Annual Review of Biomedical Engineering最新文献

Leveraging Preclinical Modeling for Clinical Advancements in Single Ventricle Physiology: Spotlight on the Fontan Circulation.

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-03-03 DOI: 10.1146/annurev-bioeng-102723-013709

Andreas Escher, Carlos Aguilar Vega, Markus A Horvath, Caglar Ozturk, Ellen T Roche

{"title":"Leveraging Preclinical Modeling for Clinical Advancements in Single Ventricle Physiology: Spotlight on the Fontan Circulation.","authors":"Andreas Escher, Carlos Aguilar Vega, Markus A Horvath, Caglar Ozturk, Ellen T Roche","doi":"10.1146/annurev-bioeng-102723-013709","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-102723-013709","url":null,"abstract":"Preclinical modeling of human circulation has been instrumental in advancing cardiovascular medicine. Alongside clinical research, the armamentarium of computational (e.g., lumped parameter or computational fluid dynamics) and experimental (e.g., benchtop or animal) models have substantially enhanced our understanding of risk factors and root causes for circulatory diseases. Recent innovations are further disrupting the boundaries of these preclinical models toward patient-specific simulations, surgical planning, and postoperative outcome prediction. This fast-paced progress empowers preclinical modeling to increasingly delve into the intricacies of single ventricle physiology, a rare and heterogeneous congenital heart disease that remains inadequately understood. Here, we review the current landscape of preclinical modeling (computational and experimental) proposed to advance clinical management of a prominent yet complex subset of single ventricle physiology: patients who have undergone Fontan-type surgical corrections. Further, we explore recent innovations and emerging technologies that are poised to bridge the gap between preclinical Fontan modeling and clinical implementation.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Theoretical Approach in Applying High-Frequency Acoustic and Elasticity Microscopy to Assess Cells and Tissues.

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-02-19 DOI: 10.1146/annurev-bioeng-112823-103134

Frank Winterroth, Jing Wang, Onno Wink, Bart Carelsen, Jeremy Dahl, Avnesh S Thakor

{"title":"A Theoretical Approach in Applying High-Frequency Acoustic and Elasticity Microscopy to Assess Cells and Tissues.","authors":"Frank Winterroth, Jing Wang, Onno Wink, Bart Carelsen, Jeremy Dahl, Avnesh S Thakor","doi":"10.1146/annurev-bioeng-112823-103134","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-112823-103134","url":null,"abstract":"Medical ultrasound is a diagnostic imaging modality used for visualizing internal organs; the frequencies typically used are 2-10 MHz. Scanning acoustic microscopy (SAM) is a form of ultrasound where frequencies typically exceed 50 MHz. Increasing the acoustic frequency increases the specimen's spatial resolution but reduces the imaging depth. The advantages of using SAM over conventional light and electron microscopy include the ability to image cells and tissues without any preparation that could kill or alter them, providing a more accurate representation of the specimen. After scanning the specimen, acoustic signals are merged into an image on the basis of changes in the impedance mismatch between the immersion fluid and the specimens. The acoustic parameters determining the image quality are absorption and scattering. Surface scans can assess surface characteristics of the specimen. SAM is also capable of elastography, that is, studying elastic properties to discern differences between healthy and affected tissues. SAM has significant potential for detection/analysis in research and clinical studies.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Replicating Host-Microbiome Interactions: Harnessing Organ-on-a-Chip and Organoid Technologies to Model Vaginal and Lung Physiology.

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-02-19 DOI: 10.1146/annurev-bioeng-110122-122343

Jade Coxon, Emily Linder, Caden Sweet, Scott Magness, Leopold Green

{"title":"Replicating Host-Microbiome Interactions: Harnessing Organ-on-a-Chip and Organoid Technologies to Model Vaginal and Lung Physiology.","authors":"Jade Coxon, Emily Linder, Caden Sweet, Scott Magness, Leopold Green","doi":"10.1146/annurev-bioeng-110122-122343","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110122-122343","url":null,"abstract":"Organ-on-a-chip (OOC) and organoid technologies are at the forefront of developing sophisticated in vitro systems that replicate complex host-microbiome interactions, including those associated with vaginal health and lung infection. We explore how these technologies provide insights into host-microbiome and host-pathogen interactions and the associated immune responses. Integrating omics data and high-resolution imaging in analyzing these models enhances our understanding of host-microbiome interactions' temporal and spatial aspects, paving the way for new diagnostic and treatment strategies. This review underscores the potential of OOC and organoid technologies in elucidating the complexities of vaginal health and lung disease, which have received less attention than other organ systems in recent organoid and OCC studies. Yet, each system presents notable characteristics, rendering them ideal candidates for these designs. Additionally, this review describes the key factors associated with each organ system and how to choose the technology setup to replicate human physiology.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Evolution of Systems Biology and Systems Medicine: From Mechanistic Models to Uncertainty Quantification.

