Japanese Dental Science Review最新文献_第2页

Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic review 在牙周炎进展过程中，存活和调节细胞死亡机制之间的相互作用：一项系统综述

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2025-12-01 Epub Date: 2025-08-22 DOI: 10.1016/j.jdsr.2025.08.001

Alfredo Torres , Leonardo Díaz , Jaime Oyarzún , M. Angélica Michea , Xiaowei Xu , Flavio Salazar-Onfray , Fermín E. González

{"title":"Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic review","authors":"Alfredo Torres , Leonardo Díaz , Jaime Oyarzún , M. Angélica Michea , Xiaowei Xu , Flavio Salazar-Onfray , Fermín E. González","doi":"10.1016/j.jdsr.2025.08.001","DOIUrl":"10.1016/j.jdsr.2025.08.001","url":null,"abstract":"<div><div>Regulated cell death (RCD) and survival pathways have emerged as critical factors in periodontal tissue breakdown. However, their precise roles and interactions remain poorly understood. This systematic review aimed to synthesize current evidence regarding the involvement of RCD and survival mechanisms in the progression of periodontitis. A systematic literature search was conducted in PubMed/MEDLINE, Web of Science and Scopus, complemented by manual searching in Google Scholar, following PRISMA guidelines. After removing duplicates, 549 studies underwent title and abstract screening. Of these, 56 articles were selected for full-text review and 18 studies met the eligibility criteria and were included in the final synthesis. Ferroptosis, pyroptosis and necroptosis were consistently associated with inflammatory exacerbation, alveolar bone loss and disease progression. In contrast, autophagy and apoptosis exhibited dual roles—protective or destructive—depending on cell types, disease stage and experimental conditions. Most studies utilized ligature-induced periodontitis animal models. Several studies also demonstrated the therapeutic potential of modulating specific RCD pathways to control inflammation and promote periodontal tissue regeneration, highlighting possible translational strategies for host-modulation therapy of periodontitis. This systematic review consolidates the pivotal role of RCD in the progression of periodontitis. Targeting RCD pathways may represent novel therapeutic strategies to reduce periodontal inflammation and tissue destruction.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 213-226"},"PeriodicalIF":6.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in dental education: A call for critical dialogue 牙科教育的挑战：呼吁进行批判性对话。

IF 5.7 2区医学

Japanese Dental Science Review Pub Date : 2025-12-01 Epub Date: 2025-01-17 DOI: 10.1016/j.jdsr.2025.01.001

Juliana Cassol Spanemberg, Vinicius Coelho Carrard

引用次数: 0

Antiseptics as effective virucidal agents against SARS-CoV-2: Systematic review and Bayesian network meta-analysis 防腐剂作为有效的抗病毒药物对抗SARS-CoV-2：系统评价和贝叶斯网络meta分析

IF 5.7 2区医学

Japanese Dental Science Review Pub Date : 2025-12-01 Epub Date: 2025-06-10 DOI: 10.1016/j.jdsr.2025.05.001

Noelia Seijas-Otero, Triana Blanco-Pintos , Alba Regueira-Iglesias, Berta Suárez-Rodríguez, Alba Sánchez-Barco, Carlos Balsa-Castro, Inmaculada Tomás

{"title":"Antiseptics as effective virucidal agents against SARS-CoV-2: Systematic review and Bayesian network meta-analysis","authors":"Noelia Seijas-Otero, Triana Blanco-Pintos , Alba Regueira-Iglesias, Berta Suárez-Rodríguez, Alba Sánchez-Barco, Carlos Balsa-Castro, Inmaculada Tomás","doi":"10.1016/j.jdsr.2025.05.001","DOIUrl":"10.1016/j.jdsr.2025.05.001","url":null,"abstract":"<div><div>This study represents the first Bayesian network meta-analysis (NMA), which aimed to determine the virucidal efficacy of oral and nasal antiseptics against SARS-CoV-2 in saliva. Eligible studies evaluated the antiseptics’ effect on viral load in SARS-CoV-2-infected subjects. The search was performed in September 2024 through PubMed, World Health Organisation, Embase, Scopus, bioRxiv, and medRxiv. The methodological quality was evaluated using the Cochrane RoB-2 checklist. Twenty-six articles and 16 antiseptics were assessed. Bayesian NMA was possible for seven antiseptics, ranked by probability of best option for viral load reduction (SUCRA values): PVP-I (0.85); CPC and CHX (0.72); H<sub>2</sub>O<sub>2</sub> (0.70); CHX (0.64); CPC (0.50); H<sub>2</sub>O<sub>2</sub> and CHX (0.38); and HClO (0.34). Virucidal efficacy at baseline was significant for (viral load reduction): PVP-I (42 %), H<sub>2</sub>O<sub>2</sub> (34 %), and CHX (31 %). Compared to the control group, PVP-I remained significant (34 %), whereas H<sub>2</sub>O<sub>2</sub> and CHX approached significance (26 % and 22 %, respectively). In conclusion, a single application of PVP-I, H<sub>2</sub>O<sub>2</sub> or CHX are the best options for reducing the SARS-CoV-2 viral load in saliva, which can be particularly relevant in high-risk settings. However, methodologically well-designed studies using more appropriate quantification techniques are needed to clarify better the clinical efficacy of antiseptics against SARS-CoV-2 and other respiratory viruses.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 138-154"},"PeriodicalIF":5.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between oral health parameters and nutritional status in geriatric populations: An umbrella review with meta-analysis 老年人群口腔健康参数与营养状况之间的关系：一项综合综述和荟萃分析

