Japanese Dental Science Review最新文献

{"title":"Effectiveness of surgical procedures in the acceleration of orthodontic tooth movement: Findings from systematic reviews and meta‐analyses","authors":"Roberta Gasparro ,&nbsp;Rosaria Bucci ,&nbsp;Fabrizia De Rosa ,&nbsp;Gilberto Sammartino ,&nbsp;Paolo Bucci ,&nbsp;Vincenzo D’Antò ,&nbsp;Gaetano Marenzi","doi":"10.1016/j.jdsr.2022.03.003","DOIUrl":"10.1016/j.jdsr.2022.03.003","url":null,"abstract":"<div><p>The current overview aimed to summarise the findings provided by systematic reviews (SRs) on the effect of surgical procedures in the acceleration of tooth movement and to assess the methodological quality of the included SRs. Three electronic databases have been explored. SRs addressing the effects of surgical procedures on the acceleration of tooth movement were included. The methodological quality of the included SRs was assessed using the updated version of “A Measurement Tool to Assess Systematic Review” (AMSTAR‐2). Twenty-eight (28) SRs were included. The methodological quality of the included reviews ranged between critically low (6 studies) and high (12 studies). The most common critical weakness in the included reviews was the absence of clearly a‐prior established review methods and any significant deviations from the protocol. The most studied surgical procedure was corticotomy, followed by micro-osteoperforation, piezocision and periodontally accelerated osteogenic orthodontics. The majority of the included SRs supported short-term favourable effects of corticotomy on treatment time and tooth movement rate, in the short-term. However, the authors of the included SRs reported that results were based on weak quality evidence. Conflicting results arise from the existent SRs with regards to the effectiveness of piezocision and micro-osteoperforation. Few SRs summarised complications and side effects of surgical techniques, supporting absence of loss of tooth vitality, periodontal problems, or severe root resorption. The current overview of SRs highlighted the need of high quality SRs comparing different surgical approaches for tooth movement acceleration though network meta-analysis, in order to determine the most efficient instrument for orthodontic movement acceleration.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 137-154"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761622000084/pdfft?md5=1721885e0a3a7a179869a4895414aae6&pid=1-s2.0-S1882761622000084-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89767493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical advantage of nasal high-flow in respiratory management during procedural sedation: A scoping review on the application of nasal high-flow during dental procedures with sedation","authors":"Shinji Kurata ,&nbsp;Takuro Sanuki ,&nbsp;Hitoshi Higuchi ,&nbsp;Takuya Miyawaki ,&nbsp;Seiji Watanabe ,&nbsp;Shigeru Maeda ,&nbsp;Shuntaro Sato ,&nbsp;Max Pinkham ,&nbsp;Stanislav Tatkov ,&nbsp;Takao Ayuse","doi":"10.1016/j.jdsr.2022.05.003","DOIUrl":"10.1016/j.jdsr.2022.05.003","url":null,"abstract":"<div><h3>Structured summary</h3><p>Rationale: Nasal high-flow (NHF), a new method for respiratory management during procedural sedation, has greater advantages than conventional nasal therapy with oxygen. However, its clinical relevance for patients undergoing oral maxillofacial surgery and/or dental treatment remains uncertain and controversial, due to a paucity of studies. This scoping review compared and evaluated NHF and conventional nasal therapy with oxygen in patients undergoing oral maxillofacial surgery and/or dental treatment.</p></div><div><h3>Materials and methods</h3><p>A literature search of two public electronic databases was conducted, and English writing randomized controlled trials (RCTs) of nasal high flow during dental procedure with sedation reviewed. The primary and secondary outcomes of interest were the incidence of hypoxemia and hypercapnia during sedation and the need for intervention to relieve upper airway obstruction, respectively.</p></div><div><h3>Results</h3><p>The search strategy yielded 7 studies, of which three RCTs met our eligibility criteria, with a total of 78 patients. Compared with conventional nasal therapy with oxygen, NHF significantly reduced the incidence of hypoxemia and hypercapnia during procedural sedation.</p></div><div><h3>Conclusion</h3><p>NHF can maintain oxygenation and possibly prevent hypercapnia in patients undergoing dental treatment. Additional RCTs are needed to clarify and confirm these findings.