Elastin-Like Polypeptides for Biomedical Applications.

IF 12.8 1区工程技术 Q1 ENGINEERING, BIOMEDICAL

Annual Review of Biomedical Engineering Pub Date : 2020-06-04 Epub Date: 2020-04-28 DOI:10.1146/annurev-bioeng-092419-061127

Anastasia K Varanko, Jonathan C Su, Ashutosh Chilkoti

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引用次数: 98

Abstract

Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties-including lower critical solution temperature phase behavior and minimal immunogenicity-make them attractive materials for a variety of biomedical applications. ELPs also benefit from recombinant synthesis and genetically encoded design; these enable control over the molecular weight and precise incorporation of peptides and pharmacological agents into the sequence. Because their size and sequence are defined, ELPs benefit from exquisite control over their structure and function, qualities that cannot be matched by synthetic polymers. As such, ELPs have been engineered to assemble into unique architectures and display bioactive agents for a variety of applications. This review discusses the design and representative biomedical applications of ELPs, focusing primarily on their use in tissue engineering and drug delivery. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 22 is June 4, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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生物医学应用的类弹性蛋白多肽。

弹性蛋白样多肽(ELPs)是来源于人体弹性蛋白的刺激反应性生物聚合物。它们独特的性质——包括较低的临界溶液温度相行为和最小的免疫原性——使它们成为各种生物医学应用的有吸引力的材料。elp还受益于重组合成和基因编码设计;这使得控制分子量和精确结合肽和药理学制剂进入序列。由于它们的大小和序列是确定的，因此elp受益于对其结构和功能的精细控制，而这些特性是合成聚合物无法比拟的。因此，elp已被设计成独特的结构，并显示各种应用的生物活性剂。本文综述了elp的设计和具有代表性的生物医学应用，主要侧重于其在组织工程和药物传递中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Biomedical Engineering 工程技术-工程：生物医学

CiteScore

18.80

自引率

0.00%

发文量

期刊介绍： Since 1999, the Annual Review of Biomedical Engineering has been capturing major advancements in the expansive realm of biomedical engineering. Encompassing biomechanics, biomaterials, computational genomics and proteomics, tissue engineering, biomonitoring, healthcare engineering, drug delivery, bioelectrical engineering, biochemical engineering, and biomedical imaging, the journal remains a vital resource. The current volume has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.