Journal of Hematopathology最新文献

Acquired Pseudo-Pelger-Huet anomaly in a patient with chronic lymphocytic leukemia treated with acalabrutinib. 阿卡拉布替尼治疗慢性淋巴细胞白血病患者的获得性伪佩尔格- huet异常。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2026-05-09 DOI: 10.1007/s12308-026-00697-3

Christoph Robier

{"title":"Acquired Pseudo-Pelger-Huet anomaly in a patient with chronic lymphocytic leukemia treated with acalabrutinib.","authors":"Christoph Robier","doi":"10.1007/s12308-026-00697-3","DOIUrl":"https://doi.org/10.1007/s12308-026-00697-3","url":null,"abstract":"We report the case of an 82-year-old male acalabrutinib-treated patient with chronic lymphocytic leukemia (CLL) who was admitted to hospital because of a crural ulceration. Examination of a peripheral blood smear revealed 81% of the neutrophils as hypolobulated in addition to the leukemic lymphoma- and smudge cells. The nuclei of the abnormal neutrophils showed a markedly clumped chromatin and appeared as unilobular (round or oval) in 51%, bilobular in 13% and peanut- and band-shaped in 17%, respectively. A suspected diagnosis of a drug-induced acquired Pseudo-Pelger-Huet anomaly (PPHA) was made, because the morphological anomaly was not apparent in several blood smears prior to the initiation of acalabrutinib. Retrospectively, the presence of hypolobulation was first mentioned in a medical report two weeks after starting acalabrutinib. PPHA has been reported in a few patients with CLL, associated with different therapy regimens such as bendamustin- and fludarabine-containing chemotherapy protocols, venetoclax as well as the Bruton tyrosine kinase inhibitors ibrutinib and zanubrutinib. To our knowledge, an association of PPHA with acalabrutinib has not been previously described. The prevalence, the underlying pathomechanism as well as a potential clinical implication of this phenomenon have not been elucidated so far.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reviewer recognition. 评论家的认可。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2026-04-20 DOI: 10.1007/s12308-026-00682-w

Nathanael Bailey

引用次数: 0

Prognostic value of combined digital PCR and multiparametric flow cytometry monitoring MRD in non-transplant acute myeloid leukemia. 数字PCR与多参数流式细胞术联合监测MRD在非移植急性髓系白血病中的预后价值。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2026-04-14 DOI: 10.1007/s12308-026-00692-8

Shaojie Ye, Huimei Guo, Jianmei Xu, Xi Su, Lin Wang, Jiangbo Zhang, Jia Liu, Songying Zhao, Jing Wang, Hua Xue

{"title":"Prognostic value of combined digital PCR and multiparametric flow cytometry monitoring MRD in non-transplant acute myeloid leukemia.","authors":"Shaojie Ye, Huimei Guo, Jianmei Xu, Xi Su, Lin Wang, Jiangbo Zhang, Jia Liu, Songying Zhao, Jing Wang, Hua Xue","doi":"10.1007/s12308-026-00692-8","DOIUrl":"https://doi.org/10.1007/s12308-026-00692-8","url":null,"abstract":"Objective: To evaluate the synergistic prognostic value of digital PCR (dPCR)-based multigene measurable residual disease (MRD) monitoring combined with multiparametric flow cytometry (MFC) in patients with non-transplant acute myeloid leukemia (AML).Methods: This observational cohort study analyzed 86 newly diagnosed AML patients (excluding APL) at the Affiliated Hospital of Hebei University (January 2018-May 2025). MRD was assessed using MFC (threshold: 0.1%) and dPCR (variant allele frequency [VAF] < 0.001%). Outcomes included relapse-free survival (RFS), overall survival (OS), and cumulative relapse rates.Results: With a median follow-up time of 18.5 months, dPCR-MRD negativity predicted superior 2-year RFS (67.1% vs 42.3%, HR = 0.365, P = 0.003). Combined MFC/dPCR negativity further enhanced prognostic discrimination (2-year RFS: 68.2% vs 40.5%, HR = 0.323, P = 0.001). Subgroup analysis revealed MFC-driven RFS benefits in intensive chemotherapy (72.2% vs 33.3%, HR = 0.180, P = 0.014), while dual-platform monitoring showed trends favoring non-intensive regimens (58.7% vs 31.7%, HR = 0.407, P = 0.051).Conclusion: dPCR-MRD monitoring complements MFC for the stratification of risk of relapse, particularly among non-transplant AML patients. Dual-platform integration improves predictive accuracy, supporting personalized MRD-guided strategies.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EBV-positive CD8 + peripheral T-cell lymphoma in the post-transplant setting: case report and review of the literature. 移植后ebv阳性CD8 +外周t细胞淋巴瘤：病例报告和文献回顾

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2026-04-13 DOI: 10.1007/s12308-026-00694-6

Ahmed A Ahmed, Shanxiang Zhang, Arash Ronaghy, Safina Hafeez, Dinesh Pradhan, Neha Gupta

