Journal of Hematopathology最新文献_第2页

Synchronous T-cell lymphoblastic lymphoma, chronic myelomonocytic leukemia and myeloma with sequential acute myeloid leukemia transformation. 同步t细胞淋巴母细胞淋巴瘤、慢性髓细胞白血病和骨髓瘤伴序贯急性髓细胞白血病转化。

IF 1 4区医学

Journal of Hematopathology Pub Date : 2026-09-15 DOI: 10.1007/s12308-026-00733-2

Grace Collord, Sabine Pomplun, Marc R Mansour, Rajeev Gupta, Ke Xu

引用次数: 0

Chromosome 17p deletion in aplastic anaemia with paroxysmal nocturnal haemoglobinuria clone: a diagnostic challenge. 染色体17p缺失在再生障碍性贫血与阵发性夜间血红蛋白尿克隆：一个诊断挑战。

IF 1 4区医学

Journal of Hematopathology Pub Date : 2026-09-13 DOI: 10.1007/s12308-026-00731-4

Kavya Ronanki, Lumen Agarkar Prattipati, Prisla Maria Dalton, Nabanita Mayur, Uttam Kumar Nath

{"title":"Chromosome 17p deletion in aplastic anaemia with paroxysmal nocturnal haemoglobinuria clone: a diagnostic challenge.","authors":"Kavya Ronanki, Lumen Agarkar Prattipati, Prisla Maria Dalton, Nabanita Mayur, Uttam Kumar Nath","doi":"10.1007/s12308-026-00731-4","DOIUrl":"10.1007/s12308-026-00731-4","url":null,"abstract":"Background: Aplastic anaemia (AA) and paroxysmal nocturnal haemoglobinuria (PNH) are closely related acquired bone marrow failure syndromes sharing an immune-mediated pathogenesis. Cytogenetic abnormalities are uncommon in AA-PNH overlap syndrome, and their significance remains uncertain. We report a case of non-severe AA-PNH overlap syndrome harbouring a low-level chromosome 17p deletion in the absence of morphologic or molecular evidence of myeloid neoplasm.Case presentation: A 56-year-old female presented with recurrent aphthous ulcers and pancytopenia. Complete blood count revealed haemoglobin of 6.3 g/dL, total leukocyte count of 2800/µL with an absolute neutrophil count of 982/µL, and platelet count of 10,000/µL. Bone marrow aspirate showed adequate erythropoiesis with normoblastic to megaloblastic maturation and active myelopoiesis. Bone marrow biopsy revealed a markedly hypocellular marrow (10% cellularity) with focal erythroid prominence. No dysplasia, excess blasts, ring sideroblasts, and abnormal topography were identified. Flow cytometric PNH evaluation demonstrated a large type III clone involving 78% of neutrophils and 64% of monocytes. FISH analysis using TP53/CEP17 probes revealed chromosome 17p deletion in 12 of 200 nuclei (6%). Next-generation sequencing did not identify TP53 or other myeloid-associated mutations. The patient was treated with horse anti-thymocyte globulin, cyclosporine, romiplostim, erythropoietin, and irradiated blood products. She achieved transfusion independence and remains clinically stable on follow-up of 27 months.Conclusion: Low-level chromosome 17p deletion may occur in AA-PNH overlap syndrome without morphologic or molecular evidence of myeloid neoplasm. Careful clinicopathologic correlation and long-term surveillance are essential before attributing such abnormalities to clonal evolution.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large B-cell lymphoma with IRF4 rearrangement: clinicopathologic heterogeneity across the age spectrum. IRF4重排的大b细胞淋巴瘤：跨年龄谱的临床病理异质性。

IF 1 4区医学

Journal of Hematopathology Pub Date : 2026-09-11 DOI: 10.1007/s12308-026-00730-5

Sehbal Arslankoz, Ece Özoğul, Tezer Kutluk, Serkan Akın, Emine Arzu Sağlam Ayhan, Ayşegül Üner

