Materials Science & Engineering C-Materials for Biological Applications最新文献_第3页

Carbohydrate polymers in cancer theranostics: Smart solutions for advanced diagnosis and therapy 碳水化合物聚合物在癌症治疗：先进诊断和治疗的智能解决方案。

IF 6 2区医学

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-24 DOI: 10.1016/j.bioadv.2025.214522

Preeti Rajesh , Harsimran Kaur , Vishal Ahuja , Deepak Sharma , Gholamreza Abdi

{"title":"Carbohydrate polymers in cancer theranostics: Smart solutions for advanced diagnosis and therapy","authors":"Preeti Rajesh , Harsimran Kaur , Vishal Ahuja , Deepak Sharma , Gholamreza Abdi","doi":"10.1016/j.bioadv.2025.214522","DOIUrl":"10.1016/j.bioadv.2025.214522","url":null,"abstract":"<div><div>The versatility and chemical flexibility of polymeric carbohydrates have significantly advanced the field of cancer therapy and theranostics. The controlled release, biodegradability, and biocompatibility of these polymers are currently being researched intensively for their utility in targeted drug delivery systems for the treatment of breast and colon cancer, among others. Due to their abundance, low <em>in vivo</em> toxicity, and amenability to functionalization, these polymers are becoming more and more popular as therapeutic nanoparticles and as nanoplatforms for simultaneous drug delivery and imaging. Functionalized carbohydrate polymers can improve the accuracy of cancer detection using molecular imaging methods. The fusion of imaging modalities with drug delivery systems enables a controlled and targeted release of drugs, hence improving therapeutic efficacy with fewer side effects. The inherent immunomodulatory property of such systems also enables modulation of immune cell function and restoration of the tumor microenvironment, hence facilitating anti-cancer immunity. Through stimulus-responsive mechanisms, advanced polymeric systems can respond to the specific conditions within individual tumors, enhancing cancer treatment efficacy. Advances in glycobiology and nanotechnology have improved the potential of carbohydrate polymers, and identified as potential candidates for next-generation cancer theranostics. Future research and translation of findings to clinical applications will likely result in more personalized and effective ways of treating cancer.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"179 ","pages":"Article 214522"},"PeriodicalIF":6.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of a fully biodegradable and biomimetic epicardial patch providing synergic physico-chemical, mechanical and electrical cues for myocardial infarction therapy 实现完全可生物降解的仿生心外膜贴片，为心肌梗死治疗提供物理化学、机械和电的协同提示。

IF 6 2区医学

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-24 DOI: 10.1016/j.bioadv.2025.214523

Caterina Cristallini , Daniela Rossin , Niccoletta Barbani , Roberto Vanni , Massimiliano Labardi , Cheherazade Trouki , Silvia Burchielli , Claudia Kusmic , Domiziana Terlizzi , Francesca Sergi , Chiara Bulgheresi , Dawid Rossino , Erika Fiorino , Matteo Aubry , Marco Lo Iacono , Sadia Perveen , Giorgia Scarpellino , Luca Munaron , Sara Amorim , Ricardo A. Pires , Claudia Giachino

