{"title":"两个内皮素的故事：黄体的兴衰。","authors":"Magdalena Szymanska, Raghavendra Basavaraja, Rina Meidan","doi":"10.1071/RD24158","DOIUrl":null,"url":null,"abstract":"<p><p>Endothelins are small 21 amino acid peptides that interact with G-protein-coupled receptors. They are highly conserved across species and play important roles in vascular biology as well as in disease development and progression. Endothelins, mainly endothelin-1 and endothelin-2, are intricately involved in ovarian function and metabolism. These two peptides differ only in two amino acids but are encoded by different genes, which suggests an independent regulation and a cell-specific mode of expression. This review aims to comprehensively discuss the distinct regulation and roles of endothelin-1 and endothelin-2 regarding corpus luteum function throughout its life span.</p>","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":"37 ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A tale of two endothelins: the rise and fall of the corpus luteum.\",\"authors\":\"Magdalena Szymanska, Raghavendra Basavaraja, Rina Meidan\",\"doi\":\"10.1071/RD24158\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Endothelins are small 21 amino acid peptides that interact with G-protein-coupled receptors. They are highly conserved across species and play important roles in vascular biology as well as in disease development and progression. Endothelins, mainly endothelin-1 and endothelin-2, are intricately involved in ovarian function and metabolism. These two peptides differ only in two amino acids but are encoded by different genes, which suggests an independent regulation and a cell-specific mode of expression. This review aims to comprehensively discuss the distinct regulation and roles of endothelin-1 and endothelin-2 regarding corpus luteum function throughout its life span.</p>\",\"PeriodicalId\":516117,\"journal\":{\"name\":\"Reproduction, fertility, and development\",\"volume\":\"37 \",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reproduction, fertility, and development\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1071/RD24158\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproduction, fertility, and development","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1071/RD24158","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
内皮素是一种 21 个氨基酸的小肽，能与 G 蛋白偶联受体相互作用。它们在不同物种中高度保守，在血管生物学以及疾病的发生和发展中发挥着重要作用。内皮素，主要是内皮素-1 和内皮素-2，与卵巢功能和新陈代谢密切相关。这两种肽只有两个氨基酸不同，但由不同的基因编码，这表明它们有独立的调控和细胞特异性表达模式。本综述旨在全面讨论内皮素-1 和内皮素-2 对黄体功能的不同调控和作用。
A tale of two endothelins: the rise and fall of the corpus luteum.
Endothelins are small 21 amino acid peptides that interact with G-protein-coupled receptors. They are highly conserved across species and play important roles in vascular biology as well as in disease development and progression. Endothelins, mainly endothelin-1 and endothelin-2, are intricately involved in ovarian function and metabolism. These two peptides differ only in two amino acids but are encoded by different genes, which suggests an independent regulation and a cell-specific mode of expression. This review aims to comprehensively discuss the distinct regulation and roles of endothelin-1 and endothelin-2 regarding corpus luteum function throughout its life span.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
