The bidirectional association between diabetes and periodontitis, from basic to clinical

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review Pub Date : 2023-12-12 DOI:10.1016/j.jdsr.2023.12.002

Takanori Shinjo, Fusanori Nishimura

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引用次数: 0

Abstract

The prevalence and severity of periodontitis are increased and advanced in diabetes. Severe periodontitis elicits adverse effects on diabetes by impairing insulin actions due to systemic microinflammation. Recent studies unveil the emerging findings and molecular basis of the bidirectional relationship between periodontitis and diabetes. In addition to conventional mechanisms such as hyperglycemia, hyperlipidemia, and chronic inflammation, deficient insulin action may play a pathogenic role in the progression of periodontitis under diabetes. Epidemiologically, from the viewpoint of the adverse effect of periodontitis on diabetes, recent studies have suggested that Asians including Japanese and Asian Americans with diabetes and mild obesity (BMI <25 kg/m2) should pay more attention to their increased risk for cardiovascular diseases. In this review, we summarize recent findings on the effect of diabetes on periodontitis from the viewpoint of abnormalities in metabolism and insulin resistance with novel mechanisms, and the influence of periodontitis on diabetes mainly focused on micro-inflammation related to mature adipose tissue and discuss future perspectives about novel approaches to interrupt the adverse interrelationship.

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从基础到临床，糖尿病与牙周炎之间的双向联系

糖尿病患者牙周炎的发病率和严重程度都会增加和加深。严重的牙周炎会因全身微炎症而影响胰岛素的作用，从而对糖尿病产生不利影响。最近的研究揭示了牙周炎与糖尿病之间双向关系的新发现和分子基础。除了高血糖、高脂血症和慢性炎症等传统机制外，胰岛素作用不足也可能在糖尿病牙周炎的发展过程中起到致病作用。从流行病学角度来看，从牙周炎对糖尿病的不良影响的角度来看，最近的研究表明，包括日本人和亚裔美国人在内的患有糖尿病和轻度肥胖（BMI <25 kg/m2）的亚洲人应更多地关注其心血管疾病风险的增加。在这篇综述中，我们从新陈代谢异常和具有新机制的胰岛素抵抗的角度，总结了糖尿病对牙周炎影响的最新研究结果，以及牙周炎对糖尿病的影响主要集中在与成熟脂肪组织相关的微炎症方面，并探讨了阻断这种不良相互关系的新方法的未来前景。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.