Chemical Papers最新文献_第5页

InFlamPred: a machine learning framework for anti-inflammatory small molecule prediction 一个用于抗炎小分子预测的机器学习框架

IF 2.5 4区化学

Chemical Papers Pub Date : 2025-06-21 DOI: 10.1007/s11696-025-04165-7

Subathra Selvam, Priya Dharshini Balaji, R. Annie Uthra, C. G. Anupama, Honglae Sohn, Thirumurthy Madhavan

{"title":"InFlamPred: a machine learning framework for anti-inflammatory small molecule prediction","authors":"Subathra Selvam, Priya Dharshini Balaji, R. Annie Uthra, C. G. Anupama, Honglae Sohn, Thirumurthy Madhavan","doi":"10.1007/s11696-025-04165-7","DOIUrl":"10.1007/s11696-025-04165-7","url":null,"abstract":"<div><p>Several anti-inflammatory small molecules have been discovered and utilized in the treatment of various inflammatory and autoimmune diseases. Despite experimental identification of numerous anti-inflammatory peptides, the development of peptide-based drugs remains expensive, time-consuming, and labor-intensive. Small molecules offer higher stability compared to peptides, owing to their chemical synthesis or natural sources. Consequently, there is an urgent need to develop advanced machine learning (ML) methods utilizing a large-scale dataset consisting of experimentally acquired small molecule to enhance precision and efficiency. This study introduces a predictive ML-method, named InFlamPred (Anti-inflammatory Small Molecule Predictor), tailored for anti-inflammatory small molecules. The proposed ML classifier facilitates compound screening in inflammatory diseases. We trained five different ML classifiers—RF, KNN, LGBM, DT, and XGB achieving an overall accuracy ranging from 61 to 75%. Notably, the LGBM, RF, and XGB models demonstrated strong performance on the training dataset, with XGB maintaining high accuracy and robustness on the test dataset, achieving an accuracy of 75% and an AUC of 81%. When evaluated on an external validation dataset consisting of 80 compounds (equally distributed between active and inactive classes), the XGB model effectively identified all active and inactive molecules. These results highlight the reliability and generalizability of the proposed ML approach in accurately predicting small molecules with anti-inflammatory potential.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"79 9","pages":"5957 - 5969"},"PeriodicalIF":2.5,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catalytic performance of lipase-inorganic hybrid nanoflower in the presence of some oils/fat/waste oils and detergents/surfactants 脂肪酶-无机杂化纳米花在油/脂肪/废油和洗涤剂/表面活性剂存在下的催化性能

IF 2.5 4区化学

Chemical Papers Pub Date : 2025-06-20 DOI: 10.1007/s11696-025-04168-4

Kezban Yildiz-Dalginli

{"title":"Catalytic performance of lipase-inorganic hybrid nanoflower in the presence of some oils/fat/waste oils and detergents/surfactants","authors":"Kezban Yildiz-Dalginli","doi":"10.1007/s11696-025-04168-4","DOIUrl":"10.1007/s11696-025-04168-4","url":null,"abstract":"<div><p>In this study, the conventional hybrid nanoflower synthesis method was used for lipase-inorganic hybrid nanoflowers. Following a comprehensive pH and temperature scanning of the nanoflowers, their activity was investigated in some detergents/surfactants and oils/fats/waste oils to evaluate the activity, stability and compatibility of the biocatalyst. The optimal morphology for L@ihNFs was determined to be 0.05 mg/mL. To obtain the optimum activity, conditions were explored pH values ranging from 6 to 12 and temperatures between 30 and 80 °C. Both the free form and L@ihNF exhibited higher activity in alkaline conditions, with a significant decrease in activity observed at pH 11 and 12. L@ihNF showed superior activity and remarkable compatibility compared to the free enzyme in the presence of various commercial liquid/powder detergents and surfactants. Moreover, it displayed over a twofold increase in activity in some oils/fat/waste oils. The reusability of the synthesized L@ihNF was examined in 10 cycles, and it was observed that it still showed 58% activity at the end of the 8th cycle, which is a good indicator of reusability. L@ihNFs exhibited good storage stability, retaining approximately 50% activity after 20 days compared to the free enzyme.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"79 9","pages":"5997 - 6010"},"PeriodicalIF":2.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eco-friendly synthesis of cobalt nanoparticles from Erythrina crista-galli leaves for enhanced anticorrosive performance 从赤藓叶中环保合成钴纳米颗粒，增强防腐性能

