Journal of Hematopathology最新文献_第7页

Two cases of mycosis fungoides with large cell transformation with KMT2A rearrangements 蕈样真菌病伴大细胞转化伴KMT2A重排2例

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-11-23 DOI: 10.1007/s12308-023-00567-2

Paul A. Wadsworth, Lauren Lawrence, Carlos J. Suarez, Atif Saleem, Michael S. Khodadoust, Youn H. Kim, Kerri E. Rieger, Sebastian Fernandez-Pol

{"title":"Two cases of mycosis fungoides with large cell transformation with KMT2A rearrangements","authors":"Paul A. Wadsworth, Lauren Lawrence, Carlos J. Suarez, Atif Saleem, Michael S. Khodadoust, Youn H. Kim, Kerri E. Rieger, Sebastian Fernandez-Pol","doi":"10.1007/s12308-023-00567-2","DOIUrl":"https://doi.org/10.1007/s12308-023-00567-2","url":null,"abstract":"Cutaneous T-cell lymphomas (CTCL) are a clinically and molecularly heterogeneous class of lymphomas of the skin-homing T cell, and their genetic profiles are not fully characterized. Previously, rearrangements of the Lysine Methyltransferase 2A (KMT2A) gene have been identified as driver mutations only in acute leukemias. KMT2A plays a role in epigenetic regulation, and cancers with such rearrangements are responsive to epigenetic therapy including hypomethylating agents. Here, we report two cases of CTCL with novel genetic profiles. KMT2A rearrangements were identified in two aggressive cases of mycosis fungoides with large cell transformation. A KMT2A::DSCAML1 gene rearrangement was seen in Case 1, while a KMT2A::MAPRE1 fusion was identified in Case 2. These cases demonstrate that KMT2A rearrangements can be found in primary CTCLs rather than solely acute leukemias, illustrating the importance of correlating molecular findings with clinical and histologic features in diagnosis. Additionally, this finding suggests that the subset of CTCLs driven by aberrancy of the KMT2A pathway may be responsive to therapy with hypomethylating agents or menin inhibitors, as seen in acute leukemias.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"21 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138533218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased IgG4+ plasma cells are common in excised lymph nodes from children and adolescents without IgG4-related disease 在没有IgG4相关疾病的儿童和青少年的切除淋巴结中，IgG4+浆细胞增加是常见的

4区医学

Journal of Hematopathology Pub Date : 2023-11-09 DOI: 10.1007/s12308-023-00565-4

Rachel M. Whitehair, Nadine S. Aguilera, Patcharin Pramoonjago, Jeffrey W. Craig

引用次数: 0

Oral follicular lymphoma: a clinicopathologic and molecular study 口腔滤泡性淋巴瘤:临床病理和分子研究

4区医学

Journal of Hematopathology Pub Date : 2023-11-02 DOI: 10.1007/s12308-023-00563-6

Lucas Lacerda de Souza, Cinthia Veronica Bardález López de Cáceres, Maria Sissa Pereira Sant’Ana, Paulo Victor Mendes Penafort, Bruno Augusto Benevenuto de Andrade, Hélder Antônio Rebelo Pontes, Wagner Henriques de Castro, Ricardo Alves Mesquita, José Cândido Caldeira Xavier-Júnior, Alan Roger Santos-Silva, Márcio Ajudarte Lopes, Ciro Dantas Soares, Liam Robinson, Willie F. P. van Heerden, Rommel Mario Rodríguez Burbano, Guilherme Rossi Assis-Mendonça, José Vassallo, Silvia Ferreira de Sousa, Pablo Agustin Vargas, Felipe Paiva Fonseca

引用次数: 0

B-lymphoblastic leukemia with transient spontaneous remission in the setting of severe group A streptococcus infection 严重A组链球菌感染的b淋巴细胞白血病短暂自发缓解

