelet-rich plasma (PRP) is a plasma component containing high concentrations of platelets, growth factors, antioxidants and proliferative properties.</p><p><strong>Aim: </strong>To mitigate the negative effects of cryopreservation on ram semen by utilising PRP.</p><p><strong>Methods: </strong>Semen was collected from six rams twice a week for 3 weeks during the breeding season. Pooling was performed by dilution with tris + egg yolk diluent. Pooling was divided into three equal parts and re-diluted with diluents containing control (0% PRP), 5% PRP and 10% PRP. Sperms were frozen in an automatic freezing device and stored in liquid nitrogen. After thawing, spermatological, flow-cytometric, oxidative stress, cholesterol, fatty acid, ELISA, quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analyses were performed.</p><p><strong>Key results: </strong>Compared with the control group, the 5% PRP group exhibited a significant increase in progressive motility, viability and cholesterol ratios, glutathione-peroxidase activity, CATSPER1 (Cation Channel of Sperm), CATSPER3, vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) levels and KCNJ11 (Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11), HSA-MIR-181A, HSA-MIR-150 and HSA-MIR-374 transcripts. Apoptotic protein, malondialdehyde and HSA-MIR-410, OAR-MIR-10B, BTA-MIR-22-3P and RNO-MIR-494 transcripts were decreased in 5% PRP group compared with control. PRP supplementation at 10% increased dead sperm and heptadecenoic acid ratios, VEGF and PDGF levels and HSA-MIR-410, PPY-MIR-16, CFA-MIR-199, HSA-MIR-181A, HSA-MIR-150, OAR-MIR-127, HSA-LET-7A and HSA-MIR-374 transcripts as well as CATSPER3, HSD3β2, PDGFB and VEGFA proteins compared with the control. PRP supplementation at 10% significantly decreased plasma membrane integrity, insulin-like growth factor 1 (IGF1) level and CATSPER3 and KCNJ11 transcripts compared with the control.</p><p><strong>Conclusions: </strong>The addition of 5% PRP before cryopreservation has beneficial effects on the functional and molecular properties of frozen-thawed ram spermatozoa, whereas the addition of 10% PRP has negative effects.</p><p><strong>Implications: </strong>Five per cent PRP should be added to ram semen diluents.</p>","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":"37 15","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145552727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: Reconstruction of endometrial histoarchitecture and receptivity genes in Asherman's syndrome patients using a 3D acellular amnion bilayer scaffold seeded with endometrial cells.","authors":"Budi Wiweko, Normalina Sandora, Muharam Raden, Achmad Kemal Harzif, Tyas Rahmah Kusuma, Nur Amalina Fitria, Benati Karimah, Mila Maidarti, Kanadi Sumapraja, Andon Hestiantoro, Gita Pratama, Muhammad Dwi Priangga, Natasha Karlina Law","doi":"10.1071/RD24200_CO","DOIUrl":"https://doi.org/10.1071/RD24200_CO","url":null,"abstract":"","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":"37 15","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145552647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of endometrial histoarchitecture and receptivity genes in Asherman's syndrome patients using a 3D acellular amnion bilayer scaffold seeded with endometrial cells.","authors":"Budi Wiweko, Normalina Sandora, Muharam Raden, Achmad Kemal Harzif, Tyas Rahmah Kusuma, Nur Amalina Fitria, Benati Karimah, Mila Maidarti, Kanadi Sumapraja, Gita Pratama, Muhammad Dwi Priangga, Natasha Karlina Law, Andon Hestiantoro","doi":"10.1071/RD24200","DOIUrl":"10.1071/RD24200","url":null,"abstract":"<p><p>Context Thin endometrium with Asherman's syndrome is a challenge in in vitro fertilisation, as patients cannot conceive even if the embryo is well. Aims This study aimed to regenerate thin endometria unresponsive to treatments, using autologous endometrial cells and acellular amnion bilayer as a womb patch. Methods This preliminary quasi-experimental study investigated thin endometria before and after intervention with an amnion bilayer (AB) and AB with self-endometrial cells (AB+Cells). Patients were IVF candidates with oligomenorrhea, endometrial thickness (EMT) Key results Average EMT increased significantly from 5.03±0.95mm to 6.75±1.39mm after AB, and further to 7.33±1.92mm after AB+Cells. Cell density was significantly higher after AB+Cells. The histoarchitecture after AB+Cells developed into a complex tubular system, and E-cadherin and oestrogen receptor alpha (ER-α) was detected. Homeobox A10 (HOXA10 ) expression increased significantly, up to 4.5-fold after AB+Cells treatment compared with before treatment (P =0.01), while leukaemia inhibitory factor (LIF ) and osteopontin (SPP1 ) levels also increased, but not significantly. Significant changes in gene expression and cell populations were observed, with improvements in receptivity genes. Conclusions Patients with thin endometria showed improvement in EMT, histoarchitecture, and receptivity genes after AB and AB+Cells intervention. Implications The study demonstrates the potential of using a 3D amnion bilayer scaffold with endometrial cells to improve endometrial regeneration.</p>","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":"37 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent fasting restores fertility dysfunction caused by a high-fat diet in male rats: role of SIRT-1/NRF2/P38 MAPK/NLRP3.","authors":"Dalia A Hemead, Nanees F El-Malkey, Mohamed Aref, Nievin Ahmed Mahran, Esraa ElSheikh, Mohamed A Nassan, Mohamed H A Gadelmawla, Gamal A Salem, Amira F A Ahmed, Sahar M El-Sayed, Eman H Elsheikh, Nehal I Hendy","doi":"10.1071/RD24187","DOIUrl":"https://doi.org/10.1071/RD24187","url":null,"abstract":"<p><p>Context Intermittent fasting (IF) is a dietary approach against obesity; however, investigations on its role in male fertility showed contradictory results. Aims As nuclear factor erythroid 2-related factor 2 (NRF2)/mitogen-activated protein kinase p38 (MAPK)/nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) signaling pathways regulate inflammation and pyrotosis, this study aimed to elucidate whether these pathways are involved in the underlying molecular mechanisms and to investigate the prophylactic effects of IF on male reproduction dysfunction in obese rats. Methods Twenty-four adult rats were divided as follows: Control lean (CL), control positive (CP), which were fed standard diet for four non-consecutive days/week, with alternate fasting on the other 3days (24h fasting), high-fat diet group (HFD), and the HFD-fasting group (HFD-IF), which was fed a HFD, followed by fasting protocol as in CP group. Serum testosterone, inflammatory markers, semen analysis, testicular malondialdehyde (MDA) concentration, and superoxide dismutase (SOD) activity were measured. Also, testicular and epididymal histological study, immunohistochemical analysis of NLRP3 and NRF2 and reverse-transcription quantitative polymerase chain reaction (RT-qPCR) for mRNA expression of SIRT1, NRF2, p38AMPK and NLRP3 were performed. Key results Combining IF with HFD limited rats' testicular spermatic and steroidogenesis impairment, histopathological alterations, by upregulating SIRT1/NRF2 and downregulating p38 MAPK/NLRP3 signaling pathways versus the HFD group. In the HFD-IF group, oxidative and inflammatory markers had a significant decrease versus in the HFD group. Conclusions IF has a beneficial effect on male reproductive health and emphasizes the significance of customized dietary strategies for addressing male fertility issues. Implications Further investigation is required to clarify more prophylactic mechanisms of IF.</p>","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":"37 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}