{"title":"Repetitive transcranial magnetic stimulation for cognitive rehabilitation in stroke survivors: A systematic review and meta-analysis of randomized controlled trials.","authors":"Anas R Alashram","doi":"10.1080/23279095.2025.2496523","DOIUrl":"https://doi.org/10.1080/23279095.2025.2496523","url":null,"abstract":"<p><p>Cognitive impairments are one of the most common consequences in stroke survivors. Repetitive transcranial magnetic stimulation (rTMS) produces electromagnetic pulses transmitted through a coil over the individual's head. This review aims to examine the effects of rTMS on cognition in stroke survivors, identify who would be most likely to benefit from the therapy, define the optimal therapeutic parameters, and provide recommendations. \"PubMed, Medline, Scopus, EMBASE, PEDro, and Web of Science\" were searched until December 5, 2024. Comprehensive Meta-Analysis version 4 was used for quantitative analysis. The \"Cochrane Collaboration tool\" was employed to assess the quality of the selected studies. Thirteen studies met the eligibility criteria. In total, 608 stroke survivors (mean age 60.17 years) were involved in the present review. The meta-analysis showed a small, non-significant effect of rTMS on global cognitive function in stroke survivors (Functional independence measure-cognitive; SMD = 0.386, 95% CI: -0.331 to 1.103, <i>p</i> = .291), (Mini-Mental State Examination; SMD = 0.162, 95% CI: -0.405 to 0.730, <i>p</i> = .575), and (Montreal Cognitive Assessment; SMD = 0.204, 95% CI: -0.613 to 1.021, <i>p</i> = .625) with high heterogeneity (I<sup>2</sup> = 77-85%). While some studies reported improvements in specific cognitive domains, overall findings indicate substantial variability and uncertainty. This review highlights inconclusive evidence on the effects of rTMS on various cognitive domains in patients with stroke. The frequency of rTMS and coil location are essential factors in determining outcomes. Future studies are strongly warranted.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-15"},"PeriodicalIF":1.4,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of depression on cognitive function among women in a psychiatric hospital: Analysis via the Beck Scale Short Version and the Moroccan Version of the Montreal Cognitive Assessment (MoCA) test.","authors":"Yasmine Benzahra, Siham Belbachir, Loubna Achour, Ali Hbibi Tadlaoui, Leila Tbatou, Fatima Ouasmani, Abdelhalem Mesfioui","doi":"10.1080/23279095.2025.2490290","DOIUrl":"https://doi.org/10.1080/23279095.2025.2490290","url":null,"abstract":"<p><strong>Aim: </strong>This study assessed the impact of depression on cognitive function in newly diagnosed women presenting to psychiatric emergency services through the cold track.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at Ar-Razi Psychiatric Hospital in Salé, Morocco, involving 86 women aged 18-58 years, newly diagnosed with depression. Depression severity was measured using the 13-item Beck Depression Inventory Short Version, and cognitive functions were assessed with the Moroccan version of the Montreal Cognitive Assessment (MoCA) test. Data analysis used SPSS v.26, employing correlation tests and one-way analysis of variance (ANOVA) to explore relationships and group differences. A confidence level of 95% and a significance threshold of 0.05 were applied.</p><p><strong>Results: </strong>Among the participants, severe depression was prevalent, particularly among women aged 38-48 years. Depression scores were significantly higher in women with only primary education, while widowed women exhibited the highest overall scores. Students and unemployed participants were the most severely affected. A negative correlation was observed between depression symptoms and cognitive function, with higher depression levels associated with lower cognitive scores. Feelings of sadness and concentration deficits were negatively correlated, as were feelings of discouragement and executive functions. Positive correlations emerged between feelings of guilt and verbal fluency.</p><p><strong>Conclusion: </strong>This study underscores the relationship between depression and cognitive impairment in women, emphasizing the need for comprehensive evaluations of cognitive deficits in depressed patients. Tailored interventions should be prioritized to improve their quality of life.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Despoti, I Patsaki, A Alexandropoulou, E Magkouti, D Tzoumi, N Leventakis, G Roussou, Α Papathanasiou, N Dimitriadi, P Presvelou, S Nanas, E Karatzanos