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 179-182"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761622000126/pdfft?md5=26f40071da22c510140f28865739eb29&pid=1-s2.0-S1882761622000126-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85731823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic overlap between temporomandibular disorders and primary headaches: A systematic review","authors":"Diogo Cruz ,&nbsp;Francisca Monteiro ,&nbsp;Maria Paço ,&nbsp;Manuel Vaz-Silva ,&nbsp;Carolina Lemos ,&nbsp;Miguel Alves-Ferreira ,&nbsp;Teresa Pinho","doi":"10.1016/j.jdsr.2022.02.002","DOIUrl":"10.1016/j.jdsr.2022.02.002","url":null,"abstract":"<div><p>Primary headache disorders (PHD), specifically migraine, are strongly associated with temporomandibular disorders (TMD), sharing some patterns of orofacial pain. Both disorders have significant genetic contributions already studied. PRISMA guidelines were followed to conduct this systematic review, which comprehensively summarize and discuss the genetic overlap between TMD and PHD to aid future research in potential therapy targets. This review included eight original articles published between 2015 and 2020, written in English and related to either TMD and/or PHD. The genes simultaneously assessed in PHD and TMD studies were <em>COMT, MTHFR,</em> and <em>ESR1. COMT</em> was proved to play a critical role in TMD pathogenesis, as all studies have concluded about its impact on the occurrence of the disease, although no association with PHD was found. No proof on the impact of <em>MTHFR</em> gene regulation on either TMD or PHD was found. The most robust results are concerning the <em>ESR1</em> gene, which is present in the genetic profile of both clinical conditions. This novel systematic review highlights not only the need for a clear understanding of the role of <em>ESR1</em> and <em>COMT</em> genes in pain pathogenesis, but it also evaluates their potential as a promising therapeutic target to treat both pathologies.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 69-88"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761622000035/pdfft?md5=49dcb79f9dbacdad92d3650afb67ca21&pid=1-s2.0-S1882761622000035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89161703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporation of MMP inhibitors into dental adhesive systems and bond strength of coronal composite restorations: A systematic review and meta-analysis of in vitro studies","authors":"Rayan B. Yaghmoor ,&nbsp;Hasan Jamal ,&nbsp;Hassan Abed ,&nbsp;Elaine Allan ,&nbsp;Paul Ashley ,&nbsp;Anne Young","doi":"10.1016/j.jdsr.2022.09.004","DOIUrl":"10.1016/j.jdsr.2022.09.004","url":null,"abstract":"<div><h3>Purpose</h3><p>To systematically review <em>in vitro</em> studies that incorporated MMP inhibitors into adhesive systems in terms of the effect on immediate and aged bond strength of dental composite to dentine.</p></div><div><h3>Materials and methods</h3><p>Independently, two reviewers conducted an electronic search in three databases (MEDLINE, EMBASE, and Google Scholar) following the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols (PRISMA-P), up to 6 March 2022.</p></div><div><h3>Results</h3><p>The search resulted in 894 papers, 33 of which were eligible to be included in the review; of those, 13 fulfilled the meta-analysis eligibility criteria. Nineteen inhibitors were used among the studies, and those included in the meta-analysis were 2%, 0.2% chlorhexidine (CHX), 5 µM GM1489, and 0.5%, 1% benzalkonium chloride (BAC). In the meta-analysis, while above inhibitors showed no adverse effect on bond strength, 0.2% CHX and 5 µM GM1489 caused a significant increase in immediate and 12-months bond strength. All other inhibitors resulted in a significant increase in bond strength at six months of ageing.</p></div><div><h3>Conclusions</h3><p>Incorporation of MMP inhibitors into the adhesive system has no unfavourable effect on immediate bond strength but a favourable effect on longer-term bond strength. Additionally, inhibitors other than CHX could have similar or better effects on bond strength.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 298-315"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/a2/main.PMC9557023.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9521254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biobanking in dentistry: A review","authors":"Stefano Sivolella ,&nbsp;Anna Scanu ,&nbsp;Zijing Xie ,&nbsp;Sara Vianello ,&nbsp;Edoardo Stellini","doi":"10.1016/j.jdsr.2021.12.002","DOIUrl":"10.1016/j.jdsr.2021.12.002","url":null,"abstract":"<div><p>Biobanks are not-for-profit services for the collection, processing, storage and distribution of biological samples and data for research and diagnostic purposes. In dentistry, biological materials and data obtained from questionnaires investigating oral conditions can be stored and used for large-scale studies on oral and systemic diseases. To give some examples: gene expression microarrays obtained on biobanked specimens were used in the identification of genetic alterations in oral cancer; efforts to identify genetic mechanisms behind dental caries have been based on an integrative analysis of transcriptome-wide associations and messenger RNA expression. One of the largest studies on facial pain was conducted using Biobank data. Cryopreservation of dental pulp stem cells is a common practice in tooth biobanks. With the exception of teeth and pulp, also leftover oral soft and hard tissues may represent a source of healthy samples that has rarely been exploited as yet. While biobanks are increasingly attracting the attention of the scientific community and becoming economically sustainable, a systematic approach to this resource in dentistry seems to be lacking. This review illustrates the applications of biobanking in dentistry, describing biobanked pathological and healthy samples and data, and discussing future developments.