Annual Review of Biomedical Engineering最新文献_第8页

Computer-Aided Design of Microfluidic Circuits. 微流体电路的计算机辅助设计。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-04-28 DOI: 10.1146/annurev-bioeng-082219-033358

Elishai Ezra Tsur

引用次数: 14

Micromechanobiology: Focusing on the Cardiac Cell-Substrate Interface. 微力学生物学:聚焦于心脏细胞-基质界面。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 DOI: 10.1146/annurev-bioeng-092019-034950

Erica A Castillo, Kerry V Lane, Beth L Pruitt

{"title":"Micromechanobiology: Focusing on the Cardiac Cell-Substrate Interface.","authors":"Erica A Castillo, Kerry V Lane, Beth L Pruitt","doi":"10.1146/annurev-bioeng-092019-034950","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-092019-034950","url":null,"abstract":"Engineered, in vitro cardiac cell and tissue systems provide test beds for the study of cardiac development, cellular disease processes, and drug responses in a dish. Much effort has focused on improving the structure and function of engineered cardiomyocytes and heart tissues. However, these parameters depend critically on signaling through the cellular microenvironment in terms of ligand composition, matrix stiffness, and substrate mechanical properties-that is, matrix micromechanobiology. To facilitate improvements to in vitro microenvironment design, we review how cardiomyocytes and their microenvironment change during development and disease in terms of integrin expression and extracellular matrix (ECM) composition. We also discuss strategies used to bind proteins to common mechanobiology platforms and describe important differences in binding strength to the substrate. Finally, we review example biomaterial approaches designed to support and probe cell-ECM interactions of cardiomyocytes in vitro, as well as open questions and challenges.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"22 ","pages":"257-284"},"PeriodicalIF":9.7,"publicationDate":"2020-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-092019-034950","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38012712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Mitigating the Consequences of Subconcussive Head Injuries. 减轻头部脑震荡的后果。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-04-29 DOI: 10.1146/annurev-bioeng-091219-053447

Eric A Nauman, Thomas M Talavage, Paul S Auerbach

{"title":"Mitigating the Consequences of Subconcussive Head Injuries.","authors":"Eric A Nauman, Thomas M Talavage, Paul S Auerbach","doi":"10.1146/annurev-bioeng-091219-053447","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-091219-053447","url":null,"abstract":"Subconcussive head injury represents a pathophysiology that spans the expertise of both clinical neurology and biomechanical engineering. From both viewpoints, the terms injury and damage, presented without qualifiers, are synonymously taken to mean a tissue alteration that may be recoverable. For clinicians, concussion is evolving from a purely clinical diagnosis to one that requires objective measurement, to be achieved by biomedical engineers. Subconcussive injury is defined as subclinical pathophysiology in which underlying cellular- or tissue-level damage (here, to the brain) is not severe enough to present readily observable symptoms. Our concern is not whether an individual has a (clinically diagnosed) concussion, but rather, how much accumulative damage an individual can tolerate before they will experience long-term deficit(s) in neurological health. This concern leads us to look for the history of damage-inducing events, while evaluating multiple approaches for avoiding injury through reduction or prevention of the associated mechanically induced damage.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"22 ","pages":"387-407"},"PeriodicalIF":9.7,"publicationDate":"2020-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-091219-053447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37883522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The New Age of Cell-Free Biology. 无细胞生物学的新时代。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-03-09 DOI: 10.1146/annurev-bioeng-092019-111110

Vincent Noireaux, Allen P Liu

引用次数: 33

Layer-by-Layer Biomaterials for Drug Delivery. 用于给药的逐层生物材料。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-02-21 DOI: 10.1146/annurev-bioeng-060418-052350

Dahlia Alkekhia, Paula T Hammond, Anita Shukla

引用次数: 102

4D Flow with MRI. 4D Flow with MRI。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-03-10 DOI: 10.1146/annurev-bioeng-100219-110055

Gilles Soulat, Patrick McCarthy, Michael Markl

引用次数: 48

Transgenic and Diet-Enhanced Silk Production for Reinforced Biomaterials: A Metamaterial Perspective. 转基因和膳食增强丝生产增强生物材料:一个超材料的观点。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-03-11 DOI: 10.1146/annurev-bioeng-082719-032747

