{"title":"Involvement of the Notch signaling system in alveolar bone resorption","authors":"Aleksandar Jakovljevic , Nadja Nikolic , Lucrezia Paternò Holtzman , Pierre Tournier , Alexis Gaudin , Luca Cordaro , Iva Milinkovic","doi":"10.1016/j.jdsr.2023.02.003","DOIUrl":"10.1016/j.jdsr.2023.02.003","url":null,"abstract":"<div><p>The Notch pathway is an evolutionarily preserved signaling pathway involved in a variety of vital cell functions. Additionally, it is one of the key regulators of inflammation, and controls the differentiation and function of different cells. Moreover, it was found to be involved in skeletal development and bone remodeling process. This review provides an overview of the involvement of the Notch signaling pathway in the pathogenesis of alveolar bone resorption in different forms of pathological conditions such as apical periodontitis, periodontal disease, and peri-implantitis. <em>In vitro</em> and in vivo evidence have confirmed the involvement of Notch signaling in alveolar bone homeostasis. Nonetheless, Notch signaling system, along with complex network of different biomolecules are involved in pathological process of bone resorption in apical periodontitis, periodontitis, and peri-implantitis. In this regard, there is a substantial interest to control the activity of this pathway in the treatment of disorders associated with its dysregulation. This review provides knowledge on Notch signaling and outlines its functions in alveolar bone homeostasis and alveolar bone resorption. Further investigations are needed to determine whether inhibition of the Notch signaling pathways might be beneficial and safe as a novel approach in the treatment of these pathological conditions.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 38-47"},"PeriodicalIF":6.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10860892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia","authors":"Mohammad Zakir Hossain, Junichi Kitagawa","doi":"10.1016/j.jdsr.2023.09.002","DOIUrl":"https://doi.org/10.1016/j.jdsr.2023.09.002","url":null,"abstract":"<div><p>Oropharyngeal dysphagia is a serious health concern in older adults and patients with neurological disorders. Current oropharyngeal dysphagia management largely relies on compensatory strategies with limited efficacy. A long-term goal in swallowing/dysphagia-related research is the identification of pharmacological treatment strategies for oropharyngeal dysphagia. In recent decades, several pre-clinical and clinical studies have investigated the use of transient receptor potential (TRP) channels as a therapeutic target to facilitate swallowing. Various TRP channels are present in regions involved in the swallowing process. Animal studies have shown that local activation of these channels by their pharmacological agonists initiates swallowing reflexes; the number of reflexes increases when the dose of the agonist reaches a particular level. Clinical studies, including randomized clinical trials involving patients with oropharyngeal dysphagia, have demonstrated improved swallowing efficacy, safety, and physiology when TRP agonists are mixed with the food bolus. Additionally, there is evidence of plasticity development in swallowing-related neuronal networks in the brain upon TRP channel activation in peripheral swallowing-related regions. Thus, TRP channels have emerged as a promising target for the development of pharmacological treatments for oropharyngeal dysphagia.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 421-430"},"PeriodicalIF":6.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761623000297/pdfft?md5=f8439552d95bd31845ae796d076803b0&pid=1-s2.0-S1882761623000297-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92131737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tooth agenesis patterns and variants in PAX9: A systematic review","authors":"Narin Intarak , Karn Tongchairati , Kittipat Termteerapornpimol , Soranun Chantarangsu , Thantrira Porntaveetus","doi":"10.1016/j.jdsr.2023.04.001","DOIUrl":"https://doi.org/10.1016/j.jdsr.2023.04.001","url":null,"abstract":"<div><p>Mutations in <em>PAX9</em> are the most common genetic cause of tooth agenesis (TA). The aim of this study was to systematically review the profiles of the TA and <em>PAX9</em> variants and establish their genotype-phenotype correlation. Forty articles were eligible for 178 patients and 61 mutations (26 in frame and 32 null mutations). <em>PAX9</em> mutations predominantly affected molars, mostly the second molar, and the mandibular first premolar was the least affected. More missing teeth were found in the maxilla than the mandible, and with null