Annual Review of Biomedical Engineering最新文献_第10页

Intracranial Pressure and Intracranial Elastance Monitoring in Neurocritical Care. 颅内压和颅内弹性在神经危重症监护中的监测。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 DOI: 10.1146/annurev-bioeng-060418-052257

Thomas Heldt, Tommaso Zoerle, Daniel Teichmann, Nino Stocchetti

引用次数: 34

Exploring Dynamics and Structure of Biomolecules, Cryoprotectants, and Water Using Molecular Dynamics Simulations: Implications for Biostabilization and Biopreservation. 利用分子动力学模拟探索生物分子、冷冻保护剂和水的动力学和结构:对生物稳定和生物保存的影响。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2018-12-10 DOI: 10.1146/annurev-bioeng-060418-052130

Lindong Weng, Shannon L Stott, Mehmet Toner

{"title":"Exploring Dynamics and Structure of Biomolecules, Cryoprotectants, and Water Using Molecular Dynamics Simulations: Implications for Biostabilization and Biopreservation.","authors":"Lindong Weng, Shannon L Stott, Mehmet Toner","doi":"10.1146/annurev-bioeng-060418-052130","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052130","url":null,"abstract":"Successful stabilization and preservation of biological materials often utilize low temperatures and dehydration to arrest molecular motion. Cryoprotectants are routinely employed to help the biological entities survive the physicochemical and mechanical stresses induced by cold or dryness. Molecular interactions between biomolecules, cryoprotectants, and water fundamentally determine the outcomes of preservation. The optimization of assays using the empirical approach is often limited in structural and temporal resolution, whereas classical molecular dynamics simulations can provide a cost-effective glimpse into the atomic-level structure and interaction of individual molecules that dictate macroscopic behavior. Computational research on biomolecules, cryoprotectants, and water has provided invaluable insights into the development of new cryoprotectants and the optimization of preservation methods. We describe the rapidly evolving state of the art of molecular simulations of these complex systems, summarize the molecular-scale protective and stabilizing mechanisms, and discuss the challenges that motivate continued innovation in this field.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"1-31"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36806334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48

A Contemporary Look at Biomechanical Models of Myocardium. 心肌生物力学模型的当代研究。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 DOI: 10.1146/annurev-bioeng-062117-121129

Reza Avazmohammadi, João S Soares, David S Li, Samarth S Raut, Robert C Gorman, Michael S Sacks

{"title":"A Contemporary Look at Biomechanical Models of Myocardium.","authors":"Reza Avazmohammadi, João S Soares, David S Li, Samarth S Raut, Robert C Gorman, Michael S Sacks","doi":"10.1146/annurev-bioeng-062117-121129","DOIUrl":"10.1146/annurev-bioeng-062117-121129","url":null,"abstract":"Understanding and predicting the mechanical behavior of myocardium under healthy and pathophysiological conditions are vital to developing novel cardiac therapies and promoting personalized interventions. Within the past 30 years, various constitutive models have been proposed for the passive mechanical behavior of myocardium. These models cover a broad range of mathematical forms, microstructural observations, and specific test conditions to which they are fitted. We present a critical review of these models, covering both phenomenological and structural approaches, and their relations to the underlying structure and function of myocardium. We further explore the experimental and numerical techniques used to identify the model parameters. Next, we provide a brief overview of continuum-level electromechanical models of myocardium, with a focus on the methods used to integrate the active and passive components of myocardial behavior. We conclude by pointing to future directions in the areas of optimal form as well as new approaches for constitutive modeling of myocardium.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"417-442"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-062117-121129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37309793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Programming Stimuli-Responsive Behavior into Biomaterials. 在生物材料中编程刺激响应行为。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-03-11 DOI: 10.1146/annurev-bioeng-060418-052324

Barry A Badeau, Cole A DeForest

{"title":"Programming Stimuli-Responsive Behavior into Biomaterials.","authors":"Barry A Badeau, Cole A DeForest","doi":"10.1146/annurev-bioeng-060418-052324","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052324","url":null,"abstract":"Stimuli-responsive materials undergo triggered changes when presented with specific environmental cues. These dynamic systems can leverage biological signals found locally within the body as well as exogenous cues administered with spatiotemporal control, providing powerful opportunities in next-generation diagnostics and personalized medicine. Here, we review the synthetic and strategic advances used to impart diverse responsiveness to a wide variety of biomaterials. Categorizing systems on the basis of material type, number of inputs, and response mechanism, we examine past and ongoing efforts toward endowing biomaterials with customizable sensitivity. We draw an analogy to computer science, whereby a stimuli-responsive biomaterial transduces a set of inputs into a functional output as governed by a user-specified logical operator. We discuss Boolean and non-Boolean operations, as well as the various chemical and physical modes of signal transduction. Finally, we examine current limitations and promising directions in the ongoing development of programmable stimuli-responsive biomaterials.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"241-265"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37044538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 76

Digital Manufacturing for Microfluidics. 微流体的数字化制造。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 DOI: 10.1146/annurev-bioeng-092618-020341

