Reproduction, fertility, and development最新文献_第4页

Collection: Non-photoperiodic actions of melatonin. 收集：褪黑素的非光周期作用。

IF 2.1

Reproduction, fertility, and development Pub Date : 2026-02-03 DOI: 10.1071/RD26027

Jose Alfonso Abecia, Graeme Martin

引用次数: 0

When less really is more: reducing embryo manipulation to lower metabolic stress and improving long term outcomes. 当少即是多：减少胚胎操作以降低代谢压力并改善长期结果。

IF 2.1

Reproduction, fertility, and development Pub Date : 2026-01-09 DOI: 10.1071/RD25163

Paolo Rinaudo, Rhodel Simbulan

引用次数: 0

Exploring the potential of prepubertal oocytes: a small ruminant model. 探索青春期前卵母细胞的潜力：一个小型反刍动物模型。

IF 2.1

Reproduction, fertility, and development Pub Date : 2026-01-09 DOI: 10.1071/RD25155

Maria-Teresa Paramio, Mònica Ferrer-Roda, Dolors Izquierdo, Teresa Mogas

{"title":"Exploring the potential of prepubertal oocytes: a small ruminant model.","authors":"Maria-Teresa Paramio, Mònica Ferrer-Roda, Dolors Izquierdo, Teresa Mogas","doi":"10.1071/RD25155","DOIUrl":"10.1071/RD25155","url":null,"abstract":"Juvenile in vitro embryo transfer (JIVET) employs oocytes from prepubertal females to reduce generation intervals. In human, it offers potential applications for fertility preservation in young cancer patients. Ruminant animals are good models for human research because of similar follicular dynamics and oocyte competence. Several studies have shown low embryo development of prepubertal oocytes. However, oocytes from follicles larger than 3 mm can develop into blastocysts at rates comparable to oocytes from adults. This review analyzes biomarkers of oocytes as a function of follicle size (larger or smaller than 3 mm). Follicular fluid from prepubertal females contains lower levels of n-3 fatty acids than that of adults; expression of epidermal growth factor receptor (EGFR) receptor in cumulus cells is higher in large than small follicles; the condensed germinal vesicle (GV) configuration is similar in prepubertal females to the adult ones, and prepubertal large follicles and oocytes are more susceptible to oxidative stress than adult ones. In vitro maturation (IVM) strategies have been investigated: capacitation IVM (CAPA-IVM) increases EGF receptor expression and promotes GV compaction; supplementation with bone morphogenetic protein 15 (BMP15) increases EGF receptor expression; and addition of antioxidants to IVM is essential. In conclusion, oocyte competence seems to be more related to follicular state than to female age, highlighting the importance of follicular selection and optimization of IVM conditions for improving JIVET outcomes.","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145608167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From reservoir to rendezvous: the journey of sperm through the oviduct. 从储存库到约会地点：精子通过输卵管的旅程。

IF 2.1

Reproduction, fertility, and development Pub Date : 2026-01-09 DOI: 10.1071/RD25172

David J Miller

引用次数: 0

Gene editing and multi-omics approaches to study early embryogenesis in cattle. 基因编辑和多组学方法研究牛早期胚胎发生。

IF 2.1

Reproduction, fertility, and development Pub Date : 2026-01-09 DOI: 10.1071/RD25167

Chen Chen, Yassin Kassim, Xu Xu, Xiaolin He, Haiwei Lin, Yanna Dang, Yan Shi, Huanan Wang, Shaohua Wang, Kun Zhang

