Annual Review of Biomedical Engineering最新文献

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Supracortical Microstimulation: Advances in Microelectrode Design and In Vivo Validation.
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2025-02-06 DOI: 10.1146/annurev-bioeng-103023-072855
Cecilia Schmitz, J Evan Smith, Iakov Rachinskiy, Bijan Pesaran, Flavia Vitale, Marc Sommer, Jonathan Viventi
{"title":"Supracortical Microstimulation: Advances in Microelectrode Design and In Vivo Validation.","authors":"Cecilia Schmitz, J Evan Smith, Iakov Rachinskiy, Bijan Pesaran, Flavia Vitale, Marc Sommer, Jonathan Viventi","doi":"10.1146/annurev-bioeng-103023-072855","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-103023-072855","url":null,"abstract":"<p><p>Electrical stimulation of the brain is being developed as a treatment for an increasing number of neurological disorders. Technologies for delivering electrical stimulation are advancing rapidly and vary in specificity, coverage, and invasiveness. Supracortical microstimulation (SCMS), characterized by microelectrode contacts placed on the epidural or subdural cortical surface, achieves a balance between the advantages and limitations of other electrical stimulation technologies by delivering spatially precise activation without disrupting the integrity of the cortex. However, in vivo experiments involving SCMS have not been comprehensively summarized. Here, we review the field of SCMS, focusing on recent advances, to guide the development of clinically translatable supracortical microelectrodes. We also highlight the gaps in our understanding of the biophysical effects of this technology. Future work investigating the unique electrochemical properties of supracortical microelectrodes and validating SCMS in nonhuman primate preclinical studies can enable rapid clinical translation of innovative treatments for humans with neurological disorders.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lessons Learned and Challenges Ahead in the Translation of Implantable Microscale Sensors and Actuators.
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2025-02-06 DOI: 10.1146/annurev-bioeng-110122-121128
Jae Young Park, Nikolas Barrera, Tianyu Bai, Ellis Meng, Hui Fang, Hyowon Lee
{"title":"Lessons Learned and Challenges Ahead in the Translation of Implantable Microscale Sensors and Actuators.","authors":"Jae Young Park, Nikolas Barrera, Tianyu Bai, Ellis Meng, Hui Fang, Hyowon Lee","doi":"10.1146/annurev-bioeng-110122-121128","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110122-121128","url":null,"abstract":"<p><p>Microscale sensors and actuators have been widely explored by the scientific community to augment the functionality of conventional medical implants. However, despite the many innovative concepts proposed, a negligible fraction has successfully made the leap from concept to clinical translation. This shortfall is primarily due to the considerable disparity between academic research prototypes and market-ready products. As such, it is critically important to examine the lessons learned in successful commercialization efforts to inform early-stage translational research efforts. Here, we review the regulatory prerequisites for market approval and provide a comprehensive analysis of commercially available microimplants from a device design perspective. Our objective is to illuminate both the technological advances underlying successfully commercialized devices and the key takeaways from the commercialization process, thereby facilitating a smoother pathway from academic research to clinical impact.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Technologies for Multiphoton Writing and Reading of Polymeric Architectures for Biomedical Applications.
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2025-01-28 DOI: 10.1146/annurev-bioeng-110122-015901
Jieliyue Sun, Sixian Jia, Chenhui Shao, Michelle R Dawson, Kimani C Toussaint
{"title":"Emerging Technologies for Multiphoton Writing and Reading of Polymeric Architectures for Biomedical Applications.","authors":"Jieliyue Sun, Sixian Jia, Chenhui Shao, Michelle R Dawson, Kimani C Toussaint","doi":"10.1146/annurev-bioeng-110122-015901","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110122-015901","url":null,"abstract":"<p><p>The rise in popularity of two-photon polymerization (TPP) as an additive manufacturing technique has impacted many areas of science and engineering, particularly those related to biomedical applications. Compared with other fabrication methods used for biomedical applications, TPP offers 3D, nanometer-scale fabrication dexterity (free-form). Moreover, the existence of turnkey commercial systems has increased accessibility. In this review, we discuss the diversity of biomedical applications that have benefited from the unique features of TPP. We also present the state of the art in approaches for patterning/writing and reading 3D TPP-fabricated structures. The reading process influences the fidelity for both in situ and ex situ characterization methods. We also review efforts to leverage machine learning to facilitate process control for TPP. Finally, we conclude with a discussion of both the current challenges and exciting opportunities for biomedical applications that lie ahead for this intriguing and emerging technology.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designer Organs: Ethical Genetic Modifications in the Era of Machine Perfusion.