4区医学

Journal of Hematopathology Pub Date : 2023-10-14 DOI: 10.1007/s12308-023-00564-5

Aubre Gilbert, Jonathan Tan, Sruti Nadimpalli, Ruzan Orkusyan, Zoila Isabel Fernandez, Jean Oak, Sebastian Fernandez-Pol

引用次数: 0

Indolent B-cell lymphoma with t(14;19) investigated from a molecular perspective 从分子角度研究惰性b细胞淋巴瘤伴t(14;19)

4区医学

Journal of Hematopathology Pub Date : 2023-10-13 DOI: 10.1007/s12308-023-00562-7

Jeremiah X. Karrs, Shivaprasad H. Sathyanarayana, Xinjie Xu, Donald C. Green, Wahab A. Kahn, Eric Y. Loo, Prabhjot Kaur

引用次数: 0

Lupus erythematosus cells in a bone marrow aspirate 骨髓抽吸中的红斑狼疮细胞

4区医学

Journal of Hematopathology Pub Date : 2023-10-02 DOI: 10.1007/s12308-023-00561-8

Jingjing Zhang, Brent Tan, Sebastian Fernandez-Pol

引用次数: 0

Chronic myeloid leukaemia (CML) presenting in B-lymphoblastic crisis: a diagnostic challenge 慢性髓性白血病(CML)表现为b淋巴细胞危象:一个诊断挑战

4区医学

Journal of Hematopathology Pub Date : 2023-09-11 DOI: 10.1007/s12308-023-00560-9

Ke Xu, Elisabeth Nacheva

引用次数: 0

Epithelioid inflammatory myofibroblastic sarcoma: a pitfall in the differential diagnosis of ALK-positive anaplastic large cell lymphoma. 上皮样炎性肌纤维肉瘤：ALK阳性无性大细胞淋巴瘤鉴别诊断中的一个陷阱。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-06-01 Epub Date: 2023-03-14 DOI: 10.1007/s12308-023-00537-8

Amr Fadl, Andrew L Feldman

{"title":"Epithelioid inflammatory myofibroblastic sarcoma: a pitfall in the differential diagnosis of ALK-positive anaplastic large cell lymphoma.","authors":"Amr Fadl, Andrew L Feldman","doi":"10.1007/s12308-023-00537-8","DOIUrl":"10.1007/s12308-023-00537-8","url":null,"abstract":"An 18-year-old female presented with a 4.5 cm abdominal mass. Biopsy showed sheet-like growth of large tumor cells with round to oval nuclei, 1-2 nucleoli, and abundant cytoplasm. Immunohistochemistry showed strong, uniform CD30 staining and cytoplasmic ALK staining. B-cell markers (CD20, CD79a, PAX5, kappa/lambda) and T-cell markers (CD2, CD3, CD4, CD5, CD43, granzyme B, T-cell receptor-β) were negative. Other hematopoietic markers (CD45, CD34, CD117, CD56, CD163, EBV) were negative, but CD138 was positive. Non-hematopoietic markers showed desmin positivity and negativity for S100, melan A, HBM45, PAX8, PAX2, WT1, MYO-D1, myogenin, pancytokeratin, and CAM5.2. Sequencing identified PRRC2B::ALK fusion. A diagnosis of epithelioid inflammatory myofibroblastic sarcoma (EIMS) was made. EIMS is a rare, aggressive form of inflammatory myofibroblastic tumor typically presenting in children and young adults. The tumor comprises large epithelioid cells that express ALK and often CD30. ALK-positive ALCL has a similar age range and also is a large-cell tumor expressing CD30 and ALK. Other ALK-positive neoplasms (e.g., carcinomas, ALK-positive large B-cell lymphoma, ALK-positive histiocytosis) typically lack CD30 and have distinct clinicopathologic features that aid diagnosis. Hematopathologists need to distinguish EIMS from ALK-positive ALCL, which frequently shows loss of pan-T-cell antigens. Careful morphologic evaluation for the hallmark cells of ALCL and comprehensive phenotyping are critical to avoid this diagnostic pitfall. If known, the ALK rearrangement partner gene may also provide diagnostic clues; for example PRRC2B::ALK and RANBP2::ALK occur in EIMS but not ALCL.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"16 2","pages":"125-126"},"PeriodicalIF":0.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coincidence of plasma cell leukemia and COVID-19: a diagnostic pitfall. 浆细胞白血病与 COVID-19 的并发症：诊断陷阱。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-06-01 Epub Date: 2023-04-10 DOI: 10.1007/s12308-023-00542-x

