Japanese Dental Science Review最新文献_第10页

Incorporation of MMP inhibitors into dental adhesive systems and bond strength of coronal composite restorations: A systematic review and meta-analysis of in vitro studies 将MMP抑制剂纳入牙科粘合剂系统和冠状复合修复体的结合强度:体外研究的系统回顾和荟萃分析

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2022-11-01 DOI: 10.1016/j.jdsr.2022.09.004

Rayan B. Yaghmoor , Hasan Jamal , Hassan Abed , Elaine Allan , Paul Ashley , Anne Young

{"title":"Incorporation of MMP inhibitors into dental adhesive systems and bond strength of coronal composite restorations: A systematic review and meta-analysis of in vitro studies","authors":"Rayan B. Yaghmoor , Hasan Jamal , Hassan Abed , Elaine Allan , Paul Ashley , Anne Young","doi":"10.1016/j.jdsr.2022.09.004","DOIUrl":"10.1016/j.jdsr.2022.09.004","url":null,"abstract":"<div><h3>Purpose</h3><p>To systematically review <em>in vitro</em> studies that incorporated MMP inhibitors into adhesive systems in terms of the effect on immediate and aged bond strength of dental composite to dentine.</p></div><div><h3>Materials and methods</h3><p>Independently, two reviewers conducted an electronic search in three databases (MEDLINE, EMBASE, and Google Scholar) following the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols (PRISMA-P), up to 6 March 2022.</p></div><div><h3>Results</h3><p>The search resulted in 894 papers, 33 of which were eligible to be included in the review; of those, 13 fulfilled the meta-analysis eligibility criteria. Nineteen inhibitors were used among the studies, and those included in the meta-analysis were 2%, 0.2% chlorhexidine (CHX), 5 µM GM1489, and 0.5%, 1% benzalkonium chloride (BAC). In the meta-analysis, while above inhibitors showed no adverse effect on bond strength, 0.2% CHX and 5 µM GM1489 caused a significant increase in immediate and 12-months bond strength. All other inhibitors resulted in a significant increase in bond strength at six months of ageing.</p></div><div><h3>Conclusions</h3><p>Incorporation of MMP inhibitors into the adhesive system has no unfavourable effect on immediate bond strength but a favourable effect on longer-term bond strength. Additionally, inhibitors other than CHX could have similar or better effects on bond strength.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 298-315"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/a2/main.PMC9557023.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9521254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biobanking in dentistry: A review 牙科生物银行:综述

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2022-11-01 DOI: 10.1016/j.jdsr.2021.12.002

Stefano Sivolella , Anna Scanu , Zijing Xie , Sara Vianello , Edoardo Stellini

{"title":"Biobanking in dentistry: A review","authors":"Stefano Sivolella , Anna Scanu , Zijing Xie , Sara Vianello , Edoardo Stellini","doi":"10.1016/j.jdsr.2021.12.002","DOIUrl":"10.1016/j.jdsr.2021.12.002","url":null,"abstract":"<div><p>Biobanks are not-for-profit services for the collection, processing, storage and distribution of biological samples and data for research and diagnostic purposes. In dentistry, biological materials and data obtained from questionnaires investigating oral conditions can be stored and used for large-scale studies on oral and systemic diseases. To give some examples: gene expression microarrays obtained on biobanked specimens were used in the identification of genetic alterations in oral cancer; efforts to identify genetic mechanisms behind dental caries have been based on an integrative analysis of transcriptome-wide associations and messenger RNA expression. One of the largest studies on facial pain was conducted using Biobank data. Cryopreservation of dental pulp stem cells is a common practice in tooth biobanks. With the exception of teeth and pulp, also leftover oral soft and hard tissues may represent a source of healthy samples that has rarely been exploited as yet. While biobanks are increasingly attracting the attention of the scientific community and becoming economically sustainable, a systematic approach to this resource in dentistry seems to be lacking. This review illustrates the applications of biobanking in dentistry, describing biobanked pathological and healthy samples and data, and discussing future developments.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 31-40"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/2b/main.PMC8728430.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39930369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis 心理应激对口腔-肠道微生物群和潜在的口腔-肠道-脑轴的影响

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2022-11-01 DOI: 10.1016/j.jdsr.2022.11.003

Durga Paudel , Osamu Uehara , Sarita Giri , Koki Yoshida , Tetsuro Morikawa , Takao Kitagawa , Hirofumi Matsuoka , Hiroko Miura , Akira Toyofuku , Yasuhiro Kuramitsu , Tohru Ohta , Masanobu Kobayashi , Yoshihiro Abiko

