Journal of Hematopathology最新文献_第5页

Two cases of mycosis fungoides with large cell transformation with KMT2A rearrangements 蕈样真菌病伴大细胞转化伴KMT2A重排2例

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-11-23 DOI: 10.1007/s12308-023-00567-2

Paul A. Wadsworth, Lauren Lawrence, Carlos J. Suarez, Atif Saleem, Michael S. Khodadoust, Youn H. Kim, Kerri E. Rieger, Sebastian Fernandez-Pol

{"title":"Two cases of mycosis fungoides with large cell transformation with KMT2A rearrangements","authors":"Paul A. Wadsworth, Lauren Lawrence, Carlos J. Suarez, Atif Saleem, Michael S. Khodadoust, Youn H. Kim, Kerri E. Rieger, Sebastian Fernandez-Pol","doi":"10.1007/s12308-023-00567-2","DOIUrl":"https://doi.org/10.1007/s12308-023-00567-2","url":null,"abstract":"Cutaneous T-cell lymphomas (CTCL) are a clinically and molecularly heterogeneous class of lymphomas of the skin-homing T cell, and their genetic profiles are not fully characterized. Previously, rearrangements of the Lysine Methyltransferase 2A (KMT2A) gene have been identified as driver mutations only in acute leukemias. KMT2A plays a role in epigenetic regulation, and cancers with such rearrangements are responsive to epigenetic therapy including hypomethylating agents. Here, we report two cases of CTCL with novel genetic profiles. KMT2A rearrangements were identified in two aggressive cases of mycosis fungoides with large cell transformation. A KMT2A::DSCAML1 gene rearrangement was seen in Case 1, while a KMT2A::MAPRE1 fusion was identified in Case 2. These cases demonstrate that KMT2A rearrangements can be found in primary CTCLs rather than solely acute leukemias, illustrating the importance of correlating molecular findings with clinical and histologic features in diagnosis. Additionally, this finding suggests that the subset of CTCLs driven by aberrancy of the KMT2A pathway may be responsive to therapy with hypomethylating agents or menin inhibitors, as seen in acute leukemias.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138533218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased IgG4+ plasma cells are common in excised lymph nodes from children and adolescents without IgG4-related disease 在没有IgG4相关疾病的儿童和青少年的切除淋巴结中，IgG4+浆细胞增加是常见的

4区医学

Journal of Hematopathology Pub Date : 2023-11-09 DOI: 10.1007/s12308-023-00565-4

Rachel M. Whitehair, Nadine S. Aguilera, Patcharin Pramoonjago, Jeffrey W. Craig

引用次数: 0

Oral follicular lymphoma: a clinicopathologic and molecular study 口腔滤泡性淋巴瘤:临床病理和分子研究

4区医学

Journal of Hematopathology Pub Date : 2023-11-02 DOI: 10.1007/s12308-023-00563-6

Lucas Lacerda de Souza, Cinthia Veronica Bardález López de Cáceres, Maria Sissa Pereira Sant’Ana, Paulo Victor Mendes Penafort, Bruno Augusto Benevenuto de Andrade, Hélder Antônio Rebelo Pontes, Wagner Henriques de Castro, Ricardo Alves Mesquita, José Cândido Caldeira Xavier-Júnior, Alan Roger Santos-Silva, Márcio Ajudarte Lopes, Ciro Dantas Soares, Liam Robinson, Willie F. P. van Heerden, Rommel Mario Rodríguez Burbano, Guilherme Rossi Assis-Mendonça, José Vassallo, Silvia Ferreira de Sousa, Pablo Agustin Vargas, Felipe Paiva Fonseca

引用次数: 0

B-lymphoblastic leukemia with transient spontaneous remission in the setting of severe group A streptococcus infection 严重A组链球菌感染的b淋巴细胞白血病短暂自发缓解

4区医学

Journal of Hematopathology Pub Date : 2023-10-14 DOI: 10.1007/s12308-023-00564-5

Aubre Gilbert, Jonathan Tan, Sruti Nadimpalli, Ruzan Orkusyan, Zoila Isabel Fernandez, Jean Oak, Sebastian Fernandez-Pol

