Journal of Hematopathology最新文献_第6页

Correction to: Another cause of pseudobasophilia: flower cells. 更正：假两性畸形的另一个原因：花细胞。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 DOI: 10.1007/s12308-023-00549-4

Joaquín Jerez, Francisca Sánchez, Francisco Flores, Lissette Guajardo, José Luis Briones, Carolina Selman

引用次数: 0

Another cause of pseudobasophilia: flower cells. 假性嗜碱性细胞增多症的另一个原因：花细胞。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 Epub Date: 2023-05-15 DOI: 10.1007/s12308-023-00548-5

Joaquín Jerez, Francisca Sánchez, Francisco Flores, Lissette Guajardo, José Luis Briones, Carolina Selman

引用次数: 0

Initial and follow-up evaluations on cerebrospinal fluid involvement by hematologic malignancy. 血液恶性肿瘤累及脑脊液的初步评估和随访评估。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 Epub Date: 2023-06-16 DOI: 10.1007/s12308-023-00550-x

Nouran Momen, Joseph Tario, Kai Fu, You-Wen Qian

{"title":"Initial and follow-up evaluations on cerebrospinal fluid involvement by hematologic malignancy.","authors":"Nouran Momen, Joseph Tario, Kai Fu, You-Wen Qian","doi":"10.1007/s12308-023-00550-x","DOIUrl":"10.1007/s12308-023-00550-x","url":null,"abstract":"Central nervous system (CNS) involvement is a serious complication in hematologic malignancy, and early detection and management of CNS involvement in these cases significantly impact the prognosis. Currently, there is no consensus on the use of multiparametric flow cytometry (MFC) and conventional cytology (CC) testing for initial and follow-up cerebrospinal fluid (CSF) specimens to diagnose CNS involvement by hematologic malignancy. In our institution, after initial MFC and CC, two subsequent negative MFCs are required before discontinuing MFC. The aim of this study is to evaluate the outcome of this approach. CSF cytology and MFC reports were retrieved from Laboratory Information System, and data was reviewed. Between January 2020 and December 2021, 1789 CSF samples from 280 patients were submitted for CSF analysis. For those 517 CSF samples tested by both MFC and CC, 97 cases tested positive by both MFC and CC with 95% concordance. Eighteen cases were MFC + /CC - and 7 were MFC - /CC + . Thirty-six cases had initially positive MFCs followed by more than one MFC evaluation. Among those 36 cases, 22 cases (61.1%) converted to negative after the second follow-up sample, 9 cases (25%) were continuously positive for at least three samples, and 5 cases (13.9%) exhibited negative to positive conversion. Compared to negative CSF cases, positive CSFs had higher total nucleated cell count and higher total protein levels while red blood cells, glucose, and lactate dehydrogenase levels remained at comparable levels. The concordance between MFC and CC was excellent. The high incidence of positive MFCs on two or more follow-up samples and the high frequency of negative MFC to positive conversion indicate the necessity of repeated negative MFCs before discontinuing MFC. The fact that more than half of the positive cases converted to negative after the second CSF specimen and most follow-up positive cases can be detected by CC alone suggests it is adequate to use CC alone for follow-up CSF study after two consecutive negative MFCs.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72470256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Quadruple-hit" primary testicular diffuse large B-cell lymphoma with MYD88 L265P mutation, IGH::MYC, and IRF4- and BCL6-rearrangements. 原发性睾丸弥漫大B细胞淋巴瘤 "四重打击"：MYD88 L265P突变、IGH::MYC以及IRF4和BCL6重排。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 Epub Date: 2023-08-04 DOI: 10.1007/s12308-023-00556-5

Frido K Bruehl, Rhett P Ketterling, Lisa M Rimsza, Edward F Santos, Ellen D McPhail

引用次数: 0

Research use only and cell population data items obtained from the Beckman Coulter DxH800 automated hematology analyzer are useful in discriminating MDS patients from those with cytopenia without MDS. 从贝克曼库尔特 DxH800 全自动血液分析仪获得的细胞群数据项仅供研究使用，有助于区分 MDS 患者和无 MDS 的细胞减少症患者。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 Epub Date: 2023-07-01 DOI: 10.1007/s12308-023-00552-9

