Applied Neuropsychology-Adult最新文献

{"title":"Cognitive function and breast cancer molecular subtype before and after chemotherapy.","authors":"Yen-Hsuan Hsu, Hui-Jyuan Chen, Shu-I Wu, Bor-Show Tzang, Ching-Chuan Hsieh, Yi-Ping Weng, Ya-Ting Hsu, Han-Pin Hsiao, Vincent Chin-Hung Chen","doi":"10.1080/23279095.2023.2176233","DOIUrl":"10.1080/23279095.2023.2176233","url":null,"abstract":"<p><p>Chemotherapy-related cognitive impairment has been reported in patients with breast cancer and received growing attention due to increased survival rate. However, cognitive outcome according to pathological tumor features, especially human epidermal growth factor receptor (HER2) status, has not been clearly elucidated. Despite its potential link with cognitive status through neuroinflammatory response, existing research is sparse and limited to cross-sectional studies. In this observational cohort study, 52 breast cancer patients received a series of neuropsychological examinations before and after chemotherapy. Patients' performances were compared with normative data, and analyzed with Reliable Change Indices and mixed-model analysis of covariance. Results showed that there was a higher percentage of HER2⁺ patients than HER2^- patients who showed defective attention and processing speed before chemotherapy, and that there were more patients with HER2⁺ status showing cognitive decline on tests of attention and executive functions following chemotherapy. Group-wise analyses confirmed the foregoing pattern and further revealed that patients with HER2⁺ status also tended to deteriorate more in verbal memory after chemotherapy. These findings indicate that HER2 overexpression may serve as prognostic factors that help explain the heterogeneous cognitive outcome in breast cancer survivors. Further studies are needed to replicate this finding and delineate the underlying mechanisms.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"442-449"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9242054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor vehicle crash concussion mechanism displays a greater total number of symptoms and greater affective symptom severity but no neurocognitive differences compared with sport-related concussion mechanism.","authors":"Eric J Shumski, Melissa N Anderson, Julianne D Schmidt, Robert C Lynall","doi":"10.1080/23279095.2023.2190522","DOIUrl":"10.1080/23279095.2023.2190522","url":null,"abstract":"<p><p>Previous research among adolescents has shown differences in symptoms and neurocognitive performance between sport-related (SRC) and motor vehicle crash (MVC) concussion mechanisms. Limited research has focused on young adults. The purpose of our study was to compare symptoms, balance, and neurocognitive performance between SRC and MVC mechanisms in young adults. Forty-three (58.1% female, age = 25.5 ± 3.2 years, days since concussion = 12.8 ± 12.7) and 26 (76.9% female, age = 24.1 ± 5.6 years, days since concussion = 12.6 ± 8.3) individuals with an SRC and MVC mechanism, respectively, participated. Primary outcome measures included the total number, severity, cluster (disorientation, migraine, lethargy, and affective) of post-concussion symptoms endorsed, Balance Error Scoring System (BESS), and CNS Vital Signs scores. Clusters are subgroups of symptoms used for targeted rehabilitation. We used independent <i>t</i>-tests and Mann-Whitney <i>U</i> tests to compare symptoms, BESS, and neurocognitive performance. Cliff's Delta effect size was interpreted as negligible (<0.15), small (0.15-0.33), medium (0.34-0.47), and large (≥0.48). There were no group differences for any demographic factors or preexisting conditions (<i>p</i>-range = 0.112-0.991). Participants with an MVC mechanism reported a greater number of total post-concussion symptoms (<i>p</i> = 0.025, Cliff's Delta = 0.32) and a more severe affective symptom cluster (<i>p</i> = 0.010, Cliff's Delta = 0.37). There were no group differences for BESS or neurocognitive performance after correcting for multiple comparisons. The MVC mechanism resulted in a greater total symptom burden relative to the SRC mechanism. Medical practitioners and individuals experiencing a concussion should know that concussions are heterogeneous within and across various mechanisms.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"538-544"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9130068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecological validity in neurocognitive assessment: Systematized review, content analysis, and proposal of an instrument.","authors":"Joana O Pinto, Artemisa R Dores, Bruno Peixoto, Fernando Barbosa","doi":"10.1080/23279095.2023.2170800","DOIUrl":"10.1080/23279095.2023.2170800","url":null,"abstract":"<p><strong>Objectives: </strong>The main objectives of this study are to identify the dimensions of Ecological Validity (EV) within the definitions of this concept, understand how they are operationalized in neurocognitive tests, and propose a checklist for EV attributes in neurocognitive tests.