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Annual Review of Biomedical Engineering最新文献

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Fly Me to the Micron: Microtechnologies for Drosophila Research. 让我飞向微米：果蝇研究的微技术》。
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2024-07-01 DOI: 10.1146/annurev-bioeng-050423-054647
Utku M Sonmez, Nolan Frey, Philip R LeDuc, Jonathan S Minden
{"title":"Fly Me to the Micron: Microtechnologies for <i>Drosophila</i> Research.","authors":"Utku M Sonmez, Nolan Frey, Philip R LeDuc, Jonathan S Minden","doi":"10.1146/annurev-bioeng-050423-054647","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-050423-054647","url":null,"abstract":"<p><p>Multicellular model organisms, such as <i>Drosophila melanogaster</i> (fruit fly), are frequently used in a myriad of biological research studies due to their biological significance and global standardization. However, traditional tools used in these studies generally require manual handling, subjective phenotyping, and bulk treatment of the organisms, resulting in laborious experimental protocols with limited accuracy. Advancements in microtechnology over the course of the last two decades have allowed researchers to develop automated, high-throughput, and multifunctional experimental tools that enable novel experimental paradigms that would not be possible otherwise. We discuss recent advances in microtechnological systems developed for small model organisms using <i>D. melanogaster</i> as an example. We critically analyze the state of the field by comparing the systems produced for different applications. Additionally, we suggest design guidelines, operational tips, and new research directions based on the technical and knowledge gaps in the literature. This review aims to foster interdisciplinary work by helping engineers to familiarize themselves with model organisms while presenting the most recent advances in microengineering strategies to biologists.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"26 1","pages":"441-473"},"PeriodicalIF":12.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D Traction Force Microscopy in Biological Gels: From Single Cells to Multicellular Spheroids. 生物凝胶中的三维牵引力显微镜：从单细胞到多细胞球。
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2024-07-01 Epub Date: 2024-06-20 DOI: 10.1146/annurev-bioeng-103122-031130
Brian C H Cheung, Rana J Abbed, Mingming Wu, Susan E Leggett
{"title":"3D Traction Force Microscopy in Biological Gels: From Single Cells to Multicellular Spheroids.","authors":"Brian C H Cheung, Rana J Abbed, Mingming Wu, Susan E Leggett","doi":"10.1146/annurev-bioeng-103122-031130","DOIUrl":"10.1146/annurev-bioeng-103122-031130","url":null,"abstract":"<p><p>Cell traction force plays a critical role in directing cellular functions, such as proliferation, migration, and differentiation. Current understanding of cell traction force is largely derived from 2D measurements where cells are plated on 2D substrates. However, 2D measurements do not recapitulate a vital aspect of living systems; that is, cells actively remodel their surrounding extracellular matrix (ECM), and the remodeled ECM, in return, can have a profound impact on cell phenotype and traction force generation. This reciprocal adaptivity of living systems is encoded in the material properties of biological gels. In this review, we summarize recent progress in measuring cell traction force for cells embedded within 3D biological gels, with an emphasis on cell-ECM cross talk. We also provide perspectives on tools and techniques that could be adapted to measure cell traction force in complex biochemical and biophysical environments.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":"93-118"},"PeriodicalIF":12.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical Microrobots 医疗微型机器人
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2024-04-10 DOI: 10.1146/annurev-bioeng-081523-033131
Veronica Iacovacci, Eric Diller, Daniel Ahmed, Arianna Menciassi
{"title":"Medical Microrobots","authors":"Veronica Iacovacci, Eric Diller, Daniel Ahmed, Arianna Menciassi","doi":"10.1146/annurev-bioeng-081523-033131","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-081523-033131","url":null,"abstract":"Scientists around the world have long aimed to produce miniature robots that can be controlled inside the human body to aid doctors in identifying and treating diseases. Such microrobots hold the potential to access hard-to-reach areas of the body through the natural lumina. Wireless access has the potential to overcome drawbacks of systemic therapy, as well as to enable completely new minimally invasive procedures. The aim of this review is fourfold: first, to provide a collection of valuable anatomical and physiological information on the target working environments together with engineering tools for the design of medical microrobots; second, to provide a comprehensive updated survey of the technological state of the art in relevant classes of medical microrobots; third, to analyze currently available tracking and closed loop control strategies compatible with the in-body environment; and fourth, to explore the challenges still in place, to steer and inspire future research.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"15 1","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient-Specific, Mechanistic Models of Tumor Growth Incorporating Artificial Intelligence and Big Data 结合人工智能和大数据的肿瘤生长患者特异性机制模型
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2024-04-10 DOI: 10.1146/annurev-bioeng-081623-025834
Guillermo Lorenzo, Syed Rakin Ahmed, David A. Hormuth II, Brenna Vaughn, Jayashree Kalpathy-Cramer, Luis Solorio, Thomas E. Yankeelov, Hector Gomez
