Annual Review of Biomedical Engineering最新文献_第9页

Digital Manufacturing for Microfluidics. 微流体的数字化制造。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 DOI: 10.1146/annurev-bioeng-092618-020341

Arman Naderi, Nirveek Bhattacharjee, Albert Folch

{"title":"Digital Manufacturing for Microfluidics.","authors":"Arman Naderi, Nirveek Bhattacharjee, Albert Folch","doi":"10.1146/annurev-bioeng-092618-020341","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-092618-020341","url":null,"abstract":"The microfluidics field is at a critical crossroads. The vast majority of microfluidic devices are presently manufactured using micromolding processes that work very well for a reduced set of biocompatible materials, but the time, cost, and design constraints of micromolding hinder the commercialization of many devices. As a result, the dissemination of microfluidic technology-and its impact on society-is in jeopardy. Digital manufacturing (DM) refers to a family of computer-centered processes that integrate digital three-dimensional (3D) designs, automated (additive or subtractive) fabrication, and device testing in order to increase fabrication efficiency. Importantly, DM enables the inexpensive realization of 3D designs that are impossible or very difficult to mold. The adoption of DM by microfluidic engineers has been slow, likely due to concerns over the resolution of the printers and the biocompatibility of the resins. In this article, we review and discuss the various printer types, resolution, biocompatibility issues, DM microfluidic designs, and the bright future ahead for this promising, fertile field.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"325-364"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-092618-020341","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37044839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Frontiers of Medical Robotics: From Concept to Systems to Clinical Translation. 医学机器人的前沿:从概念到系统到临床翻译。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-03-01 DOI: 10.1146/annurev-bioeng-060418-052502

Jocelyne Troccaz, Giulio Dagnino, Guang-Zhong Yang

引用次数: 81

Challenges and Opportunities in the Design of Liver-on-Chip Microdevices. 肝脏片上微器件设计的挑战与机遇。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 DOI: 10.1146/annurev-bioeng-060418-052305

Avner Ehrlich, Daniel Duche, Gladys Ouedraogo, Yaakov Nahmias

{"title":"Challenges and Opportunities in the Design of Liver-on-Chip Microdevices.","authors":"Avner Ehrlich, Daniel Duche, Gladys Ouedraogo, Yaakov Nahmias","doi":"10.1146/annurev-bioeng-060418-052305","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052305","url":null,"abstract":"The liver is the central hub of xenobiotic metabolism and consequently the organ most prone to cosmetic- and drug-induced toxicity. Failure to detect liver toxicity or to assess compound clearance during product development is a major cause of postmarketing product withdrawal, with disastrous clinical and financial consequences. While small animals are still the preferred model in drug development, the recent ban on animal use in the European Union created a pressing need to develop precise and efficient tools to detect human liver toxicity during cosmetic development. This article includes a brief review of liver development, organization, and function and focuses on the state of the art of long-term cell culture, including hepatocyte cell sources, heterotypic cell-cell interactions, oxygen demands, and culture medium formulation. Finally, the article reviews emerging liver-on-chip devices and discusses the advantages and pitfalls of individual designs. The goal of this review is to provide a framework to design liver-on-chip devices and criteria with which to evaluate this emerging technology.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"219-239"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37044836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 66

The Meniscus in Normal and Osteoarthritic Tissues: Facing the Structure Property Challenges and Current Treatment Trends. 正常和骨关节炎组织中的半月板:面临结构特性挑战和当前治疗趋势。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-04-08 DOI: 10.1146/annurev-bioeng-060418-052547

Caroline A Murphy, Atul K Garg, Joana Silva-Correia, Rui L Reis, Joaquim M Oliveira, Maurice N Collins

引用次数: 52

Single-Cell Omics Analyses Enabled by Microchip Technologies. 微芯片技术支持单细胞组学分析。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-03-18 DOI: 10.1146/annurev-bioeng-060418-052538

Yanxiang Deng, Amanda Finck, Rong Fan

{"title":"Single-Cell Omics Analyses Enabled by Microchip Technologies.","authors":"Yanxiang Deng, Amanda Finck, Rong Fan","doi":"10.1146/annurev-bioeng-060418-052538","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052538","url":null,"abstract":"Single-cell omics studies provide unique information regarding cellular heterogeneity at various levels of the molecular biology central dogma. This knowledge facilitates a deeper understanding of how underlying molecular and architectural changes alter cell behavior, development, and disease processes. The emerging microchip-based tools for single-cell omics analysis are enabling the evaluation of cellular omics with high throughput, improved sensitivity, and reduced cost. We review state-of-the-art microchip platforms for profiling genomics, epigenomics, transcriptomics, proteomics, metabolomics, and multi-omics at single-cell resolution. We also discuss the background of and challenges in the analysis of each molecular layer and integration of multiple levels of omics data, as well as how microchip-based methodologies benefit these fields. Additionally, we examine the advantages and limitations of these approaches. Looking forward, we describe additional challenges and future opportunities that will facilitate the improvement and broad adoption of single-cell omics in life science and medicine.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"365-393"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37228165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Biomaterials: Been There, Done That, and Evolving into the Future. 生物材料:去过那里，做过那件事，并进化到未来。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 DOI: 10.1146/annurev-bioeng-062117-120940