mutations than in-frame mutations. The number of missing teeth was correlated with the locations of the in-frame mutations with the C-terminus mutations demonstrating the fewest missing teeth. The null mutation location did not influence the number of missing teeth. Null mutations in all locations predominantly affected molars. For the in-frame mutations, a missing second molar was commonly associated with mutations in the highly conserved paired DNA-binding domain, particularly the linking peptide (100% prevalence). In contrast, C-terminus mutations were rarely associated with missing second molars and anterior teeth, but were commonly related to an absent second premolar. These finding indicate that the mutation type and position contribute to different degrees of loss of <em>PAX9</em> function that further differentially influences the manifestations of TA. This study provides novel information on the correlation of the <em>PAX9</em> genotype-phenotype, aiding in the genetic counseling for TA.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 129-137"},"PeriodicalIF":6.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49739912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A review in titanium-zirconium binary alloy for use in dental implants: Is there an ideal Ti-Zr composing ratio?","authors":"Qian Zhao, Takeshi Ueno, Noriyuki Wakabayashi","doi":"10.1016/j.jdsr.2023.01.002","DOIUrl":"10.1016/j.jdsr.2023.01.002","url":null,"abstract":"<div><p>Binary titanium-zirconium alloys have been studied as promising alternatives for Ti implants. The commercial Ti-15Zr alloy (Roxolid, Straumann) has been the major subject of numerous binary Ti-Zr alloys-related studies and has gained wide recognition in laboratory studies and clinical practices. However, binary Ti-Zr alloys of other composition ratios are still being investigated by researchers. This review aims to provide information on the potential of binary Ti-Zr alloys other than Ti-15Zr as implant materials in terms of mechanical strengths, chemical or electrochemical corrosion resistance capabilities, and biological performances. In addition, in this review, the Ti-15Zr alloy is discussed only when compared with other binary Ti-Zr alloys. From the included 26 studies, it is confirmed that the mechanical, chemical, electrochemical, and biological properties of Ti-Zr alloys are related to the Ti and Zr composition ratio in the alloy, phase, manufacturing process, and surface treatment. Among the studied alloys, α-or α′ phase-Ti-5 wt, 45 wt/30at, and 50 wt. %Zr exhibited relatively more promising results for further investigation. More research is necessary to evaluate the potential for future use of these materials for implants.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 28-37"},"PeriodicalIF":6.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10765009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Moritz Müller , Christine Schmucker , Johannes Naumann , Nadine Schlueter , Roman Huber , Ann-Kathrin Lederer
{"title":"Acupuncture in management of acute dental pain – A systematic review and meta-analysis","authors":"Moritz Müller , Christine Schmucker , Johannes Naumann , Nadine Schlueter , Roman Huber , Ann-Kathrin Lederer","doi":"10.1016/j.jdsr.2023.02.005","DOIUrl":"10.1016/j.jdsr.2023.02.005","url":null,"abstract":"<div><p>Acute dental pain is a common issue leading to dental consultation. Besides causal therapy, patients are treated with acupuncture, but efficacy in acute dental pain is still not clarified. We aimed to evaluate results of recent research to estimate the efficacy of acupuncture compared to pain-relieving approaches in treatment of acute dental pain. A systematic review of controlled trials being published between database inception and 2020 were conducted to evaluate the efficacy of acupuncture (alone or as complementary therapy) compared to local anesthesia or conventional analgesic medications in acute dental pain (intraoperatively and postoperatively) and to clarify whether acupuncture reduces the use of postoperative analgesic medications. Of 1672 publications, 23 publications met the inclusion criteria. From these, 11 randomized controlled trials (n = 668) reported on the efficacy of acupuncture on postoperative acute dental pain. Patients, who received acupuncture, showed lower pain scores postoperatively compared to sham acupuncture (Relative Risk −0.77, 95% Confidence interval −1.52 to −0.03). Overall, the results suggest a potential role of acupuncture in improving acute dental pain intraoperatively and postoperatively as well as improving the efficacy of local anesthesia, but the results are limited due to methodological shortcomings emphasizing the necessity for future high-quality research.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 114-128"},"PeriodicalIF":6.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/3b/main.PMC10025006.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9159675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naotaka Kishimoto , Takuro Sanuki , Younan Liu , Simon D. Tran , Kenji Seo
