Antonia Olivares , Valentina Barraza , Sebastian Aguayo
{"title":"Micro- and nano-scale adhesion of oral bacteria to biomaterials using atomic force microscopy: A systematic review","authors":"Antonia Olivares , Valentina Barraza , Sebastian Aguayo","doi":"10.1016/j.jdsr.2025.03.002","DOIUrl":"10.1016/j.jdsr.2025.03.002","url":null,"abstract":"<div><div>To evaluate the available evidence regarding in-vitro studies carried out with atomic force microscopy (AFM) to study the adhesion of oral bacteria under the research question: <em>“Which adhesion parameters have been reported for oral bacteria attachment to surfaces following AFM experiments?”</em></div><div>This review was carried out following PRISMA guidelines. The Pubmed, Web of Science and Scopus databases were accessed and original articles reporting in-vitro findings on AFM-based oral bacteria adhesion experiments were included. Study selection and data extraction was performed by two independent researchers. Of the initial 249 screened articles, 24 were included in the final analysis.</div><div>Overall, the adhesion of oral bacteria to 12 different biomaterial surface types has been explored with AFM including soft materials, dental materials, and other materials. <em>S. mutans</em> was the most frequently studied bacterial species in its early attachment to biomaterials. Regarding AFM-based adhesion parameters, the maximum adhesion force, adhesion energy, rupture and contour lengths, and number of rupture events between oral bacteria and substrates have been quantified and reported.</div><div>Initial oral bacterial attachment to biomaterials is modulated by a range of cell, environmental, and surface-derived properties. Further research is needed to transfer this knowledge into the clinical setting.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 41-54"},"PeriodicalIF":5.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioactivity and potential applications of surface pre-reacted glass-ionomer (S-PRG) filler-containing dental materials for geriatric oral health: A scoping review","authors":"Thein Soe , Akiho Sunami , Okkar Kyaw , Keita Hatano , Manabu Kanazawa , Masanao Inokoshi","doi":"10.1016/j.jdsr.2025.11.002","DOIUrl":"10.1016/j.jdsr.2025.11.002","url":null,"abstract":"<div><div>This scoping review explores the potential applications of surface pre-reacted glass-ionomer (S-PRG) filler-containing dental materials in geriatric dentistry. A literature search across four databases (CINAHL, MEDLINE, PubMed, and Web of Science) identified 324 articles, of which 51, including 39 <em>in vitro</em>, 1 <em>in situ</em>, 1 preclinical, and 10 clinical studies, met the inclusion criteria. These reports demonstrate that, across the domains of preventive, restorative, endodontic, and prosthodontic dentistry, S-PRG filler-containing materials consistently exhibit bioactive properties, such as fluoride-release and recharge, multi-ion release, acid-buffering, anti-demineralization, remineralization, and antimicrobial activity. In preventive dentistry, S-PRG filler-based dentin coating agents, varnishes, and toothpastes show promising effects for caries prevention and periodontal pathogen control. In restorative dentistry, S-PRG filler-based composites and adhesives demonstrate bioactivity and favorable long-term clinical results. In prosthodontics, S-PRG filler-based denture base resins, tissue conditioners, and denture adhesives offer protective and antimicrobial effects. These multifunctional properties support the roles of S-PRG filler-containing dental materials as both preventive and therapeutic agents for managing common oral health issues in older adults, including root caries, periodontal disease, and denture stomatitis. Further clinical and longitudinal studies are needed to confirm their effectiveness and guide their use in geriatric care.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 280-291"},"PeriodicalIF":6.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reinaldo Adelino de Sales-Junior , Mariana Silva de Bessa , Francisca Jennifer Duarte de Oliveira , Bárbara Faria de Sá Barbosa , Kaiza de Sousa Santos , Michael Owen , Victor Pinheiro Feitosa , Boniek Castillo Dutra Borges
