Annual Review of Biomedical Engineering最新文献

Supracortical Microstimulation: Advances in Microelectrode Design and In Vivo Validation. 超实用微刺激：微电极设计和体内验证的进展。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-05-01 Epub Date: 2025-02-06 DOI: 10.1146/annurev-bioeng-103023-072855

Cecilia Schmitz, J Evan Smith, Iakov Rachinskiy, Bijan Pesaran, Flavia Vitale, Marc Sommer, Jonathan Viventi

{"title":"Supracortical Microstimulation: Advances in Microelectrode Design and In Vivo Validation.","authors":"Cecilia Schmitz, J Evan Smith, Iakov Rachinskiy, Bijan Pesaran, Flavia Vitale, Marc Sommer, Jonathan Viventi","doi":"10.1146/annurev-bioeng-103023-072855","DOIUrl":"10.1146/annurev-bioeng-103023-072855","url":null,"abstract":"Electrical stimulation of the brain is being developed as a treatment for an increasing number of neurological disorders. Technologies for delivering electrical stimulation are advancing rapidly and vary in specificity, coverage, and invasiveness. Supracortical microstimulation (SCMS), characterized by microelectrode contacts placed on the epidural or subdural cortical surface, achieves a balance between the advantages and limitations of other electrical stimulation technologies by delivering spatially precise activation without disrupting the integrity of the cortex. However, in vivo experiments involving SCMS have not been comprehensively summarized. Here, we review the field of SCMS, focusing on recent advances, to guide the development of clinically translatable supracortical microelectrodes. We also highlight the gaps in our understanding of the biophysical effects of this technology. Future work investigating the unique electrochemical properties of supracortical microelectrodes and validating SCMS in nonhuman primate preclinical studies can enable rapid clinical translation of innovative treatments for humans with neurological disorders.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":"235-254"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Organoids as an Emerging Tool for Genome Screenings. 人类类器官作为基因组筛选的新兴工具。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-05-01 DOI: 10.1146/annurev-bioeng-103023-122327

Francesco Andreatta, Delilah Hendriks, Benedetta Artegiani

{"title":"Human Organoids as an Emerging Tool for Genome Screenings.","authors":"Francesco Andreatta, Delilah Hendriks, Benedetta Artegiani","doi":"10.1146/annurev-bioeng-103023-122327","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-103023-122327","url":null,"abstract":"Over the last decade, a plethora of organoid models have been generated to recapitulate aspects of human development, disease, tissue homeostasis, and repair. Organoids representing multiple tissues have emerged and are typically categorized based on their origin. Tissue-derived organoids are established directly from tissue-resident stem/progenitor cells of either adult or fetal origin. Starting from pluripotent stem cells (PSCs), PSC-derived organoids instead recapitulate the developmental trajectory of a given organ. Gene editing technologies, particularly the CRISPR-Cas toolbox, have greatly facilitated gene manipulation experiments with considerable ease and scalability, revolutionizing organoid-based human biology research. Here, we review the recent adaptation of CRISPR-based screenings in organoids. We examine the strategies adopted to perform CRISPR screenings in organoids, discuss different screening scopes and readouts, and highlight organoid-specific challenges. We then discuss individual organoid-based genome screening studies that have uncovered novel genes involved in a variety of biological processes. We close by providing an outlook on how widespread adaptation of CRISPR screenings across the organoid field may be achieved, to ultimately leverage our understanding of human biology.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"27 1","pages":"157-183"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurons as Immunomodulators: From Rapid Neural Activity to Prolonged Regulation of Cytokines and Microglia. 神经元作为免疫调节剂：从快速的神经活动到细胞因子和小胶质细胞的长期调节。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-05-01 Epub Date: 2025-01-13 DOI: 10.1146/annurev-bioeng-110122-120158