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-02-19 DOI: 10.1146/annurev-bioeng-102723-065309

Lingxia Qiao, Ali Khalilimeybodi, Nathaniel J Linden-Santangeli, Padmini Rangamani

{"title":"The Evolution of Systems Biology and Systems Medicine: From Mechanistic Models to Uncertainty Quantification.","authors":"Lingxia Qiao, Ali Khalilimeybodi, Nathaniel J Linden-Santangeli, Padmini Rangamani","doi":"10.1146/annurev-bioeng-102723-065309","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-102723-065309","url":null,"abstract":"Understanding interaction mechanisms within cells, tissues, and organisms is crucial for driving developments across biology and medicine. Mathematical modeling is an essential tool for simulating such biological systems. Building on experiments, mechanistic models are widely used to describe small-scale intracellular networks. The development of sequencing techniques and computational tools has recently enabled multiscale models. Combining such larger scale network modeling with mechanistic modeling provides us with an opportunity to reveal previously unknown disease mechanisms and pharmacological interventions. Here, we review systems biology models from mechanistic models to multiscale models that integrate multiple layers of cellular networks and discuss how they can be used to shed light on disease states and even wellness-related states. Additionally, we introduce several methods that increase the certainty and accuracy of model predictions. Thus, combining mechanistic models with emerging mathematical and computational techniques can provide us with increasingly powerful tools to understand disease states and inspire drug discoveries.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Ultrasound for Multimodal Cancer Treatment: A Spotlight on Breast Cancer.

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-02-19 DOI: 10.1146/annurev-bioeng-103023-111151

Zehra E F Demir, Natasha D Sheybani

引用次数: 0

Supracortical Microstimulation: Advances in Microelectrode Design and In Vivo Validation.

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-02-06 DOI: 10.1146/annurev-bioeng-103023-072855

Cecilia Schmitz, J Evan Smith, Iakov Rachinskiy, Bijan Pesaran, Flavia Vitale, Marc Sommer, Jonathan Viventi

{"title":"Supracortical Microstimulation: Advances in Microelectrode Design and In Vivo Validation.","authors":"Cecilia Schmitz, J Evan Smith, Iakov Rachinskiy, Bijan Pesaran, Flavia Vitale, Marc Sommer, Jonathan Viventi","doi":"10.1146/annurev-bioeng-103023-072855","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-103023-072855","url":null,"abstract":"Electrical stimulation of the brain is being developed as a treatment for an increasing number of neurological disorders. Technologies for delivering electrical stimulation are advancing rapidly and vary in specificity, coverage, and invasiveness. Supracortical microstimulation (SCMS), characterized by microelectrode contacts placed on the epidural or subdural cortical surface, achieves a balance between the advantages and limitations of other electrical stimulation technologies by delivering spatially precise activation without disrupting the integrity of the cortex. However, in vivo experiments involving SCMS have not been comprehensively summarized. Here, we review the field of SCMS, focusing on recent advances, to guide the development of clinically translatable supracortical microelectrodes. We also highlight the gaps in our understanding of the biophysical effects of this technology. Future work investigating the unique electrochemical properties of supracortical microelectrodes and validating SCMS in nonhuman primate preclinical studies can enable rapid clinical translation of innovative treatments for humans with neurological disorders.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons Learned and Challenges Ahead in the Translation of Implantable Microscale Sensors and Actuators.

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-02-06 DOI: 10.1146/annurev-bioeng-110122-121128

Jae Young Park, Nikolas Barrera, Tianyu Bai, Ellis Meng, Hui Fang, Hyowon Lee

引用次数: 0

Emerging Technologies for Multiphoton Writing and Reading of Polymeric Architectures for Biomedical Applications.