{"title":"Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis","authors":"Durga Paudel , Osamu Uehara , Sarita Giri , Koki Yoshida , Tetsuro Morikawa , Takao Kitagawa , Hirofumi Matsuoka , Hiroko Miura , Akira Toyofuku , Yasuhiro Kuramitsu , Tohru Ohta , Masanobu Kobayashi , Yoshihiro Abiko","doi":"10.1016/j.jdsr.2022.11.003","DOIUrl":"10.1016/j.jdsr.2022.11.003","url":null,"abstract":"<div><p>Psychological stress in a chronic course is implicated in various diseases, such as coronary artery disease, diabetes, ulcerative colitis, and psychosomatic pain disorders. Commensal microbiota in the host tissues interact with each other and maintain overall health. Oral and gut microbiomes are considered as the most ecologically rich and taxonomically diverse microbiota communities in humans. The effects of psychological stress on the gut microbiome have been well documented, and the interaction is commonly referred as the microbiota-gut-brain axis. Like the gut microbiome, the oral microbiome contributes to maintaining both local and systemic health. Although the effects of psychological stress on the oral microbiome have been studied, comprehensive knowledge about the oral-brain axis is lacking. The oral cavity and gut can communicate with each other through the microbiota. Three-way interactions within the oral-gut-brain microbiota might exist in patients with psychological stress and disorders. The effect of psychological stress on the gut and oral microbiomes, and the potential interactions within the oral-gut-brain axis are discussed in this review.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 365-375"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/0b/main.PMC9678961.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40510661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Role of the smear layer in adhesive dentistry and the clinical applications to improve bonding performance 涂片层在牙科粘接中的作用及其在提高粘接性能中的临床应用

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2022-11-01 DOI: 10.1016/j.jdsr.2021.12.001

Pipop Saikaew , Vanthana Sattabanasuk , Choltacha Harnirattisai , Abu Faem Mohammad Almas Chowdhury , Ricardo Carvalho , Hidehiko Sano

{"title":"Role of the smear layer in adhesive dentistry and the clinical applications to improve bonding performance","authors":"Pipop Saikaew , Vanthana Sattabanasuk , Choltacha Harnirattisai , Abu Faem Mohammad Almas Chowdhury , Ricardo Carvalho , Hidehiko Sano","doi":"10.1016/j.jdsr.2021.12.001","DOIUrl":"10.1016/j.jdsr.2021.12.001","url":null,"abstract":"<div><p>Currently, dental adhesives can be divided into two systems; a smear layer-removal approach with etch-and-rinse adhesives or a smear layer-modified approach with self-etching adhesives. After phosphoric acid etching, the smear layer is completely removed. More attention is, however, required when using self-etching adhesives. The smear layer is partially demineralized by the weak acidic monomer and subsequently incorporated into the hybrid layer. Therefore, the characteristics of the smear layer play an important role on the bonding performance of self-etching adhesives. Such characteristics, for instance, smear layer thickness and smear layer density, are influenced by many factors, <em>e.g.</em>, instruments used for dentin surface preparation, cutting speed, and the abrasive particle size of the cutting instruments. This review discusses the contributing factors that affect the smear layer characteristics, and the influence of the smear layer on the bonding performance of dental adhesives. Also, the application techniques regarding how to improve the bonding performance of self-etching adhesives – the smear layer removal by using chemical agents, or the modification of the adhesive application procedures – are provided.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 59-66"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b0/4c/main.PMC8814382.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39609462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Managements of sleep bruxism in adult: A systematic review 成人睡眠磨牙症的处理:系统回顾

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2022-11-01 DOI: 10.1016/j.jdsr.2022.02.004

Hajime Minakuchi , Masanori Fujisawa , Yuka Abe , Takashi Iida , Kyosuke Oki , Kazuo Okura , Norimasa Tanabe , Akira Nishiyama

{"title":"Managements of sleep bruxism in adult: A systematic review","authors":"Hajime Minakuchi , Masanori Fujisawa , Yuka Abe , Takashi Iida , Kyosuke Oki , Kazuo Okura , Norimasa Tanabe , Akira Nishiyama","doi":"10.1016/j.jdsr.2022.02.004","DOIUrl":"10.1016/j.jdsr.2022.02.004","url":null,"abstract":"<div><p>This systematic review aimed to update the management of sleep bruxism (SB) in adults, as diagnosed using polysomnography (PSG) and/or electromyography (EMG). Management methods covered were oral appliance therapy (OAT) with stabilization splints, cognitive-behavioral therapy (CBT), biofeedback therapy (BFT), and pharmacological therapy. A comprehensive search was conducted on MEDLINE, Cochrane Library, and Web of Science up to October 1st, 2021. Reference list searches and hand searches were also performed by an external organization. Two reviewers for each therapy independently performed article selection, data extraction, and risk of bias assessment. The reviewers resolved any disagreements concerning the assortment of the articles by discussion. Finally, 11, 3, 14, and 22 articles were selected for each therapy. The results suggested that OAT tended to reduce the number of SB events, although there was no significant difference compared to other types of splints, that the potential benefits of CBT were not well supported, and that BFT, rabeprazole, clonazepam, clonidine, and botulinum toxin type A injection showed significant reductions in specific SB parameters, although several side effects were reported. It can be concluded that more methodologically rigorous randomized large-sample long-term follow-up clinical trials are needed to clarify the efficacy and safety of management for SB.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 124-136"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/ff/main.PMC8958360.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10189810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration 骨形态发生蛋白的载体系统:用于牙槽骨和颌面骨再生的生物材料概述

