{"title":"用于早期检测口腔鳞状细胞癌（OSCC）和头颈部鳞状细胞癌（HNSCC）的唾液生物标志物：系统综述和网络荟萃分析","authors":"Shahnawaz Khijmatgar , Josh Yong , Nicole Rübsamen , Felice Lorusso , Pooja Rai , Niccolo Cenzato , Franscesca Gaffuri , Massimo Del Fabbro , Gianluca Martino Tartaglia","doi":"10.1016/j.jdsr.2023.10.003","DOIUrl":null,"url":null,"abstract":"<div><p>Oral cancer became a very common condition. WHO estimates that there are 4 cases of lip and oral cavity cancer for every 100,000 people worldwide. The early diagnosis of cancers is currently a top focus in the health sector. Recent systematic reviews and meta-analyses have identified promising biomarkers for early detection in several original research investigations. However, it is still unclear the quality of these evidence and which biomarker performs the best in terms of early detection. Therefore, the objective was, to map the methodological and reporting quality of available oral squamous cell carcinoma (OSCC) or head/neck squamous cell carcinoma (HNSCC) systematic reviews and meta-analysis. Secondly, to evaluate diagnostic accuracy of salivary biomarkers for common craniofacial cancers and to compare the diagnostic value of different salivary biomarkers.</p><p>PubMed, Scopus, Web of Science, Embase and Cochrane Library electronic databases were used to map the methodological and reporting quality of the systematic reviews and meta-analysis conducted on the HNSCC, OSCC using the AMSTAR-2 checklist. The inclusion criteria were systematic reviews and meta-analysis published in the topic of HNSCC and OSCC biomarkers. Exclusion criteria were no animal studies; original primary studies, due to limitation of competency in other languages articles with language other than English were excluded. The sensitivity and specificity were calculated for salivary biomarkers and ranked according to network meta-analysis principles.</p><p>A total of N = 5893 patients were included from four meta-analysis studies. All together, these included n = 37 primary studies. n = 94 biomarkers were pooled from these four meta-analyses and categorised into the stages at which they were detected (I-IV). In OSCC, Chemerin and MMP-9 displayed the highest sensitivity, registering 0.94 (95% CI 0.78, 1.00) and a balanced accuracy of 0.93. Phytosphingosine closely followed, with a sensitivity of 0.91 (95% CI 0.68, 0.99) and a balanced accuracy of 0.87.</p><p>For HNSCC, the top three biomarkers are Actin, IL-1β Singleplex, and IL-8 ELISA. Actin leads with a sensitivity of 0.91 (95% CI 0.68–0.99), a specificity of 0.67, and an overall accuracy of 0.79. Subsequently, IL-1β Singleplex exhibits a sensitivity of 0.62 (95% CI 0.30–0.88), a specificity of 0.89, and an accuracy of 0.75, followed by IL-8 ELISA with a sensitivity of 0.81 (95% CI 0.54–0.97), a specificity of 0.59, and an accuracy of 0.70.</p><p>In conclusion, there was highest sensitivity for MMP-9 and chemerin salivary biomarkers. There is need of further more studies to identify biomarkers for HNSCC and OSCC.</p></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"60 ","pages":"Pages 32-39"},"PeriodicalIF":5.7000,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1882761623000340/pdfft?md5=bb0f989a8928bebb430478278099a117&pid=1-s2.0-S1882761623000340-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Salivary biomarkers for early detection of oral squamous cell carcinoma (OSCC) and head/neck squamous cell carcinoma (HNSCC): A systematic review and network meta-analysis\",\"authors\":\"Shahnawaz Khijmatgar , Josh Yong , Nicole Rübsamen , Felice Lorusso , Pooja Rai , Niccolo Cenzato , Franscesca Gaffuri , Massimo Del Fabbro , Gianluca Martino Tartaglia\",\"doi\":\"10.1016/j.jdsr.2023.10.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Oral cancer became a very common condition. WHO estimates that there are 4 cases of lip and oral cavity cancer for every 100,000 people worldwide. The early diagnosis of cancers is currently a top focus in the health sector. Recent systematic reviews and meta-analyses have identified promising biomarkers for early detection in several original research investigations. However, it is still unclear the quality of these evidence and which biomarker performs the best in terms of early detection. Therefore, the objective was, to map the methodological and reporting quality of available oral squamous cell carcinoma (OSCC) or head/neck squamous cell carcinoma (HNSCC) systematic reviews and meta-analysis. Secondly, to evaluate diagnostic accuracy of salivary biomarkers for common craniofacial cancers and to compare the diagnostic value of different salivary biomarkers.</p><p>PubMed, Scopus, Web of Science, Embase and Cochrane Library electronic databases were used to map the methodological and reporting quality of the systematic reviews and meta-analysis conducted on the HNSCC, OSCC using the AMSTAR-2 checklist. The inclusion criteria were systematic reviews and meta-analysis published in the topic of HNSCC and OSCC biomarkers. Exclusion criteria were no animal studies; original primary studies, due to limitation of competency in other languages articles with language other than English were excluded. The sensitivity and specificity were calculated for salivary biomarkers and ranked according to network meta-analysis principles.