{"title":"Patient-Specific, Mechanistic Models of Tumor Growth Incorporating Artificial Intelligence and Big Data","authors":"Guillermo Lorenzo, Syed Rakin Ahmed, David A. Hormuth II, Brenna Vaughn, Jayashree Kalpathy-Cramer, Luis Solorio, Thomas E. Yankeelov, Hector Gomez","doi":"10.1146/annurev-bioeng-081623-025834","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-081623-025834","url":null,"abstract":"Despite the remarkable advances in cancer diagnosis, treatment, and management over the past decade, malignant tumors remain a major public health problem. Further progress in combating cancer may be enabled by personalizing the delivery of therapies according to the predicted response for each individual patient. The design of personalized therapies requires the integration of patient-specific information with an appropriate mathematical model of tumor response. A fundamental barrier to realizing this paradigm is the current lack of a rigorous yet practical mathematical theory of tumor initiation, development, invasion, and response to therapy. We begin this review with an overview of different approaches to modeling tumor growth and treatment, including mechanistic as well as data-driven models based on big data and artificial intelligence. We then present illustrative examples of mathematical models manifesting their utility and discuss the limitations of stand-alone mechanistic and data-driven models. We then discuss the potential of mechanistic models for not only predicting but also optimizing response to therapy on a patient-specific basis. We describe current efforts and future possibilities to integrate mechanistic and data-driven models. We conclude by proposing five fundamental challenges that must be addressed to fully realize personalized care for cancer patients driven by computational models.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"94 1","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140585094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating Upper-Limb Prostheses with the Human Body: Technology Advances, Readiness, and Roles in Human–Prosthesis Interaction 上肢假肢与人体的结合：技术进步、准备情况以及在人与假肢互动中的作用
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2024-04-10 DOI: 10.1146/annurev-bioeng-110222-095816
He (Helen) Huang, Levi J. Hargrove, Max Ortiz-Catalan, Jonathon W. Sensinger
{"title":"Integrating Upper-Limb Prostheses with the Human Body: Technology Advances, Readiness, and Roles in Human–Prosthesis Interaction","authors":"He (Helen) Huang, Levi J. Hargrove, Max Ortiz-Catalan, Jonathon W. Sensinger","doi":"10.1146/annurev-bioeng-110222-095816","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110222-095816","url":null,"abstract":"Significant advances in bionic prosthetics have occurred in the past two decades. The field's rapid expansion has yielded many exciting technologies that can enhance the physical, functional, and cognitive integration of a prosthetic limb with a human. We review advances in the engineering of prosthetic devices and their interfaces with the human nervous system, as well as various surgical techniques for altering human neuromusculoskeletal systems for seamless human–prosthesis integration. We discuss significant advancements in research and clinical translation, focusing on upper limb prosthetics since they heavily rely on user intent for daily operation, although many discussed technologies have been extended to lower limb prostheses as well. In addition, our review emphasizes the roles of advanced prosthetics technologies in complex interactions with humans and the technology readiness levels (TRLs) of individual research advances. Finally, we discuss current gaps and controversies in the field and point out future research directions, guided by TRLs.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"32 1","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasmonic-Driven Regulation of Biomolecular Activity In Situ 等离子体驱动的生物分子活性原位调控
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2024-04-10 DOI: 10.1146/annurev-bioeng-110222-105043
Chen Xie, Tingting Zhang, Zhenpeng Qin
{"title":"Plasmonic-Driven Regulation of Biomolecular Activity In Situ","authors":"Chen Xie, Tingting Zhang, Zhenpeng Qin","doi":"10.1146/annurev-bioeng-110222-105043","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110222-105043","url":null,"abstract":"Selective and remote manipulation of activity for biomolecules, including protein, DNA, and lipids, is crucial to elucidate the molecular function and to develop biomedical applications. While advances in tool development, such as optogenetics, have significantly impacted these directions, the requirement for genetic modification significantly limits their therapeutic applications. Plasmonic nanoparticle heating has brought new opportunities to the field, as hot nanoparticles are unique point heat sources at the nanoscale. In this review, we summarize fundamental engineering problems such as plasmonic heating and the resulting biomolecular responses. We highlight the biological responses and applications of manipulating biomolecules and provide perspectives for future directions in the field.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"38 1","pages":""},"PeriodicalIF":9.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive Models for Health Deterioration: Understanding Disease Pathways for Personalized Medicine. 健康恶化的预测模型:了解个性化医疗的疾病途径。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-02-28 DOI: 10.1146/annurev-bioeng-110220-030247
Bjoern M Eskofier, Jochen Klucken
{"title":"Predictive Models for Health Deterioration: Understanding Disease Pathways for Personalized Medicine.","authors":"Bjoern M Eskofier, Jochen Klucken","doi":"10.1146/annurev-bioeng-110220-030247","DOIUrl":"10.1146/annurev-bioeng-110220-030247","url":null,"abstract":"<p><p>Artificial intelligence (AI) and machine learning (ML) methods are currently widely employed in medicine and healthcare. A PubMed search returns more than 100,000 articles on these topics published between 2018 and 2022 alone. Notwithstanding several recent reviews in various subfields of AI and ML in medicine, we have yet to see a comprehensive review around the methods' use in longitudinal analysis and prediction of an individual patient's health status within a personalized disease pathway. This review seeks to fill that gap. After an overview of the AI and ML methods employed in this field and of specific medical applications of models of this type, the review discusses the strengths and limitations of current studies and looks ahead to future strands of research in this field. We aim to enable interested readers to gain a detailed impression of the research currently available and accordingly plan future work around predictive models for deterioration in health status.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"131-156"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epitranscriptional Regulation: From the Perspectives of Cardiovascular Bioengineering. 表转录调控:从心血管生物工程的角度。