{"title":"Large B-cell lymphoma with IRF4 rearrangement: clinicopathologic heterogeneity across the age spectrum.","authors":"Sehbal Arslankoz, Ece Özoğul, Tezer Kutluk, Serkan Akın, Emine Arzu Sağlam Ayhan, Ayşegül Üner","doi":"10.1007/s12308-026-00730-5","DOIUrl":"10.1007/s12308-026-00730-5","url":null,"abstract":"Background: Large B-cell lymphoma with IRF4 rearrangement (IRF4-R LBCL) is a rare entity recognised in the current WHO-HAEM5 classification and the International Consensus Classification (ICC).Purpose: This study aimed to evaluate the clinicopathologic and fluorescence in situ hybridisation (FISH) findings of IRF4-R LBCL across a broad age spectrum.Materials and methods: Seven cases diagnosed with IRF4-R LBCL at the Department of Pathology, Hacettepe University Faculty of Medicine, were retrospectively reviewed. Clinical, morphological, immunohistochemical, and FISH findings were evaluated.Results: Patients' ages ranged from 13 to 77 years; three were aged 40 years or older. Cases under 40 years of age were localised to the head and neck region and gastrointestinal tract, and all remained in remission. In contrast, cases aged 40 years or older demonstrated more heterogeneous anatomical distribution and clinical behaviour, with one disease-related death during follow-up. Immunohistochemical analysis showed CD20 and MUM1/IRF4 positivity in all cases, whilst CD10, BCL6, and BCL2 expression was variable. IRF4 rearrangement was identified in all cases. MYC and BCL2 rearrangements were absent in all cases, whereas BCL6 rearrangement was detected in one adult patient and could not be assessed in one case.Conclusion: Consistent with the literature, IRF4-R LBCL in children and young adults generally shows a favourable clinical course and characteristic clinicopathologic features. In adult patients, however, greater clinicopathologic and cytogenetic heterogeneity, including occasional additional abnormalities such as BCL6 rearrangement, may be observed. Accurate identification of IRF4 rearrangement is critical for differential diagnosis and may also have implications for clinical management, particularly when interpreted in conjunction with patient age and clinicopathologic features.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular profiling of thalassemia in Southeastern Romania. 罗马尼亚东南部地中海贫血的分子分析。

IF 1 4区医学

Journal of Hematopathology Pub Date : 2026-09-09 DOI: 10.1007/s12308-026-00732-3

Costel Stelian Brînzan, Miruna-Gabriela Vizireanu, Anca Florentina Mitroi, Georgeta Camelia Cozaru, Mariana Așchie, Florina Madalina Oniceanu, Adrian Nelutu Mitroi, Ionut Eduard Iordache

{"title":"Molecular profiling of thalassemia in Southeastern Romania.","authors":"Costel Stelian Brînzan, Miruna-Gabriela Vizireanu, Anca Florentina Mitroi, Georgeta Camelia Cozaru, Mariana Așchie, Florina Madalina Oniceanu, Adrian Nelutu Mitroi, Ionut Eduard Iordache","doi":"10.1007/s12308-026-00732-3","DOIUrl":"10.1007/s12308-026-00732-3","url":null,"abstract":"Background: Thalassemias represent a major group of hereditary hemoglobin disorders with significant global health impact, yet molecular data from Eastern European populations, particularly from Romania, remain limited.Purpose: This study was aimed at comprehensively characterizing the molecular spectrum of α-, β-, and δβ-thalassemia in the southeastern part of Romania using an expanded panel of molecular diagnostic techniques.Methods: A total of 324 patients with suspected thalassemia were evaluated between 2017 and 2025. Molecular testing included multiplex PCR with reverse dot-blot hybridization, Sanger sequencing, MLPA for α-globin deletions/duplications, and multiplex gap-PCR for δβ fusion gene detection.Results: Pathogenic variants were identified in 137 individuals (42.28%). Of these, 21.89% had α-thalassemia, 66.42% had β-thalassemia, 10.21% had combined α and β defects, and 1.45% had Lepore Hb variants. The -α3·7 deletion and anti-α3·7 triplication were the predominant α-globin abnormalities, while IVS I-6 [T > C], IVS I-110 [G > A], codon 39 [C > T], and IVS II-745 [C > G] were the most frequent β-globin mutations. Two cases of the Hb Lepore Boston-Washington subtype were confirmed through gap-PCR and sequencing.Conclusions: The mutation distribution observed in southeastern Romania mirrors Mediterranean thalassemia patterns rather than those of Central or Northern Europe.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testicular aggressive B-cell lymphoma with plasmablastic morphology harboring concurrent IGH::MYC and IGH::BCL2 rearrangements. 具有浆母细胞形态的睾丸侵袭性b细胞淋巴瘤同时存在IGH::MYC和IGH::BCL2重排。