IF 2.5 4区化学

Chemical Papers Pub Date : 2025-06-20 DOI: 10.1007/s11696-025-04159-5

Dilpreet Kaur, Monika Verma, Ruchi Bharti, Shivani Naik, Renu Sharma

{"title":"Eco-friendly synthesis of cobalt nanoparticles from Erythrina crista-galli leaves for enhanced anticorrosive performance","authors":"Dilpreet Kaur, Monika Verma, Ruchi Bharti, Shivani Naik, Renu Sharma","doi":"10.1007/s11696-025-04159-5","DOIUrl":"10.1007/s11696-025-04159-5","url":null,"abstract":"<div><p>Corrosion of mild steel in acidic environments poses a significant challenge to industrial sustainability due to its economic and structural implications. Conventional corrosion inhibitors often involve toxic and non-biodegradable chemicals, leading to environmental concerns. To address this, the present study explores an environmentally benign method for the synthesis of cobalt nanoparticles (CoNPs) using Erythrina crista-galli leaf extract, which acts as a natural reducing and stabilizing agent. The novelty of this work lies in the green synthesis of CoNPs with enhanced anticorrosive activity, which surpasses traditional methods by eliminating hazardous reagents and minimizing environmental impact. Synthesis parameters such as extract concentration, pH, precursor-to-extract ratio, reaction temperature, and time were optimized to achieve nanoparticles with improved stability, morphology, and crystallinity. The synthesized CoNPs were thoroughly characterized using UV–visible spectroscopy, FTIR, DLS, Zeta potential analysis, SEM–EDX, and XRD, confirming the formation of well-dispersed nanoparticles with controlled size and shape. Electrochemical studies using potentiodynamic polarization and weight loss techniques revealed a maximum corrosion inhibition efficiency of 90.08% for CoNPs in 0.5 M HCl solution, demonstrating their strong barrier effect on steel surfaces. These findings underscore the potential of green-synthesized CoNPs as a sustainable and highly efficient alternative to synthetic corrosion inhibitors for industrial applications.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"79 9","pages":"5875 - 5897"},"PeriodicalIF":2.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromotropic acid-activated silver nanoparticles: a convenient colorimetric sensor for selective determination of divalent and trivalent iron ions 变色酸活化银纳米粒子：一种方便的二价和三价铁离子选择性测定的比色传感器

IF 2.5 4区化学

Chemical Papers Pub Date : 2025-06-20 DOI: 10.1007/s11696-025-04180-8

Nam-Phuong Nguyen-Huynh, Hong-Phuong Phan, Hoa-Hung Lam, Thi-An-Sa Do, Phuc-Thanh-Duy Nguyen, Thi-Kieu-Anh Tran, Antonio Reina, Trung Dang-Bao

{"title":"Chromotropic acid-activated silver nanoparticles: a convenient colorimetric sensor for selective determination of divalent and trivalent iron ions","authors":"Nam-Phuong Nguyen-Huynh, Hong-Phuong Phan, Hoa-Hung Lam, Thi-An-Sa Do, Phuc-Thanh-Duy Nguyen, Thi-Kieu-Anh Tran, Antonio Reina, Trung Dang-Bao","doi":"10.1007/s11696-025-04180-8","DOIUrl":"10.1007/s11696-025-04180-8","url":null,"abstract":"<div><p>Iron ions play a crucial role in various biological, environmental, and industrial processes, making their quick and on-site detection in aqueous solutions a significant analytical challenge. This study presents a simultaneous colorimetric detection method for Fe(II) and Fe(III) ions in aqueous solutions using silver nanoparticles (AgNPs) functionalized with chromotropic acid (CTA). The detection of Fe(II) and Fe(III) ions based on CTA-AgNPs was monitored both visually and through ultraviolet–visible spectrophotometry (UV–vis). We discover a variation in nanoparticles size and absorption with their interaction with different ions, which allow us to determine analytical parameters such as the detection and quantification limits. This colorimetric system showed excellent selectivity to the detection of Fe(II) and Fe(III) ions, even in the presence of other metal cations that could potentially interfere the analysis. This approach offers a robust and efficient method for detecting iron ions, with potential applications in environmental monitoring and industrial processes.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"79 9","pages":"6147 - 6158"},"PeriodicalIF":2.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A kinetic study on the non-oxidative methanol conversion into formaldehyde and hydrogen over multiwall carbon nanotubes 非氧化甲醇在多壁碳纳米管上转化为甲醛和氢的动力学研究