引用次数: 0

Indolent B-cell lymphoma with t(14;19) investigated from a molecular perspective 从分子角度研究惰性b细胞淋巴瘤伴t(14;19)

4区医学

Journal of Hematopathology Pub Date : 2023-10-13 DOI: 10.1007/s12308-023-00562-7

Jeremiah X. Karrs, Shivaprasad H. Sathyanarayana, Xinjie Xu, Donald C. Green, Wahab A. Kahn, Eric Y. Loo, Prabhjot Kaur

引用次数: 0

Lupus erythematosus cells in a bone marrow aspirate 骨髓抽吸中的红斑狼疮细胞

4区医学

Journal of Hematopathology Pub Date : 2023-10-02 DOI: 10.1007/s12308-023-00561-8

Jingjing Zhang, Brent Tan, Sebastian Fernandez-Pol

引用次数: 0

Chronic myeloid leukaemia (CML) presenting in B-lymphoblastic crisis: a diagnostic challenge 慢性髓性白血病(CML)表现为b淋巴细胞危象:一个诊断挑战

4区医学

Journal of Hematopathology Pub Date : 2023-09-11 DOI: 10.1007/s12308-023-00560-9

Ke Xu, Elisabeth Nacheva

引用次数: 0

Disseminated Talaromyces marneffei infection in a child with HIV infection. 一名感染艾滋病毒的儿童感染了马内菲氏塔拉罗米菌（Talaromyces marneffei）。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 Epub Date: 2023-06-15 DOI: 10.1007/s12308-023-00551-w

Fang Long, Ting Li, Yun Zhang, Xiaopeng Gao, Xingqin Huang

引用次数: 0

Monomorphic epitheliotropic intestinal T-cell lymphoma involving the central nervous system: a rare case report with comprehensive autopsy neuropathological examinations. 单形上皮细胞性肠T细胞淋巴瘤累及中枢神经系统：一例罕见病例报告及全面尸检神经病理学检查。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 Epub Date: 2023-08-12 DOI: 10.1007/s12308-023-00557-4

Desiree Joy Anne Talabong, Emmanuella Laguerre, Ning Neil Chen, Jianying Zeng

{"title":"Monomorphic epitheliotropic intestinal T-cell lymphoma involving the central nervous system: a rare case report with comprehensive autopsy neuropathological examinations.","authors":"Desiree Joy Anne Talabong, Emmanuella Laguerre, Ning Neil Chen, Jianying Zeng","doi":"10.1007/s12308-023-00557-4","DOIUrl":"10.1007/s12308-023-00557-4","url":null,"abstract":"Monomorphic epitheliotropic T-cell lymphoma (MEITL) of gastrointestinal tract is an aggressive T-cell lymphoma that can rarely involve the brain. We present detailed descriptions of clinical and autopsy neuropathological findings of a rare case of an elderly woman who had surgery and chemotherapy for MEITL of the small intestine. Following her surgery, she progressively exhibited neurologic decline towards the end of her treatment. The patient eventually succumbed to her illness and was found to have MEITL with intracranial involvement on autopsy. Brain autopsy was performed and examination of tissues with hematoxylin-eosin staining under optical microscopy with 100 X magnification. Immunostaining for CD3, CD4, CD5, CD7, CD8, CD56, CD20, beta-amyloid, c-Myc, TCR-beta, TCR-delta, and EBER-ish was conducted on the formalin-fixed paraffin-embedded (FFPE) brain tissues. A neuropathological exam revealed multifocal friable necrotic and hemorrhagic areas in the supratentorial region. Histologically, monotonous small to medium-sized atypical lymphocytes infiltrated the brain parenchyma, prominently around the vessels. The immunophenotype of the atypical lymphocytes was positive for CD-3, CD-7, and CD-56 and negative for CD-5, CD-4, CD-8, CD-20, and c-Myc. EBER-ish was negative. The histology and immunophenotype confirmed the MEITL brain involvement. Neurologic decline and cognitive changes in patients with known MEITL can be the first clue of brain involvement upon which prompt evaluation is warranted.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86574723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Staphylococcal toxic shock syndrome. 葡萄球菌中毒性休克综合征。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-09-01 Epub Date: 2023-05-11 DOI: 10.1007/s12308-023-00547-6

Marco P Barros Pinto

引用次数: 0