Japanese Dental Science Review最新文献_第4页

Multi-omics analysis in developmental bone biology 发育骨生物学的多组学分析

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2023-11-10 DOI: 10.1016/j.jdsr.2023.10.006

Yuki Matsushita , Azumi Noguchi , Wanida Ono , Noriaki Ono

{"title":"Multi-omics analysis in developmental bone biology","authors":"Yuki Matsushita , Azumi Noguchi , Wanida Ono , Noriaki Ono","doi":"10.1016/j.jdsr.2023.10.006","DOIUrl":"https://doi.org/10.1016/j.jdsr.2023.10.006","url":null,"abstract":"<div><p>Single-cell omics and multi-omics have revolutionized our understanding of molecular and cellular biological processes at a single-cell level. In bone biology, the combination of single-cell RNA-sequencing analyses and in vivo lineage-tracing approaches has successfully identified multi-cellular diversity and dynamics of skeletal cells. This established a new concept that bone growth and regeneration are regulated by concerted actions of multiple types of skeletal stem cells, which reside in spatiotemporally distinct niches. One important subtype is endosteal stem cells that are particularly abundant in young bone marrow. The discovery of this new skeletal stem cell type has been facilitated by single-cell multi-omics, which simultaneously measures gene expression and chromatin accessibility. Using single-cell omics, it is now possible to computationally predict the immediate future state of individual cells and their differentiation potential. In vivo validation using histological approaches is the key to interpret the computational prediction. The emerging spatial omics, such as spatial transcriptomics and epigenomics, have major advantage in retaining the location of individual cells within highly complex tissue architecture. Spatial omics can be integrated with other omics to further obtain in-depth insights. Single-cell multi-omics are now becoming an essential tool to unravel intricate multicellular dynamics and intercellular interactions of skeletal cells.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 412-420"},"PeriodicalIF":6.6,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761623000364/pdfft?md5=06ad12e4cb7a467a90807876697dc169&pid=1-s2.0-S1882761623000364-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92026380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between periodontal disease and chronic obstructive pulmonary disease 牙周病与慢性阻塞性肺病的关系

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2023-11-07 DOI: 10.1016/j.jdsr.2023.10.004

Peiya Lin , Anhao Liu , Yosuke Tsuchiya , Kanako Noritake , Yujin Ohsugi , Keita Toyoshima , Yuta Tsukahara , Takahiko Shiba , Hiroshi Nitta , Akira Aoki , Takanori Iwata , Sayaka Katagiri

{"title":"Association between periodontal disease and chronic obstructive pulmonary disease","authors":"Peiya Lin , Anhao Liu , Yosuke Tsuchiya , Kanako Noritake , Yujin Ohsugi , Keita Toyoshima , Yuta Tsukahara , Takahiko Shiba , Hiroshi Nitta , Akira Aoki , Takanori Iwata , Sayaka Katagiri","doi":"10.1016/j.jdsr.2023.10.004","DOIUrl":"https://doi.org/10.1016/j.jdsr.2023.10.004","url":null,"abstract":"<div><p>Chronic obstructive pulmonary disease (COPD) and periodontal disease are chronic inflammatory conditions that significantly affect an individual’s overall health and well-being. Generally, the prevalence of periodontitis is higher in patients with COPD than those without COPD, which may partly be attributed to common risk factors in COPD, such as smoking, respiratory infections, and inflammation. In particular, periodontitis may exacerbate the progression of COPD and further deteriorate the respiratory system by promoting inflammatory responses and bacterial infections. Immunocytes, including neutrophils, and microorganisms such as <em>Fusobacterium nucleatum</em> originating from oral biofilms are believed to be crucial factors influencing to COPD. Furthermore, the potential benefits of treating periodontal disease in COPD outcomes have been investigated. Although the relationship between COPD and periodontal disease has been preliminarily studied, there is currently a lack of large-scale clinical studies to validate this association. In addition to clinical examinations, investigating biomarkers and microbiology may contribute to explore the underlying mechanisms involved in the management of these conditions. This review aims to contribute to a better understanding of the clinical and basic research aspects of COPD and periodontitis, allowing for potential therapeutic approaches and interdisciplinary management strategies.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 389-402"},"PeriodicalIF":6.6,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761623000339/pdfft?md5=d5f67f3b6eedec2c0e6dbd399c905647&pid=1-s2.0-S1882761623000339-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92026378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationships between mastication and cognitive function: A systematic review and meta-analysis 咀嚼与认知功能的关系:系统回顾与元分析

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2023-10-28 DOI: 10.1016/j.jdsr.2023.10.001

Ma. Therese Sta. Maria , Yoko Hasegawa , Aye Mya Mya Khaing , Simonne Salazar , Takahiro Ono