{"title":"Comparing virtual reality with traditional methods in cognitive rehabilitation in PICS syndrome.","authors":"A Despoti, I Patsaki, A Alexandropoulou, E Magkouti, D Tzoumi, N Leventakis, G Roussou, Α Papathanasiou, N Dimitriadi, P Presvelou, S Nanas, E Karatzanos","doi":"10.1080/23279095.2025.2477184","DOIUrl":"https://doi.org/10.1080/23279095.2025.2477184","url":null,"abstract":"<p><strong>Introduction: </strong>Post Intensive Care Unit Syndrome (PICS) manifests deficits in physical, cognitive, and mental functions following ICU hospitalization and complicates the recovery process.</p><p><strong>Aim: </strong>The clinical trial aimed to assess the impact of neuropsychological rehabilitation on cognitive deficits arising from ICU hospitalization. Additionally, it sought to compare the effectiveness of VR-based rehabilitation with traditional methods and investigate the safety and feasibility of VR intervention.</p><p><strong>Methodology: </strong>Thirty participants were divided into experimental and control groups. The experimental group underwent cognitive training using VR, while the control group utilized traditional methods. Neuropsychological assessments (Addenbrooke's Cognitive Examination-Revised (ACE-R), Frontal Assessment Battery (FAB), and Geriatric Depression Scale (GDS)) were conducted before and after a 12-session intervention (three times a week for four weeks).</p><p><strong>Results: </strong>Regardless of the intervention type, participants exhibited statistically significant improvements in general cognitive function (<i>p</i> = 0.02), attention (<i>p</i> = 0.016), visuospatial (<i>p</i> = 0.03), and executive functions (<i>p</i> = 0.011). The experimental group showed greater improvement in visuospatial function (<i>p</i> = 0.011), while the control group demonstrated enhanced language fluency (<i>p</i> = 0.019). Correlations between cognitive functions were observed in baseline measures and their differences. VR was found to be a safe, suitable, and enjoyable rehabilitation method, as indicated by Suitability Evaluation Questionnaire (SEQ) scores, with a mean of 60.7 (SD = 5.5).</p><p><strong>Discussion: </strong>These preliminary data suggest that VR can be effective in the rehabilitation of cognitive functions in ICU survivors with PICS, especially in visuospatial abilities. Large-scale longitudinal clinical trials involving diverse patient groups are needed to explore the long-term impact of VR interventions on cognitive functions.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-12"},"PeriodicalIF":1.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George Whitman Kent, John-Christopher A Finley, Mira I Leese, Tyler J Kukla, Hajar Ismail, Brian M Cerny, Jason R Soble, Matthew S Phillips
{"title":"Preferential impact of processing speed and memory on Rey Auditory Verbal Learning Test and Brief Visuospatial Memory Test-revised embedded performance validity tests.","authors":"George Whitman Kent, John-Christopher A Finley, Mira I Leese, Tyler J Kukla, Hajar Ismail, Brian M Cerny, Jason R Soble, Matthew S Phillips","doi":"10.1080/23279095.2025.2492697","DOIUrl":"https://doi.org/10.1080/23279095.2025.2492697","url":null,"abstract":"<p><p>This study evaluated the impact of single-domain impairment in processing speed and memory versus multidomain impairment on the Rey Auditory Verbal Learning Test Forced Choice (RAVLT FC) and Brief Visuospatial Memory Test-Revised Recognition Discrimination (BVMT-R RD) PVTs among a sample of 385 nonconsecutive mixed clinical patients referred for outpatient neuropsychological evaluation. The sample was dichotomized to form valid (<i>n</i> = 307) and invalid (<i>n</i> = 78) groups. The valid study group was subdivided into an intact cognition group (<i>n</i> = 174), single-domain processing speed (<i>n</i> = 27) and memory (<i>n</i> = 59) groups, and a combined speed and memory impairment group (<i>n</i> = 47). The impaired memory group showed acceptable classification accuracy for the RAVLT FC (≤12; 35% sensitivity/90% specificity) and BVMT RD (≤4; 33% sensitivity/90% specificity). The impaired speed group evidenced excellent classification for the RAVLT FC (≤14; 64% sensitivity/96% specificity) and acceptable accuracy for the BVMT RD (≤4; 33% sensitivity/96% specificity). For the impaired speed and memory group, classification accuracy was acceptable for the RAVLT FC (≤12; 35% sensitivity/92% specificity) and poor (although still statistically significant) for the BVMT RD (≤3; 24% sensitivity/94% specificity). Therefore, use of adjusted cut-scores among neuropsychological conditions associated with deficits in memory and/or speed is needed when using these PVTs in clinical practice.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hollie Thomson, Stephanie Crawford, Jonathan J Evans
{"title":"An investigation into the intra and inter rater scoring reliability of the Addenbrooke's Cognitive Examination-III.","authors":"Hollie Thomson, Stephanie Crawford, Jonathan J Evans","doi":"10.1080/23279095.2025.2489632","DOIUrl":"https://doi.org/10.1080/23279095.2025.2489632","url":null,"abstract":"<p><strong>Background: </strong>Cognitive screening tests are essential to the process of early detection and diagnosis of dementia. The Addenbrooke's Cognitive Examination-III (ACE-III) is one such tool. Rater reliability in scoring is an important psychometric property of all tests.</p><p><strong>Aims: </strong>To investigate rater accuracy in scoring the ACE-III across different raters and by the same raters at two different time points. A secondary exploratory analysis examined whether scoring accuracy is associated with participants' training and experience with the ACE-III.</p><p><strong>Methods: </strong>A filmed vignette of the ACE-III being administered to an older adult actor (mock patient) was used to assess scoring accuracy across different raters. The vignette had pre-determined \"true\" scores. Participants were UK National Health Service staff who routinely administer and score the ACE-III as part of their clinical practice. They were asked to view the filmed vignette and complete an ACE-III scoring sheet. After two months, participants scored the same vignette again.</p><p><strong>Results and conclusions: </strong>At Time 1, 20% of participants' scores matched the true score, with 32% deviating by 3-5 points, and an overall range of 10 points. At Time 2, 24% of scores matched the true score, with 11% deviating by three points, and an overall range of six points. Errors were mainly accounted for by the domains requiring subjective judgements, namely the visuospatial and language subtests. Intra-rater consistency was low to moderate. Previous experience of using the ACE-III, nor previous ACE-III training, led to statisically significant differences in scoring performance. Health professionals should consider these findings when scoring the ACE-III and utilize the ACE-III administration and scoring guide to improve accuracy.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Raising the bar: Preliminary investigation of alternative MSVT cutoffs for adults referred for ADHD.","authors":"Anthony D Robinson, Matthew Calamia","doi":"10.1080/23279095.2025.2488355","DOIUrl":"https://doi.org/10.1080/23279095.2025.2488355","url":null,"abstract":"<p><p>This study investigated the classification accuracy of alternative cutoffs for three Medical Symptom Validity Test (MSVT) indices, Immediate Recall (IR), Delayed Recall (DR), and Consistency (CNS). Study 1 included 83 college students randomized into two simulated ADHD groups (Incentivized simulator <i>n</i> = 25; Non-incentivized simulator <i>n</i> = 28) and one control group (<i>n</i> = 30). Study 2 included cross-sectional data from 114 ADHD referrals at a university-based clinic (<i>n</i> = 91 valid group; <i>n</i> = 23 invalid group) who completed the MSVT and at least two additional performance validity tests. Receiver Operator Characteristic (ROC) curves in study 1 revealed significant