{"title":"Implementation of a fully biodegradable and biomimetic epicardial patch providing synergic physico-chemical, mechanical and electrical cues for myocardial infarction therapy","authors":"Caterina Cristallini , Daniela Rossin , Niccoletta Barbani , Roberto Vanni , Massimiliano Labardi , Cheherazade Trouki , Silvia Burchielli , Claudia Kusmic , Domiziana Terlizzi , Francesca Sergi , Chiara Bulgheresi , Dawid Rossino , Erika Fiorino , Matteo Aubry , Marco Lo Iacono , Sadia Perveen , Giorgia Scarpellino , Luca Munaron , Sara Amorim , Ricardo A. Pires , Claudia Giachino","doi":"10.1016/j.bioadv.2025.214523","DOIUrl":"10.1016/j.bioadv.2025.214523","url":null,"abstract":"<div><div>The intrinsic limitation of myocardial tissue to self-repair after damage underscores the need for innovative approaches in addressing cardiac tissue damage post-myocardial infarction (MI). We aimed to develop an acellular, bioartificial, microstructured and electroconductive patch (PGF) made of poly(lactic-<em>co</em>-glycolic acid) (PLGA), Gelatin, and 9-fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF), to foster post-MI endogenous cardiac healing capabilities. The self-assembling semi-conductive peptide Fmoc-FF was introduced to reduce the electrical impedance of the polymer components while maintaining the complete biodegradation of the patch. Unexpectedly, the electroconductive component was found to increase the patch microstructure stability, improve cardiomyoblast elongation, augment stromal cell differentiation and sustain Human induced Pluripotent Stem Cell-derived Cardiomyocytes (hiPSC-CM) beating for at least 30 days. The main outcome was demonstrated <em>in vivo</em>, where epicardial implantation of the PGF patch in a rat model of ischaemia-reperfusion promoted significant cardiac tissue repair: this was evidenced by preservation of the myocardial tissue, reduced fibrosis, and recruitment of endogenous c-Kit+ cells. This newly implemented patch configuration promotes efficient myocardial healing, offering a promising therapeutic approach for infarcted patients.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"179 ","pages":"Article 214523"},"PeriodicalIF":6.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A biomimetic approach to skin-targeted drug delivery: A perspective on mesoporous silica–polysaccharide hybrids for regenerative cosmeceuticals 皮肤靶向药物递送的仿生方法：用于再生药妆的介孔硅-多糖混合物的前景

IF 6 2区医学

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-23 DOI: 10.1016/j.bioadv.2025.214524

Noor Ul Ain , Bilqees Hussain , Qura tul Ain , Muhammad Ramzan , Bibimaryam Khan , Farid Menaa

{"title":"A biomimetic approach to skin-targeted drug delivery: A perspective on mesoporous silica–polysaccharide hybrids for regenerative cosmeceuticals","authors":"Noor Ul Ain , Bilqees Hussain , Qura tul Ain , Muhammad Ramzan , Bibimaryam Khan , Farid Menaa","doi":"10.1016/j.bioadv.2025.214524","DOIUrl":"10.1016/j.bioadv.2025.214524","url":null,"abstract":"<div><div>Skin disorders such as acne and photoaging arise from intersecting biological processes including microbial imbalance, chronic inflammation, oxidative stress, and extracellular matrix degradation. Conventional therapies often provide partial or short-term relief while carrying risks of irritation or resistance. A promising alternative lies in biomimetic systems that integrate mesoporous silica nanoparticles (MSNs) with herbal polysaccharides. MSNs offer structural tunability, high loading capacity, and controlled release, while polysaccharides contribute intrinsic antioxidant, anti-inflammatory, antimicrobial, and regenerative properties. When combined, these hybrids function as adaptive carriers and bioactive agents, capable of reinforcing skin repair and hydration while attenuating pathological signaling. By aligning nanostructured design with natural bioactivity, MSN–polysaccharide systems represent a forward-looking strategy for regenerative cosmeceuticals, bridging traditional therapeutics and precision nanotechnology.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"179 ","pages":"Article 214524"},"PeriodicalIF":6.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygen generating magnesium peroxide nanoparticles by in-situ catalytic reaction with nano‑manganese oxide promote rapid healing of chronic diabetic wounds 通过原位催化反应生成氧的氧化镁纳米颗粒与纳米锰氧化物促进慢性糖尿病伤口的快速愈合。

IF 6 2区医学

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-23 DOI: 10.1016/j.bioadv.2025.214521

Rajdeep Bhattacharjee , Pragya Pallavi , Bajrang Bajrang , Snehasish Mandal , Lipi Pradhan , Malay Nayak , Sudip Mukherjee