{"title":"Simulation training for medical emergencies of dental patients: A review of the dental literature","authors":"Naotaka Kishimoto , Takuro Sanuki , Younan Liu , Simon D. Tran , Kenji Seo","doi":"10.1016/j.jdsr.2023.02.004","DOIUrl":"10.1016/j.jdsr.2023.02.004","url":null,"abstract":"<div><p>In recent years, due to the aging of the population, the number of dental patients with comorbidities such as hypertension and diabetes has increased. Although it has been reported that these patients are increasingly developing medical emergencies during their dental treatments, many dental providers still do not possess the skills to manage medical emergencies appropriately. Simulation training is essential to improve this situation however, there is no report describing how to conduct an effective simulation in detail for dental office medical emergencies. The purpose of this review is to provide information on simulations that is effective and practical. The authors will highlight the key characteristics for providing effective simulation trainings, such as the selection of simulators, simulation locations, instructors, debriefings, methods for evaluating educational effectiveness, and the use of telesimulation as a method for simulation training due to the global COVID-19 pandemic. In addition, this review provides recommendations on tailoring an ideal simulation training course for those who wish to create one. The authors hope that this review will promote the spread of effective simulation training and in turn, contribute to improving the medical safety of dental patients.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 104-113"},"PeriodicalIF":6.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9499412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapeutic potential for KCC2-targeted neurological diseases","authors":"Kazuo Tomita , Yoshikazu Kuwahara , Kento Igarashi , Junichi Kitanaka , Nobue Kitanaka , Yuko Takashi , Koh-ichi Tanaka , Mehryar Habibi Roudkenar , Amaneh Mohammadi Roushandeh , Akihiro Kurimasa , Yoshihiro Nishitani , Tomoaki Sato","doi":"10.1016/j.jdsr.2023.11.001","DOIUrl":"https://doi.org/10.1016/j.jdsr.2023.11.001","url":null,"abstract":"<div><p>Patients with neurological diseases, such as schizophrenia, tend to show low K<sup>+</sup>-Cl<sup>-</sup> co-transporter 2 (KCC2) levels in the brain. The cause of these diseases has been associated with stress and neuroinflammation. However, since the pathogenesis of these diseases is not yet fully investigated, drug therapy is still limited to symptomatic therapy. Targeting KCC2, which is mainly expressed in the brain, seems to be an appropriate approach in the treatment of these diseases. In this review, we aimed to discuss about stress and inflammation, KCC2 and Gamma-aminobutyric acid (GABA) function, diseases which decrease the KCC2 levels in the brain, factors that regulate KCC2 activity, and the possibility to overcome neuronal dysfunction targeting KCC2. We also aimed to discuss the relationships between neurological diseases and LPS caused by <em>Porphyromonas gingivalis</em> (<em>P. g</em>), which is a type of oral bacterium. Clinical trials on oxytocin, sirtuin 1 (SIRT1) activator, and transient receptor potential cation channel subfamily V Member 1 activator have been conducted to develop effective treatment methods. We believe that KCC2 modulators that regulate mitochondria, such as oxytocin, glycogen synthase kinase 3β (GSK3β), and SIRT1, can be potential targets for neurological diseases.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 431-438"},"PeriodicalIF":6.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761623000376/pdfft?md5=addaca35aa3b955def1a22b2e7ada8ef&pid=1-s2.0-S1882761623000376-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92026379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuki Matsushita , Azumi Noguchi , Wanida Ono , Noriaki Ono