IF 2.5 4区化学

Chemical Papers Pub Date : 2025-06-20 DOI: 10.1007/s11696-025-04182-6

Oleksii Zhokh, Andrii Trypolskyi, Igor Bychko, Valentina Gritsenko, Peter Strizhak

{"title":"A kinetic study on the non-oxidative methanol conversion into formaldehyde and hydrogen over multiwall carbon nanotubes","authors":"Oleksii Zhokh, Andrii Trypolskyi, Igor Bychko, Valentina Gritsenko, Peter Strizhak","doi":"10.1007/s11696-025-04182-6","DOIUrl":"10.1007/s11696-025-04182-6","url":null,"abstract":"<div><p>Nonoxidative methanol conversion to formaldehyde and hydrogen is an important process. Formaldehyde is a valuable chemical both in itself and as a precursor, whereas hydrogen is a novel clean fuel. In this paper, the kinetics of the corresponding process was studied experimentally using multiwall carbon nanotubes as a catalyst. The carbon nanotubes demonstrated catalytic activity at temperatures as low as 443 K and 100% selectivity to desired products. A set of kinetic schemes for the methanol dehydrogenation to formaldehyde and hydrogen was established under Langmuir–Hinshelwood formalism. After the evaluation of the kinetic parameters, the kinetic scheme based on the dual-site Langmuir–Hinshelwood mechanism with the loss of the first hydrogen atom as a rate-determining step was found to be suitable in the experimental scenario. The identified kinetic model may correspond to either the alkoxy or hydroxyalkyl route of the methanol decomposition. To the best of our knowledge, this is the first experimental study reporting on the kinetics of the methanol conversion to formaldehyde and hydrogen over multiwall carbon nanotubes.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"79 9","pages":"6183 - 6193"},"PeriodicalIF":2.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On topological characterization of Bismuth tri-Iodide using topological indices and MATLAB 利用拓扑指数和MATLAB研究三碘化铋的拓扑表征

IF 2.5 4区化学

Chemical Papers Pub Date : 2025-06-20 DOI: 10.1007/s11696-025-04174-6

Zeeshan Saleem Mufti, Muhammad Arfan Ali, Muhammad Farhan Hanif

{"title":"On topological characterization of Bismuth tri-Iodide using topological indices and MATLAB","authors":"Zeeshan Saleem Mufti, Muhammad Arfan Ali, Muhammad Farhan Hanif","doi":"10.1007/s11696-025-04174-6","DOIUrl":"10.1007/s11696-025-04174-6","url":null,"abstract":"<div><p>Bismuth tri-iodide <span>((BiI_3))</span> is a structurally flexible inorganic compound and shows high potential in the field of materials science owing to the many chain and sheet configurations it can form. In the present work, we carry out an in-depth topological characterization of <span>((BiI_3))</span> on the basis of ev-degree and ve-degree-based descriptors, providing insight into its molecular structure by applying graph-theoretical methods. Using symbolic computation and visualization through MATLAB, we calculate and examine a set of topological descriptors ranging from the Zagreb, Randic, Atom-Bond Connectivity, and Geometric-Arithmetic indices for the chain <span>((BiI_3))</span> and the sheet <span>((BiI_3))</span> forms. We then statistically examine the properties and relate them with the topological descriptors through the help of QSPR models. We find high correlations between the branching parameters and the topological indices, reflecting the potential for prediction. We emphasize the practical application of degree-based descriptors in molecular connectivity and explicate the potential for the design of structural descriptors in inorganic compounds in the fields of nanotechnology and materials science.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"79 9","pages":"6057 - 6077"},"PeriodicalIF":2.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On analysis of two-dimensional nickel-based organometallic network via statistical method 二维镍基有机金属网络的统计分析

