Annual Review of Biomedical Engineering最新文献_第10页

Derivation and Differentiation of Human Pluripotent Stem Cells in Microfluidic Devices. 人多能干细胞在微流控装置中的衍生与分化。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2022-04-04 DOI: 10.1146/annurev-bioeng-092021-042744

C. Luni, O. Gagliano, N. Elvassore

{"title":"Derivation and Differentiation of Human Pluripotent Stem Cells in Microfluidic Devices.","authors":"C. Luni, O. Gagliano, N. Elvassore","doi":"10.1146/annurev-bioeng-092021-042744","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-092021-042744","url":null,"abstract":"An integrative approach based on microfluidic design and stem cell biology enables capture of the spatial-temporal environmental evolution underpinning epigenetic remodeling and the morphogenetic process. We examine the body of literature that encompasses microfluidic applications where human induced pluripotent stem cells are derived starting from human somatic cells and where human pluripotent stem cells are differentiated into different cell types. We focus on recent studies where the intrinsic features of microfluidics have been exploited to control the reprogramming and differentiation trajectory at the microscale, including the capability of manipulating the fluid velocity field, mass transport regime, and controllable composition within micro- to nanoliter volumes in space and time. We also discuss studies of emerging microfluidic technologies and applications. Finally, we critically discuss perspectives and challenges in the field and how these could be instrumental for bringing about significant biological advances in the field of stem cell engineering. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 24 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46237375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Cuffless Blood Pressure Measurement. 无袖带血压测量。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2022-04-01 DOI: 10.1146/annurev-bioeng-110220-014644

R. Mukkamala, G. Stergiou, A. Avolio

{"title":"Cuffless Blood Pressure Measurement.","authors":"R. Mukkamala, G. Stergiou, A. Avolio","doi":"10.1146/annurev-bioeng-110220-014644","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-110220-014644","url":null,"abstract":"Cuffless blood pressure (BP) measurement has become a popular field due to clinical need and technological opportunity. However, no method has been broadly accepted hitherto. The objective of this review is to accelerate progress in the development and application of cuffless BP measurement methods. We begin by describing the principles of conventional BP measurement, outstanding hypertension/hypotension problems that could be addressed with cuffless methods, and recent technological advances, including smartphone proliferation and wearable sensing, that are driving the field. We then present all major cuffless methods under investigation, including their current evidence. Our presentation includes calibrated methods (i.e., pulse transit time, pulse wave analysis, and facial video processing) and uncalibrated methods (i.e., cuffless oscillometry, ultrasound, and volume control). The calibrated methods can offer convenience advantages, whereas the uncalibrated methods do not require periodic cuff device usage or demographic inputs. We conclude by summarizing the field and highlighting potentially useful future research directions. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 24 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":9.7,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43701137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Regenerative Approaches for Chronic Wounds. 慢性伤口的再生方法。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2022-02-28 DOI: 10.1146/annurev-bioeng-010220-113008

F. Berthiaume, H. Hsia

{"title":"Regenerative Approaches for Chronic Wounds.","authors":"F. Berthiaume, H. Hsia","doi":"10.1146/annurev-bioeng-010220-113008","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-010220-113008","url":null,"abstract":"Chronic skin wounds are commonly found in older individuals who have impaired circulation due to diabetes or are immobilized due to physical disability. Chronic wounds pose a severe burden to the health-care system and are likely to become increasingly prevalent in aging populations. Various treatment approaches exist to help the healing process, although the healed tissue does not generally recapitulate intact skin but rather forms a scar that has inferior mechanical properties and that lacks appendages such as hair or sweat glands. This article describes new experimental avenues for attempting to improve the regenerative response of skin using biophysical techniques as well as biochemical methods, in some cases by trying to harness the potential of stem cells, either endogenous to the host or provided exogenously, to regenerate the skin. These approaches primarily address the local wound environment and should likely be combined with other modalities to address regional and systemic disease, as well as social determinants of health. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 24 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"1 1","pages":""},"PeriodicalIF":9.7,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42540923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Cell and Tissue Therapy for the Treatment of Chronic Liver Disease. 细胞和组织疗法治疗慢性肝病。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2021-07-13 Epub Date: 2021-05-11 DOI: 10.1146/annurev-bioeng-112619-044026

Yaron Bram, Duc-Huy T Nguyen, Vikas Gupta, Jiwoon Park, Chanel Richardson, Vasuretha Chandar, Robert E Schwartz