Arman Naderi, Nirveek Bhattacharjee, Albert Folch

{"title":"Digital Manufacturing for Microfluidics.","authors":"Arman Naderi, Nirveek Bhattacharjee, Albert Folch","doi":"10.1146/annurev-bioeng-092618-020341","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-092618-020341","url":null,"abstract":"The microfluidics field is at a critical crossroads. The vast majority of microfluidic devices are presently manufactured using micromolding processes that work very well for a reduced set of biocompatible materials, but the time, cost, and design constraints of micromolding hinder the commercialization of many devices. As a result, the dissemination of microfluidic technology-and its impact on society-is in jeopardy. Digital manufacturing (DM) refers to a family of computer-centered processes that integrate digital three-dimensional (3D) designs, automated (additive or subtractive) fabrication, and device testing in order to increase fabrication efficiency. Importantly, DM enables the inexpensive realization of 3D designs that are impossible or very difficult to mold. The adoption of DM by microfluidic engineers has been slow, likely due to concerns over the resolution of the printers and the biocompatibility of the resins. In this article, we review and discuss the various printer types, resolution, biocompatibility issues, DM microfluidic designs, and the bright future ahead for this promising, fertile field.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"325-364"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-092618-020341","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37044839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Frontiers of Medical Robotics: From Concept to Systems to Clinical Translation. 医学机器人的前沿:从概念到系统到临床翻译。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-03-01 DOI: 10.1146/annurev-bioeng-060418-052502

Jocelyne Troccaz, Giulio Dagnino, Guang-Zhong Yang

引用次数: 81

Challenges and Opportunities in the Design of Liver-on-Chip Microdevices. 肝脏片上微器件设计的挑战与机遇。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 DOI: 10.1146/annurev-bioeng-060418-052305

Avner Ehrlich, Daniel Duche, Gladys Ouedraogo, Yaakov Nahmias

{"title":"Challenges and Opportunities in the Design of Liver-on-Chip Microdevices.","authors":"Avner Ehrlich, Daniel Duche, Gladys Ouedraogo, Yaakov Nahmias","doi":"10.1146/annurev-bioeng-060418-052305","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052305","url":null,"abstract":"The liver is the central hub of xenobiotic metabolism and consequently the organ most prone to cosmetic- and drug-induced toxicity. Failure to detect liver toxicity or to assess compound clearance during product development is a major cause of postmarketing product withdrawal, with disastrous clinical and financial consequences. While small animals are still the preferred model in drug development, the recent ban on animal use in the European Union created a pressing need to develop precise and efficient tools to detect human liver toxicity during cosmetic development. This article includes a brief review of liver development, organization, and function and focuses on the state of the art of long-term cell culture, including hepatocyte cell sources, heterotypic cell-cell interactions, oxygen demands, and culture medium formulation. Finally, the article reviews emerging liver-on-chip devices and discusses the advantages and pitfalls of individual designs. The goal of this review is to provide a framework to design liver-on-chip devices and criteria with which to evaluate this emerging technology.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"219-239"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37044836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 66

The Meniscus in Normal and Osteoarthritic Tissues: Facing the Structure Property Challenges and Current Treatment Trends. 正常和骨关节炎组织中的半月板:面临结构特性挑战和当前治疗趋势。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-04-08 DOI: 10.1146/annurev-bioeng-060418-052547

Caroline A Murphy, Atul K Garg, Joana Silva-Correia, Rui L Reis, Joaquim M Oliveira, Maurice N Collins

引用次数: 52

Single-Cell Omics Analyses Enabled by Microchip Technologies. 微芯片技术支持单细胞组学分析。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-03-18 DOI: 10.1146/annurev-bioeng-060418-052538

Yanxiang Deng, Amanda Finck, Rong Fan

{"title":"Single-Cell Omics Analyses Enabled by Microchip Technologies.","authors":"Yanxiang Deng, Amanda Finck, Rong Fan","doi":"10.1146/annurev-bioeng-060418-052538","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052538","url":null,"abstract":"Single-cell omics studies provide unique information regarding cellular heterogeneity at various levels of the molecular biology central dogma. This knowledge facilitates a deeper understanding of how underlying molecular and architectural changes alter cell behavior, development, and disease processes. The emerging microchip-based tools for single-cell omics analysis are enabling the evaluation of cellular omics with high throughput, improved sensitivity, and reduced cost. We review state-of-the-art microchip platforms for profiling genomics, epigenomics, transcriptomics, proteomics, metabolomics, and multi-omics at single-cell resolution. We also discuss the background of and challenges in the analysis of each molecular layer and integration of multiple levels of omics data, as well as how microchip-based methodologies benefit these fields. Additionally, we examine the advantages and limitations of these approaches. Looking forward, we describe additional challenges and future opportunities that will facilitate the improvement and broad adoption of single-cell omics in life science and medicine.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"365-393"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37228165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Biomaterials: Been There, Done That, and Evolving into the Future. 生物材料:去过那里，做过那件事，并进化到未来。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 DOI: 10.1146/annurev-bioeng-062117-120940

Buddy D Ratner

引用次数: 65