IF 2.5 4区化学

Chemical Papers Pub Date : 2025-06-19 DOI: 10.1007/s11696-025-04173-7

Muhammad Farhan Hanif, Mazhar Hussain, Muhammad Kamran Siddiqui, Ebraheem Alzahrani, Zeeshan Saleem Mufti

{"title":"On analysis of two-dimensional nickel-based organometallic network via statistical method","authors":"Muhammad Farhan Hanif, Mazhar Hussain, Muhammad Kamran Siddiqui, Ebraheem Alzahrani, Zeeshan Saleem Mufti","doi":"10.1007/s11696-025-04173-7","DOIUrl":"10.1007/s11696-025-04173-7","url":null,"abstract":"<div><p>In this paper, we investigate the structural and topological properties of two-dimensional nickel-based organometallic frameworks (2D Ni-MOFs) using various topological descriptors and entropy measures. The frameworks are analyzed by calculating degree-based, edge-based, and Shannon entropy measures to quantify structural complexity and connectivity patterns. Additionally, logarithmic regression models are applied to establish the relationship between entropy measures and topological indices. The results demonstrate that entropy measures effectively capture the structural characteristics of the networks, with logarithmic models providing excellent fits, as evidenced by high <span>(R^2)</span> values. Violin plots are used to represent the distribution of entropy values and how they correlate with the respective topological indices. This article offers insightful information on the application of topological descriptors and entropy values in the exploration of complex networks and offers a useful approach to interpreting the structural characteristics of two-dimensional nickel-based organometallic frameworks.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"79 9","pages":"6041 - 6056"},"PeriodicalIF":2.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of automobile exhaust emission on human health and environment in India: a systematic review 印度汽车尾气排放对人类健康和环境的影响：系统综述

IF 2.5 4区化学

Chemical Papers Pub Date : 2025-06-19 DOI: 10.1007/s11696-025-04082-9

Julie Minoo Pardiwala, Mitul Prajapati, Manan Shah, Jinal Tailor

{"title":"Effect of automobile exhaust emission on human health and environment in India: a systematic review","authors":"Julie Minoo Pardiwala, Mitul Prajapati, Manan Shah, Jinal Tailor","doi":"10.1007/s11696-025-04082-9","DOIUrl":"10.1007/s11696-025-04082-9","url":null,"abstract":"<div><p>The paper discusses vehicles that generate air pollution more than any other human activity. Public transportation is done in two ways: formal and informal. It is the responsibility of the government to provide public transportation. As the population is increasing daily, government transportation cannot fulfil the demand for vehicles like public government buses. So in some rural and developing countries, the public does not get the proper mode of shifting due to a lack of transportation facilities. Private vehicles like auto-rickshaws, vans, jeeps, and minibuses are informally overloaded with the public, and transportation is done. It is noted that in India, most transportation is done in an informal way, which is against the policy and norms. This informal way of transportation leads to environmental pollution and health effects by emitting air pollution. Using different fuels in vehicles and overloading the passengers in informal transportation lead to unsafe modes. There is a research gap between people’s knowledge of public and traffic norms, so it is important to survey the vehicle and transportation facilities. Furthermore, this review paper gives the idea of health effects, types of air pollution, emission control systems, and norms, including individual and public efforts to minimize air pollution.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"79 8","pages":"4839 - 4848"},"PeriodicalIF":2.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green synthesis of zinc oxide nanoparticles using green seaweed Caulerpa taxifolia and its anticancer activity on cervical cancer 绿色紫杉藻绿色合成氧化锌纳米颗粒及其对宫颈癌的抗癌作用

IF 2.5 4区化学

Chemical Papers Pub Date : 2025-06-18 DOI: 10.1007/s11696-025-04101-9

Parthasarathi Perumal, Jayaraman Vinayagam, Samundeswari Loganathan, Nazeer Ahamed Sathakkathulla, Bhavani Sri Murugesan, Fasna Musthafa, Suresh Rathinasamy, Ashok Kumar Balaraman