areas under the curve for IR, DR, and CNS (AUC = .81 - .86), high to perfect specificity (.93 - .10), and moderate to high sensitivity (.45 - .75) using cutoffs of ≤85, ≤90, and ≤95. ROC curve analyses in study 2 yielded significant areas under the curve for IR (AUC = .73), DR (AUC = .74), and CNS (AUC = .78). An optimal cut score of ≤90 across all three subtests yielded modest sensitivity (.35 - .52) while still maintaining adequate specificity (.91 - .96). The manual-recommended cutoff for invalidity (IR, DR, or CNS ≤85) demonstrated high specificity (95%) but only modest sensitivity (35%) whereas the modified cutoff (IR, DR, or CNS ≤90) increased sensitivity substantially (56%) while maintaining adequate specificity (90%). This study provides preliminary support for alternative MSVT cutoffs in adult ADHD assessments. However, additional research is warranted before utilizing these alternative cutoffs in clinical contexts.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nisa Türütgen, İsmail Okur, Aylin Aydoğdu Delibay, Çimen Ölçay Demir, Simge Dönmez, Lütfiye Akkurt, Maria Antonietta Annunziata
{"title":"Cross-cultural adaptation, validity and reliability of the Turkish version of the Cognitive Functioning Self-Assessment Scale (CFSS).","authors":"Nisa Türütgen, İsmail Okur, Aylin Aydoğdu Delibay, Çimen Ölçay Demir, Simge Dönmez, Lütfiye Akkurt, Maria Antonietta Annunziata","doi":"10.1080/23279095.2025.2490846","DOIUrl":"10.1080/23279095.2025.2490846","url":null,"abstract":"<p><p>The Cognitive Functioning Self-Assessment Scale (CFSS) is a scale that enables individuals to assess their subjective cognitive performance. The study aimed to cross-culturally adapt the CFSS to Turkish (CFSS-TR) and prove its psychometric properties. The study included 180 community-dwelling adults over 18 years of age with no psychological or neurological disorders. Participants were assessed using the CFSS-TR, Hospital Anxiety Depression Scale (HADS), and the Cognitive Failures Questionnaire (CFQ) via online survey. Two weeks later, the CFSS-TR was taken from the participants for the second time. The mean age of the individuals was 41.06 ± 13.34 years. The CFSS-TR had good test-retest reliability (ICC: 0.84, CI 95%: 0.78-0.88) and good internal consistency (α = 0.88). The standard error of measurement (SEM) and the 95% confidence interval minimal detectable change (MDC95) values for the total score were 0.11 and 0.30, respectively. CFSS-TR had a strong correlation with CFQ, moderate correlation with HADS depression subscore, and weak correlation with HADS anxiety subscore (respectively r = 0.71, r = 0.52, r = 0.39, p < 0.001). CFSS-TR is a reliable and valid questionnaire for self-assessment of cognitive function in Turkish-speaking community-dwelling adults.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Evangelina Valeria Cores, Florencia Carla Cossini, Carolina Cuesta, Karen Daniela Román, Daniel Gustavo Politis
{"title":"Remembering delayed intentions in patients with mild cognitive impairment and Alzheimer's disease.","authors":"Evangelina Valeria Cores, Florencia Carla Cossini, Carolina Cuesta, Karen Daniela Román, Daniel Gustavo Politis","doi":"10.1080/23279095.2025.2487199","DOIUrl":"10.1080/23279095.2025.2487199","url":null,"abstract":"<p><p>Prospective memory (PM) is the ability to remember intended actions and to evoke delayed intentions. It is a crucial skill in daily life functioning in the elderly and can be prematurely compromised in neurodegenerative processes. In the Latin American region, there are no established impartial metrics for its assessment. The purpose of this study is to explore PM in patients diagnosed with Mild cognitive impairment (MCI) and Alzheimer's disease (AD). The specific objectives are to: to differentiate the performance of healthy subjects, patients with MCI, and patients with AD; to measure the relationship between PM and other cognitive test performance; and lastly, to analyze the internal consistency and inter-rater reliability of the Mini Cóndor Test, a brief PM assessment tool adapted for elderly patients with low-education levels The test only exist in Spanish. A comparative study of independent