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2025-12-01 Epub Date: 2025-11-01 DOI: 10.1016/j.jdsr.2025.10.002

Wafa Ali Asaad , Salah Ameen Abdu , Wenjie Li , Yunqi Li , Yunhong Lin , Chun Yang , Xingxing Li

{"title":"Associations between oral health parameters and nutritional status in geriatric populations: An umbrella review with meta-analysis","authors":"Wafa Ali Asaad , Salah Ameen Abdu , Wenjie Li , Yunqi Li , Yunhong Lin , Chun Yang , Xingxing Li","doi":"10.1016/j.jdsr.2025.10.002","DOIUrl":"10.1016/j.jdsr.2025.10.002","url":null,"abstract":"<div><h3>Background</h3><div>Oral health impairments may compromise dietary intake and increase malnutrition risk in older adults. This review quantified associations between oral health indicators and malnutrition risk while synthesizing qualitative evidence.</div></div><div><h3>Methods</h3><div>Following PRISMA 2020 guidelines, we searched five databases for systematic reviews examining oral health indicators and nutritional outcomes in older adults. Quality was assessed using the JBI Critical Appraisal Checklist. RevMan 5.4 was used for meta-analyses, with sensitivity analyses using Comprehensive Meta-Analysis v3.7.</div></div><div><h3>Results</h3><div>Sixteen systematic reviews (518,647 participants) were included. Functional problems (chewing difficulty, xerostomia) were more associated with malnutrition than structural indicators, and while edentulism was frequently related to increased risk, dentures showed mixed correlations. Meta-analysis showed malnutrition risk was associated with masticatory dysfunction (RR) (1.75; p = 0.0001) and edentulism without dentures (RR) (1.71; p < 0.0005), but not with dental prostheses (RR) (1.01; p = 0.96); tooth count showed no significant association (MD) (-0.16; p = 0.19).</div></div><div><h3>Conclusions</h3><div>Functional oral impairment, particularly masticatory dysfunction and edentulism without dentures is more likely associated with malnutrition. Routine integration of oral and nutritional screening in geriatric care is warranted, with standardized measures needed to clarify the impact of salivary function and prosthetic rehabilitation on nutritional outcomes.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 264-279"},"PeriodicalIF":6.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are resin sealants effective to treat caries lesions in the outer 1/3 of dentin compared to composite resin restorations? Systematic review and meta-analysis 与复合树脂修复体相比，树脂密封剂对治疗牙本质外1/3的龋齿是否有效？系统回顾和荟萃分析

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2025-12-01 Epub Date: 2025-08-15 DOI: 10.1016/j.jdsr.2025.07.002

Larissa Yumi Ito, Letícia Simeoni Avais, Elis Carolina Pacheco, Leticia Maira Wambier, Alexandra Mara de Paula, Taíse Alessandra Hanzen, Alessandra Reis, Denise Stadler Wambier, Ana Cláudia Rodrigues Chibinski

