Associations between metabolic disorders and Sjögren's disease

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review Pub Date : 2024-10-21 DOI:10.1016/j.jdsr.2024.06.002

Chihiro Iwaya , Junichi Iwata

引用次数: 0

Abstract

Sjögren’s disease (SjD) is a systemic autoimmune disorder characterized by dry eyes and mouth caused by chronic inflammation and is often accompanied by various extra-glandular manifestations, including fatigue and diffuse pain. Although the pathogenesis of the disease remains elusive, several factors (e.g. environmental, genetic and hormonal factors, abnormal metabolic status) are associated with this condition. Accumulating evidence suggests a potential role of cholesterol metabolism in immune and non-immune modulation in various diseases. In this review, we summarize the current findings on the associations between cholesterol metabolism and SjD.

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代谢紊乱与斯约戈伦病之间的关系

斯约格伦病（Sjögren's disease，SjD）是一种全身性自身免疫性疾病，其特征是慢性炎症引起的眼干和口干，通常伴有各种腺体外表现，包括疲劳和弥漫性疼痛。虽然该病的发病机制仍然难以捉摸，但有几种因素（如环境、遗传和激素因素、异常代谢状态）与此病有关。越来越多的证据表明，胆固醇代谢在各种疾病的免疫和非免疫调节中发挥着潜在的作用。在这篇综述中，我们总结了目前关于胆固醇代谢与 SjD 之间关系的研究结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.