{"title":"Multi-omics analysis in developmental bone biology","authors":"Yuki Matsushita , Azumi Noguchi , Wanida Ono , Noriaki Ono","doi":"10.1016/j.jdsr.2023.10.006","DOIUrl":"https://doi.org/10.1016/j.jdsr.2023.10.006","url":null,"abstract":"<div><p>Single-cell omics and multi-omics have revolutionized our understanding of molecular and cellular biological processes at a single-cell level. In bone biology, the combination of single-cell RNA-sequencing analyses and in vivo lineage-tracing approaches has successfully identified multi-cellular diversity and dynamics of skeletal cells. This established a new concept that bone growth and regeneration are regulated by concerted actions of multiple types of skeletal stem cells, which reside in spatiotemporally distinct niches. One important subtype is endosteal stem cells that are particularly abundant in young bone marrow. The discovery of this new skeletal stem cell type has been facilitated by single-cell multi-omics, which simultaneously measures gene expression and chromatin accessibility. Using single-cell omics, it is now possible to computationally predict the immediate future state of individual cells and their differentiation potential. In vivo validation using histological approaches is the key to interpret the computational prediction. The emerging spatial omics, such as spatial transcriptomics and epigenomics, have major advantage in retaining the location of individual cells within highly complex tissue architecture. Spatial omics can be integrated with other omics to further obtain in-depth insights. Single-cell multi-omics are now becoming an essential tool to unravel intricate multicellular dynamics and intercellular interactions of skeletal cells.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 412-420"},"PeriodicalIF":6.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761623000364/pdfft?md5=06ad12e4cb7a467a90807876697dc169&pid=1-s2.0-S1882761623000364-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92026380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immune dysregulation in immunoglobulin G4–related disease","authors":"Takashi Maehara , Risako Koga , Seiji Nakamura","doi":"10.1016/j.jdsr.2022.12.002","DOIUrl":"10.1016/j.jdsr.2022.12.002","url":null,"abstract":"<div><p>(IgG4-RD) is an immune-mediated fibrotic disorder characterized by severe resolution of inflammation and dysregulation of wound healing. IgG4-RD has been considered a unique disease since 2003, and significant progress has been achieved in the understanding of its essential features. The central role of B cells in IgG4-RD has been demonstrated by the robust clinical responsiveness of IgG4-RD to B cell depletion and the identification of multiple self-antigens that promote B cell expansion. Studies have increasingly revealed critical roles of these B cells and T cells in the pathogenesis of IgG4-RD, and we and other authors further identified CD4<sup>+</sup> cytotoxic T lymphocytes as the main tissue-infiltrating CD4<sup>+</sup> T cell subset in IgG4-RD tissues. Additionally, T follicular helper cell subsets that play a role in IgG4 isotype switching have been identified. In this review, we discuss research on IgG4-RD and the roles of B cell and T cell subsets, as well as the functions of CD4<sup>+</sup> cytotoxic T cells in IgG4-RD pathogenesis. We highlight our findings from ongoing research using single-cell analysis of infiltrating CD4<sup>+</sup> cytotoxic T cells, CD4<sup>+</sup> follicular helper T cells, and infiltrating B cells in IgG4-RD and propose a model for the pathogenesis of IgG4-RD.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 1-7"},"PeriodicalIF":6.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9100283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deep learning and artificial intelligence in dental diagnostic imaging","authors":"Akitoshi Katsumata","doi":"10.1016/j.jdsr.2023.09.004","DOIUrl":"10.1016/j.jdsr.2023.09.004","url":null,"abstract":"<div><p>The application of artificial intelligence (AI) based on deep learning in dental diagnostic imaging is increasing. Several popular deep learning tasks have been applied to dental diagnostic images.</p><p>Classification tasks are used to classify images with and without positive abnormal findings or to evaluate the progress of a lesion based on imaging findings. Region (object) detection and segmentation tasks have been used for tooth identification in panoramic radiographs. This technique is useful for automatically creating a patient's dental chart. Deep learning methods can also be used for detecting and evaluating anatomical structures of interest from images. Furthermore, generative AI based on natural language processing can automatically create written reports from the findings of diagnostic imaging.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"59 ","pages":"Pages 329-333"},"PeriodicalIF":6.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}