Chemical Papers最新文献

{"title":"Engineering strategies, applications for safety and sustainability in chitosan-based emerging food systems","authors":"Ahmet Gökhan Ağgül,&nbsp;Mustafa Dolaz,&nbsp;Veyis Karakoç,&nbsp;Emrah Dikici,&nbsp;Tuba Gök,&nbsp;Burcu Önal Acet,&nbsp;Mehmet Odabaşı,&nbsp;Ömür Acet","doi":"10.1007/s11696-026-05460-7","DOIUrl":"10.1007/s11696-026-05460-7","url":null,"abstract":"<div><p>Chitosan, a versatile and sustainable biopolymer, has emerged as a promising platform for developing advanced strategies in food safety and preservation. Its tunable molecular weight, degree of deacetylation, and hierarchical structure enable the rational design of diverse functional architectures, including nanostructures, coatings, membranes, and smart packaging systems with enhanced antimicrobial, antioxidant, barrier, and biocompatible properties. Beyond conventional preservation approaches, chitosan-based materials offer multifunctional solutions by extending shelf life, maintaining food quality, reducing environmental impacts, and enabling active and intelligent food packaging applications. Emerging applications include contaminant management strategies, such as microbial control and the adsorption of hazardous compounds, including aflatoxins and heavy metals. This review provides a comprehensive overview of the structural characteristics, modification strategies, functional properties, and diverse applications of chitosan-based materials in sustainable food protection systems. Furthermore, current challenges related to scalability, regulatory requirements, consumer acceptance, and commercialization are discussed, highlighting future perspectives for the successful translation of chitosan-based technologies into practical food applications.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"80 10","pages":"11383 - 11429"},"PeriodicalIF":2.5,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biocompatible GO–HAp–ZrO2–Fc composite bone pin material prototype with enhanced mechanical, tribological and biological performance: a promising candidate for advanced orthopedic implants","authors":"Santosh R. Patil,&nbsp;Mahesh J. Thorat,&nbsp;Rajanikant M. Kurane,&nbsp;Rahul M. Mane","doi":"10.1007/s11696-026-05027-6","DOIUrl":"10.1007/s11696-026-05027-6","url":null,"abstract":"<p>Bone fixation and replacement materials require a balanced combination of biocompatibility, mechanical reliability, wear resistance, and interfacial stability. In this study, a quaternary graphene oxide–hydroxyapatite–zirconia–ferrocene (GO–HAp–ZrO₂–Fc) composite was developed as a bone pin material prototype using a controlled precipitation route followed by powder metallurgy processing. The composite was compacted at 400 MPa and sintered at <span>(800^{circ }hbox {C})</span> to improve densification and structural integrity. Structural and physicochemical analyses using HRTEM, SAED, XRD, FTIR, Raman spectroscopy, EDX, TGA–DSC, and BET confirmed the successful integration of GO, HAp, ZrO₂, and Fc into a stable multiphase nanocomposite with mesoporous surface characteristics and good thermal stability. Biological evaluation showed low cytotoxicity, with 91.13% cell viability at <span>(25,upmu )</span>g/mL in short-term MTT testing and 94.74% viability at <span>(20,upmu )</span>g/mL after extended cytocompatibility assessment. The composite also exhibited antibacterial activity against <i>Escherichia coli</i> and maintained cellular redox balance without inducing intracellular ROS generation in L929 fibroblast cells. Mechanical testing demonstrated a Micro-Vickers hardness of 530 HV, compressive strength of 81.2 MPa, and direct tensile strength of 92 MPa. In addition, Brazilian diametrical compression testing showed direction-dependent tensile strengths of approximately 112 MPa, 74 MPa, and 42 MPa in the longitudinal, circumferential, and radial directions, respectively, indicating bone-relevant anisotropic mechanical behavior. Tribological testing showed a low coefficient of friction in the range of 0.0738–0.102 under applied loads of 0–2 kg and sliding speeds of 50–150 rpm. Overall, the GO–HAp–ZrO₂–Fc composite demonstrates a promising combination of structural stability, biological safety, mechanical compatibility, and wear resistance for further evaluation as a load-sharing bone pin material prototype, although osteoblast-specific, degradation, fatigue, and in vivo studies are required before clinical translation.