{"title":"Gene editing and multi-omics approaches to study early embryogenesis in cattle.","authors":"Chen Chen, Yassin Kassim, Xu Xu, Xiaolin He, Haiwei Lin, Yanna Dang, Yan Shi, Huanan Wang, Shaohua Wang, Kun Zhang","doi":"10.1071/RD25167","DOIUrl":"10.1071/RD25167","url":null,"abstract":"Advancements in multi-omics profiling and targeted molecular functional tools have led to significant progress in our understanding of early embryonic development in mammals. This is very relevant in the beef and dairy industries for exploring the etiology of early embryo loss. This review highlights how state-of-the-art single-cell and integrative low-input omics technologies, including single-cell RNA-seq, ATAC-seq, metabolomics, and proteomics, have uncovered complex developmental dynamics during the first week of bovine embryogenesis. This review also provides a concurrent overview of the application of functional tools, including CRISPR-Cas9, RNA editing, base editing, and Trim-Away, in the analysis of critical genes/proteins during the various stages of early embryo development in cattle. The integration of high-dimensional molecular profiling with targeted manipulations enables researchers to analyze key developmental events with unparalleled resolution. It is evident that these approaches provide a more comprehensive mechanistic depiction of early embryogenesis, thereby informing translational efforts in improving bovine fertility.","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145608190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterospermic semen: implications for managing bull-to-bull variation in fertility. 异精子精液：管理公牛与公牛之间的生育力差异的意义。

IF 2.1

Reproduction, fertility, and development Pub Date : 2026-01-09 DOI: 10.1071/RD25157

Rúben Miguel Santos, Sean Fair

引用次数: 0

Translational pig models for human diseases. 人类疾病的转化猪模型。

IF 2.1

Reproduction, fertility, and development Pub Date : 2026-01-09 DOI: 10.1071/RD25164

Eckhard Wolf, Asghar Ali, Michaela Blasi, Andreas Blutke, Cornelia A Deeg, Thomas Fröhlich, Arne Hinrichs, Hristiyan Hristov, Florian Jaudas, Elisabeth Kemter, Barbara Keßler, Nikolai Klymiuk, Mayuko Kurome, Kaspar Matiasek, Hiroshi Nagashima, Simone Renner, Valeri Zakhartchenko

{"title":"Translational pig models for human diseases.","authors":"Eckhard Wolf, Asghar Ali, Michaela Blasi, Andreas Blutke, Cornelia A Deeg, Thomas Fröhlich, Arne Hinrichs, Hristiyan Hristov, Florian Jaudas, Elisabeth Kemter, Barbara Keßler, Nikolai Klymiuk, Mayuko Kurome, Kaspar Matiasek, Hiroshi Nagashima, Simone Renner, Valeri Zakhartchenko","doi":"10.1071/RD25164","DOIUrl":"10.1071/RD25164","url":null,"abstract":"The translation of novel discoveries in biomedical research into clinical applications is a lengthy and resource-intensive process, with variable success. Predictive model organisms for non-clinical research are a key asset in this process. Rodents remain the most widely used models, but they have limitations in recapitulating human pathophysiology and disease phenotypes. Over the past two decades, pigs have played an increasingly important role in bridging this translational gap. Given their close anatomical and physiological similarity to humans, most vividly illustrated by successful pig-to-human organ xenotransplantation, pigs provide unparalleled advantages for translational research. Advances in genetic engineering now allow the precise recreation of human disease mechanisms in pigs, generating tailored large-animal models with exceptional clinical relevance. This review highlights the potential of genetically modified pig models for human diseases, with a focus on metabolic disorders and rare monogenic diseases such as Duchenne muscular dystrophy, cystic fibrosis, and Laron syndrome.","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145608211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synchronized breeding and reproductive resilience in dairy cattle: mitigating metritis, heat stress, and transgenerational fertility impairment. 奶牛的同步育种和生殖恢复力：减轻炎、热应激和跨代生育障碍。

IF 2.1

Reproduction, fertility, and development Pub Date : 2026-01-09 DOI: 10.1071/RD25175