{"title":"Cell and Tissue Therapy for the Treatment of Chronic Liver Disease.","authors":"Yaron Bram, Duc-Huy T Nguyen, Vikas Gupta, Jiwoon Park, Chanel Richardson, Vasuretha Chandar, Robert E Schwartz","doi":"10.1146/annurev-bioeng-112619-044026","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-112619-044026","url":null,"abstract":"Liver disease is an important clinical problem, impacting 600 million people worldwide. It is the 11th-leading cause of death in the world. Despite constant improvement in treatment and diagnostics, the aging population and accumulated risk factors led to increased morbidity due to nonalcoholic fatty liver disease and steatohepatitis. Liver transplantation, first established in the 1960s, is the second-most-common solid organ transplantation and is the gold standard for the treatment of liver failure. However, less than 10% of the global need for liver transplantation is met at the current rates of transplantation due to the paucity of available organs. Cell- and tissue-based therapies present an alternative to organ transplantation. This review surveys the approaches and tools that have been developed, discusses the distinctive challenges that exist for cell- and tissue-based therapies, and examines the future directions of regenerative therapies for the treatment of liver disease.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":"517-546"},"PeriodicalIF":9.7,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38970617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Red Blood Cell Hitchhiking: A Novel Approach for Vascular Delivery of Nanocarriers. 红细胞搭便车：纳米载体血管输送的新方法

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2021-07-13 Epub Date: 2021-03-31 DOI: 10.1146/annurev-bioeng-121219-024239

Jacob S Brenner, Samir Mitragotri, Vladimir R Muzykantov

引用次数: 0

In Situ Programming of CAR T Cells. CAR - T细胞的原位编程。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2021-07-13 Epub Date: 2021-04-16 DOI: 10.1146/annurev-bioeng-070620-033348

Neha N Parayath, Matthias T Stephan

引用次数: 21

Biology and Models of the Blood-Brain Barrier. 血脑屏障的生物学和模型。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2021-07-13 DOI: 10.1146/annurev-bioeng-082120-042814

Cynthia Hajal, Baptiste Le Roi, Roger D Kamm, Ben M Maoz

引用次数: 53

Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science. 整合生物材料和基因组编辑方法，推动生物医学科学的发展。

IF 11.5 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2021-07-13 Epub Date: 2021-04-28 DOI: 10.1146/annurev-bioeng-122019-121602

Amr A Abdeen, Brian D Cosgrove, Charles A Gersbach, Krishanu Saha

{"title":"Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science.","authors":"Amr A Abdeen, Brian D Cosgrove, Charles A Gersbach, Krishanu Saha","doi":"10.1146/annurev-bioeng-122019-121602","DOIUrl":"10.1146/annurev-bioeng-122019-121602","url":null,"abstract":"The recent discovery and subsequent development of the CRISPR-Cas9 (clustered regularly interspaced short palindromic repeat-CRISPR-associated protein 9) platform as a precise genome editing tool have transformed biomedicine. As these CRISPR-based tools have matured, multiple stages of the gene editing process and the bioengineering of human cells and tissues have advanced. Here, we highlight recent intersections in the development of biomaterials and genome editing technologies. These intersections include the delivery of macromolecules, where biomaterial platforms have been harnessed to enable nonviral delivery of genome engineering tools to cells and tissues in vivo. Further, engineering native-like biomaterial platforms for cell culture facilitates complex modeling of human development and disease when combined with genome engineering tools. Deeper integration of biomaterial platforms in these fields could play a significant role in enabling new breakthroughs in the application of gene editing for the treatment of human disease.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"23 ","pages":"493-516"},"PeriodicalIF":11.5,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9340769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Aptamer-Based Biosensors for Global Health Applications. 基于适体体的生物传感器在全球健康应用中的最新进展。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2021-07-13 Epub Date: 2021-04-19 DOI: 10.1146/annurev-bioeng-082020-035644

Lia A Stanciu, Qingshan Wei, Amit K Barui, Noor Mohammad

引用次数: 34

Engineering Selectively Targeting Antimicrobial Peptides. 工程选择性靶向抗菌肽。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2021-07-13 Epub Date: 2021-04-14 DOI: 10.1146/annurev-bioeng-010220-095711

Ming Lei, Arul Jayaraman, James A Van Deventer, Kyongbum Lee

{"title":"Engineering Selectively Targeting Antimicrobial Peptides.","authors":"Ming Lei, Arul Jayaraman, James A Van Deventer, Kyongbum Lee","doi":"10.1146/annurev-bioeng-010220-095711","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-010220-095711","url":null,"abstract":"The rise of antibiotic-resistant strains of bacterial pathogens has necessitated the development of new therapeutics. Antimicrobial peptides (AMPs) are a class of compounds with potentially attractive therapeutic properties, including the ability to target specific groups of bacteria. In nature, AMPs exhibit remarkable structural and functional diversity, which may be further enhanced through genetic engineering, high-throughput screening, and chemical modification strategies. In this review, we discuss the molecular mechanisms underlying AMP selectivity and highlight recent computational and experimental efforts to design selectively targeting AMPs. While there has been an extensive effort to find broadly active and highly potent AMPs, it remains challenging to design targeting peptides to discriminate between different bacteria on the basis of physicochemical properties. We also review approaches for measuring AMP activity, point out the challenges faced in assaying for selectivity, and discuss the potential for increasing AMP diversity through chemical modifications.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":" ","pages":"339-357"},"PeriodicalIF":9.7,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017812/pdf/nihms-1789832.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25587872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23