{"title":"The relationships between mastication and cognitive function: A systematic review and meta-analysis","authors":"Ma. Therese Sta. Maria , Yoko Hasegawa , Aye Mya Mya Khaing , Simonne Salazar , Takahiro Ono","doi":"10.1016/j.jdsr.2023.10.001","DOIUrl":"https://doi.org/10.1016/j.jdsr.2023.10.001","url":null,"abstract":"<div><p>Masticatory function such as chewing is expected to modify human cognitive function, and/or the possibility of improving cognitive function is also predicted. This systematic review investigated whether masticatory function affects cognitive function for older/young adults. Full articles written in English from January 2000 to April 2022 were collected using PubMed and Cochrane Library. Target outcomes were cognitive function test scores, cognitive processing speed (reaction time), and masticatory function. For each research question, two independent reviewers conducted the search and screening, data extraction, quality assessment, and risk of bias assessment. The reviewers resolved any disagreements by discussion. From 226 articles retrieved, 20 were included in this review. Older adults with lower scores on the cognitive function test had lower masticatory performance, lower chewing ability, chewing difficulty, and decreased number of teeth. An increased risk of cognitive impairment was found in older adults with masticatory dysfunction. For young adults, gum chewing significantly reduced the processing speed of cognitive tasks compared to no gum chewing. Although most of the evidence included had a low level of evidence and a high risk of bias because of the research designs, the results still suggest that mastication may be a factor in improving cognitive function.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 375-388"},"PeriodicalIF":6.6,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761623000315/pdfft?md5=46b23829c25aa2407a2ea0911329bced&pid=1-s2.0-S1882761623000315-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92131736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents 使用组织工程口腔黏膜等效物重建和再生口内/口外伤口的最新趋势和前景。

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2023-10-25 DOI: 10.1016/j.jdsr.2023.10.002

Kenji Izumi , Witsanu Yortchan , Yuka Aizawa , Ryota Kobayashi , Emi Hoshikawa , Yiwei Ling , Ayako Suzuki

{"title":"Recent trends and perspectives in reconstruction and regeneration of intra/extra-oral wounds using tissue-engineered oral mucosa equivalents","authors":"Kenji Izumi , Witsanu Yortchan , Yuka Aizawa , Ryota Kobayashi , Emi Hoshikawa , Yiwei Ling , Ayako Suzuki","doi":"10.1016/j.jdsr.2023.10.002","DOIUrl":"10.1016/j.jdsr.2023.10.002","url":null,"abstract":"<div><p>Many conditions, including cancer, trauma, and congenital anomalies, can damage the oral mucosa. Multiple cultures of oral mucosal cells have been used for biocompatibility tests and oral biology studies. In recent decades, the clinical translation of tissue-engineered products has progressed significantly in developing tangible therapies and inspiring advancements in medical science. However, the reconstruction of an intraoral mucosa defect remains a significant challenge. Despite the drawbacks of donor-site morbidity and limited tissue supply, the use of autologous oral mucosa remains the gold standard for oral mucosa reconstruction and repair. Tissue engineering offers a promising solution for repairing and reconstructing oral mucosa tissues. Cell- and scaffold-based tissue engineering approaches have been employed to treat various soft tissue defects, suggesting the potential clinical use of tissue-engineered oral mucosa (TEOMs). In this review, we first cover the recent trends in the reconstruction and regeneration of extra-/intra-oral wounds using TEOMs. Next, we describe the current status and challenges of TEOMs. Finally, future strategic approaches and potential technologies to support the advancement of TEOMs for clinical use are discussed.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 365-374"},"PeriodicalIF":6.6,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of disease-associate variants of aggressive periodontitis using genome-wide association studies 利用全基因组关联研究鉴定侵袭性牙周炎的疾病相关变异。

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2023-10-13 DOI: 10.1016/j.jdsr.2023.09.001

Chiharu Fujihara , Osa Amila Hafiyyah , Shinya Murakami

{"title":"Identification of disease-associate variants of aggressive periodontitis using genome-wide association studies","authors":"Chiharu Fujihara , Osa Amila Hafiyyah , Shinya Murakami","doi":"10.1016/j.jdsr.2023.09.001","DOIUrl":"10.1016/j.jdsr.2023.09.001","url":null,"abstract":"<div><p>Aggressive periodontitis (AgP), Stage III or IV and Grade C according to the new periodontitis classification, is characterized by the rapid destruction of periodontal tissues in the systemically healthy population and often causes premature tooth loss. The presence of familial aggregation suggests the involvement of genetic factors in the pathogenesis. However, the genes associated with the onset and progression of the disease and details of its pathogenesis have not yet been fully identified. In recent years, the genome-wide approach (GWAS), a comprehensive genome analysis method using bioinformatics, has been used to search for disease-related genes, and the results have been applied in genomic medicine for various diseases, such as cancer. In this review, we discuss GWAS in the context of AgP. First, we introduce the relationship between single-nucleotide polymorphisms (SNPs) and susceptibility to diseases and how GWAS is useful for searching disease-related SNPs. Furthermore, we summarize the recent findings of disease-related genes using GWAS on AgP inside and outside Japan and a possible mechanism of the pathogenesis of AgP based on available literature and our research findings. These findings will lead to advancements in the prevention, prognosis, and treatment of AgP.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 357-364"},"PeriodicalIF":6.6,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/15/main.PMC10582758.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49684827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of different mouthwashes against COVID-19: A systematic review and network meta-analysis 不同漱口水对新冠肺炎的疗效：系统综述和网络荟萃分析。

