Annual Review of Biomedical Engineering最新文献_第9页

Point-of-Care Devices to Detect Zika and Other Emerging Viruses. 检测寨卡和其他新出现病毒的即时医疗设备。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 DOI: 10.1146/annurev-bioeng-060418-052240

Helena de Puig, Irene Bosch, James J Collins, Lee Gehrke

{"title":"Point-of-Care Devices to Detect Zika and Other Emerging Viruses.","authors":"Helena de Puig, Irene Bosch, James J Collins, Lee Gehrke","doi":"10.1146/annurev-bioeng-060418-052240","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052240","url":null,"abstract":"Rapid diagnostic tests (point-of-care devices) are critical components of informed patient care and public health monitoring (surveillance applications). We propose that among the many rapid diagnostics platforms that have been tested or are in development, lateral flow immunoassays and synthetic biology-based diagnostics (including CRISPR-based diagnostics) represent the best overall options given their ease of use, scalability for manufacturing, sensitivity, and specificity. This review describes the identification of lateral flow immunoassay monoclonal antibody pairs that detect and distinguish between closely related pathogens and that are used in combination with functionalized multicolored nanoparticles and computational methods to deconvolute data. We also highlight the promise of synthetic biology-based diagnostic tests, which use synthetic genetic circuits that activate upon recognition of a pathogen-associated nucleic acid sequence, and discuss how the combined or parallel use of lateral flow immunoassays and synthetic biology tools may represent the future of scalable rapid diagnostics.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"22 ","pages":"371-386"},"PeriodicalIF":9.7,"publicationDate":"2020-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38012711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis. 脑动脉瘤的血流动力学:连接医学成像和生物力学分析。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-03-25 DOI: 10.1146/annurev-bioeng-092419-061429

Vitaliy L Rayz, Aaron A Cohen-Gadol

{"title":"Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis.","authors":"Vitaliy L Rayz, Aaron A Cohen-Gadol","doi":"10.1146/annurev-bioeng-092419-061429","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-092419-061429","url":null,"abstract":"In the last two decades, numerous studies have conducted patient-specific computations of blood flow dynamics in cerebral aneurysms and reported correlations between various hemodynamic metrics and aneurysmal disease progression or treatment outcomes. Nevertheless, intra-aneurysmal flow analysis has not been adopted in current clinical practice, and hemodynamic factors usually are not considered in clinical decision making. This review presents the state of the art in cerebral aneurysm imaging and image-based modeling, discussing the advantages and limitations of each approach and focusing on the translational value of hemodynamic analysis. Combining imaging and modeling data obtained from different flow modalities can improve the accuracy and fidelity of resulting velocity fields and flow-derived factors that are thought to affect aneurysmal disease progression. It is expected that predictive models utilizing hemodynamic factors in combination with patient medical history and morphological data will outperform current risk scores and treatment guidelines. Possible future directions include novel approaches enabling data assimilation and multimodality analysis of cerebral aneurysm hemodynamics.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"22 ","pages":"231-256"},"PeriodicalIF":9.7,"publicationDate":"2020-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-092419-061429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37772538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Three-Dimensional Single-Molecule Localization Microscopy in Whole-Cell and Tissue Specimens. 全细胞和组织标本中的三维单分子定位显微镜。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-04-03 DOI: 10.1146/annurev-bioeng-060418-052203

Sheng Liu, Hyun Huh, Sang-Hyuk Lee, Fang Huang

引用次数: 0

Swine Disease Models for Optimal Vascular Engineering. 最佳血管工程猪疾病模型。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-03-02 DOI: 10.1146/annurev-bioeng-082919-053009

Michael Sturek, Mouhamad Alloosh, Frank W Sellke

引用次数: 11

Polymersomes 多聚体

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-11-19 DOI: 10.1201/9781315152516-26

P. Nair, David Christian, Dennis E. Discher

引用次数: 0

The Biocompatibility Challenges in the Total Artificial Heart Evolution. 全人工心脏进化中的生物相容性挑战。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-02-22 DOI: 10.1146/annurev-bioeng-060418-052432

Eleonora Dal Sasso, Andrea Bagno, Silvia T G Scuri, Gino Gerosa, Laura Iop

{"title":"The Biocompatibility Challenges in the Total Artificial Heart Evolution.","authors":"Eleonora Dal Sasso, Andrea Bagno, Silvia T G Scuri, Gino Gerosa, Laura Iop","doi":"10.1146/annurev-bioeng-060418-052432","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052432","url":null,"abstract":"There are limited therapeutic options for final treatment of end-stage heart failure. Among them, implantation of a total artificial heart (TAH) is an acceptable strategy when suitable donors are not available. TAH development began in the 1930s, followed by a dramatic evolution of the actuation mechanisms operating the mechanical pumps. Nevertheless, the performance of TAHs has not yet been optimized, mainly because of the low biocompatibility of the blood-contacting surfaces. Low hemocompatibility, calcification, and sensitivity to infections seriously affect the success of TAHs. These unsolved issues have led to the withdrawal of many prototypes during preclinical phases of testing. This review offers a comprehensive analysis of the pathophysiological events that may occur in the materials that compose TAHs developed to date. In addition, this review illustrates bioengineering strategies to prevent these events and describes the most significant steps toward the achievement of a fully biocompatible TAH.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"85-110"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36991100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Current and Future Considerations in the Use of Mechanical Circulatory Support Devices: An Update, 2008-2018. 机械循环支撑装置使用的当前和未来考虑:更新，2008-2018。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 DOI: 10.1146/annurev-bioeng-062117-121120