{"title":"Green synthesis of zinc oxide nanoparticles using green seaweed Caulerpa taxifolia and its anticancer activity on cervical cancer","authors":"Parthasarathi Perumal, Jayaraman Vinayagam, Samundeswari Loganathan, Nazeer Ahamed Sathakkathulla, Bhavani Sri Murugesan, Fasna Musthafa, Suresh Rathinasamy, Ashok Kumar Balaraman","doi":"10.1007/s11696-025-04101-9","DOIUrl":"10.1007/s11696-025-04101-9","url":null,"abstract":"<div><p><i>Caulerpa taxifolia</i> is a remarkable marine green alga known for its abundant production of bioactive compounds exhibiting a wide range of potent biological activities. In this study, we synthesized zinc oxide nanoparticles using <i>C. taxifolia</i> and evaluated their effects against the HeLa cell line. The synthesized ZnO nanoparticles were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and dynamic light scattering (DLS) analysis. The anticancer activity of the zinc oxide nanoparticles was investigated using MTT assay, acridine orange and ethidium bromide double staining and DNA fragmentation assay. SEM analysis revealed the hexagonal shape of the synthesized zinc oxide nanoparticle, while FTIR spectra confirmed the presence of zinc atoms. XRD patterns indicated the purity of the ZnO nanoparticles, and DLS analysis provided information about their size. The anticancer activity of ZnO nanoparticles was demonstrated by an IC<sub>50</sub> value of 74.77 µg/mL and acridine orange and ethidium bromide staining as well as DNA fragmentation assay confirmed apoptosis in the HeLa cell line. These findings highlight a potent cytotoxic impact of the ZnO nanoparticles synthesized from <i>C. taxifolia</i> on cervical cancer cell lines. </p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"79 8","pages":"4999 - 5007"},"PeriodicalIF":2.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145166908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitex leucoxylon extract conjugated CMC membrane for bone regeneration, wound healing, and anticancer applications 白荆提取物偶联CMC膜用于骨再生、伤口愈合和抗癌

IF 2.5 4区化学

Chemical Papers Pub Date : 2025-06-18 DOI: 10.1007/s11696-025-04125-1

Nayef Abdulaziz Aldabaan

{"title":"Vitex leucoxylon extract conjugated CMC membrane for bone regeneration, wound healing, and anticancer applications","authors":"Nayef Abdulaziz Aldabaan","doi":"10.1007/s11696-025-04125-1","DOIUrl":"10.1007/s11696-025-04125-1","url":null,"abstract":"<div><p>Phytochemicals have gained importance due to their diverse applications in the biomedical and pharmacological fields. The present study was designed to evaluate the biomedical applications and characterization of <i>Vitex leucoxylon</i> extract conjugated CMC membranes. Phyto-conjugated CMC membranes were prepared through solvent casting technique and characterized using FTIR, XRD, SEM, EDX and contact angle analysis. Antioxidant activity was performed using DPPH assay; inflammatory marker study was conducted based on COX-2 inhibition study; hemocompatibility nature was evaluated using hemolysis; cytotoxicity and anticancer activity against triple negative breast cancer MDA-MB231 cell line was screened using MTT assay; and bone cell regeneration study was conducted using MG-63 cell line. Phyto-conjugated CMC membranes showed the presence of secondary metabolites which was confirmed by FTIR analysis. Surface morphology and EDX analysis confirmed conjugation of plant extract within the membranes. XRD revealed the change in the nature of the phyto-conjugated membrane with changes in the peak values. Wettability nature was revealed by the contact angle. Physical properties such as water vapor transmission rate (0.670%), moisture retention (92.60%), and swelling ability (68.76%) revealed optimum characteristics of the membrane. In vitro studies showed significant antioxidant activity and COX-2 inhibition. The phyto-conjugated CMC membranes showed excellent hemocompatibility and biocompatibility. The anticancer activity was confirmed by the cytotoxicity results (IC<sub>50</sub> = 157.74 µg/mL). Moreover, in vitro bone cell regeneration and migration assay results illustrated prominent bone cell regeneration (87.88%) and cell migration characteristics. These findings open new avenues for the development of advanced biomaterials, significantly enhancing the efficacy of bone tissue regeneration, wound healing, and targeted anticancer therapies.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"79 8","pages":"5277 - 5299"},"PeriodicalIF":2.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0