Periodontitis and periodontopathic bacteria as risk factors for rheumatoid arthritis: A review of the last 10 years

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review Pub Date : 2023-08-26 DOI:10.1016/j.jdsr.2023.08.002

Tetsuo Kobayashi , Peter Mark Bartold

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Abstract

Rheumatoid arthritis (RA) is characterized by chronic inflammatory destruction of joint tissue and is caused by an abnormal autoimmune response triggered by interactions between genetics, environmental factors, and epigenetic and posttranslational modifications. RA has been suggested to be interrelated with periodontitis, a serious form or stage of chronic inflammatory periodontal disease associated with periodontopathic bacterial infections, genetic predisposition, environmental factors, and epigenetic influences. Over the last decade, a number of animal and clinical studies have been conducted to assess whether or not periodontitis and associated periodontopathic bacteria constitute risk factors for RA. The present review introduces recent accumulating evidence to support the associations of periodontitis and periodontopathic bacteria with the risk of RA or the outcome of RA pharmacological treatment with disease-modifying antirheumatic drugs. In addition, the results from intervention studies have suggested an improvement in RA clinical parameters after nonsurgical periodontal treatment. Furthermore, the potential causal mechanisms underlying the link between periodontitis and periodontopathic bacteria and RA are summarized.

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牙周炎和牙周病细菌是类风湿关节炎的危险因素:近10年的综述

类风湿性关节炎（RA）的特征是关节组织的慢性炎症破坏，由遗传、环境因素以及表观遗传和翻译后修饰之间的相互作用引发的异常自身免疫反应引起。RA被认为与牙周炎有关，牙周炎是一种严重的慢性炎症性牙周病，与牙周病性细菌感染、遗传易感性、环境因素和表观遗传学影响有关。在过去的十年里，已经进行了大量的动物和临床研究来评估牙周炎和相关的牙周病细菌是否构成RA的危险因素。本综述介绍了最近积累的证据，支持牙周炎和牙周病细菌与RA风险或用疾病改良抗风湿药物进行RA药物治疗的结果之间的关系。此外，干预研究的结果表明，非手术牙周治疗后RA的临床参数有所改善。此外，总结了牙周炎与牙周病细菌和RA之间联系的潜在因果机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.