Levi B Wood, Annabelle C Singer

{"title":"Neurons as Immunomodulators: From Rapid Neural Activity to Prolonged Regulation of Cytokines and Microglia.","authors":"Levi B Wood, Annabelle C Singer","doi":"10.1146/annurev-bioeng-110122-120158","DOIUrl":"10.1146/annurev-bioeng-110122-120158","url":null,"abstract":"Regulation of the brain's neuroimmune system is central to development, normal function, and disease. Neuronal communication to microglia, the primary immune cells of the brain, is well known to involve purinergic signaling mediated via ATP secretion and the cytokine fractalkine. Recent evidence shows that neurons release multiple cytokines beyond fractalkine, yet these are less studied and poorly understood. In contrast to ATP, cytokines are a class of signaling molecule that are much larger, with longer signaling and farther diffusion. We posit that neuron-expressed cytokines are an essential mechanism of neuron-microglia communication that arises as part of both normal learning and memory and in response to tissue pathology. Thus, neurons are underappreciated immunomodulatory cells that express diverse immunomodulatory signals. While neuronally sourced cytokines have been understudied, new technical advances make this a timely topic. The goal of this review is to define what is known about the cytokines expressed from neurons, how they are regulated, and the effects of these cytokines on microglia. We delineate key knowledge gaps and needs for new tools to define and analyze neuronal roles in immunomodulation. Given that cytokines are central regulators of microglial function, a broad new body of work is required to illuminate functional links between these neuronally expressed cytokines and sustained and transient microglial function.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":"55-72"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Theoretical Approach in Applying High-Frequency Acoustic and Elasticity Microscopy to Assess Cells and Tissues. 应用高频声学和弹性显微镜评估细胞和组织的理论方法。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-05-01 Epub Date: 2025-02-19 DOI: 10.1146/annurev-bioeng-112823-103134

Frank Winterroth, Jing Wang, Onno Wink, Bart Carelsen, Jeremy Dahl, Avnesh S Thakor

{"title":"A Theoretical Approach in Applying High-Frequency Acoustic and Elasticity Microscopy to Assess Cells and Tissues.","authors":"Frank Winterroth, Jing Wang, Onno Wink, Bart Carelsen, Jeremy Dahl, Avnesh S Thakor","doi":"10.1146/annurev-bioeng-112823-103134","DOIUrl":"10.1146/annurev-bioeng-112823-103134","url":null,"abstract":"Medical ultrasound is a diagnostic imaging modality used for visualizing internal organs; the frequencies typically used are 2-10 MHz. Scanning acoustic microscopy (SAM) is a form of ultrasound where frequencies typically exceed 50 MHz. Increasing the acoustic frequency increases the specimen's spatial resolution but reduces the imaging depth. The advantages of using SAM over conventional light and electron microscopy include the ability to image cells and tissues without any preparation that could kill or alter them, providing a more accurate representation of the specimen. After scanning the specimen, acoustic signals are merged into an image on the basis of changes in the impedance mismatch between the immersion fluid and the specimens. The acoustic parameters determining the image quality are absorption and scattering. Surface scans can assess surface characteristics of the specimen. SAM is also capable of elastography, that is, studying elastic properties to discern differences between healthy and affected tissues. SAM has significant potential for detection/analysis in research and clinical studies.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":"283-305"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Hundred Ways to Encode Sound Signals for Cochlear Implants. 为人工耳蜗植入物编码声音信号的一百种方法。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-05-01 DOI: 10.1146/annurev-bioeng-102623-121249

Dietmar M Wohlbauer, Norbert Dillier

{"title":"A Hundred Ways to Encode Sound Signals for Cochlear Implants.","authors":"Dietmar M Wohlbauer, Norbert Dillier","doi":"10.1146/annurev-bioeng-102623-121249","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-102623-121249","url":null,"abstract":"Cochlear implants are the most successful neural prostheses used to restore hearing in severe-to-profound hearing-impaired individuals. The field of cochlear implant coding investigates interdisciplinary approaches to translate acoustic signals into electrical pulses transmitted at the electrode-neuron interface, ranging from signal preprocessing algorithms, enhancement, and feature extraction methodologies to electric signal generation. In the last five decades, numerous coding strategies have been proposed clinically and experimentally. Initially developed to restore speech perception, increasing computational possibilities now allow coding of more complex signals, and new techniques to optimize the transmission of electrical signals are constantly gaining attention. This review provides insights into the history of multichannel coding and presents an extensive list of implemented strategies. The article briefly addresses each method and considers promising future directions of neural prostheses and possible signal processing, with the ultimate goal of providing a current big picture of the large field of cochlear implant coding.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"27 1","pages":"335-369"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microvascularization in 3D Human Engineered Tissue and Organoids. 三维人体工程组织和类器官的微血管化。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-05-01 DOI: 10.1146/annurev-bioeng-103023-115236