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2023-10-11 DOI: 10.1016/j.jdsr.2023.09.003

Luca Sbricoli , Lucia Schiavon , Giulia Brunello , Paola Brun , Kathrin Becker , Stefano Sivolella

{"title":"Efficacy of different mouthwashes against COVID-19: A systematic review and network meta-analysis","authors":"Luca Sbricoli , Lucia Schiavon , Giulia Brunello , Paola Brun , Kathrin Becker , Stefano Sivolella","doi":"10.1016/j.jdsr.2023.09.003","DOIUrl":"10.1016/j.jdsr.2023.09.003","url":null,"abstract":"<div><p>To evaluate the effectiveness of antiseptic mouthwashes in reducing SARS-CoV-2 load clinically and in vitro. A systematic electronic search (MEDLINE/Scopus/Cochrane) was conducted to identify prospective clinical and in vitro studies published between 2019 included and 16 June 2023 assessing the effectiveness of mouthwashes in reducing SARS-CoV-2 load in saliva or surrogates. Data were summarized in tables and a network meta-analysis was performed for clinical trials. Thirty-five studies (14 RCTs, 21 in vitro) fulfilled the inclusion criteria. The risk of bias was judged to be high for 2 clinical and 7 in vitro studies. The most commonly test product was chlorhexidine alone or in combination with other active ingredients, followed by povidone-iodine, hydrogen peroxide and cetylpyridinium chloride. Overall, the descriptive analysis revealed the effectiveness of the mouthwashes in decreasing the salivary viral load both clinically and in vitro. Network meta-analysis demonstrated a high degree of heterogeneity. Among these studies, only chlorhexidine 0.20% was associated to a significant Ct increase in the saliva 5 min after rinsing compared to non-active control (p = 0.027). Data from clinical and in vitro studies suggested the antiviral efficacy of commonly used mouthwashes. Large well-balanced trials are needed to identify the best rinsing protocols.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 334-356"},"PeriodicalIF":6.6,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/18/4e/main.PMC10579871.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49684826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Deep learning and artificial intelligence in dental diagnostic imaging 牙科诊断成像中的深度学习和人工智能。

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2023-09-30 DOI: 10.1016/j.jdsr.2023.09.004

Akitoshi Katsumata

引用次数: 1

Does speed-sintering affect the optical and mechanical properties of yttria-stabilized zirconia? A systematic review and meta-analysis of in-vitro studies 快速烧结会影响氧化钇稳定氧化锆的光学和机械性能吗?体外研究的系统回顾和荟萃分析

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2023-09-06 DOI: 10.1016/j.jdsr.2023.08.007

Hengyi Liu , Masanao Inokoshi , Kaiqi Xu , Watcharapong Tonprasong , Shunsuke Minakuchi , Bart Van Meerbeek , Jef Vleugels , Fei Zhang

{"title":"Does speed-sintering affect the optical and mechanical properties of yttria-stabilized zirconia? A systematic review and meta-analysis of in-vitro studies","authors":"Hengyi Liu , Masanao Inokoshi , Kaiqi Xu , Watcharapong Tonprasong , Shunsuke Minakuchi , Bart Van Meerbeek , Jef Vleugels , Fei Zhang","doi":"10.1016/j.jdsr.2023.08.007","DOIUrl":"https://doi.org/10.1016/j.jdsr.2023.08.007","url":null,"abstract":"<div><p>Zirconia restorations are increasingly popular in dental treatment. Yttria-stabilized zirconia (YSZ) needs to be sintered for clinical applications and novel speed-sintering protocols are being developed for chairside treatments. Whether the properties of speed-sintered YSZ meet clinical requirements, however, remains unclear. Therefore, we conducted a systematic review and meta-analysis on the influence of speed-sintering on the optical and mechanical properties of dental YSZ according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. A literature search was conducted using PubMed, Embase, and Web of Science databases for relevant articles published between January 1, 2010 and February 28, 2022 in English, Chinese, or Japanese. After full-text evaluation and quality assessment, 26 articles were selected. Meta-analysis revealed that speed-sintering does not significantly affect the CIEDE2000-based translucency parameter, contrast ratio, three-point flexural strength, biaxial flexural strength, or fracture toughness of YSZ (<em>p</em> < 0.01) compared to conventional sintering. However, the CIELab-based translucency parameter of conventionally sintered YSZ is higher than that of speed-sintered YSZ. The descriptive analysis indicated that speed-sintering does not affect the hardness of YSZ compared to that of conventionally sintered YSZ. The results indicate that speed-sintering is suitable for preparing YSZ for dental restorations.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 312-328"},"PeriodicalIF":6.6,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49739930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osseointegration, antimicrobial capacity and cytotoxicity of implant materials coated with graphene compounds: A systematic review 石墨烯涂层种植材料的骨整合、抗菌能力和细胞毒性:系统综述