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2025-01-28 DOI: 10.1146/annurev-bioeng-062824-121925
Irina Filz von Reiterdank, Raphaela Bento, Insoo Hyun, Rosario Isasi, Susan M Wolf, J Henk Coert, Aebele B Mink van der Molen, Biju Parekkadan, Korkut Uygun
{"title":"Designer Organs: Ethical Genetic Modifications in the Era of Machine Perfusion.","authors":"Irina Filz von Reiterdank, Raphaela Bento, Insoo Hyun, Rosario Isasi, Susan M Wolf, J Henk Coert, Aebele B Mink van der Molen, Biju Parekkadan, Korkut Uygun","doi":"10.1146/annurev-bioeng-062824-121925","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-062824-121925","url":null,"abstract":"<p><p>Gene therapy is a rapidly developing field, finally yielding clinical benefits. Genetic engineering of organs for transplantation may soon be an option, thanks to convergence with another breakthrough technology, ex vivo machine perfusion (EVMP). EVMP allows access to the functioning organ for genetic manipulation prior to transplant. EVMP has the potential to enhance genetic engineering efficiency, improve graft survival, and reduce posttransplant complications. This will enable genetic modifications with a vast variety of applications, while raising questions on the ethics and regulation of this emerging technology. This review provides an in-depth discussion of current methodologies for delivering genetic vectors to transplantable organs, particularly focusing on the enabling role of EVMP. Organ-by-organ analysis and key characteristics of various vector and treatment options are assessed. We offer a road map for research and clinical translation, arguing that achieving scientific benchmarks while creating anticipatory governance is necessary to secure societal benefit from this technology.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-Instructive Biomaterials with Native-Like Biochemical Complexity.
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2025-01-28 DOI: 10.1146/annurev-bioeng-120823-020209
Tuba Marjan, Nuria Lafuente-Gómez, Akaansha Rampal, David J Mooney, Shelly R Peyton, Taimoor H Qazi
{"title":"Cell-Instructive Biomaterials with Native-Like Biochemical Complexity.","authors":"Tuba Marjan, Nuria Lafuente-Gómez, Akaansha Rampal, David J Mooney, Shelly R Peyton, Taimoor H Qazi","doi":"10.1146/annurev-bioeng-120823-020209","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-120823-020209","url":null,"abstract":"<p><p>Biochemical signals in native tissue microenvironments instruct cell behavior during many biological processes ranging from developmental morphogenesis and tissue regeneration to tumor metastasis and disease progression. The detection and characterization of these signals using spatial and highly resolved quantitative methods have revealed their existence as matricellular proteins in the matrisome, some of which are bound to the extracellular matrix while others are freely diffusing. Including these biochemical signals in engineered biomaterials can impart enhanced functionality and native-like complexity, ultimately benefiting efforts to understand, model, and treat various diseases. In this review, we discuss advances in characterizing, mimicking, and harnessing biochemical signals in developing advanced engineered biomaterials. An overview of the diverse forms in which these biochemical signals exist and their effects on intracellular signal transduction is also provided. Finally, we highlight the application of biochemically complex biomaterials in the three broadly defined areas of tissue regeneration, immunoengineering, and organoid morphogenesis.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the Lymphatic System: Tissue-on-Chip Modeling.
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2025-01-22 DOI: 10.1146/annurev-bioeng-110222-100246
William J Polacheck, J Brandon Dixon, Wen Yih Aw
{"title":"Understanding the Lymphatic System: Tissue-on-Chip Modeling.","authors":"William J Polacheck, J Brandon Dixon, Wen Yih Aw","doi":"10.1146/annurev-bioeng-110222-100246","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110222-100246","url":null,"abstract":"<p><p>The lymphatic vasculature plays critical roles in maintaining fluid homeostasis, transporting lipid, and facilitating immune surveillance. A growing body of work has identified lymphatic dysfunction as contributing to the severity of myriad diseases and to systemic inflammation, as well as modulating drug responses. Here, we review efforts to reconstruct lymphatic vessels in vitro toward establishing humanized, functional models to advance understanding of lymphatic biology and pathophysiology. We first review lymphatic endothelial cell biology and the biophysical lymphatic microenvironment, with a focus on features that are unique to the lymphatics and that have been used as design parameters for lymphatic-on-chip devices. We then discuss the state of the art for recapitulating lymphatic function in vitro, and we acknowledge limitations and challenges to current approaches. Finally, we discuss opportunities and the need for further development of microphysiological lymphatic systems to bridge the gap in model systems between lymphatic cell culture and animal physiology.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurons as Immunomodulators: From Rapid Neural Activity to Prolonged Regulation of Cytokines and Microglia. 神经元作为免疫调节剂:从快速的神经活动到细胞因子和小胶质细胞的长期调节。
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2025-01-13 DOI: 10.1146/annurev-bioeng-110122-120158
Levi B Wood, Annabelle C Singer