{"title":"Multifaceted characterization of antibacterial resin composites: A scoping review on efficacy, properties, and in vivo performance","authors":"Reinaldo Adelino de Sales-Junior , Mariana Silva de Bessa , Francisca Jennifer Duarte de Oliveira , Bárbara Faria de Sá Barbosa , Kaiza de Sousa Santos , Michael Owen , Victor Pinheiro Feitosa , Boniek Castillo Dutra Borges","doi":"10.1016/j.jdsr.2025.05.003","DOIUrl":"10.1016/j.jdsr.2025.05.003","url":null,"abstract":"<div><div>This scoping review aimed to collect, analyze, synthesize, and interpret the current data concerning antibacterial resin-based composites. The study followed the recommendations of the Joanna Briggs Institute and PRISMA Extension for Scoping Reviews. The searches were conducted in the PubMed, Embase, Web of Science, and Scopus databases. Studies evaluating efficacy, physical and chemical properties, cytotoxicity, and preventive effect against recurrent caries lesions provided by antibacterial resin-based composites published in the last 5 years and without language restriction were included. Fifty-three papers were analyzed. Only <em>in vitro, in situ</em>, and animal studies were published. The DMAHDM (dimethylaminohexadecyl methacrylate) was the most prevalent antibacterial agent in the resin composites and showed efficacy, did not increase cytotoxicity, nor jeopardize chemical and physical properties. The most used biofilm model and the test to evaluate the antibacterial effect was Streptococcus Mutans and the Colony Forming Unit Count. Antibacterial resin-based composites have performed exceedingly well in the large number of <em>in vitro</em> studies evaluated. However, clinical trials assessing the prevention of recurrent caries are absent and need to be further conducted to assure that using an antibacterial resin composite is a valid way to avoid restoration replacement due to recurrent caries.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 112-137"},"PeriodicalIF":5.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor Melo-Soares, Andréa Cândido dos Reis, Mariana Lima da Costa Valente
{"title":"Optimizing titanium dioxide-functionalized polymethyl methacrylate (PMMA-TiO₂) for dental applications: A systematic review on physicochemical parameters and antimicrobial outcomes","authors":"Victor Melo-Soares, Andréa Cândido dos Reis, Mariana Lima da Costa Valente","doi":"10.1016/j.jdsr.2025.09.002","DOIUrl":"10.1016/j.jdsr.2025.09.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Polymethyl methacrylate (PMMA) resins are widely used in dental prostheses due to their excellent physical, mechanical, and aesthetic properties. However, their susceptibility to microbial colonization can compromise oral and systemic health. Titanium dioxide (TiO₂), with its photocatalytic activity, has gained attention for its antimicrobial potential. This systematic review investigates how the physicochemical properties of TiO₂ affect its antimicrobial efficacy in PMMA-TiO₂ composites, aiming to optimize their performance and clinical effectiveness.</div></div><div><h3>Methods</h3><div>PubMed, Embase, Scopus, ScienceDirect, Web of Science, Google Scholar, and ProQuest were searched in October 2024. Articles were selected in two stages by two blinded researchers based on predefined eligibility criteria. Risk of bias was assessed using the RobDEMAT tool.</div></div><div><h3>Results</h3><div>A comprehensive search identified 1464 articles, which were screened by title and abstract according to inclusion criteria. Of the 28 studies selected for full-text review, 24 were included in this systematic review, all of which were in vitro studies. Due to the high heterogeneity of the selected studies, which prevented statistical analysis of the data, a descriptive analysis was performed.</div></div><div><h3>Conclusions</h3><div>The balance between concentration, size, crystallinity, and surface morphology can enhance TiO₂ photocatalytic activity and reduce microbial adhesion. Synthesis and functionalization strategies can overcome limitations, expanding the clinical applicability, efficiency, and durability of PMMA-TiO₂ composites.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 236-249"},"PeriodicalIF":6.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniele Manfredini, Steven S. Bender, Birgitta Häggman-Henrikson, Justin Durham, Charles S. Greene