IF 1 4区医学

Journal of Hematopathology Pub Date : 2026-09-07 DOI: 10.1007/s12308-026-00729-y

Binnari Kim, Hee Jeong Cha

{"title":"Testicular aggressive B-cell lymphoma with plasmablastic morphology harboring concurrent IGH::MYC and IGH::BCL2 rearrangements.","authors":"Binnari Kim, Hee Jeong Cha","doi":"10.1007/s12308-026-00729-y","DOIUrl":"10.1007/s12308-026-00729-y","url":null,"abstract":"Background: Aggressive B-cell lymphomas with plasmablastic morphology are uncommon neoplasms that may exhibit overlapping morphologic, immunophenotypic, and genetic features of plasmablastic lymphoma (PBL) and double-hit lymphoma (DHL). Concurrent IGH::MYC and IGH::BCL2 rearrangements are rarely encountered in this setting, particularly in the testis. Here, we describe an unusual case presenting significant diagnostic challenges at the interface between PBL and DHL.Case presentation: We report a 66-year-old, immunocompetent man presenting with a 5 cm left testicular mass. Histologic examination revealed diffuse proliferation of large atypical lymphoid cells with plasmablastic morphology. Immunohistochemically, the tumor expressed CD138, CD38, and MUM1, with focal BCL2, c-MYC protein, and CD79a positivity, while CD20, CD19, PAX5, CD10, BCL6, and ALK were negative. EBV-encoded RNA in situ hybridization was negative. Fluorescence in situ hybridization identified IGH::MYC [t(8;14)] rearrangement in 45% and IGH::BCL2 [t(14;18)] rearrangement in 21% of analyzed nuclei. Next-generation sequencing additionally revealed BRAF V600E mutation, CDKN2A deletion, and human leukocyte antigen class I genomic alterations.Conclusion: This case highlights a rare testicular aggressive B-cell lymphoma with plasmablastic morphology and concurrent IGH::MYC and IGH::BCL2 rearrangements, representing a diagnostically challenging neoplasm at the interface between PBL and DHL. Our findings underscore the value of integrated morphologic, immunophenotypic, cytogenetic, and molecular analyses in evaluating aggressive B-cell lymphomas with plasmablastic features arising in immune-privileged sites.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel case of cytoplasmic CD3 positive, surface CD4 positive high-grade B-cell lymphoma with MYC rearrangement. 细胞质CD3阳性，表面CD4阳性伴MYC重排的高级别b细胞淋巴瘤新病例。