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2022-11-01 DOI: 10.1016/j.jdsr.2022.10.001

Alain Arias-Betancur , Nicolás Badilla-Wenzel , Álvaro Astete-Sanhueza , Nicole Farfán-Beltrán , Fernando José Dias

{"title":"Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration","authors":"Alain Arias-Betancur , Nicolás Badilla-Wenzel , Álvaro Astete-Sanhueza , Nicole Farfán-Beltrán , Fernando José Dias","doi":"10.1016/j.jdsr.2022.10.001","DOIUrl":"10.1016/j.jdsr.2022.10.001","url":null,"abstract":"<div><p>Different types of biomaterials have been used to fabricate carriers to deliver bone morphogenetic proteins (BMPs) in both dentoalveolar and maxillofacial bone regeneration procedures. Despite that absorbable collagen sponge (ACS) is considered the gold standard for BMP delivery, there is still some concerns regarding its use mainly due to its poor mechanical properties. To overcome this, novel systems are being developed, however, due to the wide variety of biomaterial combination, the heterogeneous assessment of newly formed tissue, and the intended clinical applications, there is still no consensus regarding which is more efficient in a particular clinical scenario. The combination of two or more biomaterials in different topological configurations has allowed specific controlled-release patterns for BMPs, improving their biological and mechanical properties compared with classical single-material carriers. However, more basic research is needed. Since the BMPs can be used in multiple clinical scenarios having different biological and mechanical needs, novel carriers should be developed in a context-specific manner. Thus, the purpose of this review is to gather current knowledge about biomaterials used to fabricate delivery systems for BMPs in both dentoalveolar and maxillofacial contexts. Aspects related with the biological, physical and mechanical characteristics of each biomaterial are also presented and discussed.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 316-327"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/96/66/main.PMC9587372.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40586700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Dental manifestation and management of hypophosphatasia 口腔低磷症的表现与处理

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2022-11-01 DOI: 10.1016/j.jdsr.2022.06.002

Rena Okawa, Kazuhiko Nakano

{"title":"Dental manifestation and management of hypophosphatasia","authors":"Rena Okawa, Kazuhiko Nakano","doi":"10.1016/j.jdsr.2022.06.002","DOIUrl":"10.1016/j.jdsr.2022.06.002","url":null,"abstract":"<div><p>Hypophosphatasia is an inherited metabolic disorder characterized by defective mineralization of bones and teeth with a wide variety of manifestations, ranging from stillbirth to dental symptoms alone. Recently, the prognosis of severe hypophosphatasia patients has been greatly improved by the introduction of enzyme replacement therapy. The typical dental manifestation is early exfoliation of primary teeth due to disturbed cementum formation, so dentures are recommended to ensure that important oral functions are acquired. Some studies have shown that enzyme replacement therapy improves dental mineralization, resulting in the stabilization of periodontal tissues and better growth of tooth roots. A nationwide Japanese survey revealed the common genetic and dental manifestations of patients with mild hypophosphatasia, which markedly differ from those of the severe forms. There may be many undiagnosed mild patients, so dentists should contribute to the early diagnosis by screening possible cases based on the typical finding of early exfoliation of primary teeth. Early diagnosis is important for patients to receive early intervention in both medical and dental fields. The establishment of fundamental dental therapy to solve the dental problems is still underway and is eagerly anticipated.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 208-216"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/15/main.PMC9260292.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40605770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Dental applications of induced pluripotent stem cells and their derivatives 诱导多能干细胞及其衍生物在牙科的应用

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2022-11-01 DOI: 10.1016/j.jdsr.2022.03.002