{"title":"Are resin sealants effective to treat caries lesions in the outer 1/3 of dentin compared to composite resin restorations? Systematic review and meta-analysis","authors":"Larissa Yumi Ito, Letícia Simeoni Avais, Elis Carolina Pacheco, Leticia Maira Wambier, Alexandra Mara de Paula, Taíse Alessandra Hanzen, Alessandra Reis, Denise Stadler Wambier, Ana Cláudia Rodrigues Chibinski","doi":"10.1016/j.jdsr.2025.07.002","DOIUrl":"10.1016/j.jdsr.2025.07.002","url":null,"abstract":"<div><div>This systematic review analyzed effectiveness of resin sealants in arresting caries lesions in the outer 1/3 of dentin compared to restorations in deciduous/permanent teeth. Seven databases were searched for randomized clinical trials (December/2024), considering the outcomes “caries progression”, “material retention”, “tertiary dentin formation”, with a minimum 6 months follow-up. Risk of bias was assessed with RoB 2; meta-analysis used risk difference as effect measure in random effects model and Cochran Q test / I<sup>2</sup> statistics for heterogeneity; GRADE assessed the evidence certainty. From 6251, 6 papers addressing deciduous (3 high; 3 low risk of bias) and 3 permanent teeth (1 high; 2 low) were included. In deciduous teeth, difference wasn’t observed for “caries progression” [0.02 (-0.04–0.08; p = 0.54); I<sup>2</sup>= 0 % (p = 0.79)] or “material retention” [0.09 (-0.01–0.19); I<sup>2</sup>= 35 % (p = 0.18)]. In permanent teeth, there was no difference for “caries progression” [-0.01 (-0.08–0.06); I<sup>2</sup> = 30 % (p = 0.23)] and “tertiary dentin” [0.04 (-0.00–0.09); I<sup>2</sup> = 0 % (p = 0.51)]; “material retention” favored restorations after 48 months [0.08 (0.04–0.12); I<sup>2</sup> = 0 % (p = 0.34)]. In conclusion, sealants can be used to treat initial dentin caries lesions in deciduous and permanent teeth; however, the certainty of the evidence is low and moderate, respectively, and the findings must be taken carefully.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 200-212"},"PeriodicalIF":6.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the dental cellular landscape: A comprehensive review of single-cell RNA sequencing in human dental tissues 揭示牙齿细胞景观：人类牙齿组织单细胞RNA测序的全面回顾

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2025-12-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jdsr.2025.11.004

Maanas S. Shah , Takeru Kondo , Mano Sundarabupathi , Lakshman P. Samaranayake , Mohamed Jamal , Hiroshi Egusa

{"title":"Unveiling the dental cellular landscape: A comprehensive review of single-cell RNA sequencing in human dental tissues","authors":"Maanas S. Shah , Takeru Kondo , Mano Sundarabupathi , Lakshman P. Samaranayake , Mohamed Jamal , Hiroshi Egusa","doi":"10.1016/j.jdsr.2025.11.004","DOIUrl":"10.1016/j.jdsr.2025.11.004","url":null,"abstract":"<div><div>Single-cell RNA sequencing (scRNA-seq) has advanced the understanding of cellular heterogeneity and molecular dynamics in human dental tissues. This systematic review critically evaluated scRNA-seq studies exploring the cellular composition of human dental tissues, comparing <em>in situ</em> and cultured environments under both healthy and diseased conditions. Original research articles meeting the inclusion criteria were assessed for cell type identification, transcriptional profiles, analytical platforms, and other key biological insights by two independent authors. A total of fifteen studies that met the inclusion criteria revealed diverse cell populations, including mesenchymal stem cells (MSCs), immune cells, endothelial cells, and odontoblast-like cells, each exhibiting distinct transcriptional signatures in homeostasis, regeneration, and disease. Key findings included distinct MSC subpopulations, including <em>THY1</em><sup>+</sup>, <em>CD24</em><sup>+</sup>, <em>FRZB</em><sup>+</sup>, and <em>NOTCH3</em><sup>+</sup>/<em>PDGFRB</em><sup>+</sup>, exhibiting unique differentiation potential, along with significant heterogeneity in odontoblast lineage. Moreover, carious dental pulp undergoes a fibrotic transcriptional shift (e.g., <em>COL1A1</em>, <em>FN1</em>, and <em>TNC</em>), whereas periodontitis exhibits increased expression of pro-inflammatory cytokines (<em>IL-1β</em> and <em>TNFα)</em> and diminished periodontal MSC regenerative capacity. This review underscores the contributions of scRNA-seq in providing unprecedented insights into the complexity and functional heterogeneity of dental tissues, offering a foundation for advancing targeted regenerative therapies and guiding future translational research in dental medicine.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 301-316"},"PeriodicalIF":6.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral diseases as emerging risk factors for Alzheimer’s disease: A scoping review 口腔疾病是阿尔茨海默病的新危险因素：范围综述