</p><p><strong>Method: </strong>A systematized review was combined with content analysis of the selected papers, using the inductive method. We analyzed 82 studies on the EV of neurocognitive tests, 19 literature reviews and 63 empirical studies. Based on this review, we identified the relevant criteria for evaluating EV.</p><p><strong>Results: </strong>EV is a multidimensional concept with two main dimensions: representativeness and generalization. Representativeness involves the subdimensions simplicity-complexity and artificial-natural and several criteria organized on a continuum from low EV to high EV. Generalization is dependent on representativeness and is influenced by different cognitive and non-cognitive factors. We propose six stages for operationalizing EV, from defining the objectives of the neurocognitive assessment to the methodology for scoring and interpreting the results.</p><p><strong>Conclusion: </strong>This systematized review helps to operationalize the concept of EV by providing a tool for evaluating and improving EV while developing new tests. Further studies with a longitudinal design can compare the predictive value of tests with higher versus lower EV-checklist scores.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"577-594"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10666319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental validity of brief and abbreviated neuropsychological tests toward predicting functional outcomes in multiple sclerosis.","authors":"Jeremy G Grant, Lisa J Rapport, Rachel Darling, Brigid Waldron-Perrine, Eva Bernitsas","doi":"10.1080/23279095.2023.2176766","DOIUrl":"10.1080/23279095.2023.2176766","url":null,"abstract":"<p><strong>Objective: </strong>This study examined the relationships among functional outcomes and performance on standard-length and abbreviated cognitive screening measures for multiple sclerosis (MS).</p><p><strong>Method: </strong>72 adults with MS underwent neurological examination and cognitive screening. They completed standard-length and abbreviated versions of tests from the Minimal Assessment of Cognitive Function in MS (MACFIMS), the abbreviated aMACFIMS, and the Brief International Cognitive Assessment for MS (BICAMS). Functional outcomes included neurological disability, physical and psychological dysfunction, and employment status.</p><p><strong>Results: </strong>Concordance of impairment classifications was examined between standard-length and abbreviated tests using logistic regression and ROC curve analyses. Overall, the abbreviated test versions showed a broad range of concordance with impairment classifications made using the full-length tests. Processing speed was the strongest correlate of neurological disability and employment status; immediate recall was the strongest predictor of subjective physical dysfunction. Test performance provided unique value toward predicting neurological disability and employment status, but not physical and psychological dysfunction.</p><p><strong>Conclusions: </strong>The findings replicate some support for abbreviated tests in MS assessment, although caveats regarding loss of validity associated with abbreviation remain. The findings extend prior research showing that abbreviated tests of processing speed and immediate recall can provide unique predictive information regarding objective functional outcomes.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"460-470"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10705016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of 3D-MOT training on the execution of manual dexterity skills in a population of older adults with mild cognitive impairment and mild dementia.","authors":"Laura P Burgos-Morelos, José de Jesús Rivera-Sánchez, Ángel Daniel Santana-Vargas, Claudia Arreola-Mora, Adolfo Chávez-Negrete, J Eduardo Lugo, Jocelyn Faubert, Argelia Pérez-Pacheco","doi":"10.1080/23279095.2023.2169884","DOIUrl":"10.1080/23279095.2023.2169884","url":null,"abstract":"<p><p>Computerized cognitive training tools are an alternative to preventive treatments related to cognitive impairment and aging. In this study, the transfer of 3D multiple object tracking (3D-MOT) training on manual dexterity concerning fine and gross motor skills in 38 elderly participants, half of them with mild cognitive impairment (MCI) and the other half with mild dementia (MD) was explored. A total of 36 sessions of the 3D-MOT training program were administered to the subjects. The Montreal Cognitive Assessment (MoCA) test was used to assess the baseline cognitive status of the participants. Two batteries of manual motor skills (GPT and MMDT) were applied before and after the 3D-MOT training program. The results showed an interaction effect of training and improvement in manual dexterity tests, from the first training session until the fifteenth session, and after this range of sessions, the interaction effect was lost. However, the training effect continued to the end of the thirty-six-session program. The experimental results show the effect of cognitive training on the improvement of motor skills in older adults. This type of intervention could have a broad impact on the aging population in terms of their attention, executive functions, and therefore, their quality of life.