IF 1 4区医学

Journal of Hematopathology Pub Date : 2026-08-28 DOI: 10.1007/s12308-026-00728-z

Vladimir Miltchev, Natalia Golardi

{"title":"Novel case of cytoplasmic CD3 positive, surface CD4 positive high-grade B-cell lymphoma with MYC rearrangement.","authors":"Vladimir Miltchev, Natalia Golardi","doi":"10.1007/s12308-026-00728-z","DOIUrl":"10.1007/s12308-026-00728-z","url":null,"abstract":"High-grade B-cell lymphoma, not otherwise specified (HGBCL-NOS), is an aggressive mature B-cell neoplasm whose diagnosis remains challenging due to significant morphologic overlap with diffuse large B-cell lymphoma and Burkitt lymphoma, and the absence of defining molecular alterations. Aberrant antigen expression can further complicate diagnoses and may result in lineage ambiguity. We report a unique case of HGBCL-NOS with MYC rearrangement demonstrating aberrant cytoplasmic CD3 and surface CD4 expression, leading to an initial misdiagnosis as a T-cell lymphoma at an outside hospital. A 50-year-old man with a previous diagnosis of peripheral T-cell lymphoma presented to our institution with central nervous system symptoms and a persistent bladder mass. Evaluation by bladder biopsy and cerebrospinal fluid flow cytometry revealed a high-grade B-cell neoplasm with diffuse CD10 and CD79a expression, patchy CD20 positivity, strong PAX5 expression, lambda light-chain restriction, Ki-67 approaching 100%, and flow cytometry confirmed expression of cytoplasmic CD3 and dim surface CD4 expression in a clonal B-cell population. Fluorescence in situ hybridization demonstrated a t(8;14)(q24;q32) MYC::IGH rearrangement without BCL2 or BCL6 rearrangements. This extremely rare phenotype has not previously been described. This case expands the spectrum of aberrant immunophenotypes reported in both B-cell lymphomas and HGBCL-NOS and highlights the importance of comprehensive lineage assessment in lymphomas with unusual antigen expression.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flow cytometric detection of isolated central nervous system relapse in acute myeloid leukemia under FLT3-targeted therapy. 流式细胞术检测flt3靶向治疗急性髓系白血病离体中枢神经系统复发。

IF 1 4区医学

Journal of Hematopathology Pub Date : 2026-08-24 DOI: 10.1007/s12308-026-00727-0

Chen Glait Santar, Odelia Amit, Ben Zion Katz

{"title":"Flow cytometric detection of isolated central nervous system relapse in acute myeloid leukemia under FLT3-targeted therapy.","authors":"Chen Glait Santar, Odelia Amit, Ben Zion Katz","doi":"10.1007/s12308-026-00727-0","DOIUrl":"10.1007/s12308-026-00727-0","url":null,"abstract":"Central nervous system (CNS) relapse in acute myeloid leukemia (AML) is rare in adults and infrequently occurs as an isolated manifestation following allogeneic hematopoietic stem cell transplantation. We report a 68-year-old man with FLT3-ITD-mutated AML with monocytic differentiation who achieved sustained morphological and molecular remission following induction chemotherapy, consolidation, allogeneic transplantation, and FLT3 inhibitor maintenance therapy. Approximately 18 months after diagnosis, the patient developed isolated CNS relapse despite continued bone marrow remission and complete donor chimerism. Cerebrospinal fluid (CSF) flow cytometry identified leukemic blasts, and PCR detected FLT3-ITD, confirming CNS involvement. Following intrathecal chemotherapy, systemic therapy, gilteritinib treatment, and a second transplantation, the patient developed recurrent CNS disease with optic nerve involvement and vision loss. Notably, repeat CSF studies demonstrated persistent leukemic infiltration detectable by flow cytometry despite repeated negative FLT3-ITD PCR results, suggesting immunophenotypic-molecular discordance under FLT3-targeted therapy. This case highlights the CNS as a sanctuary site in AML and underscores the critical role of CSF flow cytometry in the diagnosis and monitoring of CNS relapse, particularly when molecular studies are negative. This case provides a valuable teaching point highlighting the limitations of relying on a single diagnostic method.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute myeloid leukemia with unusual mature lymphoid-like morphology in a subset of blasts. 母细胞亚群中具有异常成熟淋巴样形态的急性髓性白血病。

IF 1 4区医学

Journal of Hematopathology Pub Date : 2026-08-22 DOI: 10.1007/s12308-026-00726-1

Christopher Vossen, Clarissa E Jordan

引用次数: 0

Erythroblastic sarcoma with biallelic TP53 mutations and novel NUP214:: ABL1-new finding in erythroblastic sarcoma/acute erythroid leukemia. 具有双等位基因TP53突变和新型NUP214:: abl1的红母细胞肉瘤/急性红系白血病的新发现