{"title":"Oxygen generating magnesium peroxide nanoparticles by in-situ catalytic reaction with nano‑manganese oxide promote rapid healing of chronic diabetic wounds","authors":"Rajdeep Bhattacharjee , Pragya Pallavi , Bajrang Bajrang , Snehasish Mandal , Lipi Pradhan , Malay Nayak , Sudip Mukherjee","doi":"10.1016/j.bioadv.2025.214521","DOIUrl":"10.1016/j.bioadv.2025.214521","url":null,"abstract":"<div><div>Wound healing is a natural physiological reaction to tissue damage/injury, which involves a complex process between various cells, cytokines, and the vascular system. Chronic diabetic wounds take several weeks to months to heal due to persistent hypoxia and elevated inflammation. Herein, we developed a nanococktail of magnesium peroxide and manganese oxide (MgO<sub>2</sub> + MnO<sub>2</sub>) to promote <em>in</em>-<em>situ</em> catalytic generation of therapeutic levels of oxygen (O<sub>2</sub>) for rapid wound-healing in mouse models. <em>In vitro</em> studies showed the ability to reduce reactive oxygen species (ROS) following the treatment of the nanococktail. They were biocompatible <em>in vitro</em> and <em>in vivo</em> in the chicken embryonic model at a therapeutic dose. The controlled oxygen generation from MgO<sub>2</sub> by the <em>in</em>-<em>situ</em> nanocatalysis using MnO<sub>2</sub> was utilized to promote rapid wound healing within 7 days in a normal wound model in the BALB/C and 11 days in a chronic diabetic wound model in the C57BL/6 mouse. In conclusion, our study demonstrated a synergistic MgO<sub>2</sub> + MnO<sub>2</sub> nanococktail design that provides unique advantages over single-component systems by achieving both functional and mechanistic novelty through a dual-stage oxygen generation process. Importantly, the MgO<sub>2</sub> + MnO<sub>2</sub> nanococktail exhibited significantly higher and sustained oxygen release compared to the widely studied conventional peroxidase system, thereby providing a superior therapeutic benefit for promoting tissue regenerating application in diabetic conditions.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"179 ","pages":"Article 214521"},"PeriodicalIF":6.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage-targeted black phosphorus nanocomposites inhibit renal fibrosis by disrupting the oxidative stress-inflammation cycle and improving fatty acid metabolism 巨噬细胞靶向黑磷纳米复合材料通过破坏氧化应激-炎症循环和改善脂肪酸代谢来抑制肾纤维化

IF 6 2区医学

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-22 DOI: 10.1016/j.bioadv.2025.214520

Min Yang , Zhiwen Wang , Yiyun Song , Yue Xie, Mingcun Hu, Wei Huang, Chun Zhang

{"title":"Macrophage-targeted black phosphorus nanocomposites inhibit renal fibrosis by disrupting the oxidative stress-inflammation cycle and improving fatty acid metabolism","authors":"Min Yang , Zhiwen Wang , Yiyun Song , Yue Xie, Mingcun Hu, Wei Huang, Chun Zhang","doi":"10.1016/j.bioadv.2025.214520","DOIUrl":"10.1016/j.bioadv.2025.214520","url":null,"abstract":"<div><div>Chronic kidney disease (CKD) represents a major clinical challenge due to its high prevalence and mortality rates. Unfortunately, there is still a lack of specific targeted intervention drugs available at present. Renal fibrosis is a primary contributor to the persistent advancement of CKD. Here, the inflammatory response chain triggered by macrophages and the progression of oxidative stress construct a vicious cycle that significantly exacerbates fibrosis progression. Therefore, specific targeted intervention in the cyclic feedback is of significant clinical importance for curbing fibrosis progression and improving CKD. In this study, we focus on targeted precision intervention of renal fibrosis using black phosphorus nanosheets (BPNSs) as carriers. By loading FK228, a product from our previous research, on the surface and modifying the outer layer with phosphatidylserine (PS), we achieve high specificity targeting and accumulation in the kidneys during the CKD process. The PS anchors to phosphatidylserine receptors on the surface of macrophages within the kidney, efficiently reacting to overloaded ROS in macrophages, inhibiting the progression of oxidative stress and exacerbation of inflammatory storms. Subsequently, the carrier decomposes to release the HDAC-specific small molecule inhibitor FK228, further blocking fibrosis progression, thereby effectively improving CKD.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"179 ","pages":"Article 214520"},"PeriodicalIF":6.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KR12 peptide-modified ECM coating for enhanced osteogenic and antimicrobial activity of titanium surfaces KR12肽修饰的ECM涂层增强钛表面的成骨和抗菌活性。