{"title":"Neurons as Immunomodulators: From Rapid Neural Activity to Prolonged Regulation of Cytokines and Microglia.","authors":"Levi B Wood, Annabelle C Singer","doi":"10.1146/annurev-bioeng-110122-120158","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110122-120158","url":null,"abstract":"<p><p>Regulation of the brain's neuroimmune system is central to development, normal function, and disease. Neuronal communication to microglia, the primary immune cells of the brain, is well known to involve purinergic signaling mediated via ATP secretion and the cytokine fractalkine. Recent evidence shows that neurons release multiple cytokines beyond fractalkine, yet these are less studied and poorly understood. In contrast to ATP, cytokines are a class of signaling molecule that are much larger, with longer signaling and farther diffusion. We posit that neuron-expressed cytokines are an essential mechanism of neuron-microglia communication that arises as part of both normal learning and memory and in response to tissue pathology. Thus, neurons are underappreciated immunomodulatory cells that express diverse immunomodulatory signals. While neuronally sourced cytokines have been understudied, new technical advances make this a timely topic. The goal of this review is to define what is known about the cytokines expressed from neurons, how they are regulated, and the effects of these cytokines on microglia. We delineate key knowledge gaps and needs for new tools to define and analyze neuronal roles in immunomodulation. Given that cytokines are central regulators of microglial function, a broad new body of work is required to illuminate functional links between these neuronally expressed cytokines and sustained and transient microglial function.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restoring Speech Using Brain-Computer Interfaces. 使用脑机接口恢复语音。
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2025-01-02 DOI: 10.1146/annurev-bioeng-110122-012818
Sergey D Stavisky
{"title":"Restoring Speech Using Brain-Computer Interfaces.","authors":"Sergey D Stavisky","doi":"10.1146/annurev-bioeng-110122-012818","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110122-012818","url":null,"abstract":"<p><p>People who have lost the ability to speak due to neurological injuries would greatly benefit from assistive technology that provides a fast, intuitive, and naturalistic means of communication. This need can be met with brain-computer interfaces (BCIs): medical devices that bypass injured parts of the nervous system and directly transform neural activity into outputs such as text or sound. BCIs for restoring movement and typing have progressed rapidly in recent clinical trials; speech BCIs are the next frontier. This review covers the clinical need for speech BCIs, surveys foundational studies that point to where and how speech can be decoded in the brain, describes recent progress in both discrete and continuous speech decoding and closed-loop speech BCIs, provides metrics for assessing these systems' performance, and highlights key remaining challenges on the road toward clinically useful speech neuroprostheses.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systems Biology of the Cancer Cell. 癌细胞系统生物学
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2024-12-17 DOI: 10.1146/annurev-bioeng-103122-030552
Kevin A Janes, Matthew J Lazzara
{"title":"Systems Biology of the Cancer Cell.","authors":"Kevin A Janes, Matthew J Lazzara","doi":"10.1146/annurev-bioeng-103122-030552","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-103122-030552","url":null,"abstract":"<p><p>Questions in cancer have engaged systems biologists for decades. During that time, the quantity of molecular data has exploded, but the need for abstractions, formal models, and simplifying insights has remained the same. This review brings together classic breakthroughs and recent findings in the field of cancer systems biology, focusing on cancer-cell pathways for tumorigenesis and therapeutic response. Cancer cells mutate and transduce information from their environment to alter gene expression, metabolism, and phenotypic states. Understanding the molecular architectures that make each of these steps possible is a long-term goal of cancer systems biology pursued by iterating between quantitative models and experiments. We argue that such iteration is the best path to deploying targeted therapies intelligently so that each patient receives the maximum benefit for their cancer.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":12.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing Immunomodulatory Polymers for Treatment of Autoimmunity, Allergy, and Transplant Rejection. 利用免疫调节聚合物治疗自身免疫、过敏和移植排斥反应。
IF 12.8 1区 工程技术
Annual Review of Biomedical Engineering Pub Date : 2024-07-01 DOI: 10.1146/annurev-bioeng-110122-014306
Allen B Tu, Gaddam Krishna, Kevin R Smith, Jamal S Lewis
{"title":"Harnessing Immunomodulatory Polymers for Treatment of Autoimmunity, Allergy, and Transplant Rejection.","authors":"Allen B Tu, Gaddam Krishna, Kevin R Smith, Jamal S Lewis","doi":"10.1146/annurev-bioeng-110122-014306","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110122-014306","url":null,"abstract":"<p><p>Autoimmunity, allergy, and transplant rejection are a collection of chronic diseases that are currently incurable, drastically decrease patient quality of life, and consume considerable health care resources. Underlying each of these diseases is a dysregulated immune system that results in the mounting of an inflammatory response against self or an innocuous antigen. As a consequence, afflicted patients are required to adhere to lifelong regimens of multiple immunomodulatory drugs to control disease and reclaim agency. Unfortunately, current immunomodulatory drugs are associated with a myriad of side effects and adverse events, such as increased risk of cancer and increased risk of serious infection, which negatively impacts patient adherence rates and quality of life. The field of immunoengineering is a new discipline that aims to harness endogenous biological pathways to thwart disease and minimize side effects using novel biomaterial-based strategies. We highlight and discuss polymeric micro/nanoparticles with inherent immunomodulatory properties that are currently under investigation in biomaterial-based therapies for treatment of autoimmunity, allergy, and transplant rejection.</p>","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"26 1","pages":"415-440"},"PeriodicalIF":12.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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