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"328-337"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10610108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Return to work following mild traumatic brain injury: Psychological and cognitive factors in a litigating sample in the post acute stage of recovery.","authors":"Angela Sekely, Aalim Makani, Sonya Dhillon, Konstantine K Zakzanis","doi":"10.1080/23279095.2023.2171293","DOIUrl":"10.1080/23279095.2023.2171293","url":null,"abstract":"<p><p>The purpose of this study was to investigate return to work (RTW) rates following a single uncomplicated mild Traumatic Brain Injury (mTBI) in the post-acute stage in the context of active litigation. More specifically, we sought to determine what psychological and/or cognitive factors predict a RTW after mTBI. Archival data were obtained from a random sample of litigating patients (<i>n</i> = 125; 54% female; mean age: 42.96 (SD = 12.74) who were referred to a private practice for a neuropsychological examination regarding their disability status following a single uncomplicated mTBI. A hierarchical regression analysis was used to assess the predictive value of emotional symptoms and cognition with respect to RTW status. Approximately 50% of the sample did not RTW. Attentional deficits (<i>r_s</i> = -0.248) and depressive symptoms (<i>r_s</i> = 0.248) were significantly associated with RTW. A hierarchical regression analysis found that depressive symptoms (<i>p</i> < .05) were associated with RTW outcomes. These findings suggest that individuals with increased depressive symptoms are more likely to demonstrate poor RTW outcomes in the post-acute stages of mTBI. These results are of interest to clinicians as they underscore the importance of screening and early intervention for depressive symptoms following a single uncomplicated mTBI in the post-acute stages in litigating samples.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"367-374"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10591492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus anxiety and its relationship to mood and cognition in post-acute sequelae of COVID-19.","authors":"Hannah Darwazah, Jared B Hammond, Stephen L Aita, Grant G Moncrief, Ryan C Thompson, Jonathan D Lichtenstein, Robert M Roth","doi":"10.1080/23279095.2025.2469247","DOIUrl":"https://doi.org/10.1080/23279095.2025.2469247","url":null,"abstract":"<p><p><b>Background:</b> Subjective and objective cognitive dysfunction may be observed in patients with post-acute sequelae of COVID-19 (PASC), and are associated with depression and general anxiety. Coronavirus anxiety (CA) is associated with subjective cognition, depression, and general anxiety in community samples. We determined the base rate of CA in patients with PASC and its relation to mood, subjective and objective cognition. <b>Design and Methods:</b> Participants were 79 patients with PASC referred for clinical neuropsychological evaluation, who completed the Coronavirus Anxiety Scale (CAS), BDI-II, BAI, BRIEF-A, and cognitive tests. <b>Results:</b> Base rate of clinically elevated CAS was low (5.1%), whereas BDI-II (78.6%), BAI (80%), and BRIEF-A Global Executive Composite (GEC; 60.3%) were high. Objective dysfunction was most common for Color-Word Interference (20.8%) and Trail Making Test (TMT) Part-B (23.1%). Greater CA was associated with worse depression, general anxiety, BRIEF-A GEC, and TMT Part-A. Higher GAI accounted for the CAS and BRIEF-A GEC association. Longer time since pandemic onset was only associated with decreasing CA. Exploratory factor analysis supported a unidimensional structure for the CAS. <b>Conclusions:</b> Clinically elevated CA is rare in patients with PASC seen for neuropsychological evaluation. Higher CA is associated with worse mood and subjective executive dysfunction, though the latter was accounted for by general anxiety. Patients with PASC who endorse a high level of CA would likely benefit from interventions to reduce emotional distress.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in cerebral artery flow velocity acceleration pattern correlate with cognitive impairment in diabetes mellitus.","authors":"Ahmet Tas, Muhammed Ikbal Bayhan, Mehlika Yildiz, Yaren Alan, Zeynep Atay, Fatih Sezer, Cagla Kitapli, Ilke Kara Tas, Sabahattin Umman, Murat Sezer","doi":"10.1080/23279095.2025.2469261","DOIUrl":"https://doi.org/10.1080/23279095.2025.2469261","url":null,"abstract":"<p><strong>Introduction: </strong>Flow velocity acceleration pattern is related to shear stress, pressure changes, cardiovascular risk factors, diabetes mellitus, hypertension, endothelial dysfunction and arterial stiffness. Considering the hemodynamic alterations in cognitive impairment, perturbations in cerebral artery flow acceleration pattern may correlate with cognitive impairment, which could enhance our understanding of how cardiovascular risk factors drive cognitive decline from a mechanistic point of view.