Exploring castleman disease in a cohort of hispanic patients: a recognition to its histopathology.

IF 0.6 4区医学 Q4 HEMATOLOGY

Journal of Hematopathology Pub Date : 2025-05-12 DOI:10.1007/s12308-025-00637-7

Alfonso Orozco-Collazo, María José Lizardo-Thiebaud, Sergio Rodríguez-Rodríguez, Daniel Montante-Montes de Oca, Berta Riveros-Gilardi, Beatriz Sánchez-Hernández, Alec Seidman-Sorsby, Cinthya Monroy-Ramos, José Jesús Sandoval-López, Isabel García-Carrera, Déborah Martínez-Baños

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引用次数: 0

Abstract

Castleman disease is a clinicopathological entity that shares features with hematological, rheumatological, and infectious diseases, making accurate diagnosis essential. The objective of this study is to characterize the clinical and pathological characteristics of CD in a Mexican cohort. A retrospective study was conducted on adult Mexican patients diagnosed with unicentric (UCD) and multicentric (MCD) Castleman disease from 1985 to 2023. Clinical and histopathological characteristics typical of UCD and MCD were observed. POEMS-associated MCD showed a higher relapse rate. The mixed histopathological variant was more prevalent in MCD. Immunohistochemical expression of VEGF-A was elevated in all CD cases. A multidisciplinary diagnostic approach is crucial for accurately categorizing CD. The mixed histopathological variant was more common than previously reported, especially in MCD. Further studies are needed to validate VEGF-A as a biomarker for CD.

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探索castleman病在西班牙裔患者队列：对其组织病理学的认识。

Castleman病是一种临床病理实体，与血液病、风湿病和传染病具有共同特征，因此准确诊断至关重要。本研究的目的是描述墨西哥队列中乳糜泻的临床和病理特征。对1985年至2023年诊断为单中心（UCD）和多中心（MCD） Castleman病的墨西哥成年患者进行了回顾性研究。观察UCD和MCD的临床和组织病理学特征。诗歌相关性MCD复发率较高。混合型组织病理学变异在MCD中更为普遍。所有CD病例中VEGF-A的免疫组织化学表达均升高。多学科诊断方法对于准确分类CD至关重要。混合组织病理学变异比以前报道的更常见，特别是在MCD中。需要进一步的研究来验证VEGF-A作为CD的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hematopathology HEMATOLOGYPATHOLOGY-PATHOLOGY

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Journal of Hematopathology aims at providing pathologists with a special interest in hematopathology with all the information needed to perform modern pathology in evaluating lymphoid tissues and bone marrow. To this end the journal publishes reviews, editorials, comments, original papers, guidelines and protocols, papers on ancillary techniques, and occasional case reports in the fields of the pathology, molecular biology, and clinical features of diseases of the hematopoietic system. The journal is the unique reference point for all pathologists with an interest in hematopathology. Molecular biologists involved in the expanding field of molecular diagnostics and research on lymphomas and leukemia benefit from the journal, too. Furthermore, the journal is of major interest for hematologists dealing with patients suffering from lymphomas, leukemias, and other diseases. The journal is unique in its true international character. Especially in the field of hematopathology it is clear that there are huge geographical variations in incidence of diseases. This is not only locally relevant, but due to globalization, relevant for all those involved in the management of patients.