F S Lima

{"title":"Synchronized breeding and reproductive resilience in dairy cattle: mitigating metritis, heat stress, and transgenerational fertility impairment.","authors":"F S Lima","doi":"10.1071/RD25175","DOIUrl":"10.1071/RD25175","url":null,"abstract":"Heat stress profoundly compromises reproductive efficiency in dairy cattle by disrupting follicular and oocyte development, altering steroid hormone profiles, impairing estrous expression and ovulation, reducing fertilization success, hindering embryonic development, and increasing early embryonic loss. Although the molecular mechanisms underlying these disruptions remain incompletely understood, significant advances in reproductive technologies have been developed to mitigate the negative impact of heat stress on reproductive performance. Estrous cycle synchronization programs, enabling timed artificial insemination (AI), emerged in the mid-1990s and reduced heat stress-related reproductive inefficiencies by eliminating the need for estrus detection, improving submission rates, and optimizing the ovulation-to-insemination interval, thereby enhancing pregnancy rates per AI. Embryo transfer (ET) has been adopted as a complementary strategy to bypass fertilization failure during hot periods, whereas genetic selection, most notably the introgression of the SLICK-1 allele of the prolactin receptor gene (PRLR), confers thermotolerance via a sleek hair coat and improved heat dissipation. Nevertheless, heat stress also exacerbates common postpartum disorders such as metritis, which negatively affect fertility regardless of AI, ET, or thermotolerant genotypes, underscoring the importance of preventive herd-health management. Furthermore, exposure to heat stress during fetal development imposes transgenerational consequences, diminishing the health, productivity, longevity, and fertility of subsequent generations. This review evaluates current and emerging technologies, including timed AI, ET, genetic selection for thermotolerance and reproductive resilience, and preventive approaches to postpartum disease, while also addressing strategies to mitigate the transgenerational impairments induced by heat stress in dairy cattle.","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145608163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

External factors influencing reproductive tract microbiota in cattle. 影响牛生殖道微生物群的外部因素。

IF 2.1

Reproduction, fertility, and development Pub Date : 2026-01-09 DOI: 10.1071/RD25165

Rebecca K Poole

引用次数: 0

Extended embryo culture: illuminating a black box of early development in ruminants. 扩展胚胎培养：揭示反刍动物早期发育的黑箱。

IF 2.1

Reproduction, fertility, and development Pub Date : 2026-01-09 DOI: 10.1071/RD25156

N Martínez de Los Reyes, A Siegmund-Sabater, I Flores-Borobia, L González-Brusi, A Salvo-Jiménez, P Marigorta, P Bermejo-Álvarez, P Ramos-Ibeas

{"title":"Extended embryo culture: illuminating a black box of early development in ruminants.","authors":"N Martínez de Los Reyes, A Siegmund-Sabater, I Flores-Borobia, L González-Brusi, A Salvo-Jiménez, P Marigorta, P Bermejo-Álvarez, P Ramos-Ibeas","doi":"10.1071/RD25156","DOIUrl":"10.1071/RD25156","url":null,"abstract":"Pregnancy losses due to early embryonic mortality remain a major concern in farm ungulates, including cattle, sheep, pigs and goats. The majority of these losses occur during conceptus elongation, a developmental phase unique to ungulates that follows blastocyst hatching. This stage entails complex cell differentiation, proliferation and migration processes, leading to a rapid expansion of the extraembryonic membranes (EEMs), namely the trophoblast and the hypoblast, and the formation of the embryonic disc (ED) from the epiblast. Despite its biological and economic relevance, the molecular mechanisms regulating embryo development beyond the blastocyst stage, particularly those governing the ED formation, remain poorly understood. Fortunately, recent advances in extended culture systems are enabling the study of these processes entirely in vitro, reducing the need for experimental animals. In this review, we highlight key interspecies differences in early embryogenesis across mammalian species. We discuss the progression and refinement of extended embryo culture systems, from early pioneering efforts to the latest advances, with a specific focus on ruminant species, including cow and sheep. Lastly, we review recent functional studies leveraging extended embryo culture systems in ruminants to elucidate the molecular pathways controlling post-hatching development.","PeriodicalId":516117,"journal":{"name":"Reproduction, fertility, and development","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145608244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0