Sang Hyuk Park, Hyun-Ki Kim, Joseph Jeong, Seon-Ho Lee, Yoo Jin Lee, Yoo Jin Kim, Jae-Cheol Jo, Ji-Hun Lim

{"title":"Research use only and cell population data items obtained from the Beckman Coulter DxH800 automated hematology analyzer are useful in discriminating MDS patients from those with cytopenia without MDS.","authors":"Sang Hyuk Park, Hyun-Ki Kim, Joseph Jeong, Seon-Ho Lee, Yoo Jin Lee, Yoo Jin Kim, Jae-Cheol Jo, Ji-Hun Lim","doi":"10.1007/s12308-023-00552-9","DOIUrl":"10.1007/s12308-023-00552-9","url":null,"abstract":"We investigated the performance of research use only/cell population data (RUO/CPD) items obtained from the Beckman Coulter DxH800 automated hematologic analyzer in discriminating MDS patients from cytopenic patients without MDS.Total of 14 routine CBC, 18 research use only (RUO) items, and 70 CPD items were obtained retrospectively at diagnosis. The results were then compared between 94 MDS patients and 100 cytopenic patients without MDS. In items with statistically significant differences, receiver operating characteristic (ROC) analysis was performed and the results were compared.Four CBC/RUO items [red cell distribution width-standard deviation (RDW-SD), immature reticulocyte fraction (IRF), mean sphered cell volume (MSCV), high light scatter reticulocytes (HLR)], and two CPD items [mean volume of neutrophils (NE-V-Mean) and mean volume of early granulated cells (EGC-V-Mean)] showed area-under the curve (AUC) scores > 0.750. Notably, four RUO/CPD items (MSCV > 81.4/HLR > 0.15%/NE-V-Mean > 145/EGC-V-Mean > 156) showed high sensitivity (91.9%/93.6%/88.1%/90.2%, respectively) in discriminating MDS patients from cytopenic patients without MDS. With these six items, scores ≥ 4 (defined as ≥ 4 items exceeding cutoff values out of six items) showed AUC scores/sensitivity/specificity/accuracy (0.891/87.3%/79.0%/83.0%, respectively).Six CBC/RUO/CPD items showed satisfactory AUC scores of > 0.750, and four RUO/CPD items showed high sensitivity in discriminating MDS patients from cytopenic patients without MDS. Scoring system with six items showed high sensitivity, specificity, and accuracy with decision criteria of ≥ 4 scores. Therefore, DxH800 RUO/CPD items would be useful in discriminating MDS patients from cytopenic patients without MDS.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84501342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Initial and follow-up evaluations on cerebrospinal fluid involvement by hematologic malignancy. 更正：血液恶性肿瘤累及脑脊液的初始评估和随访评估。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 DOI: 10.1007/s12308-023-00553-8

Nouran Momen, Joseph Tario, Kai Fu, You-Wen Qian

引用次数: 0

Indolent T-lymphoblastic proliferation involving hepatocellular carcinoma-presentation in novel settings and comprehensive review of literature. 涉及肝细胞癌的懒惰T淋巴细胞增生--新情况下的表现及文献综述。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 Epub Date: 2023-07-16 DOI: 10.1007/s12308-023-00554-7

