Journal of Hematopathology最新文献_第5页

Hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1 in a young adult: a case report with literature review. 由单纯疱疹病毒 1 型引起的嗜血细胞淋巴组织细胞增多症：病例报告与文献综述。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2024-06-01 Epub Date: 2024-02-29 DOI: 10.1007/s12308-024-00575-w

Hanqing Zhang, Peng Zhang, Zhifang Xiao, Yang Gao, Na Han, Xianjun He, Jinfeng Zhang, Yonghua Li

{"title":"Hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1 in a young adult: a case report with literature review.","authors":"Hanqing Zhang, Peng Zhang, Zhifang Xiao, Yang Gao, Na Han, Xianjun He, Jinfeng Zhang, Yonghua Li","doi":"10.1007/s12308-024-00575-w","DOIUrl":"10.1007/s12308-024-00575-w","url":null,"abstract":"Hemophagocytic lymphohistiocytosis is a severe hyperinflammatory syndrome that can be potentially life-threatening without appropriate treatment. Although viral infection is the most common trigger of hemophagocytic lymphohistiocytosis, cases of herpes simplex virus type 1-induced hemophagocytic lymphohistiocytosis are rare in adults. This study aims to provide a comprehensive overview of the clinical characteristics and treatment outcomes associated with HSV-1-induced HLH. We herein report an adult case of hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1, diagnosed on the basis of peripheral blood metagenomic next-generation sequencing results. The patient exhibited a favorable response to treatment, involving dexamethasone, intravenous immunoglobulin, and acyclovir. Notably, etoposide administration was deemed unnecessary, and there has been no recurrence of the disease within the year following treatment. Early and sensitive recognition, rapid and precise diagnosis, and timely and appropriate treatment facilitated the successful treatment of this case.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":" ","pages":"91-96"},"PeriodicalIF":0.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms? 世界卫生组织成熟 B 细胞和 T/NK 细胞肿瘤及间质肿瘤分类法第五版有哪些新内容？

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2024-04-29 DOI: 10.1007/s12308-024-00585-8

Ayoma D. Attygalle, John K. C. Chan, Sarah E. Coupland, Ming-Qing Du, Judith A. Ferry, Daphne de Jong, Dita Gratzinger, Megan S. Lim, Alina Nicolae, German Ott, Andreas Rosenwald, Anna Schuh, Reiner Siebert

{"title":"What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms?","authors":"Ayoma D. Attygalle, John K. C. Chan, Sarah E. Coupland, Ming-Qing Du, Judith A. Ferry, Daphne de Jong, Dita Gratzinger, Megan S. Lim, Alina Nicolae, German Ott, Andreas Rosenwald, Anna Schuh, Reiner Siebert","doi":"10.1007/s12308-024-00585-8","DOIUrl":"https://doi.org/10.1007/s12308-024-00585-8","url":null,"abstract":"The classification of tumors is essential in the diagnosis and clinical management of patients with malignant neoplasms. The World Health Organization (WHO) provides a globally applicable classification scheme of neoplasms and it was updated several times. In this review, we briefly outline the cornerstones of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours on lymphoid neoplasms. As is adopted throughout the 5th edition of the WHO classification of tumors of all organ systems, entities are listed by a hierarchical system. For the first time, tumor-like lesions have been included in the classification, and modifications of nomenclature for some entities, revisions of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities are presented along with mesenchymal lesions specific to the stroma of lymph nodes and the spleen. In addition to specific outlines on constitutional and somatic genetic changes associated with given entities, a separate chapter on germline predisposition syndromes related to hematologic neoplasms has been added.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"30 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140809934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary plasma cell leukaemia (PCL) with plasmablastic morphology 具有浆细胞形态的继发性浆细胞白血病（PCL）

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2024-04-06 DOI: 10.1007/s12308-024-00583-w

引用次数: 0

In memorium: Dr. Zeba Singh 悼念泽巴-辛格博士

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2024-04-05 DOI: 10.1007/s12308-024-00580-z

Rima Koka, Michael E. Kallen

引用次数: 0

Loss of CD5-positive T-cells following anti-thymocyte globulin treatment 抗胸腺细胞球蛋白治疗后 CD5 阳性 T 细胞的丧失

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2024-04-04 DOI: 10.1007/s12308-024-00581-y