IF 6 2区医学

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-22 DOI: 10.1016/j.bioadv.2025.214515

Emine Afra Demirci , Sakip Önder , Tayfun Acar , Selin Zeynep Sunar , Gamze Torun Köse

{"title":"KR12 peptide-modified ECM coating for enhanced osteogenic and antimicrobial activity of titanium surfaces","authors":"Emine Afra Demirci , Sakip Önder , Tayfun Acar , Selin Zeynep Sunar , Gamze Torun Köse","doi":"10.1016/j.bioadv.2025.214515","DOIUrl":"10.1016/j.bioadv.2025.214515","url":null,"abstract":"<div><div>Titanium (Ti)-based biomaterials are widely used in orthopedic and dental implants; however, their clinical success remains limited due to poor osseointegration and implant-associated infections. In this study, a functional surface modification strategy was developed by immobilizing the antimicrobial peptide KR12 <em>via</em> a collagen-binding peptide (CBP) onto decellularized extracellular matrix (ECM) coatings derived from cell sheet engineering. The ECM was obtained through a gentle decellularization process that preserved its native architecture and essential components, including collagen and fibronectin. KR12 was successfully anchored onto the ECM surface through CBP, ensuring antibacterial activity without disrupting ECM structure. Surface characterization using SEM, AFM, and XPS confirmed the morphological and chemical modifications associated with ECM deposition and KR12 immobilization. Antimicrobial assays demonstrated that while ECM alone exhibited no antibacterial effect, the addition of KR12 significantly reduced <em>Staphylococcus aureus</em> adhesion by up to 96 %. Cell studies revealed enhanced adhesion and proliferation on ECM-coated surfaces, and osteogenic assays confirmed that KR12-functionalized ECM coatings promoted early differentiation, with elevated ALP activity and increased expression of osteogenic genes such as ALP, Runx2, Col1a1, and OCN. This approach offers a promising strategy for improving implant performance by simultaneously promoting bone integration and providing long-term antibacterial protection.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"179 ","pages":"Article 214515"},"PeriodicalIF":6.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenolic-enriched Cu/C nanoparticles for enhanced wound healing via ROS generation and photothermal ablation of bacterial infections 富酚Cu/C纳米颗粒通过ROS生成和光热消融细菌感染促进伤口愈合

IF 6 2区医学

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-22 DOI: 10.1016/j.bioadv.2025.214514

Shengnan Zhang , Lidan He , Jingya Chen , Kevin H. Mayo , Le Deng

{"title":"Phenolic-enriched Cu/C nanoparticles for enhanced wound healing via ROS generation and photothermal ablation of bacterial infections","authors":"Shengnan Zhang , Lidan He , Jingya Chen , Kevin H. Mayo , Le Deng","doi":"10.1016/j.bioadv.2025.214514","DOIUrl":"10.1016/j.bioadv.2025.214514","url":null,"abstract":"<div><div>The emergence of antibiotic-resistant bacteria poses a significant threat to human health, urgently requiring the development of alternative therapeutic strategies. In this study, copper-doped carbon-based nanoparticles (Cu/C NPs) were synthesized by one-pot method using dopamine as the carbon source and reducing agent. The surface of Cu/C NPs were enriched with chelating phenolic groups to reduce Cu<sup>+</sup>/Cu<sup>2+</sup> leaching and improve biosafety. As they exhibit excellent peroxidase-like (POD-like) activity and photothermal properties, these nanoparticles were broadly used in chemodynamic and photothermal therapies against pathogenic bacterial infections, demonstrating a broad-spectrum bactericidal activity <em>in vitro</em> against <em>S. aureus</em> (100 %) and <em>E. coli</em> (97.7 %). In addition, <em>in vivo</em> anti-microbial tests also showed that Cu/C NPs promote infected-wound healing, thus providing a new approach to combating pathogenic bacterial infections in the clinic.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"179 ","pages":"Article 214514"},"PeriodicalIF":6.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fat grafting based on 3D printed polyhydroxyalkanoate scaffolds 基于3D打印聚羟基烷酸酯支架的脂肪移植