Yu Jung Shin, Dina Safina, Ying Zheng, Shulamit Levenberg

{"title":"Microvascularization in 3D Human Engineered Tissue and Organoids.","authors":"Yu Jung Shin, Dina Safina, Ying Zheng, Shulamit Levenberg","doi":"10.1146/annurev-bioeng-103023-115236","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-103023-115236","url":null,"abstract":"The microvasculature, a complex network of small blood vessels, connects systemic circulation with local tissues, facilitating the nutrient and oxygen exchange that is critical for homeostasis and organ function. Engineering these structures is paramount for advancing tissue regeneration, disease modeling, and drug testing. However, replicating the intricate architecture of native vascular systems-characterized by diverse vessel diameters, cellular constituents, and dynamic perfusion capabilities-presents significant challenges. This complexity is compounded by the need to precisely integrate biomechanical, biochemical, and cellular cues. Recent breakthroughs in microfabrication, organoids, bioprinting, organ-on-a-chip platforms, and in vivo vascularization techniques have propelled the field toward faithfully replicating vascular complexity. These innovations not only enhance our understanding of vascular biology but also enable the generation of functional, perfusable tissue constructs. Here, we explore state-of-the-art technologies and strategies in microvascular engineering, emphasizing key advancements and addressing the remaining challenges to developing fully functional vascularized tissues.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"27 1","pages":"473-498"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restoring Speech Using Brain-Computer Interfaces. 使用脑机接口恢复语音。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-05-01 Epub Date: 2025-01-02 DOI: 10.1146/annurev-bioeng-110122-012818

Sergey D Stavisky

引用次数: 0

Emerging Technologies for Multiphoton Writing and Reading of Polymeric Architectures for Biomedical Applications. 用于生物医学应用的聚合物结构的多光子写入和读取的新兴技术。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-05-01 Epub Date: 2025-01-28 DOI: 10.1146/annurev-bioeng-110122-015901

Jieliyue Sun, Sixian Jia, Chenhui Shao, Michelle R Dawson, Kimani C Toussaint

引用次数: 0

Leveraging Preclinical Modeling for Clinical Advancements in Single Ventricle Physiology: Spotlight on the Fontan Circulation. 利用临床前模型促进单心室生理学的临床进展：聚焦于方丹循环。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-05-01 Epub Date: 2025-03-03 DOI: 10.1146/annurev-bioeng-102723-013709

Andreas Escher, Carlos Aguilar Vega, Markus A Horvath, Caglar Ozturk, Ellen T Roche

{"title":"Leveraging Preclinical Modeling for Clinical Advancements in Single Ventricle Physiology: Spotlight on the Fontan Circulation.","authors":"Andreas Escher, Carlos Aguilar Vega, Markus A Horvath, Caglar Ozturk, Ellen T Roche","doi":"10.1146/annurev-bioeng-102723-013709","DOIUrl":"10.1146/annurev-bioeng-102723-013709","url":null,"abstract":"Preclinical modeling of human circulation has been instrumental in advancing cardiovascular medicine. Alongside clinical research, the armamentarium of computational (e.g., lumped parameter or computational fluid dynamics) and experimental (e.g., benchtop or animal) models have substantially enhanced our understanding of risk factors and root causes for circulatory diseases. Recent innovations are further disrupting the boundaries of these preclinical models toward patient-specific simulations, surgical planning, and postoperative outcome prediction. This fast-paced progress empowers preclinical modeling to increasingly delve into the intricacies of single ventricle physiology, a rare and heterogeneous congenital heart disease that remains inadequately understood. Here, we review the current landscape of preclinical modeling (computational and experimental) proposed to advance clinical management of a prominent yet complex subset of single ventricle physiology: patients who have undergone Fontan-type surgical corrections. Further, we explore recent innovations and emerging technologies that are poised to bridge the gap between preclinical Fontan modeling and clinical implementation.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":"449-472"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conformable Piezoelectric Devices and Systems for Advanced Wearable and Implantable Biomedical Applications. 先进可穿戴和植入式生物医学应用的合格压电装置和系统。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2025-05-01 DOI: 10.1146/annurev-bioeng-020524-121438

Jin-Hoon Kim, Hyeokjun Yoon, Shrihari Viswanath, Canan Dagdeviren

{"title":"Conformable Piezoelectric Devices and Systems for Advanced Wearable and Implantable Biomedical Applications.","authors":"Jin-Hoon Kim, Hyeokjun Yoon, Shrihari Viswanath, Canan Dagdeviren","doi":"10.1146/annurev-bioeng-020524-121438","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-020524-121438","url":null,"abstract":"With increasing demands for continuous health monitoring remotely, wearable and implantable devices have attracted considerable interest. To fulfill such demands, novel materials and device structures have been investigated, since commercial biomedical devices are not compatible with flexible and conformable form factors needed for soft tissue monitoring and intervention. Among various materials, piezoelectric materials have been widely adopted for multiple applications including sensing, energy harvesting, neurostimulation, drug delivery, and ultrasound imaging owing to their unique electromechanical conversion properties. In this review, we provide a comprehensive overview of piezoelectric-based wearable and implantable biomedical devices. We first provide the basic principles of piezoelectric devices and device design strategies for wearable and implantable form factors. Then, we discuss various state-of-the-art applications of wearable and implantable piezoelectric devices and their design strategies. Finally, we demonstrate several challenges and outlooks for designing piezoelectric-based conformable biomedical devices.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"27 1","pages":"255-282"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0