Genetic overlap between temporomandibular disorders and primary headaches: A systematic review

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review Pub Date : 2022-11-01 DOI:10.1016/j.jdsr.2022.02.002

Diogo Cruz , Francisca Monteiro , Maria Paço , Manuel Vaz-Silva , Carolina Lemos , Miguel Alves-Ferreira , Teresa Pinho

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引用次数: 7

Abstract

Primary headache disorders (PHD), specifically migraine, are strongly associated with temporomandibular disorders (TMD), sharing some patterns of orofacial pain. Both disorders have significant genetic contributions already studied. PRISMA guidelines were followed to conduct this systematic review, which comprehensively summarize and discuss the genetic overlap between TMD and PHD to aid future research in potential therapy targets. This review included eight original articles published between 2015 and 2020, written in English and related to either TMD and/or PHD. The genes simultaneously assessed in PHD and TMD studies were COMT, MTHFR, and ESR1. COMT was proved to play a critical role in TMD pathogenesis, as all studies have concluded about its impact on the occurrence of the disease, although no association with PHD was found. No proof on the impact of MTHFR gene regulation on either TMD or PHD was found. The most robust results are concerning the ESR1 gene, which is present in the genetic profile of both clinical conditions. This novel systematic review highlights not only the need for a clear understanding of the role of ESR1 and COMT genes in pain pathogenesis, but it also evaluates their potential as a promising therapeutic target to treat both pathologies.

查看原文本刊更多论文

颞下颌疾病和原发性头痛之间的遗传重叠:一项系统综述

原发性头痛疾病(PHD)，特别是偏头痛，与颞下颌疾病(TMD)密切相关，共享一些口腔面部疼痛模式。这两种疾病都有重要的遗传因素，已经得到了研究。本文遵循PRISMA指南进行系统综述，全面总结和讨论TMD与PHD之间的基因重叠，以帮助未来潜在治疗靶点的研究。本综述纳入了2015年至2020年间发表的8篇原创文章，均为英文，与TMD和/或PHD相关。在PHD和TMD研究中同时评估的基因是COMT、MTHFR和ESR1。COMT被证明在TMD发病机制中起着关键作用，所有的研究都得出了它对疾病发生的影响，尽管没有发现与PHD的关联。没有证据表明MTHFR基因调控对TMD或PHD有影响。最可靠的结果与ESR1基因有关，该基因存在于两种临床疾病的遗传谱中。这篇新颖的系统综述不仅强调了对ESR1和COMT基因在疼痛发病机制中的作用的清晰认识，而且还评估了它们作为治疗这两种疾病的有希望的治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.