Pan Gao , Shan Liu , Xiaoyi Wang , Makoto Ikeya

{"title":"Dental applications of induced pluripotent stem cells and their derivatives","authors":"Pan Gao , Shan Liu , Xiaoyi Wang , Makoto Ikeya","doi":"10.1016/j.jdsr.2022.03.002","DOIUrl":"10.1016/j.jdsr.2022.03.002","url":null,"abstract":"<div><p>Periodontal tissue regeneration is the ideal tactic for treating periodontitis. Tooth regeneration is the potential strategy to restore the lost teeth. With infinite self-renewal, broad differentiation potential, and less ethical issues than embryonic stem cells, induced pluripotent stem cells (iPSCs) are promising cell resource for periodontal and tooth regeneration. This review summarized the optimized technologies of generating iPSC lines and application of iPSC derivatives, which reduce the risk of tumorigenicity. Given that iPSCs may have epigenetic memory from the donor tissue and tend to differentiate into lineages along with the donor cells, iPSCs derived from dental tissues may benefit for personalized dental application. Neural crest cells (NCCs) and mesenchymal stem or stomal cells (MSCs) are lineage-specific progenitor cells derived from iPSCs and can differentiate into multilineage cell types. This review introduced the updated technologies of inducing iPSC-derived NCCs and iPSC-derived MSCs and their application in periodontal and tooth regeneration. Given the complexity of periodontal tissues and teeth, it is crucial to elucidate the integrated mechanisms of all constitutive cells and the spatio-temporal interactions among them to generate structural periodontal tissues and functional teeth. Thus, more sophisticated studies <em>in vitro</em> and <em>in vivo</em> and even preclinical investigations need to be conducted.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 162-171"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761622000072/pdfft?md5=3f7506af875386184845e82a0c1e9c43&pid=1-s2.0-S1882761622000072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89630164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2022-11-01 DOI: 10.1016/j.jdsr.2021.11.005

Islam E. Ali , Yuka Sumita

{"title":"Medication-related osteonecrosis of the jaw: Prosthodontic considerations","authors":"Islam E. Ali , Yuka Sumita","doi":"10.1016/j.jdsr.2021.11.005","DOIUrl":"10.1016/j.jdsr.2021.11.005","url":null,"abstract":"<div><p>Medication-related osteonecrosis of the jaw (MRONJ) can be triggered by several antiresorptive and antiangiogenic medications, including bisphosphonates (BRONJ), denosumab (DRONJ), and other agents used to treat osteoporosis and metastatic bone cancer. Prosthodontists and surgeons continue to face new challenges because of this condition. Despite the current evidence showing that extensive surgical intervention and laser surgery have the highest healing rates, surgical reconstruction is not always possible for large jaw defects requiring prosthetic reconstruction. Moreover, surgical treatment may not be an option in some patients because of other medical conditions. In these patients, MRONJ may develop into a chronic disease with limited resolution and they may seek prosthetic rehabilitation for aesthetic and functional reasons. Therefore, prosthetic intervention may be necessary for some patients with MRONJ even in the absence of a surgical defect. Denture trauma has been reported to be a risk factor for MRONJ, and few reports have discussed the prosthodontic considerations needed for patients with this condition. The aim of this review is to highlight the prosthodontic considerations that would decrease the risk of triggering MRONJ in susceptible patients.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 9-12"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/48/main.PMC8693001.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39787001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The structural motifs of mineralized hard tissues from nano- to mesoscale: A future perspective for material science 从纳米到中尺度的矿化硬组织的结构基序:材料科学的未来展望

IF 6.6 2区医学

Japanese Dental Science Review Pub Date : 2022-11-01 DOI: 10.1016/j.jdsr.2022.11.001

Jingxiao Zhong , Yo Shibata

{"title":"The structural motifs of mineralized hard tissues from nano- to mesoscale: A future perspective for material science","authors":"Jingxiao Zhong , Yo Shibata","doi":"10.1016/j.jdsr.2022.11.001","DOIUrl":"10.1016/j.jdsr.2022.11.001","url":null,"abstract":"<div><p>Biological tissues have developed structures that fulfil their various specific requirements. Mineralized tissues, such as tooth and bone, are often of mechanical competence for load bearing. Tooth enamel is the hardest and toughest mineralized tissue. Despite a few millimeters thick and with minimal regenerative capacity, human tooth enamel maintains its functions throughout a lifetime. Bone provides skeletal support and essential metabolism to our body. Degenerative diseases and ageing induce the loss of mechanical integrity of the bone, increasing the susceptibility to fractures. Tooth and bone share certain commonalities in chemical components and material characteristics, both consisting of nanocrystalline apatite and matrix proteins as their basic foundational structural units. Although the mechanical properties of such mineralized hard tissues remain unclear, it is plausible that they have an inherent toughening mechanism. Nanoindentation is able to characterize the mechanical properties of tooth enamel and bone at multiscale levels, and the results suggest that such toughening mechanisms of enamel and bone may be mainly associated with the smallest-scale structure–function relationships. These findings will benefit the development of advanced biomaterials in the field of material science and will further our understanding of degenerative bone disease in the clinical community.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 348-356"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/d3/main.PMC9672955.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40697628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3