Margot Egger, Anne Black, Christoph Robier

{"title":"Coincidence of plasma cell leukemia and COVID-19: a diagnostic pitfall.","authors":"Margot Egger, Anne Black, Christoph Robier","doi":"10.1007/s12308-023-00542-x","DOIUrl":"10.1007/s12308-023-00542-x","url":null,"abstract":"We report the case of a 66-year-old man with a known history of IgD multiple myeloma (MM) which was admitted to hospital because of acute renal failure. Routine PCR testing on admission yielded a positive result for SARS-CoV-2 infection. Examination of the peripheral blood (PB) smear revealed 17% lymphoplasmacytoid cells and a few small plasma cells mimicking morphological changes frequently seen in viral diseases. However, flow cytometric examination showed 20% clonal lambda-restricted plasma cells being consistent with a diagnosis of secondary plasma cell leukemia. Circulating plasma cells as well as similar appearing lymphocyte subtypes such as plasmacytoid lymphocytes are frequently observed in infectious disorders such as COVID-19, so that the lymphocyte morphology in our patient's case could have been easily misinterpreted as typical COVID-19-induced changes. Our observation highlights the importance of incorporating clinical, morphological, and flow-cytometric data in distinguishing between reactive and neoplastic lymphocyte changes because misinterpretation may affect disease classification and, beyond that, clinical decision-making, which may have serious consequences for patients.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"16 2","pages":"127-128"},"PeriodicalIF":0.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coincidence of plasma cell leukemia and COVID-19: a diagnostic pitfall. 浆细胞白血病和新冠肺炎的巧合：一个诊断缺陷。

IF 0.6 4区医学

Journal of Hematopathology Pub Date : 2023-04-10 eCollection Date: 2023-06-01 DOI: 10.1007/s12308-023-00542-x

Margot Egger, Anne Black, Christoph Robier

{"title":"Coincidence of plasma cell leukemia and COVID-19: a diagnostic pitfall.","authors":"Margot Egger, Anne Black, Christoph Robier","doi":"10.1007/s12308-023-00542-x","DOIUrl":"10.1007/s12308-023-00542-x","url":null,"abstract":"We report the case of a 66-year-old man with a known history of IgD multiple myeloma (MM) which was admitted to hospital because of acute renal failure. Routine PCR testing on admission yielded a positive result for SARS-CoV-2 infection. Examination of the peripheral blood (PB) smear revealed 17% lymphoplasmacytoid cells and a few small plasma cells mimicking morphological changes frequently seen in viral diseases. However, flow cytometric examination showed 20% clonal lambda-restricted plasma cells being consistent with a diagnosis of secondary plasma cell leukemia. Circulating plasma cells as well as similar appearing lymphocyte subtypes such as plasmacytoid lymphocytes are frequently observed in infectious disorders such as COVID-19, so that the lymphocyte morphology in our patient's case could have been easily misinterpreted as typical COVID-19-induced changes. Our observation highlights the importance of incorporating clinical, morphological, and flow-cytometric data in distinguishing between reactive and neoplastic lymphocyte changes because misinterpretation may affect disease classification and, beyond that, clinical decision-making, which may have serious consequences for patients.","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"16 2","pages":"127-128"},"PeriodicalIF":0.6,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9547289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0