Marc A Simon, Timothy N Bachman, John Watson, J Timothy Baldwin, William R Wagner, Harvey S Borovetz

{"title":"Current and Future Considerations in the Use of Mechanical Circulatory Support Devices: An Update, 2008-2018.","authors":"Marc A Simon, Timothy N Bachman, John Watson, J Timothy Baldwin, William R Wagner, Harvey S Borovetz","doi":"10.1146/annurev-bioeng-062117-121120","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-062117-121120","url":null,"abstract":"Our review in the 2008 volume of this journal detailed the use of mechanical circulatory support (MCS) for treatment of heart failure (HF). MCS initially utilized bladder-based blood pumps generating pulsatile flow; these pulsatile flow pumps have been supplanted by rotary blood pumps, in which cardiac support is generated via the high-speed rotation of computationally designed blading. Different rotary pump designs have been evaluated for their safety, performance, and efficacy in clinical trials both in the United States and internationally. The reduced size of the rotary pump designs has prompted research and development toward the design of MCS suitable for infants and children. The past decade has witnessed efforts focused on tissue engineering-based therapies for the treatment of HF. This review explores the current state and future opportunities of cardiac support therapies within our larger understanding of the treatment options for HF.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"33-60"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-062117-121120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37309794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Controlling Matter at the Molecular Scale with DNA Circuits. 用DNA电路在分子尺度上控制物质。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 DOI: 10.1146/annurev-bioeng-060418-052357

Dominic Scalise, Rebecca Schulman

{"title":"Controlling Matter at the Molecular Scale with DNA Circuits.","authors":"Dominic Scalise, Rebecca Schulman","doi":"10.1146/annurev-bioeng-060418-052357","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052357","url":null,"abstract":"In recent years, a diverse set of mechanisms have been developed that allow DNA strands with specific sequences to sense information in their environment and to control material assembly, disassembly, and reconfiguration. These sequences could serve as the inputs and outputs for DNA computing circuits, enabling DNA circuits to act as chemical information processors to program complex behavior in chemical and material systems. This review describes processes that can be sensed and controlled within such a paradigm. Specifically, there are interfaces that can release strands of DNA in response to chemical signals, wavelengths of light, pH, or electrical signals, as well as DNA strands that can direct the self-assembly and dynamic reconfiguration of DNA nanostructures, regulate particle assemblies, control encapsulation, and manipulate materials including DNA crystals, hydrogels, and vesicles. These interfaces have the potential to enable chemical circuits to exert algorithmic control over responsive materials, which may ultimately lead to the development of materials that grow, heal, and interact dynamically with their environments.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"469-493"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37044838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Frontiers in Cryo Electron Microscopy of Complex Macromolecular Assemblies. 复杂大分子组装体的低温电子显微镜研究前沿。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-03-20 DOI: 10.1146/annurev-bioeng-060418-052453

Jana Ognjenović, Reinhard Grisshammer, Sriram Subramaniam

{"title":"Frontiers in Cryo Electron Microscopy of Complex Macromolecular Assemblies.","authors":"Jana Ognjenović, Reinhard Grisshammer, Sriram Subramaniam","doi":"10.1146/annurev-bioeng-060418-052453","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052453","url":null,"abstract":"In recent years, cryo electron microscopy (cryo-EM) technology has been transformed with the development of better instrumentation, direct electron detectors, improved methods for specimen preparation, and improved software for data analysis. Analyses using single-particle cryo-EM methods have enabled determination of structures of proteins with sizes smaller than 100 kDa and resolutions of ∼2 Å in some cases. The use of electron tomography combined with subvolume averaging is beginning to allow the visualization of macromolecular complexes in their native environment in unprecedented detail. As a result of these advances, solutions to many intractable challenges in structural and cell biology, such as analysis of highly dynamic soluble and membrane-embedded protein complexes or partially ordered protein aggregates, are now within reach. Recent reports of structural studies of G protein-coupled receptors, spliceosomes, and fibrillar specimens illustrate the progress that has been made using cryo-EM methods, and are the main focus of this review.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"395-415"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37075511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Prevention of Opioid Abuse and Treatment of Opioid Addiction: Current Status and Future Possibilities. 预防阿片类药物滥用和治疗阿片类药物成瘾:现状和未来的可能性。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-02-20 DOI: 10.1146/annurev-bioeng-060418-052155

Kinam Park, Andrew Otte

引用次数: 19