IF 6 2区医学

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-20 DOI: 10.1016/j.bioadv.2025.214512

Leijuan Gan , Pengfei Ouyang , Yuxuan Lan , Haoran Li , Xiaoyu Zhang , Xu Liu , Mingyu Zhang , Ju Wu , Tongtong Zhang , Fang Yang , Zhongming Cai , Xuanming Xu , Guoqiang Chen , Dali Mu , Zhengyao Li

{"title":"Fat grafting based on 3D printed polyhydroxyalkanoate scaffolds","authors":"Leijuan Gan , Pengfei Ouyang , Yuxuan Lan , Haoran Li , Xiaoyu Zhang , Xu Liu , Mingyu Zhang , Ju Wu , Tongtong Zhang , Fang Yang , Zhongming Cai , Xuanming Xu , Guoqiang Chen , Dali Mu , Zhengyao Li","doi":"10.1016/j.bioadv.2025.214512","DOIUrl":"10.1016/j.bioadv.2025.214512","url":null,"abstract":"<div><div>Autologous fat grafting holds significant promise for soft tissue repair and reconstruction. However, its clinical application faces challenges, including insufficient graft strength for optimal shaping and poor long-term retention rates, particularly in large-volume transplantation. Three-dimensional (3D)-printed biodegradable scaffolds offer a potential solution by mitigating graft ischemia and hypoxia, thereby improving retention, while offering temporary mechanical support before degradation. Polyhydroxyalkanoates (PHA) containing 3-hydroxybutyrate and 4-hydroxybutyrate monomers, a promising class of biomaterials in tissue engineering, were employed in this study to fabricate 3D-printed scaffolds for fat grafting. Their effects on graft retention were explored for underlying mechanisms. In vivo studies demonstrated that 3D-printed PHA scaffolds significantly enhanced fat graft retention by stimulating angiogenesis, promoting adipocyte viability, inducing macrophage polarization toward the M2 phenotype, attenuating oxidative stress, and optimizing mitochondrial functions. Additionally, the scaffolds further improved retention by facilitating beige adipogenesis or white adipose tissue browning. In vitro experiments confirmed the excellent biocompatibility of PHA, with its degradation product ‐3-hydroxybutyrate (3HB) exhibiting no cytotoxicity. Furthermore, 3HB enhanced the energy metabolism of adipose-derived stem cells (ADSCs) by reducing oxidative stress and improving mitochondrial function. This study provides solid evidence supporting the application of PHA scaffolds in adipose tissue engineering and proposes a novel strategy for soft tissue reconstruction and repair.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"179 ","pages":"Article 214512"},"PeriodicalIF":6.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Matrix influence of collagen: fibrin interpenetrating hydrogels on microvascular networks and osteogenesis 胶原-纤维蛋白互穿水凝胶对微血管网络和成骨的基质影响

IF 6 2区医学

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-19 DOI: 10.1016/j.bioadv.2025.214518

Gennifer Chiou , Sarah Stagg , Gabriela Gonzales , Liliana Danford , Isaiah Arredondo , Rena Bizios , Joo L. Ong , Teja Guda