samples was conducted between 33 patients diagnosed with AD, 39 patients with MCI, and a control group of 33 healthy subjects. The results showed significant differences in the performance of PM, with the control group performing best, while the AD group had a significantly worse performance in the test than the MCI group. PM performance correlated significantly with retrospective memory and executive function. The Mini Cóndor Test yielded adequate indices for internal consistency and inter-rater reliability. This Test has the potential to detect cognitive impairment associated with neurodegenerative pathology at an early stage.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validating the effects of sex differences and auditory/visual-based verbal memory on recall tasks in a virtual supermarket.","authors":"Chen-Wei Chang","doi":"10.1080/23279095.2025.2484787","DOIUrl":"https://doi.org/10.1080/23279095.2025.2484787","url":null,"abstract":"<p><p>Virtual reality (VR), with its superior ecological validity, offers a potential new method for assessing and training memory recall. To further validate the utilization of VR, the current study explores the effects of sex and auditory/visual-based verbal memory-both closely related to memory recall in everyday shopping behavior-on recall tasks both inside and outside of a virtual supermarket. The International Shopping List Test (ISLT) verbal recall tasks were used in the experiment. To examine whether the same effects exist in VR, a self-developed virtual supermarket was applied. The results indicate that women and those who were in the visual-based group for verbal memory performed better both inside and outside the VR. The study further compares users' spatial-based visual memory encoding with verbal memory retrieval in VR to determine whether they align with theoretical assumptions and prior studies. The findings support the view that women's superior visual memory may be compromised in the virtual supermarket due to their relatively lower self-reported sense of direction (SOD) and higher levels of wayfinding anxiety compared to men. Empirical and practical implications based on these findings are discussed in the study.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas J Farrer, Erin D Bigler, Yoko H W Tsui-Caldwell, Tracy J Abildskov, JoAnn T Tschanz, Kathleen A Welsh-Bohmer
{"title":"Scheltens rating scores of white matter are predictive of language function among older adults with dementia.","authors":"Thomas J Farrer, Erin D Bigler, Yoko H W Tsui-Caldwell, Tracy J Abildskov, JoAnn T Tschanz, Kathleen A Welsh-Bohmer","doi":"10.1080/23279095.2025.2486464","DOIUrl":"https://doi.org/10.1080/23279095.2025.2486464","url":null,"abstract":"<p><strong>Objective: </strong>Examine the correlation between a visual rating of white matter integrity and common measures of language function in older adults from the Cache County Memory Study (CCMS) legacy data.</p><p><strong>Methods: </strong>Scheltens Ratings scores of white matter were calculated on MRI data of older adults from the CCMS cohort. A total score was used as a marker of overall white matter burden. This was used as a predictor variable of language function in a sample of 22 controls and 393 with Alzheimer's disease or related dementias (ADRD). This included both pair-wise correlations and bivariate linear regression analysis. A post-hoc t-test analysis compared the upper and lower quartiles of the Scheltens Total for performance on language function tests.</p><p><strong>Results: </strong>There were no meaningful associations between white matter integrity and language function for control participants. For the ADRD group, there were significant but small correlations. The post-hoc analysis suggested that greater white matter burden is associated with lower language function in those with ADRD.</p><p><strong>Conclusion: </strong>The findings provide continued support for the clinical utility of visual ratings in the assessment of cognitive function among older adults with dementia - white matter burden relates to greater impairments in performance on language test findings.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}