Melissa B. Herring, Sebastian Fernandez-Pol

引用次数: 0

ALK-positive large B-cell lymphoma (ALK + LBCL) with aberrant CD3 expression CD3 表达异常的 ALK 阳性大 B 细胞淋巴瘤（ALK + LBCL

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2024-04-04 DOI: 10.1007/s12308-024-00582-x

Jess Baker, Sara L. Zadeh, Nadine S. Aguilera

{"title":"ALK-positive large B-cell lymphoma (ALK + LBCL) with aberrant CD3 expression","authors":"Jess Baker, Sara L. Zadeh, Nadine S. Aguilera","doi":"10.1007/s12308-024-00582-x","DOIUrl":"https://doi.org/10.1007/s12308-024-00582-x","url":null,"abstract":"ALK-positive ( +) large B cell lymphoma (ALK + LBCL) is a rare distinct subtype of diffuse large B cell lymphoma presenting with high stage and aggressive behavior. Although B cell markers such as CD20, CD19, and CD22 are generally negative, plasmacytic markers including CD138, CD38, and MUM1 are positive. T cell markers are negative with rare exceptions. We report an unusual case of ALK1 + LBCL in a 58-year-old man with partial expression of CD3 without other T cell antigen expression. The tissue was evaluated with flow cytometry, immunohistochemistry, fluorescent in situ hybridization, and gene rearrangement studies. Gene rearrangement studies for IGH and TCR gamma were performed. Flow cytometry did not demonstrate any abnormal lymphoid populations. Tissue sectioning shows a malignant plasmacytic large cell neoplasm which expresses CD45 but is negative for CD20, CD79a, and PAX5. Plasmacytic markers CD138 and MUM1 are positive with kappa light chain restriction. Strong granular cytoplasmic expression of ALK is present. FISH showing disrupted ALK supports the diagnosis while MYC, BCL6, and BCL2 are intact. Gene rearrangement studies show coexisting IGH and TCR gamma clones; however, the TCR peak was present within a polyclonal background suggesting the disputed cells are likely only a subset of the T cell population. ALK + LBCL can present with an ambiguous immunophenotype, which warrants the use of multiple B cell, T cell, and plasmacytic antibodies. CD3 expression in this entity is rare and of uncertain clinical significance, but warrants further study.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of leukaemia Q-fusion gene screening assay (Q30) in the diagnostic evaluation of acute myeloid leukaemia (AML) 白血病 Q 融合基因筛查测定（Q30）在急性髓性白血病诊断评估中的应用

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-12-26 DOI: 10.1007/s12308-023-00571-6

Sarrah Tayabali, Robert Baker, Elisabeth Nacheva, Jenny O’Nions, Rajeev Gupta, Andrew J. Wilson, Ke Xu

引用次数: 0

Initial diagnosis of extranodal NK/T-cell lymphoma in pericardial fluid with concomitant hemophagocytic lymphohistiocytosis (HLH) 初步诊断心包积液中的结节外NK/T细胞淋巴瘤并发嗜血细胞淋巴组织细胞增多症（HLH）

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-12-26 DOI: 10.1007/s12308-023-00572-5

Amani Khasawneh, Georgeann McGuinness, Nicholas Ward

{"title":"Initial diagnosis of extranodal NK/T-cell lymphoma in pericardial fluid with concomitant hemophagocytic lymphohistiocytosis (HLH)","authors":"Amani Khasawneh, Georgeann McGuinness, Nicholas Ward","doi":"10.1007/s12308-023-00572-5","DOIUrl":"https://doi.org/10.1007/s12308-023-00572-5","url":null,"abstract":"Extranasal natural killer/T-cell lymphoma arising in the heart is rare and typically presents with non-specific clinical symptoms, necessitating a biopsy for a definitive diagnosis. We report an unusual case of a 48-year-old male who initially presented with chest pain and shortness of breath. Subsequent diagnosis via pericardial fluid analysis, including flow cytometry and immunohistochemical stains, revealed extranasal NK/T-cell lymphoma without sinonasal involvement. The analysis identified neoplastic lymphoid cells expressing CD2, cytoplasmic CD3, Epstein-Barr virus, and CD56 and exhibiting increased Ki-67 staining. Additionally, the patient developed hemophagocytosis lymphocytosis secondary to NK/T cell lymphoma. Treatment included an interleukin-1 receptor antagonist (anakinra), dexamethasone, rituximab, and etoposide. Unfortunately, the patient’s condition rapidly deteriorated, leading to multiorgan failure and eventual demise. Given the rarity of this lymphoma, early diagnosis based on a high suspicion level provides the best chance for improved overall survival.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"28 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139056132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunocytochemistry on frozen-embedded cell block for the diagnosis of hematolymphoid cytology specimen: a straightforward alternative to the conventional cell block 在冷冻包埋细胞块上进行免疫细胞化学分析以诊断血淋巴细胞学标本：传统细胞块的直接替代方法