{"title":"Matrix influence of collagen: fibrin interpenetrating hydrogels on microvascular networks and osteogenesis","authors":"Gennifer Chiou , Sarah Stagg , Gabriela Gonzales , Liliana Danford , Isaiah Arredondo , Rena Bizios , Joo L. Ong , Teja Guda","doi":"10.1016/j.bioadv.2025.214518","DOIUrl":"10.1016/j.bioadv.2025.214518","url":null,"abstract":"<div><div>Blended interpenetrating collagen: fibrin (col: fib) blend hydrogels of differing blend ratios (100:0, 25:75, 50:50, 75:25, and 0:100 col.:fib respectively) were synthesized for the purposes of supporting angiogenesis and osteogenesis. Gels were seeded with microvascular fragments (MVFs) to evaluate how the col.: fib matrix alone supported angiogenesis. Gels were also seeded with mesenchymal stem cells (MSCs) in conjunction with the MVFs to determine how stromal support in addition to the matrix supported both angiogenesis and osteogenesis, with stromal conditioning from osteogenic differentiation media. Gel blends with higher amounts of fibrin content supported angiogenesis of MVF seeded samples better with increased levels of vessel network formation and sprouting. When stromal cell support was added, this trend remained, with evidence that stromal cells aided in faster and more robust vessel formation. Gene expression levels indicate that the 50C50F blend balances osteogenic and angiogenic support. Altogether, we found that matrix composition dictates vessel infiltration and spreading and that with the addition of stromal cells, both angio- and osteogenesis were accelerated. The results of this study demonstrate that a blend ratio of 50:50 col.:fib balances angiogenesis and osteogenesis within a co-culture of MSCs and MVFs.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"179 ","pages":"Article 214518"},"PeriodicalIF":6.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microsphere-embedded gelatin-based hydrogel with self-healing, hemostatic, antioxidative, and antibacterial activity for wound healing 微球嵌入明胶为基础的水凝胶具有自我愈合，止血，抗氧化和抗菌活性的伤口愈合

IF 6 2区医学

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-19 DOI: 10.1016/j.bioadv.2025.214516

Qianfen Qi , Rongcai Liang , Luyao Ding , Yuhang Ren , Baoqi Ding , Yuan Wang , Jiaxin Liu , Zhihao Meng , Susu Zhang , Renlong Zhang , Yanhao He , Chunguang Ren , Linlin Wang

{"title":"Microsphere-embedded gelatin-based hydrogel with self-healing, hemostatic, antioxidative, and antibacterial activity for wound healing","authors":"Qianfen Qi , Rongcai Liang , Luyao Ding , Yuhang Ren , Baoqi Ding , Yuan Wang , Jiaxin Liu , Zhihao Meng , Susu Zhang , Renlong Zhang , Yanhao He , Chunguang Ren , Linlin Wang","doi":"10.1016/j.bioadv.2025.214516","DOIUrl":"10.1016/j.bioadv.2025.214516","url":null,"abstract":"<div><div>Excessive reactive oxygen species (ROS), bacterial infection and intense inflammation constitute key complications that hinder wound healing. Hydrogels have shown promising applications in wound management due to their high biocompatibility and adjustable functionality. However, the poor mechanical and self-healing properties of conventional hydrogel dressings can't meet the multifaceted demands of motion wounds. To address these issues, we designed and constructed a series of multifunctional microsphere-embedded gelatin-based dual-dynamic-bond cross-linked hydrogels (GPB hydrogels) <em>via</em> the formation of Schiff base bonds and borate ester bonds. These GPB hydrogels exhibited excellent self-healing and adhesive properties, and they also possessed good biocompatibility and certain hemostatic effects. Moreover, biological activity tests proved that the hydrogel owned excellent antibacterial and antioxidant activities and could reduce inflammatory responses. More importantly, the GPB hydrogels can effectively promote wound healing by accelerating the re-epithelialization and increasing collagen deposition, which showed great potential in the field of hydrogel wound dressings.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"179 ","pages":"Article 214516"},"PeriodicalIF":6.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0