</p>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"80 9","pages":"10579 - 10600"},"PeriodicalIF":2.5,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148871591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural integrity for bulk hazardous chemical shipments","authors":"Rino Jacob","doi":"10.1007/s11696-026-05033-8","DOIUrl":"10.1007/s11696-026-05033-8","url":null,"abstract":"<div><p>Packaging and transportation of hazardous chemical materials require a certain number of tests to be done. Intermediate Bulk Containers are widely used for packaging and shipping bulk materials. Dry refined hazardous materials are packaged inside Flexible Intermediate containers or FIBC super-sacks, which are widely used in the chemical industry for bulk handling of powders, granules, and specialty materials. These materials require packaging solutions which guarantee containment, integrity, electrostatic safety, and compliance with DOT hazardous material regulations. This paper explores progress in FIBC super-sack designs and specifications, including different fabric thicknesses, various liner materials, and UN-certified configurations for sensitive chemical compounds. A comparative examination of two specifications will help us determine potential cost savings. The project proposal is to develop the best packaging solution for hazardous chemicals. This paper studies the regulatory requirements and technical standards for UN-rated Flexible Intermediate Bulk Containers (FIBCs), commonly known as super sacks, used to transport hazardous chemicals in Packing Groups II and III. It provides an overview of classification systems, performance criteria, and compliance obligations under international and U.S. regulations (International Air Transport Association 2023; International Maritime Organization 2023). Flexible Intermediate Bulk Containers (FIBCs), commonly referred to as super sacks, are widely used for the bulk handling and transport of dry hazardous materials in the chemical industry. For substances classified under U.S. DOT regulations as Packing Group III (Class 9), UN packaging certification is required prior to shipment. This study evaluated two FIBC configurations of 190 GSM and 230 GSM woven polypropylene body fabric to determine whether the lower-specification bag meets UN certification requirements under 49 CFR Part 178, Subpart O, and whether it represents a viable cost-reducing alternative. Both configurations were U-shaped, 4-panel bags with a duffel-top inlet, a 3 mil polypropylene liner, and a safe working load of 2,500 lbs. Both the 190 GSM and 230 GSM FIBCs passed all six required PG III tests: Top Lift (178.812), Drop (178.810), Stacking (178.815), Topple (178.816), Righting (178.817), and Tear (178.818) (Pipeline and Hazardous 2022, 2025). No performance differences were observed between the two setups throughout any test. These data show that the 190 GSM bag is a suitable alternative to the 230 GSM bag for packaging hazardous chemical shipments in bulk under the tested conditions, with potential procurement cost savings for high-volume orders. Limitations encompass the single-material scope of testing and the absence of long-term storage or cyclic load assessments.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"80 9","pages":"10635 - 10645"},"PeriodicalIF":2.5,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148871763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The polar–aromatic balance index (PABi): a novel molecular descriptor for predicting physicochemical properties of organic compounds in quantitative structure–property relationship analysis","authors":"Usha Arcot,&nbsp;Noel George,&nbsp;V. Deepika,&nbsp;Muhammad Kamran Siddiqui","doi":"10.1007/s11696-026-05101-z","DOIUrl":"10.1007/s11696-026-05101-z","url":null,"abstract":"","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"80 10","pages":"11903 - 11919"},"PeriodicalIF":2.5,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11696-026-05101-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable LaNiO3/biocarbon nanocomposite derived from sugarcane bagasse for high-performance supercapacitor application","authors":"Muhammad Zaman,&nbsp;Sarah