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2025-12-01 Epub Date: 2025-11-17 DOI: 10.1016/j.jdsr.2025.11.003

Yuseung Yi , Chang-Ha Lee , Hyun-Seung Shin , Seungil Shin

{"title":"Oral diseases as emerging risk factors for Alzheimer’s disease: A scoping review","authors":"Yuseung Yi , Chang-Ha Lee , Hyun-Seung Shin , Seungil Shin","doi":"10.1016/j.jdsr.2025.11.003","DOIUrl":"10.1016/j.jdsr.2025.11.003","url":null,"abstract":"<div><div>This scoping review examined current evidence on the relationship between oral diseases and Alzheimer’s disease (AD). Systematic searches were conducted in PubMed, Scopus, Web of Science, Google Scholar, and KMbase for studies published from 1990 to December 2024, using terms of Alzheimer’s disease, dementia, oral health, periodontal disease, dental caries, and tooth loss. Human and validated animal studies investigating microbiological, immunological, inflammatory, genetic, or functional links between oral health and AD were included. Of 1328 records, 841 remained after duplicates were removed, and 98 were reviewed in full; 45 met inclusion criteria. Findings were organized into four themes: general associations; periodontal disease and AD, including inflammation, amyloid-β pathways, and APOE4-related susceptibility; dental caries; and tooth loss with prosthetic rehabilitation. Evidence indicates that chronic oral diseases, especially periodontitis and tooth loss, are associated with increased risk of AD and its progression through mechanisms involving systemic inflammation, microbial translocation, amyloidogenic processes, genetic predisposition, and impaired masticatory function. Appropriate prosthetic rehabilitation may help reduce dementia risk by restoring chewing function and supporting nutrition. While causality has yet to be established, maintaining oral health throughout life may be a practical, cost-effective component of strategies to promote cognitive health in older adults.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 292-300"},"PeriodicalIF":6.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145570982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidirectional association between oral diseases caused by plaque and the inflammatory bowel disease: A systematic review and meta-analysis 牙菌斑引起的口腔疾病与炎症性肠病之间的双向关联：一项系统综述和荟萃分析

IF 5.7 2区医学

Japanese Dental Science Review Pub Date : 2025-12-01 Epub Date: 2025-02-18 DOI: 10.1016/j.jdsr.2025.02.001

Yuqing Zhang , Ce Bian , Chaoran Yu , Mengyao Zhu , Michael D. Weir , Hockin H.K. Xu , Yuxing Bai , Ning Zhang

{"title":"Bidirectional association between oral diseases caused by plaque and the inflammatory bowel disease: A systematic review and meta-analysis","authors":"Yuqing Zhang , Ce Bian , Chaoran Yu , Mengyao Zhu , Michael D. Weir , Hockin H.K. Xu , Yuxing Bai , Ning Zhang","doi":"10.1016/j.jdsr.2025.02.001","DOIUrl":"10.1016/j.jdsr.2025.02.001","url":null,"abstract":"<div><div>The bidirectional association between oral diseases caused by plaque and the inflammatory bowel disease remains unclear. Here, we comprehensively searched PubMed, EMBASE, Web of Science, and the Cochrane Library from inception to August 2024 to identify relevant studies. The relative risk (RR) from periodontal disease studies and the decayed, missing, and filled teeth (DMFT) index from caries-related studies was pooled, and calculating 95 % confidence intervals (CIs). Subgroup analysis, sensitivity analysis, and cumulative meta-analysis were employed to evaluate the robustness of the findings. The research adhered to PRISMA 2020 guidelines, incorporating 26 studies for systematic review and 20 for meta-analysis. The results indicated no significant increase in the overall risk of inflammatory bowel disease (IBD) in patients with periodontal disease (RR 1.31, 95 % CI 0.98–1.35); however, the risk of ulcerative colitis (UC) was higher compared to controls (RR 1.34, 95 % CI 1.04–1.73). Among IBD patients, the risk of periodontal disease was significantly elevated (RR 2.14, 95 % CI 1.62–2.81), as was the risk of dental caries (WMD = 2.51, 95 % CI 0.97–4.06). Additionally, UC patients exhibited a higher incidence of caries compared to Crohn’s disease (CD) patients (WMD = 3.97, 95 % CI 1.94–6.00). Sensitivity analyses and cumulative meta-analyses confirmed the stability of the results. In conclusion, IBD patients, particularly those with UC, should prioritize stringent oral hygiene to mitigate the risks of periodontal disease and dental caries. The association between periodontal disease and IBD warrants further investigation, and high-quality clinical studies are needed to provide more definitive and reliable evidence.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 7-21"},"PeriodicalIF":5.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of genetic polymorphisms in residual ridge resorption of mandible – A scoping review 遗传多态性在下颌骨残脊吸收中的作用——综述