</p><p>A total of N = 5893 patients were included from four meta-analysis studies. All together, these included n = 37 primary studies. n = 94 biomarkers were pooled from these four meta-analyses and categorised into the stages at which they were detected (I-IV). In OSCC, Chemerin and MMP-9 displayed the highest sensitivity, registering 0.94 (95% CI 0.78, 1.00) and a balanced accuracy of 0.93. Phytosphingosine closely followed, with a sensitivity of 0.91 (95% CI 0.68, 0.99) and a balanced accuracy of 0.87.</p><p>For HNSCC, the top three biomarkers are Actin, IL-1β Singleplex, and IL-8 ELISA. Actin leads with a sensitivity of 0.91 (95% CI 0.68–0.99), a specificity of 0.67, and an overall accuracy of 0.79. Subsequently, IL-1β Singleplex exhibits a sensitivity of 0.62 (95% CI 0.30–0.88), a specificity of 0.89, and an accuracy of 0.75, followed by IL-8 ELISA with a sensitivity of 0.81 (95% CI 0.54–0.97), a specificity of 0.59, and an accuracy of 0.70.</p><p>In conclusion, there was highest sensitivity for MMP-9 and chemerin salivary biomarkers. 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引用次数: 0
摘要
口腔癌已成为一种非常常见的疾病。世卫组织估计，全世界每 10 万人中就有 4 例唇癌和口腔癌患者。癌症的早期诊断是目前卫生部门最关注的问题。最近的系统综述和荟萃分析在几项原始研究调查中发现了有希望用于早期检测的生物标志物。然而，这些证据的质量以及哪种生物标志物在早期检测方面表现最佳仍不清楚。因此，我们的目标是对现有的口腔鳞状细胞癌（OSCC）或头颈部鳞状细胞癌（HNSCC）系统综述和荟萃分析的方法和报告质量进行摸底。PubMed、Scopus、Web of Science、Embase 和 Cochrane Library 电子数据库被用来使用 AMSTAR-2 核对表对有关 HNSCC 和 OSCC 的系统综述和荟萃分析的方法学和报告质量进行绘图。纳入标准是以 HNSCC 和 OSCC 生物标志物为主题发表的系统综述和荟萃分析。排除标准为无动物研究；原始的主要研究；由于其他语言能力的限制，除英语外的其他语言文章均被排除在外。计算唾液生物标志物的敏感性和特异性，并根据网络荟萃分析原则进行排序。从这四项荟萃分析中汇总了94种生物标志物，并将其按检测阶段（I-IV）进行分类。在 OSCC 中，Chemerin 和 MMP-9 的灵敏度最高，分别为 0.94（95% CI 0.78，1.00）和 0.93 的平衡准确度。植物鞘磷脂紧随其后，灵敏度为 0.91（95% CI 0.68，0.99），平衡准确度为 0.87。对于 HNSCC，前三位生物标记物是肌动蛋白、IL-1β Singleplex 和 IL-8 ELISA。其中，Actin 的灵敏度为 0.91（95% CI 0.68-0.99），特异性为 0.67，总体准确度为 0.79。随后，IL-1β Singleplex 的灵敏度为 0.62（95% CI 0.30-0.88），特异性为 0.89，准确性为 0.75，其次是 IL-8 ELISA，灵敏度为 0.81（95% CI 0.54-0.97），特异性为 0.59，准确性为 0.70。结论是，MMP-9和螯合素唾液生物标志物的灵敏度最高，需要进一步研究以确定HNSCC和OSCC的生物标志物。
Salivary biomarkers for early detection of oral squamous cell carcinoma (OSCC) and head/neck squamous cell carcinoma (HNSCC): A systematic review and network meta-analysis
Oral cancer became a very common condition. WHO estimates that there are 4 cases of lip and oral cavity cancer for every 100,000 people worldwide. The early diagnosis of cancers is currently a top focus in the health sector. Recent systematic reviews and meta-analyses have identified promising biomarkers for early detection in several original research investigations. However, it is still unclear the quality of these evidence and which biomarker performs the best in terms of early detection. Therefore, the objective was, to map the methodological and reporting quality of available oral squamous cell carcinoma (OSCC) or head/neck squamous cell carcinoma (HNSCC) systematic reviews and meta-analysis. Secondly, to evaluate diagnostic accuracy of salivary biomarkers for common craniofacial cancers and to compare the diagnostic value of different salivary biomarkers.
PubMed, Scopus, Web of Science, Embase and Cochrane Library electronic databases were used to map the methodological and reporting quality of the systematic reviews and meta-analysis conducted on the HNSCC, OSCC using the AMSTAR-2 checklist. The inclusion criteria were systematic reviews and meta-analysis published in the topic of HNSCC and OSCC biomarkers. Exclusion criteria were no animal studies; original primary studies, due to limitation of competency in other languages articles with language other than English were excluded. The sensitivity and specificity were calculated for salivary biomarkers and ranked according to network meta-analysis principles.
A total of N = 5893 patients were included from four meta-analysis studies. All together, these included n = 37 primary studies. n = 94 biomarkers were pooled from these four meta-analyses and categorised into the stages at which they were detected (I-IV). In OSCC, Chemerin and MMP-9 displayed the highest sensitivity, registering 0.94 (95% CI 0.78, 1.00) and a balanced accuracy of 0.93. Phytosphingosine closely followed, with a sensitivity of 0.91 (95% CI 0.68, 0.99) and a balanced accuracy of 0.87.
For HNSCC, the top three biomarkers are Actin, IL-1β Singleplex, and IL-8 ELISA. Actin leads with a sensitivity of 0.91 (95% CI 0.68–0.99), a specificity of 0.67, and an overall accuracy of 0.79. Subsequently, IL-1β Singleplex exhibits a sensitivity of 0.62 (95% CI 0.30–0.88), a specificity of 0.89, and an accuracy of 0.75, followed by IL-8 ELISA with a sensitivity of 0.81 (95% CI 0.54–0.97), a specificity of 0.59, and an accuracy of 0.70.
In conclusion, there was highest sensitivity for MMP-9 and chemerin salivary biomarkers. There is need of further more studies to identify biomarkers for HNSCC and OSCC.
期刊介绍：
The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.
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