A systematic review of metastatic lesions to the oral and maxillofacial regions among Japanese people

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review Pub Date : 2025-06-25 DOI:10.1016/j.jdsr.2025.06.001

Seiji Asoda , Takazumi Yasui , Kenta Tanaka , Katsuhiro Onizawa , Hiromasa Kawana , Taneaki Nakagawa

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Abstract

This review aimed to integrate the available data published in the literature on metastatic lesions in the oral and maxillofacial region (MOMR) and to produce an updated comprehensive analysis of its clinical characteristics, treatment, and prognosis. An electronic database search was conducted for articles concerning MOMR in Japan. The incidence and characteristics of MOMR were investigated, and the survival time was analyzed. This systematic review identified 211 studies, including 356 cases. There was a male predominance (n = 250/70.2 %) and the mean age at the diagnosis was 62.1 (range, 4–91) years old. The most common primary site was the lungs (n = 104/29.2 %). Oral metastasis sites were equally frequent in the jawbone (n = 182/51.1 %) and soft tissue (n = 174/48.9 %). Among these, the mandible and gingiva were the most common. The most common clinical presentation was a nodule (n = 317/90.3 %). The presence of metastases to other organs (P = 0.009) and uncontrolled primary lesions (P < 0.001) was associated with a shortened survival. This systematic review provides important insights into the clinical features, diagnosis, and treatment of MOMR in Japan and will assist clinicians in their appropriate management.

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日本人口腔颌面部转移性病变的系统回顾

本综述旨在整合已发表的关于口腔颌面区（MOMR）转移性病变的文献资料，并对其临床特征、治疗和预后进行最新的综合分析。对日本有关MOMR的文章进行了电子数据库检索。研究了MOMR的发生率和特点，并分析了生存时间。本系统综述确定了211项研究，包括356例病例。男性居多（n = 250/70.2 %），平均诊断年龄为62.1岁（范围4-91岁）。最常见的原发部位为肺部（n = 104/29.2 %）。口腔转移部位在颌骨（n = 182/51.1 %）和软组织（n = 174/48.9 %）同样常见。其中以下颌骨和牙龈最为常见。最常见的临床表现为结节（n = 317/90.3 %）。转移到其他器官（P = 0.009）和未控制的原发病变（P <； 0.001）的存在与生存期缩短相关。本系统综述为日本MOMR的临床特征、诊断和治疗提供了重要的见解，并将协助临床医生进行适当的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.