IF 1 4区医学

Journal of Hematopathology Pub Date : 2026-08-18 DOI: 10.1007/s12308-026-00723-4

Rebecca Manzo, Changqing Xia, Zhenya Tang, Joseph D Khoury, Shanxiang Zhang

{"title":"Erythroblastic sarcoma with biallelic TP53 mutations and novel NUP214:: ABL1-new finding in erythroblastic sarcoma/acute erythroid leukemia.","authors":"Rebecca Manzo, Changqing Xia, Zhenya Tang, Joseph D Khoury, Shanxiang Zhang","doi":"10.1007/s12308-026-00723-4","DOIUrl":"10.1007/s12308-026-00723-4","url":null,"abstract":"NUP214::ABL1 generates a fusion protein with constitutively activated tyrosine kinase activity and is present in rare T-lymphoblastic leukemia (ALL), B-ALL, and in rare cases of myelodysplastic neoplasm/acute myeloid leukemia (MDS/AML). Here, we for the first time reported NUP214::ABL1 in a case of erythroblastic sarcoma (ES), a rare extramedullary form of acute erythroid leukemia (AEL). A 55-year-old female with a reported three-year history of MDS presented with worsening lower extremity paresthesia. Magnetic resonance imaging revealed an intraspinal T2-T4 extradural mass. Examination of the mass biopsy supported by extensive immunoprofiling was diagnostic of ES. Fluorescence in situ hybridization (FISH) identified concurrent deletions of 5p15.2 and 5q31 (likely monosomy 5), trisomy 8, and deletion of 7q31 while absent for translocations included in AML FISH panel. Next-generation sequencing (NGS) including DNA (406 genes) and RNA (265 genes) panels revealed NUP214::ABL1 (N31; A2) and TP53 I50fs*2 (VAF 85.9%). The patient died approximately two weeks after the ES diagnosis. This informative case emphasizes the importance for pathologists to be familiar with ES as a rare extramedullary form of AEL and a potential transformation from MDS. It is critical to apply comprehensive studies including cytogenetics/FISH and NGS in rendering prompt diagnosis for optimal management.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphologic mimicry of cutaneous T-cell lymphoma as classic Hodgkin lymphoma-a case report. 皮肤t细胞淋巴瘤为典型霍奇金淋巴瘤的形态学模拟1例。

IF 1 4区医学

Journal of Hematopathology Pub Date : 2026-08-12 DOI: 10.1007/s12308-026-00706-5

Julia Lunt, Rowan Burns, Christine Mg Schammel, Jenny Knight

{"title":"Morphologic mimicry of cutaneous T-cell lymphoma as classic Hodgkin lymphoma-a case report.","authors":"Julia Lunt, Rowan Burns, Christine Mg Schammel, Jenny Knight","doi":"10.1007/s12308-026-00706-5","DOIUrl":"10.1007/s12308-026-00706-5","url":null,"abstract":"Background: Cutaneous T-cell lymphoma (CTCL) and classic Hodgkin lymphoma (cHL) are distinct lymphoid neoplasms with differing cells of origin and immunophenotypes. Morphological overlap between these entities can pose significant diagnostic challenges, particularly in patients with a concurrent or prior lymphoma diagnosis.Case presentation: A 67-year-old male with a history of cHL and mycosis fungoides/lymphomatoid papulosis presented with new PET-positive right groin lymphadenopathy. Biopsy revealed atypical cells morphologically consistent with Hodgkin/Reed-Sternberg cells. However, clonal T-cell receptor beta gene rearrangement and immunophenotypic findings were inconsistent with cHL, and integration of these results with the patient's clinical history led to a final diagnosis of nodal involvement by CTCL.Conclusion: CTCL can morphologically mimic cHL, representing a significant diagnostic pitfall. This case underscores the critical role of immunophenotyping, molecular studies, and clinical context in accurately diagnosing complex hematolymphoid neoplasms.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"19 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13468865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0