</p><p><strong>Method: </strong>The first derivative of middle cerebral artery flow velocity waveforms obtained via transcranial Doppler were computed to visualize acceleration/deceleration waves (a,b,c,d,e) in ensemble-averaged signals. Vascular Aging Index was calculated per its definition (VAI:(b-c-d-e)/a). Relationship between multiple cognitive domains and VAI was evaluated with standard statistical tests.</p><p><strong>Results: </strong>VAI was significantly correlated with HVLT total recall (Hopkins Verbal Learning Test-revised) (<i>r</i>: -0.310 <i>p</i>: 0.046, <i>n</i>: 42), delayed recall (<i>r</i>: -0.396 <i>p</i>: 0.009), % Retention (<i>r</i>: -0.305 <i>p</i>: 0.050) and components of RCFT(Rey-Osterrieth Complex Figure Test), namely raw copy score (<i>r</i>: -0.524 <i>p</i> < 0.001), immediate recall (<i>r</i>: -0.323 <i>p</i>: 0.037). Controlling for age, body mass index, gray matter volume and diabetes duration yielded stronger correlations but lower group numbers due to missing data. Correlation coefficients for VAI with HVLT delayed recall and % Retention were -0.439 (<i>p</i>: 0.012) and -0.444(<i>p</i>: 0.011 <i>n</i>: 36) respectively. Likewise the adjusted correlations of VAI with RCFT components were improved (Raw Copy <i>r</i>: -0.557 <i>p</i> < 0.001, Immediate Recall <i>r</i>: -0.440 <i>p</i>: 0.012, Delayed Recall (<i>r</i>: -0.358 <i>p</i>: 0.044).</p><p><strong>Conclusion: </strong>In patients with diabetes, cerebral artery flow velocity acceleration pattern correlates with cognitive performance in visuo-constructional and verbal cognitive domains. Computational fluid dynamics may aid developing a better mechanistic understanding of arterial hemodynamics-cortical function coupling.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial direct current stimulation for cognitive rehabilitation in people with multiple sclerosis: A systematic review of randomized controlled trials.","authors":"Anas R Alashram","doi":"10.1080/23279095.2025.2465851","DOIUrl":"https://doi.org/10.1080/23279095.2025.2465851","url":null,"abstract":"<p><p>People with multiple sclerosis (PwMS) often experience cognitive impairments that affect independence in their activities. Transcranial direct current stimulation (tDCS) has been recently used for treating cognitive impairments in patients with neurological conditions. This review aims to investigate the effects of tDCS on cognitive function in PwMS. Databases including \"PubMed, SCOPUS, MEDLINE, EMBASEe, and Web of Science\" were searched until July 2024. The risk of bias was evaluated using the Cochrane Collaboration tool (CCT). Nine were selected for inclusion in this review, encompassing 274 PwMS, 77.74% of whom were females. Five studies have a low risk of bias, while four have a moderate risk of bias on the CCT. The findings revealed mixed evidence regarding the effects of tDCS on cognitive function in PwMS. In conclusion, most studies have shown that tDCS does not improve various cognitive domains in PwMS. However, due to the limited number of studies and their high heterogeneity, further research is needed to assess the immediate and long-term impacts of tDCS on numerous cognitive domains in PwMS, understand the relationship between PwMS characteristics and their response to the tDCS intervention, and define the optimal tDCS treatment protocols for treating cognitive impairments in PwMS.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-12"},"PeriodicalIF":1.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychology of Alzheimer's disease: From preclinical phase to dementia.","authors":"Ezgi Soncu Büyükişcan","doi":"10.1080/23279095.2025.2469236","DOIUrl":"https://doi.org/10.1080/23279095.2025.2469236","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by significant cognitive and functional decline, initially presenting with episodic memory impairment. A thorough neuropsychological assessment is essential for AD diagnosis, particularly in the early stages in which interventions may be more effective. This paper reviews the neuropsychology of Alzheimer's disease, highlighting the cognitive progression of the disease. In the typical forms of AD, episodic memory appears to be the first and foremost affected cognitive domain. As AD progresses, cognitive impairments extend beyond memory to affect various domains such as attention, executive functions, language, and visuospatial abilities. Neuropsychiatric issues, such as depression and anxiety, which often accompany cognitive decline, are also common, especially at the advanced stages of the disease. While episodic memory impairment is the earliest and most prominent feature in typical AD cases, comprehensive assessments, including social cognition and neuropsychiatric evaluations, are crucial for accurate diagnosis and treatment planning.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}