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-03-08 DOI: 10.1146/annurev-bioeng-081922-021233
Zhen Bouman Chen, Ming He, Julie Yi-Shuan Li, John Y-J Shyy, Shu Chien
{"title":"Epitranscriptional Regulation: From the Perspectives of Cardiovascular Bioengineering.","authors":"Zhen Bouman Chen, Ming He, Julie Yi-Shuan Li, John Y-J Shyy, Shu Chien","doi":"10.1146/annurev-bioeng-081922-021233","DOIUrl":"10.1146/annurev-bioeng-081922-021233","url":null,"abstract":"<p><p>The central dogma of gene expression involves DNA transcription to RNA and RNA translation into protein. As key intermediaries and modifiers, RNAs undergo various forms of modifications such as methylation, pseudouridylation, deamination, and hydroxylation. These modifications, termed epitranscriptional regulations, lead to functional changes in RNAs. Recent studies have demonstrated crucial roles for RNA modifications in gene translation, DNA damage response, and cell fate regulation. Epitranscriptional modifications play an essential role in development, mechanosensing, atherogenesis, and regeneration in the cardiovascular (CV) system, and their elucidation is critically important to understanding the molecular mechanisms underlying CV physiology and pathophysiology. This review aims at providing biomedical engineers with an overview of the epitranscriptome landscape, related key concepts, recent findings in epitranscriptional regulations, and tools for epitranscriptome analysis. The potential applications of this important field in biomedical engineering research are discussed.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"157-184"},"PeriodicalIF":12.8,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9959757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Trends in Anti-Aging Strategies. 抗衰老策略的当前趋势。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 DOI: 10.1146/annurev-bioeng-120122-123054
Robert S Rosen, Martin L Yarmush
{"title":"Current Trends in Anti-Aging Strategies.","authors":"Robert S Rosen, Martin L Yarmush","doi":"10.1146/annurev-bioeng-120122-123054","DOIUrl":"10.1146/annurev-bioeng-120122-123054","url":null,"abstract":"<p><p>The process of aging manifests from a highly interconnected network of biological cascades resulting in the degradation and breakdown of every living organism over time. This natural development increases risk for numerous diseases and can be debilitating. Academic and industrial investigators have long sought to impede, or potentially reverse, aging in the hopes of alleviating clinical burden, restoring functionality, and promoting longevity. Despite widespread investigation, identifying impactful therapeutics has been hindered by narrow experimental validation and the lack of rigorous study design. In this review, we explore the current understanding of the biological mechanisms of aging and how this understanding both informs and limits interpreting data from experimental models based on these mechanisms. We also discuss select therapeutic strategies that have yielded promising data in these model systems with potential clinical translation. Lastly, we propose a unifying approach needed to rigorously vet current and future therapeutics and guide evaluation toward efficacious therapies.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"363-385"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Emerging Penetrating Neural Electrodes: In Pursuit of Large Scale and Longevity. 新兴穿透式神经电极:追求大规模和长寿。
IF 9.7 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2023-06-08 DOI: 10.1146/annurev-bioeng-090622-050507
Lan Luan, Rongkang Yin, Hanlin Zhu, Chong Xie
{"title":"Emerging Penetrating Neural Electrodes: In Pursuit of Large Scale and Longevity.","authors":"Lan Luan, Rongkang Yin, Hanlin Zhu, Chong Xie","doi":"10.1146/annurev-bioeng-090622-050507","DOIUrl":"10.1146/annurev-bioeng-090622-050507","url":null,"abstract":"<p><p>Penetrating neural electrodes provide a powerful approach to decipher brain circuitry by allowing for time-resolved electrical detections of individual action potentials. This unique capability has contributed tremendously to basic and translational neuroscience, enabling both fundamental understandings of brain functions and applications of human prosthetic devices that restore crucial sensations and movements. However, conventional approaches are limited by the scarce number of available sensing channels and compromised efficacy over long-term implantations. Recording longevity and scalability have become the most sought-after improvements in emerging technologies. In this review, we discuss the technological advances in the past 5-10 years that have enabled larger-scale, more detailed, and longer-lasting recordings of neural circuits at work than ever before. We present snapshots of the latest advances in penetration electrode technology, showcase their applications in animal models and humans, and outline the underlying design principles and considerations to fuel future technological development.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"25 ","pages":"185-205"},"PeriodicalIF":9.7,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11078330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9606165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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