A. Alsalhi,&nbsp;Ali El-Rayyes,&nbsp;Hamud A. Altaleb,&nbsp;Eman Alzahrani,&nbsp;Hala M. Abo-Dief,&nbsp;Reda A. Haggam","doi":"10.1007/s11696-026-05096-7","DOIUrl":"10.1007/s11696-026-05096-7","url":null,"abstract":"<div><p>Researchers are collaborating on nanomaterials that can perform multiple functions since water purification as well as the demand for energy storage are serious concerns for societies. Due to their many physical, surface properties and conductive capabilities as well as outstanding chemical durability, metal oxide has got a lot of interest for potential applications in energy storage. In this study, the researchers present a simple hydrothermal process for the production of LaNiO₃/sugarcane bagasse. The morphological, structural and interfacial area of the material was determined using different physical properties such as Fourier transformation infrared (FTIR) spectroscopy, Brunauer–Emmett–Teller (BET), scanning electron microscopy (SEM) and X-ray diffraction (XRD). LaNiO₃/SB showed specific capacitance (C_s) of 1958.67 F g⁻¹ with specific power (S_P) of 259 W kg⁻¹ and specific energy (S_E) (73 Wh kg⁻¹) at 1 A g⁻¹. The electrode material is efficient and perfect for storing energy and protecting the environment because of its remarkable electrochemical properties.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"80 10","pages":"11861 - 11873"},"PeriodicalIF":2.5,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and characterization of hybrid Kender-F fibre and collagen toughened epoxy composites","authors":"M. Neela Harish,&nbsp;J. Sofia Bobby,&nbsp;P. G. Kuppusamy,&nbsp;C. L. Annapoorani","doi":"10.1007/s11696-026-05091-y","DOIUrl":"10.1007/s11696-026-05091-y","url":null,"abstract":"<div><p>This study introduces a novel biohybrid composite system by integrating silane-treated collagen biopolymer with Kender-F hybrid fibers (60% hemp and 40% flax) in an epoxy matrix, specifically engineered for prosthetic structural applications. Unlike conventional natural fiber composites, the present work uniquely combines a protein-based biopolymer with silane-modified hybrid lignocellulosic fibers to simultaneously enhance interfacial bonding, toughness, and multifunctional durability. Five composite systems (M, MSC0, MSC1, MSC2, and MSC3) were fabricated and systematically evaluated for mechanical (ASTM D3039 tensile, ASTM D790 flexural, ASTM D256 impact, ASTM D2240 hardness), tribological (ASTM G99), water absorption (ASTM D570), and flammability behavior (ASTM D635 and UL-94).The incorporation of silane-treated collagen significantly improved load transfer efficiency and interfacial adhesion, resulting in enhanced structural integrity. Among all composites, MSC2 (3 vol.% collagen) demonstrated the optimum stiffness–toughness balance, achieving a tensile strength of 152 MPa, flexural strength of 168 MPa, impact strength of 4.6 J, and Shore-D hardness of 83, along with the highest density of 1.31 g/cm3. In contrast, MSC3 (5 vol.% collagen) exhibited superior functional performance with the lowest specific wear rate (0.013 mm³/N·m), reduced coefficient of friction (0.25), decreased flame propagation rate (4.92 mm/min), and stable, non-dripping behavior under UL-94 conditions.The findings reveal a synergistic effect between collagen biopolymer and silane-treated Kender-F fibers, enabling simultaneous improvement in mechanical strength, wear resistance, moisture stability, and flame retardancy. This multifunctional optimization distinguishes the proposed composite from existing natural fiber systems and demonstrates its strong potential for advanced prosthetic components requiring high strength, durability, and safety.