{"title":"Temporomandibular disorders: A new list of key points to summarize the standard of care","authors":"Daniele Manfredini, Steven S. Bender, Birgitta Häggman-Henrikson, Justin Durham, Charles S. Greene","doi":"10.1016/j.jdsr.2024.12.001","DOIUrl":"10.1016/j.jdsr.2024.12.001","url":null,"abstract":"<div><div>This letter is being sent to editors of major dental journals around the world. Attached to it is an Announcement that summarizes a recently published position paper which deals with the topic of standards of care for Temporomandibular Disorders (TMDs). That paper, entitled “Temporomandibular disorders: INfORM/IADR key points for good clinical practice based on standard of care”, was developed by a group of expert researchers and clinicians over a one-year period. The full paper describing the outcome of this project was published in CRANIO – The Journal of Craniomandibular and Sleep Practice (1), and is available as an open access paper at the following link. <span><span>https://www.tandfonline.com/doi/full/10.1080/08869634.2024.2405298?src=exp-la</span><svg><path></path></svg></span></div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 1-2"},"PeriodicalIF":5.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A systematic review of metastatic lesions to the oral and maxillofacial regions among Japanese people","authors":"Seiji Asoda , Takazumi Yasui , Kenta Tanaka , Katsuhiro Onizawa , Hiromasa Kawana , Taneaki Nakagawa","doi":"10.1016/j.jdsr.2025.06.001","DOIUrl":"10.1016/j.jdsr.2025.06.001","url":null,"abstract":"<div><div>This review aimed to integrate the available data published in the literature on metastatic lesions in the oral and maxillofacial region (MOMR) and to produce an updated comprehensive analysis of its clinical characteristics, treatment, and prognosis. An electronic database search was conducted for articles concerning MOMR in Japan. The incidence and characteristics of MOMR were investigated, and the survival time was analyzed. This systematic review identified 211 studies, including 356 cases. There was a male predominance (n = 250/70.2 %) and the mean age at the diagnosis was 62.1 (range, 4–91) years old. The most common primary site was the lungs (n = 104/29.2 %). Oral metastasis sites were equally frequent in the jawbone (n = 182/51.1 %) and soft tissue (n = 174/48.9 %). Among these, the mandible and gingiva were the most common. The most common clinical presentation was a nodule (n = 317/90.3 %). The presence of metastases to other organs (P = 0.009) and uncontrolled primary lesions (P < 0.001) was associated with a shortened survival. This systematic review provides important insights into the clinical features, diagnosis, and treatment of MOMR in Japan and will assist clinicians in their appropriate management.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 155-166"},"PeriodicalIF":5.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kunhua Yang , Alexander Patera Nugraha , Junduo Chen , Hui Yang , Jingyu Wang , Juan Ramón Vanegas Sáenz , Guang Hong
{"title":"Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidence","authors":"Kunhua Yang , Alexander Patera Nugraha , Junduo Chen , Hui Yang , Jingyu Wang , Juan Ramón Vanegas Sáenz , Guang Hong","doi":"10.1016/j.jdsr.2025.05.002","DOIUrl":"10.1016/j.jdsr.2025.05.002","url":null,"abstract":"<div><div>This systematic review aimed to determine how cellulose nanofiber (CNF) enhance the mechanical properties, biocompatibility, and functional versatility of dental materials, based on in vitro evidence. A systematic review protocol was developed according to PRISMA 2020. The literature search was conducted using MEDLINE/PubMed, Scopus, Web of Science, Scopus, and Embase for English-language publications with no date restrictions, yielding 180 publications. After removing duplicates, 150 remained, from which 23 were evaluated in full. 17 in vitro studies met the inclusion criteria, of which 13 had a low risk of bias, 4 had a moderate risk, and none had a high risk. Across all included investigations, CNF consistently improved mechanical performance, particularly flexural and compressive strength, while maintaining or enhancing biocompatibility in various cell culture models. CNF’s nanofibrillar structure and modifiable surface chemistry also expanded its functional versatility, enabling applications such as drug encapsulation and targeted antimicrobial delivery. Overall, CNF emerges as a promising biomaterial for modern dentistry, offering superior mechanical reinforcement, favorable cell responses, and wide-ranging functional modifications. Further in vivo research and clinical trials are necessary to confirm its long-term safety and efficacy, thereby facilitating the translation of these in vitro findings into standard dental practice.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 103-111"},"PeriodicalIF":5.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shih-Ying Lin , Hung-Ying Lin , Jui-Sheng Sun , Jenny Zwei-Chieng Chang