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 31-40"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/2b/main.PMC8728430.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39930369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis","authors":"Durga Paudel ,&nbsp;Osamu Uehara ,&nbsp;Sarita Giri ,&nbsp;Koki Yoshida ,&nbsp;Tetsuro Morikawa ,&nbsp;Takao Kitagawa ,&nbsp;Hirofumi Matsuoka ,&nbsp;Hiroko Miura ,&nbsp;Akira Toyofuku ,&nbsp;Yasuhiro Kuramitsu ,&nbsp;Tohru Ohta ,&nbsp;Masanobu Kobayashi ,&nbsp;Yoshihiro Abiko","doi":"10.1016/j.jdsr.2022.11.003","DOIUrl":"10.1016/j.jdsr.2022.11.003","url":null,"abstract":"<div><p>Psychological stress in a chronic course is implicated in various diseases, such as coronary artery disease, diabetes, ulcerative colitis, and psychosomatic pain disorders. Commensal microbiota in the host tissues interact with each other and maintain overall health. Oral and gut microbiomes are considered as the most ecologically rich and taxonomically diverse microbiota communities in humans. The effects of psychological stress on the gut microbiome have been well documented, and the interaction is commonly referred as the microbiota-gut-brain axis. Like the gut microbiome, the oral microbiome contributes to maintaining both local and systemic health. Although the effects of psychological stress on the oral microbiome have been studied, comprehensive knowledge about the oral-brain axis is lacking. The oral cavity and gut can communicate with each other through the microbiota. Three-way interactions within the oral-gut-brain microbiota might exist in patients with psychological stress and disorders. The effect of psychological stress on the gut and oral microbiomes, and the potential interactions within the oral-gut-brain axis are discussed in this review.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 365-375"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/0b/main.PMC9678961.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40510661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the smear layer in adhesive dentistry and the clinical applications to improve bonding performance","authors":"Pipop Saikaew ,&nbsp;Vanthana Sattabanasuk ,&nbsp;Choltacha Harnirattisai ,&nbsp;Abu Faem Mohammad Almas Chowdhury ,&nbsp;Ricardo Carvalho ,&nbsp;Hidehiko Sano","doi":"10.1016/j.jdsr.2021.12.001","DOIUrl":"10.1016/j.jdsr.2021.12.001","url":null,"abstract":"<div><p>Currently, dental adhesives can be divided into two systems; a smear layer-removal approach with etch-and-rinse adhesives or a smear layer-modified approach with self-etching adhesives. After phosphoric acid etching, the smear layer is completely removed. More attention is, however, required when using self-etching adhesives. The smear layer is partially demineralized by the weak acidic monomer and subsequently incorporated into the hybrid layer. Therefore, the characteristics of the smear layer play an important role on the bonding performance of self-etching adhesives. Such characteristics, for instance, smear layer thickness and smear layer density, are influenced by many factors, <em>e.g.</em>, instruments used for dentin surface preparation, cutting speed, and the abrasive particle size of the cutting instruments. This review discusses the contributing factors that affect the smear layer characteristics, and the influence of the smear layer on the bonding performance of dental adhesives. Also, the application techniques regarding how to improve the bonding performance of self-etching adhesives – the smear layer removal by using chemical agents, or the modification of the adhesive application procedures – are provided.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 59-66"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b0/4c/main.PMC8814382.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39609462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managements of sleep bruxism in adult: A systematic review","authors":"Hajime Minakuchi ,&nbsp;Masanori Fujisawa ,&nbsp;Yuka Abe ,&nbsp;Takashi Iida ,&nbsp;Kyosuke Oki ,&nbsp;Kazuo Okura ,&nbsp;Norimasa Tanabe ,&nbsp;Akira Nishiyama","doi":"10.1016/j.jdsr.2022.02.004","DOIUrl":"10.1016/j.jdsr.2022.02.004","url":null,"abstract":"<div><p>This systematic review aimed to update the management of sleep bruxism (SB) in adults, as diagnosed using polysomnography (PSG) and/or electromyography (EMG). Management methods covered were oral appliance therapy (OAT) with stabilization splints, cognitive-behavioral therapy (CBT), biofeedback therapy (BFT), and pharmacological therapy. A comprehensive search was conducted on MEDLINE, Cochrane Library, and Web of Science up to October 1st, 2021. Reference