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-12-15 DOI: 10.1007/s12308-023-00569-0

{"title":"Immunocytochemistry on frozen-embedded cell block for the diagnosis of hematolymphoid cytology specimen: a straightforward alternative to the conventional cell block","authors":"","doi":"10.1007/s12308-023-00569-0","DOIUrl":"https://doi.org/10.1007/s12308-023-00569-0","url":null,"abstract":"<h3>Abstract</h3> Agarose-based cell block (CB) technique can be modified to be combined with the frozen section technique for the preparation of a high-quality frozen-embedded CB (F-CB) from an effusion or fine-needle aspiration (FNA) cytology sample. This combined technique can be effectively used for the immunocharacterization of the hematolymphoid cells on F-CB. To demonstrate the applicability of performing diagnostic ICC on F-CB, we have analyzed the immunophenotype of the hematolymphoid cells in a series of eight cases of effusions and eight cases of FNA cytology specimens by using CB-ICC on sections cut from frozen-embedded CBs. The SurePathTM residue or cytologic material scraped off from the FNA cytology smear that was diagnostic for or suspicious of hematolymphoid malignancy was pelleted and pre-embedded in agarose. Half of the agarose-embedded pellet was frozen-embedded in OCT compound for the preparation of F-CB, while the other half was processed for the preparation of paraffin-embedded CB. Sections cut from the F-CB and P-CB were used for CB-ICC. Panels of ICC on the F-CBs could enable the immunocytochemical differential diagnosis of large cell hematologic malignancies that encompass anaplastic large cell lymphoma and other forms of large-cell hematolymphoid malignancies such as large B-cell lymphomas, anaplastic plasma cell myeloma, myeloid sarcoma, and T-lymphoblastic lymphoma. It also appeared that the small B-cell lymphomas in the effusions or FNAs could be differentially diagnosed with the aid of CB-ICC on the F-CB. A modified agarose-based CB technique can be combined with the frozen-embedded CB method for the preparation of F-CB that can be directly used for the immunocytochemical differential diagnosis of hematolymphoid cytology samples.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"9 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138685415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary anaplastic large cell lymphoma arising from central nervous system 起源于中枢神经系统的原发性间变性大细胞淋巴瘤

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-12-02 DOI: 10.1007/s12308-023-00570-7

Sirichai Puttirangsan, Narittee Sukswai, Sunisa Kongkiatkamon

{"title":"Primary anaplastic large cell lymphoma arising from central nervous system","authors":"Sirichai Puttirangsan, Narittee Sukswai, Sunisa Kongkiatkamon","doi":"10.1007/s12308-023-00570-7","DOIUrl":"https://doi.org/10.1007/s12308-023-00570-7","url":null,"abstract":"A 22-year-old man presented at the emergency department with progressive headache, vomiting and horizontal diplopia over 2-month period. He also developed blurred vision in his left eye. He complained of loss of appetite for the past 2 months, resulting in a 5-kg weight loss. Examination upon arrival revealed papilledema and bilateral abducens nerve palsy. Motor and sensory functions were intact. Magnetic resonance imaging (MRI) of the brain revealed multiple extra-axial nodular enhancing lesions with size of 5–10 mm mainly along with both sides of falx cerebri and vasogenic brain oedema (Fig. 1). Stereotactic brain biopsy was performed to obtain tissue diagnosis. Histologic examination revealed brain infiltration by few atypical cells hidden amongst abundant and mixed population of inflammatory cells including lymphocytes and histiocytes. The atypical cells are large cells with horseshoe nuclei (red arrow; Fig. 2A ×100 and Fig. 2B ×400). Immunohistochemistry showed strong, uniform CD30 expression (Fig. 2C ×400) and cytoplasmic ALK staining (Fig. 2D ×400), as well as for CD3 (Fig. 2E ×400) and CD68 (Fig. 2F ×400). B-cell markers (CD20) were negative (Fig. 2G ×400).","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"14 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138533229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0