引用次数: 0

SSTR2 expression in EBV-positive and EBV-negative lymphomas. SSTR2在ebv阳性和ebv阴性淋巴瘤中的表达。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2026-04-10 DOI: 10.1007/s12308-026-00693-7

Nivaz Brar, Juan Carlos Barrios-Menéndez, Gregory W Charville, Edward L Briercheck, Yasodha Natkunam, Fabiola Valvert, Oscar Silva

{"title":"SSTR2 expression in EBV-positive and EBV-negative lymphomas.","authors":"Nivaz Brar, Juan Carlos Barrios-Menéndez, Gregory W Charville, Edward L Briercheck, Yasodha Natkunam, Fabiola Valvert, Oscar Silva","doi":"10.1007/s12308-026-00693-7","DOIUrl":"https://doi.org/10.1007/s12308-026-00693-7","url":null,"abstract":"Background: Somatostatin receptor 2 (SSTR2) protein expression is aberrantly upregulated in various tumors and can be visualized using scintigraphy or radiological techniques and therapeutically targeted using octreotide-based molecules.Purpose: In this study, we assessed SSTR2 expression in the largest cohort of hematopoietic proliferations examined to date and interrogated the relationship between EBV and SSTR2 in EBV-associated lymphomas as a possible mechanism for SSTR2 upregulation.Methods: We retrospectively identified 407 cases of lymphoma from Guatemala, a country with a high prevalence of EBV-associated lymphomas. SSTR2 protein expression was assessed by immunohistochemistry, while EBV was assessed by in situ hybridization for EBV-associated small RNAs.Results: We found SSTR2 expression in 43% (20/47) of EBV-positive classic Hodgkin lymphomas (cHL) and 0% (0/12) of EBV-negative cHL cases. All but one of the other EBV-associated lymphomas (n = 53) were negative for SSTR2. Within the EBV-negative non-Hodgkin lymphomas assessed, 33% (1/3) of diffuse large B-cell lymphoma (DLBCL)/high-grade B-cell lymphoma (HGBL) with MYC and BCL2 rearrangement, 17% (25/149) of DLBCL not otherwise specified, and 17% (5/29) of follicular lymphomas showed SSTR2 expression. All other lymphomas showed no significant SSTR2 expression.Conclusions: Our study demonstrates that EBV infection is required, but not sufficient, to upregulate SSTR2 in classic Hodgkin lymphoma, but not in other EBV-associated lymphomas. We also provide data to suggest that SSTR2 is associated with \"higher-grade\" germinal center-derived B-cell lymphomas in EBV-negative non-Hodgkin lymphomas.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosai-Dorfman disease with thyroid involvement: a case report and literature review. Rosai-Dorfman病伴甲状腺受累1例报告及文献复习。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2026-03-30 DOI: 10.1007/s12308-026-00691-9

Gustavo Abraham Canales-Azcona, Abraham Castellanos-Maldonado, Alfredo Alejandro Juárez-Reyna, Yadhira María González-Amador, Héctor Raúl Ibarra-Sifuentes, Gerardo Olivares-Guajardo

{"title":"Rosai-Dorfman disease with thyroid involvement: a case report and literature review.","authors":"Gustavo Abraham Canales-Azcona, Abraham Castellanos-Maldonado, Alfredo Alejandro Juárez-Reyna, Yadhira María González-Amador, Héctor Raúl Ibarra-Sifuentes, Gerardo Olivares-Guajardo","doi":"10.1007/s12308-026-00691-9","DOIUrl":"https://doi.org/10.1007/s12308-026-00691-9","url":null,"abstract":"Rosai-Dorfman disease is a rare non-Langerhans cell histiocytosis that usually presents with lymph node enlargement but may involve extranodal sites. Thyroid involvement is exceedingly uncommon and often leads to diagnostic difficulties. We report the case of a 46-year-old woman with a progressively enlarging, painless cervical mass accompanied by mild fever, malaise, and difficulty swallowing. Physical examination revealed cervical lymph node enlargement and a thyroid nodule. Fine needle aspiration specimens from the thyroid gland and lymph nodes showed numerous pale histiocytes with emperipolesis, lymphocytes, neutrophils, and plasma cells. Histopathological evaluation demonstrated sinus expansion with large histiocytes exhibiting vesicular nuclei and clear cytoplasm, along with characteristic emperipolesis, while immunohistochemical staining showed strong S100 protein positivity and CD1a negativity. Treatment with oral corticosteroids led to clinical improvement and normalization of inflammatory markers. This case emphasizes the need to consider Rosai-Dorfman disease in the differential diagnosis of thyroid masses.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AIns (insulin) type amyloidosis in a kidney transplant candidate with a newly identified monoclonal gammopathy. 肾移植候选者伴新发现的单克隆伽玛病的胰岛素型淀粉样变性。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2026-03-27 DOI: 10.1007/s12308-026-00690-w