IF 5.7 2区医学

Japanese Dental Science Review Pub Date : 2025-12-01 Epub Date: 2025-03-04 DOI: 10.1016/j.jdsr.2025.02.002

Swapna B. Venkatesh , Smitha Sammith Shetty

{"title":"Role of genetic polymorphisms in residual ridge resorption of mandible – A scoping review","authors":"Swapna B. Venkatesh , Smitha Sammith Shetty","doi":"10.1016/j.jdsr.2025.02.002","DOIUrl":"10.1016/j.jdsr.2025.02.002","url":null,"abstract":"<div><div>Residual ridge (RR) refers to the clinical alveolar ridge that remains after the bone and soft tissues have healed following tooth extraction. This ridge undergoes resorption, which is most rapid during the first six months of post-extraction. Subsequently, bone resorption continues at a slower pace throughout life, leading to significant loss of jaw structure over time. This process is commonly known as residual ridge resorption (RRR). RRR is a major factor contributing to the loss of stability and retention, especially in mandibular complete dentures. Severe resorption of the maxillary and mandibular ridges can also lead to a sunken cheek appearance, poorly fitting and unstable dentures, and associated pain and discomfort. Though the etiology of residual ridge resorption remains unclear. It is believed that certain cytokines and individual genetic variations may influence the RRR process. Thus, reviewing the studies that discuss genetic association with the health and resorption of alveolar bone may give clear view on the etiology, help to define the risk and strategize preventive and personalized management of the disease. Hence, we undertook a scoping review to understand the potential genetic factors influencing the Residual ridge resorption (RRR). This review employed PRISMA-ScR extension protocols for scoping review. The results of the study provided significant association between genetic polymorphisms, especially of single gene nucleotide polymorphisms with mandibular residual ridge resorption. Hence understanding the genetic predisposition of patients can guide the clinicians in identifying patients at higher risk of RRR, enabling preventive measures, proactive intervention and careful designing of the prothesis.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 22-30"},"PeriodicalIF":5.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effectiveness of mobilization in treating patients with temporomandibular disorders: A systematic review and meta-analysis 运动治疗颞下颌疾病的有效性：系统回顾和荟萃分析

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1016/j.jdsr.2025.09.001

Prangtip Potewiratnanond , Sudaporn Pummoung , Chidsanu Changsiripun

{"title":"The effectiveness of mobilization in treating patients with temporomandibular disorders: A systematic review and meta-analysis","authors":"Prangtip Potewiratnanond , Sudaporn Pummoung , Chidsanu Changsiripun","doi":"10.1016/j.jdsr.2025.09.001","DOIUrl":"10.1016/j.jdsr.2025.09.001","url":null,"abstract":"<div><div>This systematic review and meta-analysis evaluated the effectiveness of temporomandibular joint (TMJ) mobilization in individuals with temporomandibular disorders (TMDs), using data from randomized controlled trials (RCTs) and before-after studies without control groups. Human studies assessing outcomes, including muscle activity, pain intensity, oral and cervical range of motion, and self-reported measures before and after mobilization, and comparing these results with those of individuals who received other conventional TMD treatments, were considered. Study selection and data extraction were performed by two independent reviewers, with a third reviewer resolving any disagreements. Of the 652 studies identified, five met the inclusion criteria. The evidence shows improvements in pain intensity, range of motion, and other patient-reported outcomes, following TMJ mobilization. These effects were observed immediately after treatment, showed a slight decrease at one week, and were further enhanced at four weeks. Compared to the control group, our meta-analyses demonstrate a significant reduction in pain intensity (mean difference = −2.90) and a significant improvement in mouth opening (mean difference = 10.76) at four weeks post-mobilization. The findings indicate that TMJ mobilization may serve as an effective short-term intervention for managing TMD, especially in the initial stages of treatment. However, further RCTs with long-term follow-up are warranted.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 227-235"},"PeriodicalIF":6.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0