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"80 10","pages":"11791 - 11804"},"PeriodicalIF":2.5,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of CeCuO3 nanomaterials anchored on rGO sheets utilized as excellent electrode materials for supercapacitor","authors":"Muhammad Imtiaz,&nbsp;Saira Riaz,&nbsp;Haifa A. Alyousef,&nbsp;B. M. Alotaibi,&nbsp;Albandari .W. Alrowaily,&nbsp;Eman Alzahrani,&nbsp;Abhinav Kumar,&nbsp;Rizwan Ul Hassan","doi":"10.1007/s11696-026-05119-3","DOIUrl":"10.1007/s11696-026-05119-3","url":null,"abstract":"<div><p>The rise in energy consumption requires the progression of effective energy storing systems to fulfil the energy necessities. A feasible approach is the development of unique nanostructures, which have proven to be excellent materials in hybrid supercapacitor electrodes. A cerium-based binary metal oxide in the perovskite phase, CeCuO₃ (CCO), for its outstanding performance and cost-effectiveness when combined with the remarkably versatile reduced graphene oxide, was developed via hydrothermal approach. The composite manufacturing process provides a substantial electroactive surface area (SA) of 52.1 m²/g for pristine sample and an increased SA of 81.96 m²/g for rGO@CCO, contributing via BET analysis and structurally validated using X-ray diffraction, Infrared spectroscopy and SEM (scanning electron microscopy). The key highlights of the study were to assess the electrochemical evaluation of rGO@CeCuO₃ by cyclic voltammetry, impedance spectroscopic analysis and galvanostatic charging-discharging tests. The rGO@CCO sample attained a outstanding capacitance of 1242 F/g at an 1 A/g applied current density and an exceptionally negligible solution resistance of 0.82 Ω in a 3 M KOH electrolytic medium, maintaining excellent stability after 10000th CV cycles. This suggests that the potential applications for the fabricated electrode in next-generation flexible electronics include energy storage and conversion devices.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"80 10","pages":"12105 - 12118"},"PeriodicalIF":2.5,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced hydrogen evolution reaction performance of LaNiO3/rGO hybrid electrocatalyst in alkaline medium","authors":"Meshal Fatima,&nbsp;Shaimaa A. M. Abdelmohsen,&nbsp;Meznah M. Alanazi,&nbsp;Abhinav Kumar,&nbsp;Nadeem Raza,&nbsp;Eman Alzahrani,&nbsp;Hamud A. Altaleb,&nbsp;Reda A. Haggam","doi":"10.1007/s11696-026-05086-9","DOIUrl":"10.1007/s11696-026-05086-9","url":null,"abstract":"<div><p>A cost-effective and high-performance LaNiO₃/rGO nanocomposite electrode was fabricated for effectual H₂ evolution in alkaline media. The combinition of LaNiO₃ nanoparticles with conductive rGO sheets created a porous 3D network, providing abundant catalytic sites and rapid electron transport channels. Electrochemical tests (1 M KOH) confirmed that LaNiO₃/rGO electrode significantly outperforms pristine LaNiO₃, displaying a low ƞ (191 mV) at 10 mA/cm² and Tafel plot (40 mV/dec), suggesting that HER follows the Heyrovsky pathway. Physical analyses confirmed uniform nanoparticle distribution on rGO and a stable perovskite crystalline structure, ensuring structural integrity during extended operation. The synergistic combination of LaNiO₃ and rGO enhances the active surface area and promotes efficient electron–proton transfer, leading to superior HER activity and long-term stability. These results highlight LaNiO₃/rGO as a capable catalyst for renewable H₂ production and energy applications.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"80 10","pages":"11717 - 11727"},"PeriodicalIF":2.5,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MIL-125(Ti)@Fe metal–organic framework as a dual-functional catalyst for adsorption and Fenton-like photodegradation of azo dyes in textile effluents","authors":"Felycia Edi Soetaredjo,&nbsp;Suryadi Ismadji,&nbsp;Shella Permatasari Santoso,&nbsp;Jessica Chrisanta Soegianto,&nbsp;Jindrayani Nyoo Putro,&nbsp;Darwin Kurniawan,&nbsp;Michael Suryananda Ismadji,&nbsp;Alfin Kurniawan,&nbsp;Jenyfer Sugianto","doi":"10.1007/s11696-026-05084-x","DOIUrl":"10.1007/s11696-026-05084-x","url":null,"abstract":"<div><p>A bifunctional Fe-modified titanium metal–organic framework, MIL-125(Ti)@Fe, was rationally designed to integrate adsorption preconcentration and photo-Fenton degradation for efficient removal of anionic azo dyes from textile wastewater. Structural characterization confirmed that low-level Fe incorporation preserves the MIL-125(Ti) framework while narrowing the band gap from 3.20 to 2.28 eV, thereby extending light absorption into the visible region. Compared with pristine MIL-125(Ti), MIL-125(Ti)@Fe exhibited substantially enhanced adsorption capacities toward CI Direct Blue 1 and CI Direct Yellow 4, as well as near-complete degradation of the residual dye after adsorption equilibrium under UV/visible irradiation in the presence of H₂O₂. Kinetic analysis revealed pseudo-first-order