Carlos Villarroel, Matthew Howard, Aaron J Wyse, Udit Yadav, Sarah E Gibson

{"title":"AIns (insulin) type amyloidosis in a kidney transplant candidate with a newly identified monoclonal gammopathy.","authors":"Carlos Villarroel, Matthew Howard, Aaron J Wyse, Udit Yadav, Sarah E Gibson","doi":"10.1007/s12308-026-00690-w","DOIUrl":"https://doi.org/10.1007/s12308-026-00690-w","url":null,"abstract":"Background: Amyloidosis is a heterogeneous group of disorders with 42 types of amyloidogenic proteins currently described. The most common forms include AL (immunoglobulin light chain), ATTR (transthyretin), and AA ([Apo] serum amyloid A). Beyond routine Congo red staining, amyloid typing is essential to ensure the appropriate diagnosis and clinical management of patients with amyloidosis.Purpose: In this report, we discuss the utility of proteomics-based amyloid typing in the setting of a patient with a newly identified monoclonal gammopathy (IgG kappa) discovered during an evaluation for kidney transplantation. This case highlights the value of recognizing non-AL amyloid proteins.Methods: Amyloid protein identification by liquid chromatography tandem mass spectrometry (LC-MS/MS) was performed on an abdominal subcutaneous fat aspirate (SFA) from the patient.Results: The bone marrow biopsy demonstrated involvement by plasma cell myeloma (15% kappa monotypic plasma cells). Although a Congo red stain on the biopsy showed no amyloid deposition, amyloid was identified in the concurrent SFA. Instead of AL amyloid, LC-MS/MS demonstrated AIns (insulin) type amyloid, which was confirmed to be related to the patient's subcutaneous insulin injections. With this information, the patient was diagnosed with SMM and remained a viable candidate for kidney transplantation.Conclusions: Proteomics-based amyloid typing allows sensitive and specific identification of both common and rare amyloid types. Amyloid typing by this method ensures appropriate clinical management of patients with both systemic and localized amyloidosis.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147533976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary diffuse large B-cell lymphoma of cauda equina: a rare and challenging diagnosis. 马尾原发性弥漫性大b细胞淋巴瘤：罕见且具有挑战性的诊断。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2026-03-14 DOI: 10.1007/s12308-026-00689-3

Tamara Pikivaca, Mark A Rudolf, Anamarija M Perry

引用次数: 0

ALK-positive, EBV-positive Large B-cell lymphoma in an HIV patient: a diagnostic pitfall mimicking plasmablastic lymphoma. alk阳性，ebv阳性的HIV患者的大b细胞淋巴瘤：一个模拟浆母细胞淋巴瘤的诊断陷阱。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2026-03-10 DOI: 10.1007/s12308-026-00688-4

Chutima Pinnark Surintrspanont, Benjamaporn Buasatit, Narittee Sukswai, Suphakit Hemla, Chinachote Teerapakpinyo, Shanop Shuangshoti

{"title":"ALK-positive, EBV-positive Large B-cell lymphoma in an HIV patient: a diagnostic pitfall mimicking plasmablastic lymphoma.","authors":"Chutima Pinnark Surintrspanont, Benjamaporn Buasatit, Narittee Sukswai, Suphakit Hemla, Chinachote Teerapakpinyo, Shanop Shuangshoti","doi":"10.1007/s12308-026-00688-4","DOIUrl":"https://doi.org/10.1007/s12308-026-00688-4","url":null,"abstract":"ALK-positive large B-cell lymphoma (ALK + LBCL) is a rare subtype of large B-cell lymphoma characterized by plasmablastic morphology, intra-sinusoidal or sheet-like proliferation, loss of pan-B-cell markers, and expression of plasmacytic markers. According to WHO classification, CD30 expression is generally absent and Epstein-Barr virus (EBV) infection is not detected [1,2,5] . We aim to report the first case of ALK-positive, EBV-positive large B-cell lymphoma (ALK + EBV + LBCL) in an HIV-infected patient. A 60-year-old Thai male with HIV infection and severe immunosuppression (CD4 count: 93 cells/mm3) presented with generalized lymphadenopathy and an epiglottic mass. Biopsy showed a plasmablastic neoplasm proliferating in loose sheets, negative for pan-B-cell markers except OCT2, and positive for plasmacytic markers and CD30. The tumor also expressed EBER, ALK1 (paranuclear dot pattern), and ALK D5F3; HHV8 was negative. FISH confirmed ALK gene rearrangement, and targeted sequencing revealed a GORASP2::ALK fusion gene. The diagnosis of ALK + EBV + LBCL in the setting of HIV-related immunodeficiency was established. The patient developed pneumonia with septic shock and died during admission. EBV-positive plasmablastic B-cell neoplasms in HIV-infected patients are not always plasmablastic lymphoma. Immunohistochemistry for ALK and HHV8 should be included in the diagnostic panel. Importantly, CD30 and EBER positivity do not exclude ALK + LBCL.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathologic findings of tularemia lymphadenitis. 兔热病淋巴结炎的组织病理学表现。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2026-03-03 DOI: 10.1007/s12308-026-00687-5

Anna Dar, Ritu Banerjee, Emily F Mason

引用次数: 0