Jung Woo Leem, Malcolm J Fraser, Young L Kim

{"title":"Transgenic and Diet-Enhanced Silk Production for Reinforced Biomaterials: A Metamaterial Perspective.","authors":"Jung Woo Leem, Malcolm J Fraser, Young L Kim","doi":"10.1146/annurev-bioeng-082719-032747","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-082719-032747","url":null,"abstract":"Silk fibers, which are protein-based biopolymers produced by spiders and silkworms, are fascinating biomaterials that have been extensively studied for numerous biomedical applications. Silk fibers often have remarkable physical and biological properties that typical synthetic materials do not exhibit. These attributes have prompted a wide variety of silk research, including genetic engineering, biotechnological synthesis, and bioinspired fiber spinning, to produce silk proteins on a large scale and to further enhance their properties. In this review, we describe the basic properties of spider silk and silkworm silk and the important production methods for silk proteins. We discuss recent advances in reinforced silk using silkworm transgenesis and functional additive diets with a focus on biomedical applications. We also explain that reinforced silk has an analogy with metamaterials such that user-designed atypical responses can be engineered beyond what naturally occurring materials offer. These insights into reinforced silk can guide better engineering of superior synthetic biomaterials and lead to discoveries of unexplored biological and medical applications of silk.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"22 ","pages":"79-102"},"PeriodicalIF":9.7,"publicationDate":"2020-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-082719-032747","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37727746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Elastin-Like Polypeptides for Biomedical Applications. 生物医学应用的类弹性蛋白多肽。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-04-28 DOI: 10.1146/annurev-bioeng-092419-061127

Anastasia K Varanko, Jonathan C Su, Ashutosh Chilkoti

{"title":"Elastin-Like Polypeptides for Biomedical Applications.","authors":"Anastasia K Varanko, Jonathan C Su, Ashutosh Chilkoti","doi":"10.1146/annurev-bioeng-092419-061127","DOIUrl":"https://doi.org/10.1146/annurev-bioeng-092419-061127","url":null,"abstract":"Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties-including lower critical solution temperature phase behavior and minimal immunogenicity-make them attractive materials for a variety of biomedical applications. ELPs also benefit from recombinant synthesis and genetically encoded design; these enable control over the molecular weight and precise incorporation of peptides and pharmacological agents into the sequence. Because their size and sequence are defined, ELPs benefit from exquisite control over their structure and function, qualities that cannot be matched by synthetic polymers. As such, ELPs have been engineered to assemble into unique architectures and display bioactive agents for a variety of applications. This review discusses the design and representative biomedical applications of ELPs, focusing primarily on their use in tissue engineering and drug delivery. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 22 is June 4, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"22 ","pages":"343-369"},"PeriodicalIF":9.7,"publicationDate":"2020-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-bioeng-092419-061127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37880115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 98

Integrated Biophysical Modeling and Image Analysis: Application to Neuro-Oncology. 综合生物物理建模和图像分析：在神经肿瘤学中的应用。

IF 12.8 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 DOI: 10.1146/annurev-bioeng-062117-121105

Andreas Mang, Spyridon Bakas, Shashank Subramanian, Christos Davatzikos, George Biros

{"title":"Integrated Biophysical Modeling and Image Analysis: Application to Neuro-Oncology.","authors":"Andreas Mang, Spyridon Bakas, Shashank Subramanian, Christos Davatzikos, George Biros","doi":"10.1146/annurev-bioeng-062117-121105","DOIUrl":"10.1146/annurev-bioeng-062117-121105","url":null,"abstract":"Central nervous system (CNS) tumors come with vastly heterogeneous histologic, molecular, and radiographic landscapes, rendering their precise characterization challenging. The rapidly growing fields of biophysical modeling and radiomics have shown promise in better characterizing the molecular, spatial, and temporal heterogeneity of tumors. Integrative analysis of CNS tumors, including clinically acquired multi-parametric magnetic resonance imaging (mpMRI) and the inverse problem of calibrating biophysical models to mpMRI data, assists in identifying macroscopic quantifiable tumor patterns of invasion and proliferation, potentially leading to improved (a) detection/segmentation of tumor subregions and (b) computer-aided diagnostic/prognostic/predictive modeling. This article presents a summary of (a) biophysical growth modeling and simulation,(b) inverse problems for model calibration, (c) these models' integration with imaging workflows, and (d) their application to clinically relevant studies. We anticipate that such quantitative integrative analysis may even be beneficial in a future revision of the World Health Organization (WHO) classification for CNS tumors, ultimately improving patient survival prospects.","PeriodicalId":50757,"journal":{"name":"Annual Review of Biomedical Engineering","volume":"22 ","pages":"309-341"},"PeriodicalIF":12.8,"publicationDate":"2020-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520881/pdf/nihms-1631192.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38016228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Approaches for Addressing Opioid Use Disorder in the Community. 解决社区阿片类药物使用障碍的工程方法。

IF 9.7 1区工程技术

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-04-07 DOI: 10.1146/annurev-bioeng-082719-040832

Paul M Griffin

引用次数: 7