degradation behavior with thermally assisted reaction rates. The synergistic enhancement arises from adsorption preconcentration coupled with Fe-assisted H₂O₂ activation, as supported by radical trapping experiments showing an •OH-dominated degradation pathway. Potential interfacial electron-transfer effects are discussed as a plausible contribution rather than as directly confirmed charge-separation evidence. The catalyst retained over 90% of its activity after five consecutive cycles, demonstrating excellent structural robustness. This work establishes a design principle for Fe-assisted Ti-MOF platforms that couple adsorption and photo-Fenton catalysis, offering a sustainable and reusable strategy for advanced wastewater treatment. Unlike conventional Fe oxide-loaded MOFs or photocatalysis-focused Ti-MOF systems, the present low-level Fe-modified MIL-125(Ti) couples high adsorption capacity, •OH-dominated photo-Fenton degradation, low Fe leaching, and stable recyclability within a single framework-preserved material.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"80 10","pages":"11685 - 11700"},"PeriodicalIF":2.5,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, and anticancer evaluation of thiazole-chalcone hybrids against colon cancer cells","authors":"Aysegul Nazli Özcan,&nbsp;Esra Bulut Atalay,&nbsp;İbrahim Topçu,&nbsp;Meliha Burcu Gürdere,&nbsp;Mustafa Ceylan","doi":"10.1007/s11696-026-05100-0","DOIUrl":"10.1007/s11696-026-05100-0","url":null,"abstract":"<div><p>Cancer is one of the leading global health problems that lead to death, and the need for novel antitumor agents has encouraged us to synthesize a novel series of thiazole-chalcone hybrids (containing lactone, enamine, thiazole and chalcone units at same structure). The compounds were synthesized via three steps starting from 2-acetyl-γ-butyrolactone and characterized by its structures on the basis of spectroscopic methods. Then, the anticancer potentials of compounds 3, 5 and 7a–i was evaluated against the human colon cancer cell line SW620 using cell viability (MTT); proliferation and morphological analyses at 24 and 48 h were performed. Most of the compounds (7a, 7b, 7c, 7g, 7h, and 7i) exhibited significant cytotoxic activity at 24 h, with IC₅₀ values ranging from 13.0 ± 1.00 to 30.8 ± 1.80 µM. After 48 h, a significant time-dependent increase in the activity of the compounds was observed, while IC₅₀ values decreased significantly (IC₅₀ values for 7i (3.3 ± 0.11 µM), 7b (3.9 ± 0.12 µM), 7g (4.2 ± 0.32 µM) and 7h (6.2 ± 0.09 µM)). Their cytotoxic potential was evaluated in a noncancerous cell line (CCD-18Co) and a human colon cancer cell line (SW620) using cell viability (MTT) at 24 and 48 h. Anticancer potential was evaluated in SW620 using proliferation and morphological analyses. Several compounds, particularly 7a, 7b, 7c, 7g, 7h, and 7i, exhibited significant cytotoxic activity at 24 h in SW620, with IC₅₀ values ranging from 10.17 (5.82–19.96) to 37.51 (17.06–106.5) µM (<i>p</i> &lt; 0.05). Notably, a pronounced time-dependent enhancement of activity was observed at 48 h in SW620, with substantially reduced IC₅₀ values for the most active derivatives, including 7i (4.97 (3.44–7.56) µM), 7b (5.86 (2.74–15.27) µM), 7g (5.25 (2.38–12.54) µM), and 7h (8.21 (4.09–18.48) µM) (<i>p</i> &lt; 0.05). Treatment with these compounds induced marked morphological alterations, such as cell rounding, vacuolization, and disruption of normal cellular architecture, while proliferation assays demonstrated complete inhibition of cell growth by day four for selected derivatives. Importantly, halogen-substituted thiazole–chalcone hybrids (Cl, Br, and F), particularly 7c, 7g, and 7i, showed enhanced and time-dependent anticancer efficacy, underscoring the critical role of halogen substitution in modulating biological activity. These findings suggest that thiazole–chalcone hybrids represent promising anticancer pharmacophores and warrant further mechanistic and in vivo investigations. These findings suggest that thiazole-chalcone hybrids represent promising anticancer pharmacophores and warrant further mechanistic and in vivo investigations.</p></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":"80 10","pages":"11891 - 11901"},"PeriodicalIF":2.5,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}