Epitranscriptional Regulation: From the Perspectives of Cardiovascular Bioengineering.

IF 12.8 1区工程技术 Q1 ENGINEERING, BIOMEDICAL

Annual Review of Biomedical Engineering Pub Date : 2023-06-08 Epub Date: 2023-03-08 DOI:10.1146/annurev-bioeng-081922-021233

Zhen Bouman Chen, Ming He, Julie Yi-Shuan Li, John Y-J Shyy, Shu Chien

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引用次数: 0

Abstract

The central dogma of gene expression involves DNA transcription to RNA and RNA translation into protein. As key intermediaries and modifiers, RNAs undergo various forms of modifications such as methylation, pseudouridylation, deamination, and hydroxylation. These modifications, termed epitranscriptional regulations, lead to functional changes in RNAs. Recent studies have demonstrated crucial roles for RNA modifications in gene translation, DNA damage response, and cell fate regulation. Epitranscriptional modifications play an essential role in development, mechanosensing, atherogenesis, and regeneration in the cardiovascular (CV) system, and their elucidation is critically important to understanding the molecular mechanisms underlying CV physiology and pathophysiology. This review aims at providing biomedical engineers with an overview of the epitranscriptome landscape, related key concepts, recent findings in epitranscriptional regulations, and tools for epitranscriptome analysis. The potential applications of this important field in biomedical engineering research are discussed.

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表转录调控:从心血管生物工程的角度。

基因表达的中心规律包括DNA转录成RNA和RNA翻译成蛋白质。作为关键的中介和修饰剂，rna经历各种形式的修饰，如甲基化、假尿嘧啶化、脱胺化和羟基化。这些修饰被称为表转录调控，导致rna的功能改变。最近的研究表明，RNA修饰在基因翻译、DNA损伤反应和细胞命运调节中起着至关重要的作用。表转录修饰在心血管(CV)系统的发育、机械传感、动脉粥样硬化和再生中起着至关重要的作用，阐明它们对于理解CV生理和病理生理的分子机制至关重要。这篇综述旨在为生物医学工程师提供关于表转录组的概述，相关的关键概念，表转录调控的最新发现，以及表转录组分析的工具。讨论了这一重要领域在生物医学工程研究中的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Biomedical Engineering 工程技术-工程：生物医学

CiteScore

18.80

自引率

0.00%

发文量

期刊介绍： Since 1999, the Annual Review of Biomedical Engineering has been capturing major advancements in the expansive realm of biomedical engineering. Encompassing biomechanics, biomaterials, computational genomics and proteomics, tissue engineering, biomonitoring, healthcare engineering, drug delivery, bioelectrical engineering, biochemical engineering, and biomedical imaging, the journal remains a vital resource. The current volume has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.