Alireza Ghezavati, Christine A Liang, Daniel Mais, Alia Nazarullah

{"title":"Indolent T-lymphoblastic proliferation involving hepatocellular carcinoma-presentation in novel settings and comprehensive review of literature.","authors":"Alireza Ghezavati, Christine A Liang, Daniel Mais, Alia Nazarullah","doi":"10.1007/s12308-023-00554-7","DOIUrl":"10.1007/s12308-023-00554-7","url":null,"abstract":"Indolent T-lymphoblastic proliferation (iT-LBP) is a rare, non-clonal, extrathymic lymphoid proliferation with an immature T cell phenotype, indolent clinical course, and excellent prognosis. Although their pathogenesis is unclear, they are reported to be associated with Castleman disease, follicular dendritic cell tumors/sarcomas, angioimmunoblastic T cell lymphoma, hepatocellular carcinoma (HCC), myasthenia gravis, and acinic cell carcinoma. There are around 51 reported cases of iT-LBP in the literature. Recognition and accurate diagnosis of this entity is critical as it shares morphologic and immunophenotypic features with an aggressive malignancy-acute T cell leukemia/lymphoma (T-ALL). IT-LBP in HCC post-liver transplant and in metastatic sites has not been reported in the literature. Two case reports of patients presenting with recurrent and metastatic HCC in post-liver transplant settings are described. A 50-year-old man with an end-stage liver disease with HCC underwent liver transplant. A year later, he developed pulmonary metastasis with associated iT-LBP. A 69-year-old man underwent liver transplant for end-stage liver disease and HCC. Eighteen months later, he developed recurrent HCC in the transplanted liver and omental metastasis; both sites showed HCC with iT-LBP. iT-LBP in both patients expressed TdT, CD3, and CD4 and lacked CD34 and clonal T cell receptor gene rearrangements. On retrospective review, the pre-transplant HCC specimens lacked iT-LBP. We present two cases of iT-LBP associated with HCC in novel settings-in post-liver transplant patients and in recurrent/metastatic sites of HCC. In addition, a comprehensive literature review of clinical, histological, and immunophenotypic characteristics of reported cases of iT-LBP is presented.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73787472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The lymph node in IgA vasculitis (Henöch-Schonlein purpura). IgA 血管炎（Henöch-Schonlein 紫癜）的淋巴结。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 Epub Date: 2023-05-26 DOI: 10.1007/s12308-023-00546-7

Samuel M Law, Jeffrey J Fadrowski, Ivo M B Francischetti

引用次数: 0

Iron-laden blasts in refractory acute myeloid leukemia. 难治性急性髓性白血病中的含铁囊泡

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 Epub Date: 2023-07-29 DOI: 10.1007/s12308-023-00555-6

Christopher Vossen, Roeun Im, Pedro Horna

引用次数: 0

Effect of changes in lymphocyte subsets at diagnosis in acute myeloid leukemia on prognosis: association with complete remission rates and relapse free survivals. 急性髓性白血病诊断时淋巴细胞亚群的变化对预后的影响：与完全缓解率和无复发存活率的关系。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-06-01 Epub Date: 2023-03-07 DOI: 10.1007/s12308-023-00536-9

Sang Hyuk Park, Mi-Hyun Bae, Chan-Jeoung Park, Young-Uk Cho, Seongsoo Jang, Je-Hwan Lee, Kyoo-Hyung Lee

{"title":"Effect of changes in lymphocyte subsets at diagnosis in acute myeloid leukemia on prognosis: association with complete remission rates and relapse free survivals.","authors":"Sang Hyuk Park, Mi-Hyun Bae, Chan-Jeoung Park, Young-Uk Cho, Seongsoo Jang, Je-Hwan Lee, Kyoo-Hyung Lee","doi":"10.1007/s12308-023-00536-9","DOIUrl":"10.1007/s12308-023-00536-9","url":null,"abstract":"We prospectively investigated whether the characteristics of lymphocyte subsets at diagnosis in acute myeloid leukemia (AML) patients are different from healthy controls and affect treatment outcomes. A total of 91 AML patients classified into 3 genetic risk subgroups (favorable/intermediate/poor) according to 2022 NCCN guidelines were enrolled. We measured lymphocyte subsets by flow cytometry with peripheral blood samples at diagnosis and compared results with healthy controls. Influences of lymphocyte subsets on complete remission (CR) rates and survivals were also evaluated. AML patients had significantly lower numbers and proportions of CD56dimCD16+ natural killer (NK) cells, central memory T cells, and regulatory T cells than healthy controls. Higher proportion of helper/inducer T cells, CD4+CD31+ naïve T cells, and decreased proportion of NK cells significantly increased CR rates in 65 non-promyelocytic leukemia patients (P = 0.034, 0.027, and 0.019, respectively), and it was also significant in multivariable analysis with age/risk adjusted (P = 0.014, 0.016, and 0.045, respectively). NK cells < 4.8% of lymphocytes demonstrated significantly shorter relapse free survivals (RFS) in both univariate and multivariate analyses with risk adjusted (P = 0.006 and 0.037, respectively). AML patients showed significant lower numbers of CD56dimCD16+ NK cells, central memory T cells, and regulatory T cells than healthy controls at diagnosis. Higher proportion of helper/inducer T cells and CD4+CD31+ naïve T cells and decreased proportion of NK cells at diagnosis were independent factor of increasing probability of CR, and proportion of NK cells < 4.8% at diagnosis had adverse impact in RFS.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77820186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0