{"title":"Efficacy of adjunctive periodontal interventions in non-surgical periodontal therapy for Stage III/IV Grade C periodontitis: A systematic review and network meta-analysis","authors":"Shih-Ying Lin , Hung-Ying Lin , Jui-Sheng Sun , Jenny Zwei-Chieng Chang","doi":"10.1016/j.jdsr.2025.07.001","DOIUrl":"10.1016/j.jdsr.2025.07.001","url":null,"abstract":"<div><div>This study evaluates the effectiveness of adjunctive therapies combined with non-surgical periodontal treatment for Stage III/IV Grade C periodontitis, focusing on pocket depth (PD) reduction, clinical attachment level (CAL) gain, and adverse events. A systematic review and network meta-analysis were conducted, including randomized controlled trials up to September 2024. Inconsistencies and publication bias were detected, prompting sensitivity analyses and effectiveness rankings of adjunctive therapies. Data from 50 studies were included, with 45 entered into network meta-analysis, covering 24 interventions and 1431 patients. Compared to scaling and root planing (SRP) alone, adjunctive systemic lincosamides with nitroimidazole (Mac/Linc+Nitro-S) demonstrated the greatest PD reduction, followed by local statins (Statins-L) in the short term (≤3 months). Statins-L also provided the highest CAL gain. In the medium term (4–6 months), Statins-L remained the most effective, followed by bisphosphonates. For long-term (>6 months) follow-up, where fewer treatment approaches were available, Nitro-S achieved the most significant PD reduction and CAL gain, followed by Mac/Linc-S. Adverse effects were mild and self-limiting. Despite promising findings, inconsistencies in CAL outcomes and potential publication bias highlight the need for further research to confirm long-term safety and efficacy.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 167-187"},"PeriodicalIF":5.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nanoidentification in endodontics: Bibliometric analysis and comprehensive review on the basis of characterisation research by Nano-computed tomography imaging","authors":"Olcay Özdemir , Sena Kaşıkçı , Turkan Kopac","doi":"10.1016/j.jdsr.2025.03.003","DOIUrl":"10.1016/j.jdsr.2025.03.003","url":null,"abstract":"<div><div>Nanoimaging, crucial in endodontics, has advanced, leading to more effective and less invasive treatments. Nano-computed tomography (nano-CT) is an advanced imaging technique to evaluate bone structures or gaps in filling materials, providing submicrometer spatial resolution due to smaller focal points and voxels, higher signal-to-noise ratios, and higher tube voltages and powers compared to conventional devices, improving dental imaging precision and safety by producing detailed images with minimal radiation exposure. This study conducted a bibliometric analysis on nano-CT imaging as a nano identification tool in endodontics. Using various tools and methods, it evaluated progress and trends in nano-CT, aiming to enhance understanding of bibliometric data and complement existing endodontic knowledge. Nano-CT imaging has gained prominence in endodontics research, offering potential applications and insights into various aspects of the field. A review of relevant studies highlighted the technique's ability to visualize dentin tubules, root canal anatomy, filling quality, root resorption, cracks, microcracks, soft dental tissues, cellular layers, volumetric changes post-instrumentation, hard tissue debris, root surface deposits, and bioceramic pore structures. Nano-CT has the potential to become the gold standard for imaging in endodontics, presenting opportunities and challenges for future research. These findings provide researchers and practitioners with the latest advancements in nanoimaging.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 55-78"},"PeriodicalIF":5.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}