list searches and hand searches were also performed by an external organization. Two reviewers for each therapy independently performed article selection, data extraction, and risk of bias assessment. The reviewers resolved any disagreements concerning the assortment of the articles by discussion. Finally, 11, 3, 14, and 22 articles were selected for each therapy. The results suggested that OAT tended to reduce the number of SB events, although there was no significant difference compared to other types of splints, that the potential benefits of CBT were not well supported, and that BFT, rabeprazole, clonazepam, clonidine, and botulinum toxin type A injection showed significant reductions in specific SB parameters, although several side effects were reported. It can be concluded that more methodologically rigorous randomized large-sample long-term follow-up clinical trials are needed to clarify the efficacy and safety of management for SB.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 124-136"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/ff/main.PMC8958360.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10189810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carrier systems for bone morphogenetic proteins: An overview of biomaterials used for dentoalveolar and maxillofacial bone regeneration","authors":"Alain Arias-Betancur ,&nbsp;Nicolás Badilla-Wenzel ,&nbsp;Álvaro Astete-Sanhueza ,&nbsp;Nicole Farfán-Beltrán ,&nbsp;Fernando José Dias","doi":"10.1016/j.jdsr.2022.10.001","DOIUrl":"10.1016/j.jdsr.2022.10.001","url":null,"abstract":"<div><p>Different types of biomaterials have been used to fabricate carriers to deliver bone morphogenetic proteins (BMPs) in both dentoalveolar and maxillofacial bone regeneration procedures. Despite that absorbable collagen sponge (ACS) is considered the gold standard for BMP delivery, there is still some concerns regarding its use mainly due to its poor mechanical properties. To overcome this, novel systems are being developed, however, due to the wide variety of biomaterial combination, the heterogeneous assessment of newly formed tissue, and the intended clinical applications, there is still no consensus regarding which is more efficient in a particular clinical scenario. The combination of two or more biomaterials in different topological configurations has allowed specific controlled-release patterns for BMPs, improving their biological and mechanical properties compared with classical single-material carriers. However, more basic research is needed. Since the BMPs can be used in multiple clinical scenarios having different biological and mechanical needs, novel carriers should be developed in a context-specific manner. Thus, the purpose of this review is to gather current knowledge about biomaterials used to fabricate delivery systems for BMPs in both dentoalveolar and maxillofacial contexts. Aspects related with the biological, physical and mechanical characteristics of each biomaterial are also presented and discussed.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 316-327"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/96/66/main.PMC9587372.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40586700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental manifestation and management of hypophosphatasia","authors":"Rena Okawa,&nbsp;Kazuhiko Nakano","doi":"10.1016/j.jdsr.2022.06.002","DOIUrl":"10.1016/j.jdsr.2022.06.002","url":null,"abstract":"<div><p>Hypophosphatasia is an inherited metabolic disorder characterized by defective mineralization of bones and teeth with a wide variety of manifestations, ranging from stillbirth to dental symptoms alone. Recently, the prognosis of severe hypophosphatasia patients has been greatly improved by the introduction of enzyme replacement therapy. The typical dental manifestation is early exfoliation of primary teeth due to disturbed cementum formation, so dentures are recommended to ensure that important oral functions are acquired. Some studies have shown that enzyme replacement therapy improves dental mineralization, resulting in the stabilization of periodontal tissues and better growth of tooth roots. A nationwide Japanese survey revealed the common genetic and dental manifestations of patients with mild hypophosphatasia, which markedly differ from those of the severe forms. There may be many undiagnosed mild patients, so dentists should contribute to the early diagnosis by screening possible cases based on the typical finding of early exfoliation of primary teeth. Early diagnosis is important for patients to receive early intervention in both medical and dental fields. The establishment of fundamental dental therapy to solve the dental problems is still underway and is eagerly anticipated.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"58 ","pages":"Pages 208-216"},"PeriodicalIF":6.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/15/main.PMC9260292.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40605770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}