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-01-28 DOI: 10.1146/annurev-bioeng-110122-015901

Jieliyue Sun, Sixian Jia, Chenhui Shao, Michelle R Dawson, Kimani C Toussaint

{"title":"Emerging Technologies for Multiphoton Writing and Reading of Polymeric Architectures for Biomedical Applications.","authors":"Jieliyue Sun, Sixian Jia, Chenhui Shao, Michelle R Dawson, Kimani C Toussaint","doi":"10.1146/annurev-bioeng-110122-015901","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110122-015901","url":null,"abstract":"The rise in popularity of two-photon polymerization (TPP) as an additive manufacturing technique has impacted many areas of science and engineering, particularly those related to biomedical applications. Compared with other fabrication methods used for biomedical applications, TPP offers 3D, nanometer-scale fabrication dexterity (free-form). Moreover, the existence of turnkey commercial systems has increased accessibility. In this review, we discuss the diversity of biomedical applications that have benefited from the unique features of TPP. We also present the state of the art in approaches for patterning/writing and reading 3D TPP-fabricated structures. The reading process influences the fidelity for both in situ and ex situ characterization methods. We also review efforts to leverage machine learning to facilitate process control for TPP. Finally, we conclude with a discussion of both the current challenges and exciting opportunities for biomedical applications that lie ahead for this intriguing and emerging technology.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designer Organs: Ethical Genetic Modifications in the Era of Machine Perfusion.

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-01-28 DOI: 10.1146/annurev-bioeng-062824-121925

Irina Filz von Reiterdank, Raphaela Bento, Insoo Hyun, Rosario Isasi, Susan M Wolf, J Henk Coert, Aebele B Mink van der Molen, Biju Parekkadan, Korkut Uygun

{"title":"Designer Organs: Ethical Genetic Modifications in the Era of Machine Perfusion.","authors":"Irina Filz von Reiterdank, Raphaela Bento, Insoo Hyun, Rosario Isasi, Susan M Wolf, J Henk Coert, Aebele B Mink van der Molen, Biju Parekkadan, Korkut Uygun","doi":"10.1146/annurev-bioeng-062824-121925","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-062824-121925","url":null,"abstract":"Gene therapy is a rapidly developing field, finally yielding clinical benefits. Genetic engineering of organs for transplantation may soon be an option, thanks to convergence with another breakthrough technology, ex vivo machine perfusion (EVMP). EVMP allows access to the functioning organ for genetic manipulation prior to transplant. EVMP has the potential to enhance genetic engineering efficiency, improve graft survival, and reduce posttransplant complications. This will enable genetic modifications with a vast variety of applications, while raising questions on the ethics and regulation of this emerging technology. This review provides an in-depth discussion of current methodologies for delivering genetic vectors to transplantable organs, particularly focusing on the enabling role of EVMP. Organ-by-organ analysis and key characteristics of various vector and treatment options are assessed. We offer a road map for research and clinical translation, arguing that achieving scientific benchmarks while creating anticipatory governance is necessary to secure societal benefit from this technology.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell-Instructive Biomaterials with Native-Like Biochemical Complexity.

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-01-28 DOI: 10.1146/annurev-bioeng-120823-020209

Tuba Marjan, Nuria Lafuente-Gómez, Akaansha Rampal, David J Mooney, Shelly R Peyton, Taimoor H Qazi

{"title":"Cell-Instructive Biomaterials with Native-Like Biochemical Complexity.","authors":"Tuba Marjan, Nuria Lafuente-Gómez, Akaansha Rampal, David J Mooney, Shelly R Peyton, Taimoor H Qazi","doi":"10.1146/annurev-bioeng-120823-020209","DOIUrl":"10.1146/annurev-bioeng-120823-020209","url":null,"abstract":"Biochemical signals in native tissue microenvironments instruct cell behavior during many biological processes ranging from developmental morphogenesis and tissue regeneration to tumor metastasis and disease progression. The detection and characterization of these signals using spatial and highly resolved quantitative methods have revealed their existence as matricellular proteins in the matrisome, some of which are bound to the extracellular matrix while others are freely diffusing. Including these biochemical signals in engineered biomaterials can impart enhanced functionality and native-like complexity, ultimately benefiting efforts to understand, model, and treat various diseases. In this review, we discuss advances in characterizing, mimicking, and harnessing biochemical signals in developing advanced engineered biomaterials. An overview of the diverse forms in which these biochemical signals exist and their effects on intracellular signal transduction is also provided. Finally, we highlight the application of biochemically complex biomaterials in the three broadly defined areas of tissue regeneration, immunoengineering, and organoid morphogenesis.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0