Buddy D Ratner

引用次数: 65

Hydrogel-Based Strategies to Advance Therapies for Chronic Skin Wounds. 基于水凝胶的策略推进慢性皮肤伤口的治疗。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-03-01 DOI: 10.1146/annurev-bioeng-060418-052422

Lucília P da Silva, Rui L Reis, Vitor M Correlo, Alexandra P Marques

{"title":"Hydrogel-Based Strategies to Advance Therapies for Chronic Skin Wounds.","authors":"Lucília P da Silva, Rui L Reis, Vitor M Correlo, Alexandra P Marques","doi":"10.1146/annurev-bioeng-060418-052422","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052422","url":null,"abstract":"Chronic skin wounds are the leading cause of nontraumatic foot amputations worldwide and present a significant risk of morbidity and mortality due to the lack of efficient therapies. The intrinsic characteristics of hydrogels allow them to benefit cutaneous healing essentially by supporting a moist environment. This property has long been explored in wound management to aid in autolytic debridement. However, chronic wounds require additional therapeutic features that can be provided by a combination of hydrogels with biochemical mediators or cells, promoting faster and better healing. We survey hydrogel-based approaches with potential to improve the healing of chronic wounds by reviewing their effects as observed in preclinical models. Topics covered include strategies to ablate infection and resolve inflammation, the delivery of bioactive agents to accelerate healing, and tissue engineering approaches for skin regeneration. The article concludes by considering the relevance of treating chronic skin wounds using hydrogel-based strategies.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"145-169"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052422","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37012994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 100

Human Positron Emission Tomography Neuroimaging. 人体正电子发射断层扫描神经成像。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 DOI: 10.1146/annurev-bioeng-062117-121056

Jacob M Hooker, Richard E Carson

引用次数: 35

The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease. 驱动力：细胞功能、命运和疾病中的核机制传导。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-03-27 DOI: 10.1146/annurev-bioeng-060418-052139

Melanie Maurer, Jan Lammerding

{"title":"The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease.","authors":"Melanie Maurer, Jan Lammerding","doi":"10.1146/annurev-bioeng-060418-052139","DOIUrl":"10.1146/annurev-bioeng-060418-052139","url":null,"abstract":"Cellular behavior is continuously affected by microenvironmental forces through the process of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical responses. Mounting evidence suggests that the nucleus itself is a mechanoresponsive element, reacting to cytoskeletal forces and mediating downstream biochemical responses. The nucleus responds through a host of mechanisms, including partial unfolding, conformational changes, and phosphorylation of nuclear envelope proteins; modulation of nuclear import/export; and altered chromatin organization, resulting in transcriptional changes. It is unclear which of these events present direct mechanotransduction processes and which are downstream of other mechanotransduction pathways. We critically review and discuss the current evidence for nuclear mechanotransduction, particularly in the context of stem cell fate, a largely unexplored topic, and in disease, where an improved understanding of nuclear mechanotransduction is beginning to open new treatment avenues. Finally, we discuss innovative technological developments that will allow outstanding questions in the rapidly growing field of nuclear mechanotransduction to be answered.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"443-468"},"PeriodicalIF":12.8,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815102/pdf/nihms-1053593.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37095011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin-Mountable Biosensors and Therapeutics: A Review. 皮肤贴装式生物传感器及其治疗方法综述。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2019-06-04 Epub Date: 2019-03-18 DOI: 10.1146/annurev-bioeng-060418-052315

Eun Kwang Lee, Min Ku Kim, Chi Hwan Lee

{"title":"Skin-Mountable Biosensors and Therapeutics: A Review.","authors":"Eun Kwang Lee, Min Ku Kim, Chi Hwan Lee","doi":"10.1146/annurev-bioeng-060418-052315","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-060418-052315","url":null,"abstract":"Miniaturization of electronic components and advances in flexible and stretchable materials have stimulated the development of wearable health care systems that can reflect and monitor personal health status by health care professionals. New skin-mountable devices that offer seamless contact onto the human skin, even under large deformations by natural motions of the wearer, provide a route for both high-fidelity monitoring and patient-controlled therapy. This article provides an overview of several important aspects of skin-mountable devices and their applications in many medical settings and clinical practices. We comprehensively describe various transdermal sensors and therapeutic systems that are capable of detecting physical, electrophysiological, and electrochemical responses and/or providing electrical and thermal therapies and drug delivery services, and we discuss the current challenges, opportunities, and future perspectives in the field. Finally, we present ways to protect the embedded electronic components of skin-mountable devices from the environment by use of mechanically soft packaging materials.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"21 ","pages":"299-323"},"PeriodicalIF":9.7,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-060418-052315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37228168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39