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2023-08-29 DOI: 10.1016/j.jdsr.2023.08.005

Saulo Ribeiro Silveira, Beatriz Danieletto Sahm, Simone Kreve, Andréa Cândido dos Reis

{"title":"Osseointegration, antimicrobial capacity and cytotoxicity of implant materials coated with graphene compounds: A systematic review","authors":"Saulo Ribeiro Silveira, Beatriz Danieletto Sahm, Simone Kreve, Andréa Cândido dos Reis","doi":"10.1016/j.jdsr.2023.08.005","DOIUrl":"10.1016/j.jdsr.2023.08.005","url":null,"abstract":"<div><p>The use of graphecs excellent mechanical properties. However, it is necessary to evaluate the biological effects of this material. This systematic review aimed to observe and understand through studies the current state of the art regarding osseointegration, antimicrobial capacity, and the cytotoxicity of graphene coating applied to the surface of dental implant materials.</p><p>Searches in PubMed, Embase, Science Direct, Web of Science, and Google Scholar databases were conducted between June and July 2021 and updated in May 2022 using the keywords: graphene, graphene oxide, dental implants, zirconium, titanium, peek, aluminum, disilicate, methyl-methacrylate, cytotoxicity, osseointegration, and bone regeneration. The criteria included in vivo and in vitro studies that evaluated antimicrobial capacity and/or osseointegration and/or cytotoxicity of dental implant materials coated with graphene compounds. The risk of bias for in vitro studies was assessed by the JBI tool, and for in vivo studies, Syrcle's risk of bias tool for animal studies was used.</p><p>The database search resulted in 176 articles. Of the 18 articles selected for full reading, 16 remained in this systematic review.</p><p>The use of graphene compounds as coatings on the surface of implant materials is promising because it promotes osseointegration and has antimicrobial capacity. However, further studies are needed to ensure its cytotoxic potential.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 303-311"},"PeriodicalIF":6.6,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/db/main.PMC10480569.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10245670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The role of inflammatory markers in Temporomandibular Myalgia: A systematic review 炎症标志物在颞下颌肌痛中的作用:一项系统综述

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2023-08-29 DOI: 10.1016/j.jdsr.2023.08.006

Elisabet Farré-Guasch , Jordi Tomàs Aliberas , Natalia Felipe Spada , Ralph de Vries , Engelbert A.J.M. Schulten , Frank Lobbezoo

{"title":"The role of inflammatory markers in Temporomandibular Myalgia: A systematic review","authors":"Elisabet Farré-Guasch , Jordi Tomàs Aliberas , Natalia Felipe Spada , Ralph de Vries , Engelbert A.J.M. Schulten , Frank Lobbezoo","doi":"10.1016/j.jdsr.2023.08.006","DOIUrl":"10.1016/j.jdsr.2023.08.006","url":null,"abstract":"<div><p>Approximately 10 % of the general population is affected by temporomandibular disorder (TMD) pain. Diagnosis of myogenous TMD pain (i.e., TM myalgia) may be challenging, while an adequate assessment of this pain is crucial to establish an adequate management strategy. We aim to analyze if there is a relation between inflammation and TM myalgia, and if we can identify and measure inflammatory markers in patients suffering from this condition. An electronic literature search was conducted from inception up to July 14 2022 through the databases PubMed, Cochrane Library, Web of Science, and Embase in collaboration with a medical information specialist. Studies on patients with masticatory muscle inflammation and/or pain were included. After a screening procedure, only nine full-text articles met the criteria for inclusion. In the included studies 9–131 patients showed TM myalgia, and presence of inflammation was reported with analysis of interleukines IL-1, IL-6, IL-10, tumor necrosis factor alpha, and prostaglandins from blood, saliva, and extracellular fluid of masseter muscle using microdialysis. Our results contributed to the identification of the relation between inflammation and TM myalgia and established that measurement of inflammatory cytokines may be a valid diagnostic tool, which is an essential step towards finding a better treatment.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 281-288"},"PeriodicalIF":6.6,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/b9/main.PMC10480571.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10245669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0